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Relationship between perioperative glycemic control and postoperative infections

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World Journal of Gastroenterology 2009年第33期15卷 4122-4125页

作者： Kazuhiro Hanazaki Hiromichi maeda Takehiro Okabayashi Department of Surgery Kochi Medical SchoolKochi University

Perioperative hyperglycemia in critically ill surgery patients increases the risk of postoperative infection (POI), which is a common, and often costly, surgical complication. Hyperglycemia is associated with abnormalities in leukocyte function, including granulocyte adherence, impaired phagocytosis, delayed chemotaxis, and depressed bactericidal capacity. These leukocyte deficiencies are the cause ofinfection and improve with tight glycemic control, which leads to fewer POIs in critically ill surgical patients. Tight glycemic control, such as intensive insulin therapy, has a risk of hypoglycemia. In addition, the optimal targeted blood glucose range to reduce POI remains unknown. Since 2006, we have investigated tight perioperative blood glucose control using a closed-loop artificial endocrine pancreas system, to reduce POI and to avoid hypoglycemia. In this Topic Highlight, we review the relationship between perioperative glycemic control and POI, including the use of the artificial pancreas.

关键词： Glycemic control Surgical site infection Artificial pancreas Insulin therapy Glucose toxicity

Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging

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Neural Regeneration Research 2020年第1期15卷 25-29页

作者： hiroshi Nakanishi Department of Pharmacology Faculty of Pharmacy Yasuda Women’s University

Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent *** microglia are the main cellular source of interleukin-1βin the *** B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the *** leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial ***,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain *** active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.

关键词： brain aging caspase-1 cathepsin B inflammatory brain diseases interleukin-1β microglia mitochondrial transcription factor A neuroinflammation nuclear factor-κB oxidative stress

BAYESIAN IMAGE SUPERRESOLUTION AND HIDDEN VARIABLE MODELING

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Journal of Systems Science & Complexity 2010年第1期23卷 116-136页

作者： Atsunori KANEMURA Shin-ichi maeda Wataru FUKUDA ShinI SHII Graduate School of Informatics Kyoto University

Superresolution is an image processing technique that estimates an original high-resolutionimage from its low-resolution and degraded *** superresolution tasks,there have beenproblems regarding the computational cost for the estimation of high-dimensional *** are now being overcome by the recent development of fast computers and the developmentof powerful computational techniques such as variational Bayesian *** paper reviewsa Bayesian treatment of the superresolution problem and presents its extensions based on hierarchicalmodeling by employing hidden variables.

关键词： Bayesian estimation hidden variables image superresolution Markov random fields variational estimation.

Cooling Curve's Effect on Hardening Behavior of Steel

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材料热处理学报 2004年第5期25卷 462-464页

作者： Kazuto Fukuhara Shigeru Asada Yoshihiro Tomita Syusaku maeda Nippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka Japan

Quenching Oils are comprised mostly of mineral oil as major component, but mineral oil alone result in lower cooling performance. Therefore, various additives are formulated as required for each particular case. Cooling curves of mineral oil as determined by JIS method can be divided into three stages, vapor film stage, boiling stage and convection stage. And there are many types of additives used for quenching oil, one effective to shorten vapor film stage and another to shift boiling stage toward lower temperature side. As rapid quenching required temperature range for particular steel varies pending on its shape of CCT curve"1, it is possible to provide higher quench hardening performance using quenching oil formulated of adequate additives.

关键词：淬火油冷却效果硬化性能钢

Structural phase transition, precursory electronic anomaly, and strong-coupling superconductivity in quasi-skutterudite (Sr1-xCax)3Ir4Sn13 and Ca3Rh4Sn13

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Chinese Physics B 2018年第7期27卷 163-170页

作者： Jun Luo Jie Yang S maeda Zheng Li Guo-Qing Zheng Institute of Physics Chinese Academy of Sciences and Beijing National Laboratory for Condensed Matter Physics Beijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Okayama University Okayama 700-8530 Japan

The interplay between superconductivity and structural phase transition has attracted enormous interest in recent years. For example, in Fe-pnictide high temperature superconductors, quantum fluctuations in association with structural phase transition have been proposed to lead to many novel physical properties and even the superconductivity itself. Here we report a finding that the quasi-skutterudite superconductors （Sr1-xCax）3Ir4Sn13 （x = 0, 0.5, 1） and Ca3Rh4Snl3 show some unusual properties similar to the Fe-pnictides, through 119Sn nuclear magnetic resonance （NMR） measurements. In （Sr1-xCax）3Ir4Sn13, the NMR linewidth increases below a temperature T＊ that is higher than the structural phase transition temperature Ts. The spin-lattice relaxation rate （1/T1 ） divided by temperature （T）, 1/TI T and the Knight shift K increase with decreasing T down to T＊, but start to decrease below T＊, and followed by more distinct changes at Ts. In contrast, none of the anomalies is observed in Ca3Rh4Sn13 that does not undergo a structural phase transition. The precursory phenomenon above the structural phase transition resembles that occurring in Fe-pnictides. In the superconducting state of Ca3Ir4Sn13, 1/T1 decays as exp（-△/kBT） with a large gap △ = 2.21kBTc, yet without a Hebel-Slichter coherence peak, which indicates strong-coupling superconductivity. Our results provide new insight into the relationship between superconductivity and the electronic-structure change associated with structural phase transition.

关键词： nuclear magnetic resonance antiferromagnetic fluctuation structural phase transition phase diagram

Recent progress of chemotherapy and biomarkers for gastroesophageal cancer

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World Journal of Gastrointestinal Oncology 2019年第7期11卷 518-526页

作者： Osamu maeda Yuichi Ando Department of Clinical Oncology and Chemotherapy Nagoya University Hospital

Key cytotoxic drugs of chemotherapy for gastroesophageal cancer include fluoropyrimidine, platinum, taxanes and irinotecan. Concurrent chemoradiotherapy is one of the main treatment strategies, especially for esophageal cancer. As molecular target agents, the anti-HER2 antibody trastuzumab for HER2-positive gastric cancer and the anti-angiogenesis agent ramucirumab combined with paclitaxel have been proven to improve the survival of gastric cancer patients. Recently, anti-PD-1 antibodies have become available as second- or later-line chemotherapy. Microsatellite instability is also useful as a biomarker to select patients suitable for immunotherapy. Furthermore, genome-wide analysis has improved our understanding of the biological features and molecular mechanisms of gastroesophageal cancer and will provide optimized treatment selection.

关键词： Gastroesophageal cancer Chemotherapy Biomarker HER2

Study and evaluation of a plant form modeling system based on the Lindenmayer system

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 107-114页

作者： Taiyo maeda Yasuhiko Manabe Shigeo Kawata Department of System Engineering Graduate School of Engineering Saitama Institute of Technology 1690 Fusaiji FukayaSaitama 369-0293Japan Department of Electrical and Electronics Engineering National Institute of Technology Numazu CollegeJapan Department of Electrical and Electronic Engineering Graduate School of Engineering Utsunomiya UniversityJapan

In order to evaluate and recognize plant growth automatically based on photos of plants in plant science and engineering,we propose a diagnostic system for plant growth in which simulated plant growth is used as a reference for real growing *** our diagnostic system,we employ the Lindenmayer system[Lecture Notes in Computer Science,15,53–68,1974]to model healthy growing *** the Lindenmayer system plant growth is expressed by string expressions designed as a numerical model for the *** proposal system provides users the string expressions by using image *** users compare with two strings such as DNA sequence genetic code,users obtain developmental change of plat *** results show that our automatic plant diagnostic system is effective in checking actual healthy plant growth,and suggest that the diagnostic system should be useful in large-scale plant factories.

关键词： Plant growth Lindenmayer system string expression for plant modeling

EXPERIMENTAL STUDY AND MODELING OF PRESSURE LOSS FOR FOAM-CUTTINGS MIXTURE FLOW IN HORIZONTAL PIPE

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Journal of Hydrodynamics 2011年第4期23卷 431-438页

作者： AMNA Gumati hiroshi Takahshi Graduate School of Environmental Studies Tohoku University

In this study, we first sought to elucidate foam rheology to describe foam flow behavior, and then to experimentally investigate the pressure losses for both foam and foam-cuttings flow in a horizontal pipe by considering both varied foam qualities of 80%, 85% and 90% and foam velocities. Also, a two-layer numerical model to predict pressure loss was developed based on experimental observations of cuttings behavior. Results show that the foam behaves like a power-law fluid. Furthermore, and the pressure loss significantly increases as foam velocity increases, while the delivered cuttings concentration dramatically decreases. Moreover, results indicate that both the pressure loss and the delivered cuttings concentration increase with foam quality. Comparisons between the experimental results and numerical model predictions show satisfactory agreement.

关键词： foam rheology pressure loss horizontal pipe cuttings concentration two-layer model

Selective CO_(2) reduction into formate using Ln-Ta oxynitrides combined with a binuclear Ru(Ⅱ)complex under visible light

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Journal of Energy Chemistry 2021年第4期30卷 176-182页

作者： Kanemichi Muraoka Miharu Eguchi Osamu Ishitani Francois Chevire Kazuhiko maeda Department of Chemistry School of ScienceTokyo Institute of TechnologyMeguro-ku152-8550 TokyoJapan Japan Society for the Promotion of Science Chiyoda-ku102-0083 TokyoJapan Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan Univ Rennes CNRSISCR-UMR 6226Rennes F-35000France

Hybrid materials constructed from a visible-light-absorbing semiconductor and a functional metal complex have attracted attention as efficient photocatalysts for CO_(2) reduction with high selectivity to a desired *** this work,defect fluorite-type Ln-Ta oxynitrides LnTaO_(x)N_(y)(Ln=Nd,Sm,Gd,Tb,Dy and Ho)were examined as the semiconductor component in a hybrid photocatalyst system combined with known Ag nanoparticle promoter and binuclear ruthenium(Ⅱ)complex(RuRu’).Among the LnTaO_(x)N_(y) examined,TbTaO_(x)N_(y) gave the highest performance for CO_(2) reduction under visible light(k>400 nm),with a Ru Ru0-based turnover number of 18 and high selectivity to formate(>99%).Physicochemical analyses indicated that high crystallinity and more negative conduction band potential of Ln Ta O_(x)N_(y)with the absence of Ln-4 f states in the band gap structure contributed to higher activity of the hybrid photocatalyst.

关键词： Artificial photosynthesis Heterogeneous photocatalysis Mixed anion compounds Solar fuels