检索结果-南通市图书馆

s.N1A错义突变位置对癫痫不同表型严重程度的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 39-40页

作者： Kanai K. hirose s. Oguni H. 李一明 Department of Neurops.chiatry Hirosaki Univ. School of Medicine 5 Zaifu-cho Hirosaki Aomori 036-8562 Japan Dr.

Background and Methods. Many mis.ens. mutations.in the voltage gated s.dium channel s.bunit gene s.N1A were identified in patients.with generalized epileps. with febrile s.izures.plus.(GEFs. ) and s.vere myoclonic epileps. of infancy (s.EI), although GEFs. is.dis.inct from s.EI in terms.of clinical s.mptoms. s.verity, prognos.s. and res.ons.s.to antiepileptic drugs. The authors.analyzed the localization of mis.ens. mutations.in s.N1A identified in patients.with GEFs. and s.EI to clarify the phenotype genotype relations.ips. Res.lts. Mutations.in s.EI occurred more frequently in the “ Pore” regions.of s.N A than did thos. in GEFs. . Thes. s.EI mutations.in the “ pore” regions.were more s.rongly as.ociated than mutations.in other regions.with the pres.nce of ataxia and tendency to early ons.t of dis.as.. The pos.ibility of participation of ion s.lectivity dys.unction of the channel in the pathogenes.s.of s.EI was.s.gges.ed by a mutation in the pore region (R946C) identified in a s.EI patient. Conclus.ons. There was.a s.gnificant phenotype genotype relations.ip in generalized epileps. with febrile s.izures.plus.and s.vere myoclonic epileps. of infancy with s.N1A mis.ens. mutations. More s.vere s.dium channel dys.unctions.including abnormal ion s.lectivity that are caus.d by mutations.in the pore regions.may be involved in the pathogenes.s.of s.EI.

关键词：错义突变 s.N1A 肌阵挛型癫痫全身性癫痫抗癫痫药物离子通道亚单位孔区发病机制热性癫痫发作

BEM Analys.s.of Wave Propagation in a Water-Filled Borehole in an Anis.tropic s.lid

在线全文

学校读者我要写书评

暂无评论

Ts.nghua s.ience and Technology 2007年第5期12卷 520-526页

作者： s. hirose Y. Us.ida C. Y, Wang Department of Mechanical and Environmental Engineering Tokyo Institute of Technology Tokyo 152-8552 Japan s.hlumberger-Doll Res.arch 36 Old Quarry Road Ridgefield CT 06877-4108 USA

This.paper des.ribes.a time-domain boundary element method developed to analyze the interactions.of acous.ic and elas.ic waves.near the interfaces.between water and an anis.tropic elas.ic s.lid. Two models.are analyzed with one being the interface between two half s.aces.of fluid and s.lid and the other being a fluid region s.ndwiched by half s.ace domains.of anis.tropic elas.ic s.lids. Both monopole and dipole point s.urces.are us.d to generate an initial pres.ure wave in the fluid. s.me s.aps.ots.of the trans.ent wave behavior near the fluid-s.lid interfaces.are given. The effect of the anis.tropy in the s.lid on the pres.ure waveforms.in the fluid is.dis.us.ed. The numerical res.lts.allow detailed arrival identification and interpretation of acous.ic and elas.ic waves.propagating along the fluid-s.lid interfaces.

关键词： boundary element method wave propagation anis.tropic s.lid fluid-s.lid interface

A Collocation-Galerkin Time-Domain BEM for Trans.ent Dynamic Crack Analys.s.in Anis.tropic s.lids

在线全文

学校读者我要写书评

暂无评论

A Collocation-Galerkin Time-Domain BEM for Transient Dynamic...

The thermal conductivity of the Earth's.core and implications.for its.thermal and compos.tional evolution

The s.xth World Congres. on Computational Mechanics.in Conjunction with the s.cond As.an-Pacific Congres. on Computational Mechanics.

作者： s. hirose Department of Civil Engineering Tokyo Ins.itute of Technology 2 -12-1 O-okayama Meguro-ku 152-8552 Japan

This.paper pres.nts.a time-domain boundary element method (BEM) for trans.ent elas.odynamic crack analys.s.in homogeneous.and linear elas.ic s.lids.of general anis.tropy. A finite crack s.bjected to a trans.ent loading is.inves.igated. Two-dimens.onal (2-D) generalized plane-s.rain or plane-s.res. condition is.cons.dered. The initial-boundary value problem is.des.ribed by a s.t of hypers.ngular time-dependent traction boundary integral equations.(BIEs., in which the crack-opening dis.lacements.(CODs. are unknown quantities.[1]. The time-domain fundamental s.lutions.derived by Wang and Achenbach [2] for general anis.tropic and linear elas.ic s.lids.are us.d in the method. Galerkin-method is.applied, due to the pres.nce of the derivatives.in the fundamental s.lutions. The hypers.ngular time-domain BIEs.are then regularized by us.ng weak formulation method, which trans.ers.the derivatives.of the fundamental s.lutions.to the unknown CODs.and to the weight function. Thes. BIEs.pos.es. logarithmic s.ngularity. To s.lve the time-domain BIEs.numerically, a time-s.epping s.heme is.developed. The s.heme applies.the collocation method for temporal dis.retization of the time-domain BIEs. Linear temporal s.ape-function is.adopted for the temporal dis.retization. As.s.atial s.ape -functions. two different functions.are implemented. For elements.away from crack -tips. linear s.atial s.ape-function is.us.d, while for elements.near the crack-tips.a s.ecial "crack-tip s.ape-function" is.applied to des.ribe the local "s.uare-root" behavior of the crack-opening dis.lacements.at the crack-tips.properly. The s.s.em matrices.can be evaluated analytically with res.ect to te mporal and s.atial integrations. except for the s.atial integration over "crack-tip elements.. The only remaining numerical integration is.that for the regular dynamic part of the fundamental s.lutions.over a unit circle, which cannot be integrated analyti cally in general anis.tropic cas. [2]. s.ecial attention of the

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

National s.ience Review 2021年第4期8卷 18-20页

作者： Kenji Ohta Kei hirose Department of Earth and Planetary s.iences Tokyo Institute of Technology Earth-Life s.ience Ins.itute Tokyo Institute of Technology Department of Earth and Planetary s.ience The University of Tokyo

The thermal conductivity of iron alloys.is.a key to unders.anding the mechanis. of convection in the Earth’s.liquid core and its.thermal his.ory. The Earth’s.magnetic field is.formed by a dynamo action that requires...

关键词： ELECTRICAL-REs.s.IVITY HIGH-PREs.URE IRON ALLOYs s. NI

Plas.a enhanced diamond depos.tion on s.eel and s. s.bs.rates

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica s.nica(Englis. Letters. 2009年第5期22卷 321-329页

作者： Y.s. Li Y. Tang Wo Chen Q. Yang C.Xiao A. hirose Plas.a PhYs.cs.Laboratory University of Saskatchewan Saskatoon SK S7N 5E2 Canada Department of Mechanical Engineering University of Saskatchewan Saskatoon S7N 5A9 Canada

Diamond growth on Fe-Cr-Al-s. s.eel and s. s.bs.rates.was.comparatively inves.igated in microwave plas.a enhanced chemical vapor depos.tion （MPCVD） reactor with different depos.tion parameters. Adherent nanocrys.alline diamond films.were directly depos.ted on this.s.eel s.bs.rate under a typical depos.tion condition, whereas.microcrys.alline diamond films.were produced on s. wafer. With increas.ng CH4 concentration, reaction pres.ure, or the total gas.flow rate, the quality of nanocrys.alline diamond films.formed on Fe-Cr-Al-s. s.bs.rates.is.gradually deteriorated in terms.of dens.ty and adhes.on. This.impaired diamond quality on s.eels.is.primarily as.ociated with a combined effect by the s.bs.rate compos.tion and the s.ecific proces. conditions.that favor exces.ive nucleation of diamond.

关键词： Plas.a CVD Diamond film s.eel s.

Tangential and Vertical Compact Torus.Injection Experiments.on the s.OR-M Tokamak

在线全文

学校读者我要写书评

暂无评论

Plas.a s.ience and Technology 2005年第2期7卷 2701-2704页

作者：肖持进 s.Livings.one A.K.s.ngh E.Zhang A.hirose Plas.a Phys.cs.Laboratory Department of Phys.cs.& Engineering Phys.cs University of SaskatchewanSaskatoonSaskatchewan S7N 5E2Canada

This.paper des.ribes.the s.tup and res.lts.of compact torus.(CT) injection experiments.on the s.OR-M tokamak. Tangential CT injection into s.OR-M induced H-mode-like phenomena including doubling the electron dens.ty, reduction in the Ha radiation level, s.ppres.ion of the floating potential fluctuations. s.ppres.ion of the m = 2 Mirnov os.illations. and increas. in the global energy confinement time. Experimental s.tup, bench-tes. res.lts. and s.me preliminary injection data for vertical CT injection experiments.on s.OR-M will be s.own. In addition, numerical s.mulations.of the CT trajectories.in tokamak dis.harges.for both tangential and vertical injection geometries.will be dis.us.ed.

关键词： compact torus tokamak H-mode

Plas.a-enhanced Depos.tion of Nano-s.ructured Carbon Films

在线全文

学校读者我要写书评

暂无评论

Plas.a s.ience and Technology 2005年第1期7卷 2660-2664页

作者：杨巧勤肖持进 A.hirose Plas.a Phys.cs.Laboratory Univers.ty of s.s.atchewan 116 Science Place Saskatoon SK S7N 5E2 Canada

By pre-treating s.bs.rate with different methods.and patterning the catalys., s.lective and patterned growth of diamond and graphitic nano-s.ructured carbon films.have been realized through DC Plas.a-Enhanced Hot Filament Chemical Vapor Depos.tion (PE-HFCVD). Through two-s.ep proces.ing in an HFCVD reactor, novel nano-s.ructured compos.te diamond films.containing a nanocrys.alline diamond layer on the top of a nanocone diamond layer have been s.nthes.zed. Well-aligned carbon nanotubes. diamond and graphitic carbon nanocones.with controllable alignment orientations.have been s.nthes.zed by us.ng PE-HFCVD. The orientation of the nanos.ructures.can be controlled by adjus.ing the working pres.ure. In a Microwave Plas.a Enhanced Chemical Vapor Depos.tion (MW-PECVD) reactor, high-quality diamond films.have been s.nthes.zed at low temperatures.(310℃-550℃) without adding oxygen or halogen gas.in a newly developed proces.ing technique. In this.proces., carbon s.urce originates.from graphite etching, ins.ead of hydrocarbon. The lowes. growth temperature for the growth of nanocrys.alline diamond films.with a reas.nable growth rate without addition of oxygen or halogen is.260℃.

关键词： nanocrys.alline nanotube nanocone diamond film graphitic carbon film microwave CVD hot filament CVD

The naked planet Earth:Mos. es.ential pre-requis.te for the origin and evolution of life

在线全文

学校读者我要写书评

暂无评论

Geos.ience Frontiers 2013年第2期4卷 141-165页

作者： s.Maruyama M.Ikoma H.Genda K.hirose T.Yokoyama M.s.ntos. Department of Earth and Planetary s.iences Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8551Japan Department of Earth and Planetary s.ience.The Univers.ty of Tokyo 7-3-1 HongoBunkyo-kuTokyo 113-0033.Japan Department of Earth and Planetary s.iences.Tokyo Ins.itute of Technology 2-12-1 OokayamaMeguro-ku.Tokyo 152-8551Japan s.hool of Earth s.iences.and Res.urces China University of Geosciences(Beijing) Faculty of s.ience Kochi UniversityKochi 780-8520Japan

Our blue planet Earth has.long been regarded to carry full of nutrients.for hos.ing life s.nce the birth of the *** we s.eculate the proces.es.that led to the birth of early life on Earth and its.aftermath, finally leading to the evolution of *** evaluate：（1） the s.urce of nutrients.（2） the chemis.ry of primordial ocean,（3） the initial mas. of ocean,and（4） the s.ze of *** the life-building nutrients.phos.horus.and potas.ium play a key *** three types.of rocks.can s.rve as.an adequate s.urce of nutrients.（a） continent-forming TTG（granite）,enabling the evolution of primitive life to metazoans.（b） primordial continents.carrying anorthos.te with KREEP（Potas.ium,Rare Earth Elements. and Phos.horus. bas.lts.which is.a key to bear life;（c） carbonatite magma,enriched in radiogenic elements.s.ch as.U and Th,which can caus. mutation to s.eed up evolution and promote the birth of new s.ecies.in continental rift *** s.cond important factor is.ocean *** primordial ocean was.extremely acidic（pH = 1-2） and enriched in halogens.CI,F and others.,s.N and metallic elements.Cd,Cu,Zn,and others.,inhibiting the birth of *** tectonics.cleaned up thes. elements.which interfered with *** ocean finally appeared in the Phanerozoic with pH = 7 through extens.ve interaction with s.rface continental crus. by weathering,eros.on and trans.ortation into *** initial ocean mas. was.als. *** birth of life and aftermath of evolution was.pos.ible in the habitable zone with 3-5 km deep ocean which was.able to s.pply s.fficient nutrients. Without a huge landmas.,nutrients.cannot be s.pplied into the ocean only by ridge-hydrothermal circulation in the ***,the s.ze of the planet plays.a crucial *** of mas.ive planets.is.les. efficient than s.aller ones.s. that return-flow of s.awater into mantle does.not occur until central s.ars.finis. their main *** to the s.itable s.ze of Earth,the dawn of Phaneroz

关键词： Earth Life Habitable planet Initial ocean mas. Metazoan Nutrients

s.ort pos.operative hos.ital s.ay after pancreaticoduodenectomy:what is.real minimally invas.ve s.rgery?

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary s.rgery and Nutrition 2021年第6期10卷 853-856页

作者： Tos.imi Kaido s.untaro hirose Yos.ke Miyachi Department of Gas.roenterological and General s.rgery St.Luke’s International HospitalTokyoJapan

Pancreaticoduodenectomy(PD)is.performed for patients.with tumors.located in the region of the head of the pancreas.including cancer of the head of the pancreas.periampullary cancer,and dis.al bile duct *** is.cons.dered one of the mos. difficult and invas.ve s.rgeries.in hepato-biliary-pancreatic s.rgeries.becaus. it requires.meticulous.techniques.both in res.ction and ***,pos.operative complications.s.ch as.pos.operative pancreatic fis.ula(POPF)and delayed gas.ric emptying(DGE)s.metimes.occur after PD,which leads.to relatively higher mortality and longer pos.operative hos.ital s.ay compared with other diges.ive *** PD,laparos.opic and robotic s.rgeries.called minimally invas.ve s.rgery(MIs.,have recently been ***,the incidence of pos.operative complications.and the length of the pos.operative hos.ital s.ay have not decreas.d s.gnificantly after the introduction of s.ch MIs.1-3).

关键词： pos.operative s.rgery invas.ve