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Actuation and blocking force of stacked nanocarbon polymer actuators

International Journal of Smart and Nano Materials 2018年第3期9卷 184-198,I0003页

作者： Ken Mukai Masahiro Yamamura Junko Kamata hirosato monobe Kinji Asaka Inorganic Functional Material Research institute National Institute of Advanced Industrial Science and Technology(AIST)OsakaJapan

We have developed stacked nanocarbon polymer actuators that are composed of several nanocarbon polymer actuator films using nonwoven fabric as insulation *** nonwoven fabric prepared through electrospinning methods has extremely-low-density structures,which do not significantly prevent the motions of each nanocarbon actuator ***,stacking several thin nanocarbon polymer actuators using nonwoven fabric as insulation layers is expected to increase generated force without decreasing the displacement of a one-layer *** have prepared stacked actuators with one,two,three,four,and seven layers using this *** displacement and blocking force of these actuators are measured and compared with those of one-layer actuators of different *** is weakly dependent on the thickness of the actuator films of the stacked *** the contrary,it decreases considerably as the thickness of the actuator film of the one-layer actuator *** both cases,blocking force is proportional to the thickness of actuator *** have developed a stacked actuator model based on a trilayer actuator model and confirmed the experimental results using the model.

关键词： Nanocarbon actuator polymer stacking model

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Synthesis of functionalized triphenylene discotic liquid crystals and the influence of unsaturated periphery on mesomorphism

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Science China Chemistry 2011年第10期54卷 1576-1583页

作者： ZHAO KeQing ZHOU Hui YU WenHao HU Ping WANG BiQin monobe hirosato SHIMIZU Yo College of Chemistry and Materials Science Sichuan Normal University Chengdu 610066 China National Institute of Advanced Industrial Science and Technology Kansai Centre Midorigaoka lkeda Osaka 563-8577 Japan

Twelve triphenylene discogens with unsaturated periphery (abbreviated as C18H6(OC5H11)6-x(OR)x(x=1,2,3), R=-C3H6CH==CH2(a),-C3H6C≡CH(b),-C2H4OCH==CH2(c)) were synthesized and characterized. The thermotropic liquid crystal prop-erties were studied by using polarized optical microscopy, differential scanning calorimetry and X-ray diffractometry. The results showed that all triphenylenes exhibited hexagonal columnar mesophase. The thermotropic studies showed that series a (alkene periphery) exhibited higher clearing points than the corresponding series b (alkyne periphery), while series c (vinyloxy periphery) exhibited highest clearing points and widest mesophase temperature ranges. We also found that the symmetric discogens sym-C18H6(OC5H11)3(OR)3 displayed higher melting points and clearing points than the asymmetric ones asym-C18H6(OC5H11)3(OR)3.

关键词： discotic liquid crystal triphenylene functional periphery hexagonal columnar mesophase mesomorphism engineering

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PROTEOME ANALYSIS OF RICE ROOT PROTEINS REGULATED BY GIBBERELLIN

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Genomics, Proteomics & Bioinformatics 2005年第3期3卷 132-142页

作者： SETSUKO KOMATSU hirosato KONISHI DEPARTMENT OF MOLECULAR GENETICS NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES TSUKUBA 305-8602 JAPAN

To gain an enhanced understanding of the mechanism by which gibberellins （GAs） regulate the growth and development of plants, it is necessary to identify proteins regulated by GA. Proteome analysis techniques have been applied as a direct, effective, and reliable tool in differential protein expressions. In previous studies, sixteen proteins showed differences in accumulation levels as a result of treatment with GA3, uniconazole, or abscisic acid （ABA）, and/or the differences between the GA-deficient semi-dwarf mutant, Tan-ginbozu, and normal cultivars. Among these proteins, aldolase increased in roots treated with GA3, was present at low levels in Tan-ginbozu roots, and decreased in roots treated with uniconazole or ABA. In a root elongation assay, the growth of aldolase-antisense transgenic rice was half of that of vector control transgenic rice. These results indicate that increases in aldolase activity stimulate the glycolytic in the GA-induced growth of roots. In among GA, aldolase, and root growth. pathway and may play an important role this review, we discuss the relationship among GA, aldolase, and root growth.

关键词： aldolase gibberellin proteome rice

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Rupture of a Small Hepatocellular Carcinoma in a Stable Disease State in a Patient Receiving Sorafenib Treatment

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Chinese Medical Journal 2018年第8期131卷 999-1000页

作者： Rumiko Tsuboi Takeharu Asano Katsuhiko Matsuora Shinichi Asabe hirosato Mashima Department of Gastroenterology Saitama Medical Center Jichi Medical University Saitama 330-8503 Japan Department of Radiology Saitama Medical Center Jichi Medical University Saitama 330-8503 Japan

To the Editor： Sorafenib, a multikinase inhibitor of cell proliferation and angiogenesis, is expected to cause intratumoral necrosis and maintain stable disease in hepatocellular carcinoma （HCC）. HCC rupture during treatment of sorafenib is rare？ We describe a male patient who was treated with sorafenib and experienced a comparatively small HCC rupture during a stable disease state.

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Risk factors for postoperative bleeding after gastric endoscopic submucosal dissection in patients under antithrombotics

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World Journal of Gastrointestinal Endoscopy 2016年第7期8卷 349-356页

作者： Yuji Shindo Satohiro Matsumoto Hiroyuki Miyatani Yukio Yoshida hirosato Mashima Department of Gastroenterology Jichi Medical University Saitama Medical Center

AIM: To evaluate the risk factors for postoperative bleeding after gastric endoscopic submucosal dissection(ESD) based on the latest ***: A total of 262 gastric neoplasms were treated by ESD at our center during a 2-year period from October 2012. We analyzed the data of these cases retrospectively to identify the risk factors for postESD ***: Of the 48(18.3%) cases on antithrombotic treatment, 10 were still receiving antiplatelet drugs perioperatively, 13 were on heparin replacement after oral anticoagulant withdrawal, and the antithrombotic therapy was discontinued perioperatively in 25 cases. Postoperative bleeding occurred in 23 cases(8.8%). The postoperative bleeding rate in the heparin replacement group was 61.5%, significantly higher than that in the non-antithrombotic therapy group(6.1%). Univariate analysis identified history of antithrombotic drug use, heparin replacement, hemodialysis, cardiovascular disease, diabetes mellitus, elevated prothrombin timeinternational normalized ratio, and low hemoglobin level on admission as risk factors for post ESD bleeding. Multivariate analysis identified only heparin replacement(OR = 13.7, 95%CI: 1.2-151.3, P = 0.0329) as a significant risk factor for post-ESD ***: Continued administration of antiplatelet agents, based on the guidelines, was not a risk factor for postoperative bleeding after gastric ESD; however, heparin replacement, which is recommended after withdrawal of oral anticoagulants, was identified as a significant risk factor.

关键词： Postoperative bleeding Antithrombotic treatment Gastric neoplasms Endoscopic submucosal dissection

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Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

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Cellular & Molecular Immunology 2010年第3期7卷 227-234页

作者： Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling Department of Neurosurgery XuanWu HospitalCapital University of Medical ScienceBeijingChina Department of Oncology Chinese PLA General HospitalBeijingChina Department of Stem Cell Biology and Regenerative Medicine Graduate School of Medical ScienceKansai Medical UniversityOsakaJapan Department of Blood Transfusion Chinese PLA General HospitalBeijingChina Department of Obstetrics and Gynecology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Biomedical Research Center Division of Analytical ScienceFaculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Anesthesiology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Immunogenetics Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan

Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and ***,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum *** pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 *** current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th *** the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in *** addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 *** exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 *** findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.

关键词： bisphenol A dendritic cells Th1/2 human

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