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Atmospheric and Climate Sciences 2013年第2期3卷 186-192页

作者： hironori sato Toshitaka Suzuki Motohiro Hirabayashi Yoshinori Iizuka Hideaki Motoyama Yoshiyuki Fujii Department of Earth and Environmental Sciences Faculty of Science Yamagata University Yamagata Japan Institute of Low Temperature Science Hokkaido University Sapporo Japan National Institute of Polar Research Tokyo Japan

A quantitative analysis of the total concentrations of Al and Na in the Antarctic ice sheet during the past 340 kyr was performed by applying the acid digestion method to the Dome Fuji ice core. Atmospheric fluxes of mineral and sea-salt aerosol to Dome Fuji were calculated from the total concentration. The average fluxes of mineral aerosol to Dome Fuji in the periods of glacial maximum, 18.6 ± 10.1 mg·m–2·yr–1, were larger than the value in the interglacial periods, 3.77 ± 2.20 mg·m–2·yr–1. Conversely, the fluxes of sea-salt have no significant difference between the average value of glacial maximum, 130 ± 55 mg·m–2·yr–1, and that of interglacial, 111 ± 54 mg·m–2·yr–1. The results obtained in this study suggest that the variation of mineral aerosol flux in Dome Fuji, together with climate change, was much larger than that of sea-salt aerosol flux. This result may have occurred because the variety in the intensity of the source and transport during the glacial-interglacial cycle is more significant for mineral aerosol than that for sea-salt aerosol.

关键词： Ice Core Antarctica Dome Fuji Climate Change Aerosol Flux Full Digestion

Experimental Investigation of Performance of the Wind Turbine with the Flanged-Diffuser Shroud in Sinusoidally Oscillating and Fluctuating Velocity Flows

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Open Journal of Fluid Dynamics 2012年第4期2卷 215-221页

作者： Kazuhiko Toshimitsu hironori Kikugawa Kohei sato Takuya sato Department of Mechanical Engineering Kyushu University Fukuoka Japan Department of Mechanical Engineering Oita National College of Technology Oita Japan

The wind turbine with a flanged-diffuser shroud—so called “wind-lens turbine”—is developed as one of high performance wind turbines by Ohya et al. In this paper, the wind turbine performance is investigated for both steady and unsteady winds. The compact-type wind lens turbine shows higher efficiency than the only rotor wind turbine. Also, the flow structure around the compact-type wind turbine is made clear by CFD and PIV in steady wind. Furthermore, the performances of the only rotor and the compact-type wind-lens turbines for unsteady wind are experimentally and numerically investigated. Experimental and numerical results are presented to demonstrate the dependence of frequency of the harmonic oscillating velocity wind on power coefficient. Consequently, the compact-type wind-lens turbine show better performance than the only rotor one in sinusoidally oscillating velocity wind. Furthermore, the numerical estimation can predict the power coefficient in the oscillating flows to an accuracy of 94% to 102%. In addition, the dependence of the turbine performance on turbulent intensity and vortex scale of natural fluctuating wind is presented.

关键词： Wind Turbine Unsteady Flow Wind Energy Power Coefficients Flanged Diffuser Natural Wind

Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine

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World Journal of Gastroenterology 2005年第7期11卷 1087-1089页

作者： Keijiro Sunada hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano Department of Internal Medicine

AIM:To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine. METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, 3apan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis. RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3 out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm. CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel.

关键词： Double-balloon enteroscopy Strictures Small intestine

Development of an Educational Flow Simulation System

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Development of an Educational Flow Simulation System

Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy

The 10th EPMESC

作者： Tameo Nakanishi hironori Shibata Mutsumi sato Department of Mechanical Systems Engineering Yamagata University Yonezawa 9928510 Japan Department of Mechanical Systems Engineering Yamagata University Yonezawa 9928510 Japan Department of Mechanical Systems Engineering Yamagata University Yonezawa 9928510 Japan

we developed an interactive two-dimensional flow simulation system. The system solves incompressible laminar and turbulent flows around multiple bodies of complex geometry. The system is based on an o

关键词： computational fluid dynamics educational software incompressible flow overset grid method

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World Journal of Gastroenterology 2005年第31期11卷 4861-4864页

作者： Yoshikazu Hayashi hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano Department of Internal Medicine

AIM： To clarify clinical features of the NSAID-induced sma bowel lesions using a new method of endoscopy. METHODS： This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at .lichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient. RESULTS： Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively. The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug. CONCLUSION： NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon.

关键词： Double-balloon endoscopy NSAIDS-inducedsmall bowel injuries

Hematologic toxic inspection of temozolomide

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Hematologic toxic inspection of temozolomide

Indication of repeated surgery for recurrent glioblastoma——using of the NIH Recurrent GBM Scale

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Mitsuteru Oikawa Tamio Ito Kenichi sato Yoshimaru Ozaki hironori Sugio Hirohiko Nakamura Department of Neurosurgery Nakamura Memorial Hospital

＜正＞（Introduction） Although four years has passed after temozolomide started to be sold on the open market, there are a few reports regarding the hematological toxicity of temozolomide in Japan. We have examined f...

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Indication of repeated surgery for recurrent glioblastoma—...

Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Tamio Ito Yoshimaru Ozaki Ken-ichi sato Mitsuteru Oikawa hironori Sugio Hirohiko Nakamura Department of Neurosurgery Brain Tumor Center Nakamura Memorial Hospital

＜正＞[Purpose] Despite initial treatment with surgical resection, radiotherapy, and chemotherapy, glioblastoma （GBM） inevitably always recurs. The surgical

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World Journal of Gastroenterology 2016年第33期22卷 7569-7578页

作者： Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho sato hironori Tsuzura Shunsuke sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Department of Hepatology Shonan-East General Hospital Department of Pathology Juntendo University Shizuoka Hospital Department of Gastroenterology Juntendo University School of Medicine

AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus *** In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank *** Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 *** Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR.

关键词： Human AKR1B10 protein Hepatocellular carcinoma Chronic hepatitis C Immunohistochemistry Risk factor Sustained virological response

A study of the effects of saliva stimulation by nizatidine on dry mouth symptoms of primary biliary cirrhosis

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World Journal of Hepatology 2013年第3期5卷 90-96页

作者： Tetsu Kikuchi Katsuharu Hirano Takuya Genda hironori Tsuzura Shunsuke sato Yoshio Kanemitsu Yutaka Narita Katsuyori Iijima Takafumi Ichida Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital

AIM: To elucidate the effect of saliva stimulation by nizatidine on oral symptoms of primary biliary cirrhosis (PBC) by administering it to PBC cases. METHODS: From among 73 cases that had been definitively diagnosed as PBC at our hospital by February 2010, we selected 27 cases of PBC, 4 males and 23 females, as subjects. We obtained subjects' consent after giving them a full explanation of the administration of nizatidine. Nizatidine 150 mg was administered internally twice daily, after morning and evening meals. To observe changes in the quantity of saliva secreted, chewing gum tests were carried out four times: before the initial dose, and after 6 mo, 12 mo and 24 mo of administration. For subjective dry mouth symptoms, a visual analog scale (VAS) method was used to assess their feelings of oral dryness and eating difficulty, five times: before the initial dose, and after 1, 6, 12 and 24 mo of administration in 8 cases. The nutritional condition and the hepatic functional reserve were compared between before and after the nizatidine ***: The result of a chewing gum test on the subjects before the administration of nizatidine showed that 50% produced less than 10 mL of saliva, i.e. , the standard under which cases are considered to have hyposalivation. The results of these tests showed that the quantity of saliva secreted was 10.5 ± 6.8 mL before administration of nizatidine, 10.9 ± 6.0 mL after 6 mo, 10.6 ± 4.9 mL after 12 mo, and 11.8 ± 6.8 mL after 24 mo administration. Thus, there was a slowly increasing trend in the quantity of saliva in the whole group. The percentage of subjects with saliva production above 10 mL was 45.8% after 6 mo administration of nizatidine, that is, only a slight change from before its administration, but it was 64.3% after 12 mo, that is, a significant increase. The saliva secretion by subject patients was examined before the beginning of administration of nizatidine, 12 mo later, and 24 mo later, and Fisher's combined

关键词： Primary biliary cirrhosis Nizatidine Dry mouth Sicca syndrome Visual analog scale