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Considering FOLFOXIRI plus bevacizumab for metastatic colorectal cancer with left-sided tumors

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 528-531页

作者： Yu Sunakawa hironaga Satake Wataru Ichikawa Department of Clinical Oncology St. Marianna University School of Medicine Kawasaki Kanagawa 216-8511 Japan Cancer Treatment Center Kansai Medical University Hospital Hirakata-city Osaka 573-1191 Japan Division of Medical Oncology Showa University Fujigaoka Hospital Yokohama Kanagawa 227-8501 Japan

A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.

关键词： Tumor sidedness FOLFOXIRI Bevacizumab Colorectal cancer RAS mutation

Feasibility of Outpatient Chemotherapy with S-1 and Cisplatin for Gastric Cancer

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Journal of Cancer Therapy 2014年第8期5卷 759-765页

作者： hironaga Satake Akihito Tsuji Takeshi Kotake Mikio Fujita Department of Oncology Kobe City Medical Center General Hospital Kobe Japan

Objective: To evaluate the feasibility of S-1 and high-dose cisplatin short hydration regimens for outpatients with unresectable metastatic gastric cancer. Methods: Data for individual outpatients treated in our institution were retrospectively pooled to assess the feasibility of an S-1 and highdose cisplatin short hydration regimen (S-1: 80 to 120 mg on Days 1 to 21;cisplatin: 60 mg/m2?on Day 8, every 5 weeks), which included 2250 ml of intravenous fluids and 1000 ml oral hydration. Ten consecutive patients were treated with S-1 and high-dose cisplatin short hydration for unresectable metastatic gastric cancer from July 2011 to May 2012 and were included in the analysis. Results: With a median of 3.5 medication cycles, unscheduled admission occurred in two patients for 5 days each due to paralytic ileus and cerebral infarction. Four patients required dose reduction, in both S-1 and cisplatin in two patients, and in S-1 alone and cisplatin alone in one patient each. Renal function transiently declined after administration of cisplatin, but serum creatinine level and estimated glomerular filtration rate were both improved by the time of the next administration. Conclusion: This study suggests that an S-1 and high-dose cisplatin short hydration strategy for outpatients with unresectable metastatic gastric cancer might be feasible.

关键词： Gastric Cancer Cisplatin S-1 Short Hydration Outpatient Chemotherapy

亲水作用色谱柱与阳离子交换树脂柱结合分离无机离子(英文)

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色谱 2012年第4期30卷 404-408页

作者： Kaori ARAI Masanobu MORI Takahiro hironaga Hideyuki ITABASHI Kazuhiko TANAKA Graduate School of Engineering Gunma University Graduate School for International Development and Cooperation Hiroshima University

A combination of hydrophilic interaction chromatographic(HILIC) column and a weakly acidic cation-exchange resin(WCX) column was used for simultaneous separation of inorganic anions and cations by ion chromatography(IC).Firstly,the capability of HILIC column for the separation of analyte ions was evaluated under acidic eluent *** columns used were SeQuant ZIC-HILIC(ZIC-HILIC) with a sulfobetaine-zwitterion stationary phase(ZIC-HILIC) and Acclaim HILIC-10 with a diol stationary phase(HILIC-10).When using tartaric acid as the eluent,the HILIC columns indicated strong retentions for anions,based on ion-pair ***,HILIC-10 could strongly retain anions compared with *** selectivity for analyte anions of HILIC-10 with 5 mmol/L tartaric acid eluent was in the order of I-> NO-3 > Br-> Cl-> ***,since HILIC-10 could not separate analyte cations,a WCX column(TSKgel Super IC-A/C) was connected after the HILIC column in *** combination column system of HILIC and WCX columns could successfully separate ten ions(Na+,NH+4,K+,Mg2+,Ca2+,H2PO-4,Cl-,Br-,NO-3 and I-) with elution of 4 mmol/L tartaric acid plus 8 mmol/L *** relative standard deviations(RSDs) of analyte ions by the system were in the ranges of 0.02%-0.05% in retention times and 0.18%-5.3% in peak areas through three-time successive *** limits of detection at signal-to-noise ratio of 3 were 0.24-0.30 μmol/L for the cations and 0.31-1.2 μmol/L for the *** system was applied for the simultaneous determination of the cations and the anions in a vegetable juice sample with satisfactory results.

关键词： ion chromatography(IC) hydrophilic interaction chromatography(HILIC) cation-exchange inorganic ions vegetable sample

强碱阴离子交换树脂及碱性洗脱剂的离子排阻/阴离子交换色谱法同时测定NH_4^+，NO_2^-和NO_3^-(英文)

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色谱 2012年第4期30卷 356-360页

作者： Masanobu MORI Takahiro hironaga Hideyuki ITABASHI Nobutake NAKATANI Daisuke KOZAKI Kazuhiko TANAKA Graduate School of Engineering Gunma University Rakuno Gakuen University Bunkyodai Graduate School for International Development and Cooperation Hiroshima University

Ion-exclusion/anion-exchange chromatography(IEC/AEC) on a combination of a strongly basic anion-exchange resin in the OH——form with basic eluent has been *** separation mechanism is based on the ion-exclusion/penetration effect for cations and the anion-exchange effect for anions to anion-exchange resin *** system is useful for simultaneous separation and determination of ammonium ion(NH+4),nitrite ion(NO-2),and nitrate ion(NO-3) in water *** resolution of analyte ions can be manipulated by changing the concentration of base in eluent on a polystyrene-divinylbenzene based strongly basic anion-exchange resin *** this study,several separation columns,which consisted of different particle sizes,different functional groups and different anion-exchange capacities,were *** the results,the separation column with the smaller anion-exchange capacity(TSKgel Super IC-Anion) showed well-resolved separation of cations and *** the optimization of the basic eluent,lithium hydroxide(LiOH) was used as the eluent and the optimal concentration was concluded to be 2 mmol/L,considering the resolution of analyte ions and the whole retention *** the optimal conditions,the relative standard deviations of the peak areas and the retention times of NH+4,NO-2,and NO-3 ranged 1.28%-3.57% and 0.54%-1.55%,*** limits of detection at signal-to-noise of 3 were 4.10 μmol/L for NH+4,1.87 μmol/L for NO-2 and 2.83 μmol/L for NO-3.

关键词： ion-exclusion chromatography(IEC) anion-exchange chromatography(AEC) inorganic ions ammonium ion nitrite ion nitrate ion

The Outcome of Treatment for Patients with Borrmann Type 4 Advanced Gastric Cancer

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Journal of Cancer Therapy 2016年第12期7卷 953-962页

作者： Rie Tamaki Fumio Amano Tohru Hashida hironaga Satake Hisateru Yasui Akihito Tsuji Clinical Trial Management Center Kobe City Medical Center General Hospital Kobe Japan Laboratory of Biodefense & Regulation Osaka University of Pharmaceutical Sciences Takatsuki Japan Department of Medical Oncology Kobe City Medical Center General Hospital Kobe Japan Department of Clinical Oncology Faculty of Medicine Kagawa University Takamatsu Japan

Introduction: The survival rate of patients with Borrmann type 4 advanced gastric cancer is extremely poor in comparison to patients with gastric cancers of other histological types. An optimal chemotherapeutic regimen has yet to be determined. Patients and Methods: We retrospectively examined the outcome of patients who were treated for Borrmann type 4 advanced gastric cancer from July 2011 and June 2015. Results: The data from 42 cases were collected for this study. Of the 42 cases, 13 cases (31.0%) were locally advanced and 29 cases (69.0%) were metastatic advanced. Median Overall Survival (OS) for locally advanced cancer was 29.6 months and for metastatic advanced cancer was 11.5 months. The presence or absence of peritoneal metastases did not affect survival (8.9 and 11.5 months, respectively;p = 0.831). In the 23 patients who received chemotherapy, S-1 plus cisplatin was prescribed as first-line treatment in 16 cases (69.5%). Other treatment regimens included capecitabine plus cisplatin and S-1 plus oxaliplatinin one each (4.3%), S-1 monotherapy in two (8.6%), and capecitabine monotherapy, paclitaxel, and docetaxel in one each (4.3%). We found no median OS difference between S-1 plus cisplatin and other treatments (20.7 and 19.3 months;p = 0.094). Conclusion: We found that S-1 plus cisplatin treatment does not improve OS in patients with Borrmann type 4 advanced gastric cancer compared with other chemotherapeutic regimens.

关键词： Gastric Cancer Adenocarcinoma Scirrhous Cisplatin Chemotherapy Metastasis

Short Hydration in Chemotherapy with Cisplatin plus S-1 for Advanced or Recurrent Gastric Cancer: A Retrospective Study

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Journal of Cancer Therapy 2015年第15期6卷 1254-1261页

作者： Akihito Tsuji Yuji Negoro Yoshihiro Okita Masahito Kotaka Takamasa Nishiuchi Takeshi Kotake hironaga Satake Yukimasa Hatachi Department of Medical Oncology Kobe City Medical Center General Hospital Hyogo Japan Department of Clinical Oncology Faculty of Medicine Kagawa University Kagawa Japan Department of Medical Oncology Kochi Health Sciences Center Kochi Japan Gastrointestinal Cancer Center Sano Hospital Hyogo Japan

Background: Despite there are a few reports that assessed the S-1 + CDDP regimen with short hydration regimen for unresectable or metastatic gastric cancer, there is no consensus on the best regimen for short hydration. The aim of study was to evaluate the safety and the efficacy of S-1 plus cisplatin doublet chemotherapy with short hydration. Methods: S-1 was administered orally (p.o.) twice daily for the first 3 weeks of a 5-week cycle. Dose of S-1 administered was calculated according to the body surface area. CDDP was given as an intravenous (i.v.) infusion of 60 mg/m2 on day 8 of each cycle. Patients received the total of 1900 ml infusion containing 1000 ml of acetate Ringer’s solution as pre- and post-hydraion. 300 ml of 20% mannitol was administered as a diuretic. Results: 35 patients with unresectable or recurrent gastric cancer were enrolled. The reasons for termination of S-1 + CDDP were as follows: 21 (63.6%) by progressive disease;12 (31.4%) by toxicity. Even though 12 of 35 patients (34.2%) were discontinued S-1 + CDDP chemotherapy, only one patient was discontinued by Grade 2 of increased creatinine. TTF (time to progression) was 174 days (3 - 586 days), and the median of the total number of treatment cycles of S-1 + CDDP was 3.31. Median overall survival, as secondary endpoint, was 518 days. Conclusions: Our study suggested that the short hydration regimen is as safe and efficient as the continuous hydration regimen.

关键词： Short Hydration Cisplatin Plus S-1 Gastric Cancer

Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes

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World Journal of Diabetes 2013年第5期4卷 227-230页

作者： Eiji Kawasaki Jun-ichi Yasui Masako Tsurumaru Haruko Takashima Toshiyuki Ikeoka Fumi Mori Satoru Akazawa Ikuko Ueki Masakazu Kobayashi hironaga Kuwahara Norio Abiru Hironori Yamasaki Atsushi Kawakami Department of Metabolism/Diabetes and Clinical Nutrition Nagasaki University Hospital First Department of Internal Medicine Nagasaki University Graduates School of Biomedical Sciences Clinical Research Center Nagasaki University Hospital Center for Health and Community Medicine Nagasaki University

We have previously reported the high levels of glutamic acid decarboxylase 65 autoantibodies(GAD65A)in patients with type 1 diabetes and autoimmune thyroid *** we describe a 32-year-old Japanese female with a thirteen-year history of type 1 diabetes whose levels of GAD65A were elevated just after the emergence of anti-thyroid *** 19 years of age,she developed diabetic ketoacidosis and was diagnosed with type 1 *** had GAD65A,insulinoma-associated antigen-2 autoantibodies(IA-2A),and zinc transporter-8 autoantibodies(ZnT8A),but was negative for antibodies to thyroid peroxidase(TPOAb)and thyroglobulin(TGAb)at disease ***8A and IA-2A turned negative 2-3 years after the onset,whereas GAD65A were persistently positive at lower level(approximately 40 U/mL).However,just after the emergence of TGAb at disease duration of 12.5 years,GAD65A levels were reelevated up to5717 U/mL in the absence of ZnT8A and *** thyroid function was normal and TPOAb were consistently *** has a HLA-DRB1*03:01/*04:01-DQB1*02:01/*03:02 *** positivity for GAD65A might be associated with increased risk to develop anti-thyroid autoimmunity.

关键词： Autoimmune thyroid disease Case report Glutamic acid decarboxylase autoantibodies Type 1diabetes