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The complete mitochondrial genomes of Gnathostoma doloresi from China and Japan

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The complete mitochondrial genomes of Gnathostoma doloresi f...

Toxocariasis:a silent threat with a progressive public health impact

中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Miaomiao Sun Jun Ma hiromu sugiyama Katsuhiko Ando Wenwen Li Qianming Xu Guohua Liu Xingquan Zhu College of Animal Science and Technology Anhui Agricultural University State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu Province Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences

Gnathostoma doloresi is one of the neglected pathogens causing gnathostomiasis. Although this zoonotic parasite leads to significant socio-economic concerns globally, little is known of its genetics and systematics. In the present study, we sequenced and characterized the complete mitochondrial(mt) genomes of G. doloresi isolates from China and Japan. The lengths of the mt genomes of the Gnathostoma doloresi China and Japan isolates are 13,809 bp and 13,812 bp, respectively. Both mt genomes encode 36 genes, including 12 protein-coding genes(PCGs), 2 ribosomal RNA genes and 22 transferRNA genes. The gene order, transcription direction and genome content are identical with its congener G. spinigerum. Phylogenetic analyses based on concatenated amino acid sequences of 12 PCGs by Bayesian inference(BI) indicated that G. doloresi are closely related to G. spinigerum. Our data provide an invaluable resource for studying the molecular epidemiology, phylogenetics and population genetics of Gnathostoma spp., and should have implications for further studies of the diagnosis, prevention and control of gnathostomiasis in humans and animals.

关键词： Gnathostoma doloresi Mitochondrial genome Mitochondrial DNA Phylo genetic analyses

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Infectious Diseases of Poverty 2018年第1期7卷 570-582页

作者： Jia Chen Quan Liu Guo-Hua Liu Wen-Bin Zheng Sung-Jong Hong hiromu sugiyama Xing-Quan Zhu Hany M.Elsheikha State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences1 XujiapingYanchangbuLanzhouGansu Province 730046People’s Republic of China Ningbo University School of Medicine NingboZhejiang ProvincePeople’s Republic of China Military Veterinary Institute Academy of Military Medical SciencesKey Laboratory of Jilin Province for Zoonosis Prevention and ControlChangchunJilin ProvincePeople’s Republic of China College of Veterinary Medicine Hunan Agricultural UniversityChangshaHunan ProvincePeople’s Republic of China Department of Medical Environmental Biology Chung-Ang University College of MedicineSeoulSouth Korea Department of Parasitology National Institute of Infectious DiseasesTokyoJapan Faculty of Medicine and Health Sciences School of Veterinary Medicine and ScienceUniversity of NottinghamLoughboroughUK

Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished *** disease is caused by infection with the larvae of Toxocara canis and ***,the most ubiquitous intestinal nematode parasite in dogs and cats,*** this article,recent advances in the epidemiology,clinical presentation,diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are *** text:Over the past two decades,we have come far in our understanding of the biology and epidemiology of ***,lack of laboratory infrastructure in some countries,lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease *** encompasses four clinical forms:visceral,ocular,covert and *** or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care ***,multiple diagnostic modalities are available,which if effectively used together with the administration of appropriate pharmacologic therapies,can minimize any unnecessary patient ***:Although progress has been made in the management of toxocariasis patients,there remains much work to be *** of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers,which may help in increasing diagnostic ***,further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.

关键词： Toxocara canis Toxocariasis Zoonosis Larva migrans Epidemiology Diagnosis Control

液晶显示方法研究管内马赫数4拟似冲击波流动

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空气动力学学报 2005年第4期23卷 521-525页

作者：王东屏兆文忠杉山弘东条启大连交通大学机械工程学院辽宁大连116028 日本室兰工业大学机械工程系

在一个压力-真空型超声速风洞中,剪切应力敏感的液晶表面流动显示技术被用来研究方管内马赫数4拟似冲击波的超声速流动。实验是在日本室兰工业大学的超声速风洞中进行。它提供了关于测试表面流动结构的定性信息,诸如湍流边界层分离和再... 详细信息

在一个压力-真空型超声速风洞中,剪切应力敏感的液晶表面流动显示技术被用来研究方管内马赫数4拟似冲击波的超声速流动。实验是在日本室兰工业大学的超声速风洞中进行。它提供了关于测试表面流动结构的定性信息,诸如湍流边界层分离和再附,以及边界层流动的维数等。液晶显示结果与纹影实验照片和油膜方法进行比较,证实了它是一种非常有效的表面流动显示工具。

关键词：拟似冲击波表面流动显示剪切-敏感液晶冲击波/湍流边界层相互作用湍流边界层分离

马赫数4二维直管内拟似冲击波实验和数值研究

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航空学报 2005年第4期26卷 392-396页

作者：王东屏兆文忠杉山弘東條啓大连交通大学机械工程学院辽宁大连116028 日本室兰工业大学机械工程系

通过计算流体力学数值仿真和高速彩色纹影照片显示技术对马赫数4拟似冲击波进行研究。实验是在日本室兰工业大学的压力—真空型超声速风洞中进行的。数值计算是采用三阶精度的QUICK格式和SpalartAllmaras湍流模型进行的。用实验验证CFD... 详细信息

通过计算流体力学数值仿真和高速彩色纹影照片显示技术对马赫数4拟似冲击波进行研究。实验是在日本室兰工业大学的压力—真空型超声速风洞中进行的。数值计算是采用三阶精度的QUICK格式和SpalartAllmaras湍流模型进行的。用实验验证CFD模型,计算结果与实验显示出较好的一致性。可以得出结论,从目前的CFD模型获得的计算结果是精确的。因而,实验很难获得的拟似冲击波流场内部一些流动量可以通过数值仿真结果进行分析。另外,推测了马赫数4拟似冲击波非对称的原因。

关键词：数值仿真拟似冲击波冲击波/湍流边界层相互作用纹影实验非对称特性

Study on Internal Supersonic Flows with Pseudo-shock Wave Using Liquid Crystal Flow Visualization Method

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Chinese Journal of Aeronautics 2005年第2期18卷 102-107页

作者：王东屏兆文忠杉山弘东条启 College of Mechanical Engineering Dalian Jiaotong University Dalian 116028 China Department of Mechanical Systems Engineering Muroran Institute of Technology Muroran Hokkaido 050-8585 Department of Mechanical Systems Engineering Muroran Institute of Technology Muroran Hokkaido 050-8585 Japan

The flow visualization technique using shear-sensitive liquid crystal is applied to the investigation of a Mach 2 internal supersonic flow with pseudo-shock wave （PSW） in a pressure-vacuum supersonic wind tunnel. It provides qualitative information mainly concerning the overall flow structure, such as the turbulent boundary layer separation, reattachment locations and the dimensionalities of the flow. Besides, it can also give understanding of the surface streamlines, vortices in separation region and the corner effect of duct flow. Two kinds of crystals with different viscosities are used in experiments to analyze the viscosity effect. Results are compared with schlieren picture, confirming the effectiveness of liquid crystal in flow-visualization.

关键词： surface flow visualization turbulent boundary layer separation pseudo-shock-wave shock wave/turbulent boundary layer interaction shear-sensitive liquid crystal comer effect

Nationwide questionnaire survey on pediatric pancreatic tumors in Japan

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4166-4176页

作者： Satoshi Makita Hiroo Uchida Motohiro Kano Naonori Kawakubo hiromu Miyake Akihiro Yoneda Tatsuro Tajiri Koji Fukumoto Department of Pediatric Surgery Nagoya University Graduate School of MedicineNagoya 466-8550Japan Department of Pediatric Surgery National Center for Child Health and DevelopmentTokyo 157-8535Japan Department of Pediatric Surgery Reproductive and Developmental MedicineFaculty of Medical SciencesKyushu UniversityFukuoka 819-0395Japan Department of Pediatric Surgery Shizuoka Children’s HospitalShizuoka 420-8660Japan

BACKGROUND Pediatric pancreatic tumors are rare and account for<0.1%of all childhood *** primary treatment for pancreatic tumors is surgical ***,because of the lack of knowledge regarding pediatric pancreatic tumors,no comprehensive treatment plans for pediatric pancreatic tumors have been *** To compared the clinical features,treatment methods,and prognosis of pediatric pancreatic tumors in Japan with those in other *** Questionnaires were sent to 213 pediatric surgical units in *** tumors that were not surgically treated were excluded from the *** primary survey investigated the number of patients aged 0-18 years who underwent pancreatic tumor surgery and the type of tumors managed during the 22-year study period(from January 1,2000 to December 31,2021)by post *** secondary survey assessed the clinical images,treatment methods,and tumor outcomes via *** The primary survey enrolled 228 *** the secondary survey,213 patients were eventually *** most common type of pancreatic tumor was solid pseudopapillary neoplasm(SPN)[n=164(77.0%)],followed by pancreatoblastoma[n=16(7.5%)],pancreatic endocrine tumor[n=14(6.6%)],non-epithelial tumor[n=9(4.2%)],pancreatic tumor[n=7(3.3%)],and metastatic pancreatic tumor[n=3(1.4%)].Overall,123(57.7%)patients underwent distal pancreatectomy,of whom 49 underwent laparoscopic ***-four(20.7%)patients underwent enucleation,of whom eight underwent laparoscopic ***-two(15.0%)patients underwent pancreaticoduodenectomy,of whom one underwent laparoscopic *** patients with SPN,including those with distant metastases and recurrent disease,*** SPN was more common in Japan than in other *** of the histological type,resection is the most effective treatment for pediatric pancreatic tumors.

关键词： Pancreatic tumors Pediatric Nationwide survey Solid pseudopapillary tumors Pancreatoblastoma

Unroofing Technique for Anomalous Origin of the Left Coronary Artery from the Right Sinus of Valsalva: Report of a Case

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World Journal of Cardiovascular Surgery 2024年第6期14卷 69-77页

作者： Keisuke Morimoto Futoshi Kobayashi hiromu Horie Yuki Sakaguchi Einosuke Mizuta Department of Cardiovascular Surgery Sanin Rosai Hospital Yonago Japan Department ofCardiology Sanin Rosai Hospital Yonago Japan

Anomalous origin of the left coronary artery (AOLCA) from the right sinus of Valsalva constitutes a rare congenital coronary artery anomaly. Patients with an anomalous left main coronary artery face a significantly higher risk of sudden cardiac death compared to those with an anomalous right coronary artery. The anomalous coronary artery traversing between the ascending aorta and the pulmonary artery markedly heightens the risk of myocardial ischemia, arrhythmia, and sudden death. Symptomatic patients often exhibit a longer intramural course of the coronary artery, which may necessitate earlier intervention or influence the choice of surgical repair method. Surgical intervention is advocated for patients with this anomaly, even in the absence of symptoms. For anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva with an intramural course, coronary unroofing is the preferred revascularization procedure. This report presents a case of AOLCA originating from the right sinus of Valsalva, treated surgically using the unroofing technique for the aortic intramural segment of the anomalous coronary artery traversing between the great vessels. The unroofing technique is recommended for treating AOLCA with an extensive intramural course that does not involve the commissure.

关键词： Unroofing Technique Anomaly of Coronary Artery Anomalous Origin of Left Coronary Artery

Downregulation of Rice DWARF 14 LIKE Suppress Mesocotyl Elongation via a Strigolactone Independent Pathway in the Dark

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Journal of Genetics and Genomics 2015年第3期42卷 119-124页

作者： hiromu Kameoka Junko Kyozuka Department of Agricultural and Environmental Biology Graduate School of Agricultural and Life SciencesThe University of Tokyo

Strigolactones （SLs） are a class of plant hormones that control plant development in response to environmental conditions. In rice, mesocotyl elongation is regulated by SLs in the dark, while mesocotyls are longer in SL deficient or insensitive mutants. SLs are perceived by DWARF14 （D14）, which is a member of a small gene family. In this study, we examined the function of another D14 family gene in rice, D14 LIKE （D14L）, focusing on mesocotyl growth. The mesocotyls of D14L RNAi lines are longer than those of WT in the dark. This phenotype is enhanced when the D14L RNAi lines are combined with the d14 mutation, suggesting that D14 and D14L work independently to inhibit mesocotyl elongation. This phenotype is alleviated by the exogenous supply of GR24, a synthetic SL, suggesting that D14L is not necessary for SL signaling. D14L mRNA is predominantly expressed in vascular bundles and crown root primordia. Our results suggest that D14L and D14 confer their effects via an SL independent pathway and an SL signaling pathway respectively.

关键词： Strigolactone Mesocotyl Rice DWARF 14 (D14) D14 LIKE (D14L) KARRIKIN INSENSITIVE 2 (KAI2)

Frequency dependence of electron temperature in hollow cathode-type discharge as measured by several different floating probe methods

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Plasma Science and Technology 2018年第8期20卷 50-57页

作者： Shuichi SATO hiromu KAWANA Tatsushi FUJIMINE Mikio OHUCHI Department of Electronic Engineering Tokyo Denki University

We measured electron temperatures through a hollow cathode-type discharge tube using several different floating probe methods. This method detected a shift in the floating potential when an AC voltage was applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. In this study, the effects of the frequency and waveform on the electron temperatures were systematically investigated. The electron temperature measured when using the floating probe method with applied sinusoidal and triangular voltages was lower than that measured with an applied rectangular *** value in the high frequency range was close to that of the tail electron temperature.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath