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Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer

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World Journal of Gastroenterology 2012年第45期18卷 6577-6586页

作者： Yasutaka Sukawa Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Kunimoto hiromu Suzuki Yasushi Adachi Mayumi Nakazawa Takayuki Nobuoka Mariko Kawayama Masashi Mikami Takashi Matsuno Tadashi Hasegawa Koichi Hirata Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 60-8543Japan Department of Molecular Biology Sapporo Medical University School of MedicineSapporo 60-8543Japan First Department of Surgery Sapporo Medical University School of MedicineSapporo 60-8543Japan Department of Gastroenterology JR Sapporo HospitalSapporo 60-8543Japan Department of Surgery Sapporo Gekakinen HospitalSapporo 60-8543Japan Department of Surgical Pathology Sapporo Medical University HospitalSapporo 60-8543Japan Division of Cancer Research The Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan

AIM:To investigate human epidermal growth factor receptor 2(HER2)-phosphatidylinositol 3-kinase(PI3K)-vAkt murine thymoma viral oncogene homolog signaling pathway.METHODS:We analyzed 231 formalin-fixed,paraffinembedded gastric cancer tissue specimens from Japanese patients who had undergone surgical treatment.The patients' age,sex,tumor location,depth of invasion,pathological type,lymph node metastasis,and pathological stage were determined by a review of the medical records.Expression of HER2 was analyzed by immunohistochemistry(IHC) using the HercepTest TM kit.Standard criteria for HER2 positivity(0,1+,2+,and 3+) were used.Tumors that scored 3+ were considered HER2-positive.Expression of phospho Akt(pAkt) was also analyzed by IHC.Tumors were considered pAkt-positive when the percentage of positive tumor cells was 10% or more.PI3K,catalytic,alpha polypeptide(PIK3CA) mutations in exons 1,9 and 20 were analyzed by pyrosequencing.Epstein-Barr virus(EBV) infection was analyzed by in situ hybridization targeting EBV-encoded small RNA(EBER) with an EBER-RNA probe.Microsatellite instability(MSI) was analyzed by polymerase chain reaction using the mononucleotide markers BAT25 and BAT26.RESULTS:HER2 expression levels of 0,1+,2+ and 3+ were found in 167(72%),32(14%),12(5%) and 20(8.7%) samples,respectively.HER2 overexpression(IHC 3+) significantly correlated with intestinal histological type(15/20 vs 98 /205,P = 0.05).PIK3CA mutations were present in 20 cases(8.7%) and significantly correlated with MSI(10/20 vs 9/211,P < 0.01).The mutation frequency was high(21%) in T4 cancers and very low(6%) in T2 cancers.Mutations in exons 1,9 and 20 were detected in 5(2%),9(4%) and 7(3%) cases,respectively.Two new types of PIK3CA mutation,R88Q and R108H,were found in exon1.All PIK3CA mutations were heterozygous missense singlebase substitutions,the most common being H1047R(6/20,30%) in exon20.Eighteen cancers(8%) were EBV-positive and this positivity significantly correlated with a diffuse histological type(13/18 vs 93/198,P = 0.04).T

关键词：表皮生长因子受体磷脂酰肌醇 Epstein-Barr病毒胃癌信号通路激酶突变频率微卫星不稳定性

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Identification Method of Dynamic Coefficients of Fluid Film Bearings for HDD Spindle Motors

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Journal of Mechanics Engineering and Automation 2014年第2期4卷 123-129页

作者： Masayuki Ochiai Yuta Sunami hiromu Hashimoto Department of Mechanical Engineering Tokai University Hiratsuka 259-1292 Japan

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Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer

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World Journal of Gastroenterology 2016年第44期22卷 9765-9774页

作者： Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi Department of Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba Regenerative Medicine Research Center Jiangsu University Hospital Department of Regenerative Medicine Graduate School of Medicine Yokohama City University Department of Gastroenterology Faculty of Medicine University of Tsukuba Faculty of Life and Environmental Sciences Alliance of Research on North Africa University of Tsukuba

AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.

关键词： Colorectal cancer Linalool Oxidative stress Electron spin resonance Lipid peroxidation

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Development and Evaluation of an All Weather-Type Solar Drying House to Make for Wood Pellet Material

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Open Journal of Applied Sciences 2012年第3期2卷 153-162页

作者： Kimio Kanayama Shinya Koga hiromu Baba Tomoyoshi Sugawara Kitami Institute of Technology Kitami Japan Kyushu University Fukuoka Japan Marusho-Giken Co. Ltd. Ashoro Japan

To suppress the global environment pollutions, we tried to develop a new-type solar drying house by improving a typical agricultural green-house, so that an all weather-type solar drying house was invented ultimately. This house is capable to dry raw wood materials (Ogako) into suitable moisture content (Mc) to make a wood pellet. The all weather-type solar Ogako drying house is covered with a triple transparent film, and an open/close free-type shield sheet is spread along with house’s inner surface with a small space, which is opened when solar radiation is incident on the house in daytime and closed to prevent heat loss from the house while out of sun shining in night. Inside of the all weather-type solar Ogako drying house, there are four belt-conveyors over which four top radiation panels are hanged, and on which four Ogako agitators are touched, a turn-table, two hoppers, four small fans, and besides, a floor heating is molded in concrete floor. Also on the north wall outside the house, two insulated cylinders (chimney) are stood up vertically to exhaust inside moist air passively. Then, to make clearly the operation performance of the house, the drying tests for the proof examination were conducted nineteen times at first test site in Ashoro where is located east-central part of Hokkaido, Japan. As a result of the drying test for the proof examination, it was made clear that the all weather-type solar Ogako drying house is practically useful as a supplementary apparatus to produce the dried Ogako, and consequently to suppress CO2 exhaustion.

关键词： Solar Energy and Biomass Energy Agricultural Green-House Ogako Drying House Wood Powder (Ogako) Wood Pellet Moisture Content (Mc) Decrease of Oil Consumption Suppression of CO2 Exhaustion

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Emulsion Graft Polymerization of Methyl Methacrylate onto Cellulose Nanofibers

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Green and Sustainable Chemistry 2021年第1期11卷 9-22页

作者： hiromu Okada Chao Zhao Yusuke Mizuta Katsumi Yoshino Ryuichi Sugimoto School of Environmental Science and Engineering Kochi University of Technology Kochi Japan Shimane Institute for Industrial Technology Matsue Japan

Methyl methacrylate (MMA) was successfully grafted onto cellulose nanofibers (CNFs) at room temperature in an emulsion system using a diethyl(1,10-phenanthroline N1,N10)zinc(II) complex (Phen-DEZ) with oxygen as the radical initiator. The effects of reaction temperature, initiator concentration, and monomer content on the grafting reaction were investigated. The molecular weight of the non-grafted PMMA, which was produced during graft polymerization, was more than 1 million, as determined by size exclusion chromatography. The PMMA-grafted CNFs were analyzed by Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, which confirmed the grafting of PMMA on the nanofiber surface. The study presents a strategy for the grafting of high-molecular weight PMMA onto CNFs in an emulsion system using Phen-DEZ and O2.

关键词： Cellulose Nanofibers Graft Polymerization Methyl Methacrylate Emulsion Diethylzinc

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Energy reduction of a submerged membrane bioreactor using a polytetrafluoroethylene （PTFE） hollow-fiber membrane

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Frontiers of Environmental Science & Engineering 2018年第3期12卷 45-54页

作者： Taro Miyoshi Thanh Phong Nguyen Terumi Tsumuraya hiromu Tanaka Hiroki Itokawa Toshikazu Hashimoto Maezawa Industries Inc. 5-11 Naka-cho Kawaguchi City Saitama 332-8556 Japan Sumitomo Electric Industries LTD. 1-950 Asashironishi Kumatori-cho Sennan-gun Osaka 590-0458 Japan Japan Sewage Works Agency 2-31-27 Yushima Bunkyo City Tokyo 113-0034 Japan

在这研究，我们修改了空纤维的膜元素过去常让沉没的膜生物反应器(MBR ) 在 MBR 过程期间减少精力消费的 polytetrafluoroethylene (PTFE ) 。PTFE 膜的高机械的力量使从 2 ～ 3 m 增加膜纤维的有效长度可能。另外，收拾行李的密度被优... 详细信息

在这研究，我们修改了空纤维的膜元素过去常让沉没的膜生物反应器(MBR ) 在 MBR 过程期间减少精力消费的 polytetrafluoroethylene (PTFE ) 。PTFE 膜的高机械的力量使从 2 ～ 3 m 增加膜纤维的有效长度可能。另外，收拾行李的密度被优化膜元素配置被 20% 增加。这些修正改进膜清洗的效率与通风联系了。特定的精力消费的目标是不到 0.4 kWh ?楤晳癡吗？

关键词：膜生物反应器精力纤维沉没 MBR 操作表流动率 PTFE

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阴部外动脉和乳房注射霉康唑对牛烟曲霉菌乳房炎的疗效

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国外兽医学（畜禽疾病） 1991年第4期12卷 27-28页

作者： hiromu Katamoto 雍长福

连续三天于动脉和乳房内注射抗真菌药霉康唑,成功地治疗了一例牛霉菌性乳房炎。

关键词：牛动脉霉菌性乳房炎乳房注射

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Air Trapping: A Cause of Heterogeneous Attenuation

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Open Journal of Radiology 2012年第3期2卷 96-103页

作者： Keiko Morikawa Fumito Okada Yumiko Ando Asami Ono hiromu Mori Department of Radiology Faculty of Medicine Oita University Yufu Japan

Purpose: To investigate important factors affecting the frequency of air trapping through observation of normal lung attenuation, and propose a cause of heterogeneous attenuation. Materials and Methods: In this ethical committee-approved study, a total of 109 patients (30 males, 79 females;mean age, 58.2 years;range, 27 - 81 years) were included. All patients had undergone inspiratory and expiratory chest thin-section computed tomography (CT) examinations and pulmonary function tests. Air trapping on CT images was graded subjectively. Hounsfield units (HU) lung attenuation value and lung volume were measured on CT images. All variables (age, sex, indices of pulmonary function test results, air trapping score, HU value, and rate of change in lung volume) were compared by diagnoses and air trap- ping findings cohorts. The correlation between lung function test results and expiratory HU attenuation were analyzed. Results: Interstitial pneumonia showed higher and bronchiolitis obliterans showed lower HU attenuation at normal and air trapping regions. The variables affecting air trapping findings were age, a ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1.0/FVC), maximal expiratory flow at 50% of forced vital capacity (MEF50), HU attenuation at normal regions, and rate of change in lung volume. Compared with expiratory HU attenuation, significant positive correlation was shown to FEV1.0/FVC and negative correlation to single-breath diffusion capacity for carbon monoxide, which was confirmed by a simple regression analysis. Conclusion: It can be suggested that lung attenuation can increase when fibrosis is advanced, and this is exaggerated when lungs are compressed.

关键词： Air Trapping CT Examination Lung Attenuation

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A Small One-Fiber WDM Optical Ethernet PC Card for FTTD

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光学学报 2003年第S1期23卷 605-606页

作者： Naoto Sugimoto Seiji Fukushima Yasuhiro Suzuki Yoshihisa Sakai Hiromasa Tanobe Takeshi Kurosaki Kazuto Noguchi Kimio Oguchi hiromu Toba Photonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 JapanNetwork Innovation Laboratories Nippon Telegraph and Telephone CorporationPhotonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 Japan

A new generation of network interface card for fiber-to-the-desktop has been fabricated. The fabricated card is PC-card size and suitable for notebook PCs. It could become the key element in the coming optical Etherne... 详细信息

关键词： for et be WDM PC than link

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抗震高阻尼橡胶支撑垫的耐久性能

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橡胶参考资料 1992年第2期22卷 28-34页

作者： hiromu Kojima 景勤佳

1、前言在最近两三年里,日本约有20幢建筑物中广泛应用橡胶支撑垫作为地基防震隔离层,在最近发生的地震中证实了这种建筑具有优良的抗震性能。以前,曾通过加固房屋的方法来防止地震时倒塌,但这种结构并不能很好地解决抗震中出现的问题。

关键词：建筑物橡胶支撑垫地基减震

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