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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki hiromitsu nakahashi Osamu Shimomura Kinji Furuya Manami Doi Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to regenerate.Most of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are scarce.Additionally,there is limited knowledge about the preoperative factors that influence postoperative regeneration.AIM To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver regenera-tion.METHODS A total of 268 patients who received partial hepatectomy were enrolled.Patients were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)groups.The regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,respectively.The lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months postsurgery.RESULTS The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,respectively.The RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri group.According to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed regeneration.Furthermore,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.0 up]and liver resection percentage[OR=1.02(1.00

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

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Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats

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World Journal of Gastroenterology 2008年第16期14卷 2556-2560页

作者： Shintaro Fukushima Hiroyasu Okuno Nobuyuki Shibatani Yoshitsugu nakahashi Toshihito Seki Kazuichi Okazaki Third Department of Internal Medicine Kansai Medical University Moriguchi

AIM: To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS: Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile duct obstruction was followed by internal biliary drainage after releasing the tape. The expression of various CYP isozyme mRNAs was semi-quantitatively assessed by competitive RT- PCR. RESULTS: The total CYP content and microsomal MFO activity showed a significant decrease after biliary obstruction, but returned to respective control levels after biliary drainage. A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased significantly toward the control level after biliary drainage. Although expression of CYP4A1 mRNA showed no reduction during biliary obstruction, it still increased significantly after biliary drainage. CONCLUSION: These results suggest that not only obstructive jaundice, but also the subsequent internal biliary drainage may affect regulatory medications of the synthesis of individual CYP isozymes differently.

关键词：梗阻性黄疸胆汁引流胆管阻塞氧化酶

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An Inverse Problem for Low Sonic Boom Design of Supersonic Planes

An Inverse Problem for Low Sonic Boom Design of Supersonic P...

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： Kisa Matsushima Kazuhiro nakahashi Department of aeronautics and Space Engineering Toholcu University Aza-Aoba 01 Aramaki Aoba-ku Sendai 980-8579 Japan Department of aeronautics and Space Engineering Toholcu University Aza-Aoba 01 Aramaki Aoba-ku Sendai 980-8579 Japan

The goal of this work is to develop an automatic computational method to facilitate the low sonic boom design of supersonic planes. In spite of the retirement of Concorde, research on supersonic planes has been activated in the USA by DARPA's QSP (Quiet Supersonic Platform) program. One of the most challenging subjects of the program is the reduction of sonic boom from a plane flying at a supersonic speed. The sonic boom is felt on the ground and the typical altitude for supersonic planes to cruise is about 20,000m. In other words, the distance z from the acoustic source (a supersonic plane) to the ground is very large while the aircraft length L is less than 100m. So, ground signatures could never be captured in wind tunnel experiments or CFD simulations where we could not make the z/L sufficiently large. Usually, we do have near-field information. Geometric acoustics and non-linear wave propagation principles have been successfully applied to sonic boom problems. They calculate the ground (far-field) signature extrapolating pressure distribution at the near field using the principles. Thus, we can have the ideal near-field pressure that leads to the ground signature of minimum sonic boom. Thus the low sonic boom design can be translated to an inverse problem to determine an aircraft shape which provides desirable near-field pressure distribution.

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Surround Sensation Index Based on Differential S-IACF for Listener Envelopment with Multiple Sound Sources

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通讯和计算机（中英文版） 2017年第3期14卷 122-128页

作者： Masato Nakayama Kota nakahashi Yukoh Wakabayashi Takanobu Nishiura College of Information Science and Engineering. Ritsumeikan University Shiga Japan Graduate School of Information Science and Engineering. Ritsumeikan University Shiga Japan

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