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Food and Nutrition Sciences 2021年第11期12卷 1136-1151页

作者： Keiichi Hiramoto Kumi Orita Yurika Yamate hiromi Kobayashi Department of Pharmaceutical Sciences Suzuka University of Medical Science Suzuka Japan Department of Orthopedic Surgery Osaka City University Graduate School of Medicine Osaka Japan Kobayashi Dermatology Clinic Nishinomiya Japan

Introduction: Momordica charantia (MC) has been reported to possess various beneficial effects. Improvement in natural aging of the skin has been observed with the use of MC. However, few studies have detailed the effects of MC on atopic dermatitis (AD). Therefore, in this study, we investigated the effects of MC on the skin symptoms of AD. Methods: Specific pathogen-free and conventional NC/Nga mice were orally administered a 50 mg/kg/day dose of MC every day for 2 weeks. Results: The expression levels of lipopolysaccharide (LPS), inducible nitric oxidase synthase (iNOS), and prostaglandin E2 (PGE2) remarkably increased in AD, but were suppressed by MC administration. As a result, the degradation of filaggrin by PGE2 was suppressed. Furthermore, in AD, iNOS induced macrophage type 1 and increased NO levels. In contrast, due to suppression of iNOS with MC administration, macrophages shifted to type 2 and an increase in L-ornithine was observed, which subsequently promoted filaggrin synthesis. Conclusions: These findings indicate that the AD-like skin symptoms were decelerated by MC via the regulation of the LPS/iNOS/PGE2/filaggrin and LPS/iNOS/Arginase 1/L-ornithine/ filaggrin signaling pathways.

关键词： Atopic Dermatitis (AD) Momordica charantia (MC) LPS iNOS Filaggrin

Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

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World Journal of Gastroenterology 2008年第38期14卷 5880-5886页

作者： Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda hiromitsu Kumada Department of Hepatology Toranomon HospitalTokyo 105-8470 Japan

AIM： To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus （HCV） positive patients. METHODS： We studied 6150 HCV infected patients who were between 40-70 years old （HCV-group）. Another 2050 patients with hepatitis B virus （HBV） were selected as control （HBV-group）. The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis （IPF） in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS： Fifteen patients in HCV-group developed IPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group （P = 0.021）. The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases：（1） patients ≥ 55 years （P 〈 0.001）; （2） patients who had smoking index （package per day x year） of ≥20 （P = 0.002）; （3） patients with liver cirrhosis （P = 0.042）. CONCLUSION： Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients.

关键词： Hepatitis B virus Hepatitis C virus Idiopathic pulmonary fibrosis A retrospective cohort study

Assessment of the Effectiveness of Hand Therapy for Elderly People with Dementia

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Open Journal of Therapy and Rehabilitation 2022年第1期10卷 25-37页

作者： hiromi Toki Hiroko Kunikata Yurie Fujiwara Shin Fujisawa Department of Nursing Faculty of Health Sciences Kagawa Prefectural University of Health Sciences Kagawa Japan Iwaki Hospital Iwakikai Medical Corporation Kagawa Japan

Background: This study evaluated the effectiveness of hand therapy for elderly people with dementia and the change in effectiveness depending on sex differences between the patients and operators. Methods: The Abe’s behavioral and psychological symptoms of dementia score (ABS), index of resistance to care, and inner balance scanner scores were evaluated. Results: The mean ABS was 18.4 (before therapy), 16.0 (operator of the same sex), and 17.1 (operator of the opposite sex). The mean index scores for resistance to care were 15.3 (before therapy), 15.2 (operator of the same sex), and 13.2 (operator of the opposite sex). When the operator and patient were of the same sex, the mean value of comparison of total power (TP) decreased from 28,060.4 (before therapy) to 5974.3 (after therapy), and the mean low frequency (LF)/high frequency (HF) ratio decreased from 1.7 (before therapy) to 1.2 (after therapy). When the operator was of the opposite sex of that of the patient, the mean TP value decreased from 25,760.4 (before therapy) to 7669.5 (after therapy), and the mean LF/HF ratio increased from 1.2 (before therapy) to 1.5 (after therapy). Conclusions: Hand therapy was the most effective when the patient and operator were of the same sex.

关键词： Older Adults Cognitive Impairment Massage Therapy Case Report

Single-cell sorting based on secreted products for functionally defined cell therapies

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Microsystems & Nanoengineering 2022年第4期8卷 17-34页

作者： hiromi Miwa Robert Dimatteo Joseph de Rutte Rajesh Ghosh Dino Di Carlo Department of Bioengineering University of California-Los AngelesLos AngelesCA 90095USA Department of Chemical and Biomolecular Engineering University of California-Los AngelesLos AngelesCA 90095USA Partillion Bioscience Los AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of California-Los AngelesLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of California-Los AngelesLos AngelesCA 90095USA

Cell therapies have emerged as a promising new class of“living”therapeutics over the last decade and have been particularly successful for treating hematological ***,cellular therapeutics are being developed with the aim of treating almost any disease,from solid tumors and autoimmune disorders to fibrosis,neurodegenerative disorders and even aging ***,their therapeutic potential has remained limited due to the fundamental differences in how molecular and cellular therapies *** the structure of a molecular therapeutic is directly linked to biological function,cells with the same genetic blueprint can have vastly different functional properties(e.g.,secretion,proliferation,cell killing,migration).Although there exists a vast array of analytical and preparative separation approaches for molecules,the functional differences among cells are exacerbated by a lack of functional potency-based sorting *** this context,we describe the need for next-generation single-cell profiling microtechnologies that allow the direct evaluation and sorting of single cells based on functional properties,with a focus on secreted molecules,which are critical for the in vivo efficacy of current cell *** first define three critical processes for single-cell secretion-based profiling technology:(1)partitioning individual cells into uniform compartments;(2)accumulating secretions and labeling via reporter molecules;and(3)measuring the signal associated with the reporter and,if sorting,triggering a sorting event based on these reporter *** summarize recent academic and commercial technologies for functional single-cell analysis in addition to sorting and industrial applications of these *** approaches fall into three categories:microchamber,microfluidic droplet,and lab-on-a-particle ***,we outline a number of unmet needs in terms of the discovery,design and manufacturing of cellular therapeutics a

关键词： therapies sorting realization

Simple Life Review for Terminally Ill Cancer Patients with Low Cognitive Function

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Journal of Cancer Therapy 2012年第5期3卷 528-533页

作者： Michiyo Ando hiromi Minota Chika Shibukawa Haruko Kira Faculty of Nursing St. Mary’s College Faculty of Nursing Kurume city Fukuoka Prefecture Japan Kurume University Fukuoka Japan St. Mary’s Hospital Fukuoka Japan

Objective: The aims of the study were to develop a Simple Life Review Interview as psychotherapy for terminally ill cancer patients with slight cognitive impairment, and to examine the feasibility and effects of this approach on spiritual well-being and quality of life. Methods: The participants were 5 terminally ill cancer patients in a palliative care unit. They completed questionnaires for the Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp) scale, Good Death Inventory (Hope, Burden, Human Relationship, Respect as an Individual), and Distress and Impact Thermometer. Results: The Simple Life Review Interview consisted of viewing a DVD and reviewing the patient's life using questions that are applicable to terminally ill cancer patients with slight cognitive impairment. Overall, the FACIT-Sp score and the scores for Hope, Human Relationship, and Respect as an Individual on the Good Death Inventory increased, while the Burden score and the Distress and Impact Thermometer score decreased. However, there were some exceptions to these results. Conclusion: The Simple Life Review is feasible for terminally ill cancer patients with some cognitive impairments, and might be effective for improving spiritual well-being, Good Death, and psychological distress in these patients.

关键词： Psychotherapy Simple Life Review Terminally Ill Patients Spiritual Well-Being Quality of Life

Possible Duplicities of Five Asteroids

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International Journal of Astronomy and Astrophysics 2015年第3期5卷 193-207页

作者： Isao Satō hiromi Hamanowa Hiroyuki Tomioka Sadaharu Uehara Nihon University Sakata Yamagata Japan Hamanowa Astronomical Observatory Motomiya Fukushima Japan Hitachi Ibaraki Japan KEK Tsukuba Ibaraki Japan

Some evidences of possible duplicities of five asteroids are presented. A satellite of (279) Thule was convincingly detected by a stellar occultation on 2008 April 3 by Thule and also from follow-up light curve observations. The orbital period of the satellite is 3.007 or 6.014 days, and the minimum diameter is estimated to be 52 km. A satellite of (324) Bamberga was detected by secondary drops of the light curve in 2007. The rotation period of the primary is 1.22625 days, and the revolution period of the secondary is 3.00 or 6.00 days. Presumed contact duplicity of the main body of the L4 Trojan (624) Hektor was detected by a stellar occultation by Hektor on 2008 January 24. A possible satellite of (657) Gunl?d was suggested from a secondary occultation by Gunl?d on 2008 November 29. The minimum of the diameter is 7 km. A possible satellite of (739) Mandeville was suggested by stellar occultation observations on 1980 December 10.

关键词： Asteroid Occultation Light Curve Satellite Binary

Distribution of Chitinolytic Enzymes in the Organs and cDNA Cloning of Chitinase Isozymes from the Liver of Golden Cuttlefish <i>Sepia esculenta</i>

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Advances in Bioscience and Biotechnology 2017年第10期8卷 361-377页

作者： Ryo Nishino hiromi Kakizaki Hideto Fukushima Masahiro Matsumiya Department of Marine Science and Resources College of Bioresource Sciences Nihon University Fujisawa Kanagawa Japan

The distribution of chitinolytic enzymes in eight organs of the golden cuttlefish Sepia esculenta was determined. Chitinase activity (activity of endo-type chitinolytic enzyme) was measured using pNP-(GlcNAc)n (n = 2, 3) as substrates, with high activity detected in the liver, posterior salivary gland, and stomach. β-N-acetylhexosaminidase (Hex) activity (activity of exo-type chitinolytic enzyme) was determined using pNP-(GlcNAc) as a substrate, and high activity was observed in six organs, including the liver, branchial heart, posterior salivary gland, and stomach. In addition, two chitin-binding proteins (CBP-A, CBP-B) were isolated from the liver using a chitin affinity column. Two full-length cDNAs (SeChi-1: 1484 bp;SeChi-2: 1748 bp) encoding chitinases were obtained from the liver of S. esculenta. SeChi-1 contained a 1377-bp open reading frame (ORF) encoding 459 amino acids, and SeChi-2 contained a 1656-bp ORF encoding 552 amino acids. Domain structures predicted from the deduced amino acid sequences of SeChi-1 and SeChi-2 (SeChi-1, SeChi-2) contained signal peptides, a GH Family 18 catalytic domain, one chitin binding domain (CBD) in SeChi-1, and two CBDs in SeChi-2. Proteome analysis revealed that 125 peptide residues of CBP-A were present in SeChi-1, and 116 peptide residues of CBP-B were present in SeChi-2. Organ expression analysis revealed that SeChi-1 and SeChi-2 were expressed only in the liver of S. esculenta. Phylogenetic analysis of SeChi-1, SeChi-2, and GH family 18 chitinases revealed that SeChi-2 belongs to a group of previously reported squid chitinases, while SeChi-1 does not belong to any previously reported group of mollusk chitinases.

关键词： Chitinolytic Enzyme Chitinase Distribution cDNA Cloning Golden Cuttlefish Sepia esculenta

高锌铝合金合金化和加工工艺的研究现状及发展趋势

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材料导报 2023年第2期37卷 130-135页

作者：杨东辉唐帅吴子彬秦克张海涛崔建忠 hiromi Nagaumi 东北大学材料电磁过程研究教育部重点实验室(EPM) 沈阳110006 苏州大学沙钢钢铁学院江苏苏州215021

高锌铝合金是指含锌量为10%~45%的铝基合金,具有耐磨性好、强度硬度高和阻尼性能优异等优点,被广泛应用于滑动轴承、轴瓦等耐磨件,是锡铜合金和锌铝耐磨合金良好的替代品。高锌铝合金作为耐磨合金替代锡铜合金不仅降低了工件的生产成本... 详细信息

高锌铝合金是指含锌量为10%~45%的铝基合金,具有耐磨性好、强度硬度高和阻尼性能优异等优点,被广泛应用于滑动轴承、轴瓦等耐磨件,是锡铜合金和锌铝耐磨合金良好的替代品。高锌铝合金作为耐磨合金替代锡铜合金不仅降低了工件的生产成本,而且弥补了我国锡铜金属资源匮乏的缺憾。但是,高锌铝合金也存在尺寸稳定性差、塑性低、抗蠕变性能和耐腐蚀性差等缺点。现阶段,高锌铝合金的强韧化机制主要有以下几个方面:(1)对高锌铝合金进行合金化处理,如在Al-Zn合金中添加Cu、Si、Mn、Ti、Er、Sc、Zr等元素。首先合金元素与基体结合形成硬质颗粒可以增加合金的强度硬度;其次,合金元素在凝固过程中可以作为异质形核中心,导致晶粒尺寸减小。(2)在凝固过程中提高冷却速度,采用压铸或挤压铸造的方法可以获得较快的冷却速度。凝固过程中较快的冷却速度有利于提高形核速率,并显著细化第二相与晶粒的尺寸。(3)对高锌铝合金进行塑性变形处理,如挤压、轧制等加工工艺可以消除合金的铸造缺陷、细化晶粒、增加位错密度,从而提高高锌铝合金的强度。本文综述了近年来国内外高锌铝合金显微组织和性能的研究现状及主要存在的问题,介绍了Zn、Cu、Si、Mn、Ti、Zr、Er、Sc等合金元素对高锌铝合金组织及性能的影响,总结了变形工艺及热处理工艺对高锌铝合金组织与性能的影响,最后分析了高锌铝合金的优缺点并展望其研究方向。

关键词：高锌铝合金轴承材料力学性能加工工艺

Do membrane proteins cluster without binding between molecules?

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Open Journal of Immunology 2012年第1期2卷 1-8页

作者： Xin Wang Toshihiko Fukamachi hiromi Saito Hiroshi Kobayashi Department of Biochemistry Graduate School of Pharmaceutical Sciences Chiba University Chiba Japan

Clustering is a basic event for the initiation of immune cell responses, and simulation analyses of clustering of membrane proteins have been performed. It was claimed that a cluster is formed by the self-assembly induced by protein dimerization with a high binding speed (Woolf and Linderman, Biophys. Chem. 104, 217-227, 2003). We examined the cluster formation with Monte Carlo simulation using two algorithms. The first was that simulation processes were divided into two substeps. All proteins were subjected to movement in the first substep, followed by reaction in the second substep. The second algorithm was that proteins were first selected to react and proteins which did not react were subjected to movement. The self-assembly induced by dimerization was simulated only with the second algorithm. In this algorithm, monomers dissociated from dimers do not move because these monomers are not selected for movement, and a large proportion of such monomers are selected to form dimers in the next step. The self-assembly was again simulated with the first algorithm containing the conditions that monomers dissociated from dimers did not move in the next movement substep. This algorithm seems to be far removed from natural conditions. Thus, it is inferred that the self-assembly induced by dimerization is unlikely in situ, and that some interaction between proteins is required for cluster formation. In contrast to algorithms in previous simulations, our results suggest that it is more appropriate that proteins move to the same direction for a while and reflect when the collision occurs.

关键词： Cluster Formation Monte Carlo Simulation Self-Assembly Immune Cells Membrane Proteins