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Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C

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World Journal of Gastroenterology 2007年第39期13卷 5180-5187页

作者： Atsushi Tanaka Satoko Uegaki hiroko Kurihara Kiyoshi Aida Masaki Mikami Ikuo Nagashima Junji Shiga Hajime Takikawa Department of Medicine Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605Japan Department of Pathology Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605 Japan Department of Surgery Teikyo University School of Medicine Kaga Itabashi-ku Tokyo 173-8605 Japan

AIM: To elucidate risk factors contributing to the development of hepatocellular carcinoma (HCC) among patients with sustained viral response (SVR) after interferon (IFN) treatment and to examine whether HCV-RNA still remained in the liver of SVR patients who developed HCC. METHODS: Two-hundred and sixty-six patients, who achieved SVR, were enrolled in this study. We retrospectively reviewed clinical, viral and histological features of the patients, and examined whether the development of HCC depends on several clinical variables using Kaplan-Meier Method. RT-PCR was used to seek HCV-RNA in 3 out of 7 patients in whom liver tissue was available for molecular analysis. RESULTS: Among the enrolled 266 patients with SVR, HCC developed in 7 patients (7/266; 2.6%). We failed to detect HCV-RNA both in cancer and non-cancerous liver tissue in all three patients. The cumulative incidence for HCC was significantly different depending on hepatic fibrosis (F3-4) (P = 0.0028), hepatic steatosis (Grade 2-3) (P = 0.0002) and age (≥ 55) (P = 0.021) at the pre-interferon treatment. CONCLUSION: The current study demonstrated that age, hepatic fibrosis, and hepatic steatosis at pre- interferon treatment might be risk factors for developing HCC after SVR.

关键词： Hepatitis C virus Chronic hepatitis C Hepatocellular carcinoma Hepatic steatosis Hepaticfibrosis Interferon therapy Sustained viral response

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Isolation of the Left Subclavian Artery in D-Transposition of the Great Arteries with Right Aortic Arch

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Congenital Heart Disease 2021年第4期16卷 369-371页

作者： Kotaro Hine Kohei Ogata Keiko Saitou Norio Mizukaki hiroko Arai Hitoshi Yoda Department of Neonatology Toho University Omori Medical CenterTokyo143-8541Japan

Abnormal branching of the aorta associated with the right aortic arch(RAA)has been reported as isolation of left subclavian artery(ILSA),isolation of left common carotid artery,isolation of brachiocephalic *** is a rare aortic branch anomaly that originates in the left subclavian artery from the pulmonary artery via ductus *** reports have described ILSA associated with 22q11.2 deletion syndrome and tetralogy of ***,we present a very unusual case of RAA with ILSA associated with D-transposition of the great arteries and inferior vena cava interrupted with azygos continuation.

关键词： Isolated left subclavian artery transposition of the great arteries RAA ILSA

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The Factors Associated with the Attitudes of Nurses Working in Medical Facilities towards Family Nursing

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Open Journal of Nursing 2020年第2期10卷 171-183页

作者： Motoko Hori Akemi Yamazaki Akemi Soeda Kazumi Odatsu Momoko Buyo miyuki Matumoto Rie Tokutani hiroko Mine Akemi Tsumura Chisato Kimura Yuichi Nakayama Faculty of Nursing Senrikinran University Osaka Japan Division of Health Sciences Osaka University Graduate School of Medicine Osaka Japan Bungoohno City Hospital Oita Japan Oita Red Cross Hospital Oita Japan Career Development Center for Nursing Wakayama Medical University Wakayama Japan Kishiwada Tokushukai Hospital Osaka Japan Otsu Red Cross Hospital Shiga Japan Osaka City General Hospital Osaka Japan Shizuoka Cancer Center Shizuoka Japan Faculty of Health Sciences Tokyo Metropolitan University Tokyo Japan Faculty of Nursing Setsunan University Osaka Japan

The aim of this study was to clarify the attitudes of nurses working in medical facilities towards family nursing and the related factors. A quantitative cross-sectional design was used. The study period was from December 2017 to February 2018. 638 nurses with more than 5 years clinical experience were recruited from seven medical facilities. The questionnaire included the Families’ Importance in Nursing Care-Nurses’ Attitudes (FINC-NA), the Family Sense of Coherence (FSOC), and items on nursing practice ability, job satisfaction, and background characteristics. A multiple regression analysis with FINC-NA as the dependent variable and a path analysis of nursing practice ability as the dependent variable were performed. Responses from 416 nurses (effective response rate, 65.2%) were analyzed. Variables that were significantly related to FINC-NA (p < 0.05) were nursing practice ability, FSOC, job satisfaction, family nursing learning experience, presence of a partner and experience in family nursing. Multiple regression analysis with FINC-NA as the dependent variable revealed significant regression coefficients for nursing practice ability, FSOC and job satisfaction. Moreover, path analysis with nursing practice ability as the dependent variable showed job satisfaction, FSOC, managerial experience, family nursing learning experience were significant. In addition, it was revealed that the direct effect of FSOC on FINC-NA to mediate nursing practice ability was higher than the indirect effect, but the direct effect of job satisfaction on FINC-NA was lower than the indirect effect. It was suggested that it is important that nurses recognize their own thoughts, behaviors and ways of coping with stress within their family, and establish a good work environment and strive to enhance their nursing practice ability.

关键词： Family Nursing Attitude Stress Nursing Practice Ability

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PETO Interacts with Other Effectors of Cyclic Electron Flow in Chlamydomonas

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Molecular Plant 2016年第4期9卷 558-568页

作者： hiroko Takahashi Stefan Schmollinger Jae-Hyeok Lee Michael Schroda Fabrice Rappaport Francis-Andre Wollman Olivier Vallon Institut de Biologie Physice-Chimique UMR 7141 CNRS-UPMC 13 rue Pet M Curie Paris 75005 France Molecular Biotechnology and Systems Biology University of Kaiserslautem Kaiserlautem 67663 Germany Department of Botany University of British Columbia Vancouver BC V6T1Z4 Canada Present address: Graduate School of Science and Engineering Saitama University 255 Shimo-Okubo Sakura-ku Saitama 33808570 Japan present address: Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA

While photosynthetic linear electron flow produces both ATP and NADPH, cyclic electron flow （CEF） around photosystem I （PSI） and cytochrome bef generates only ATP. CEF is thus essential to balance the supply of ATP and NADPH for carbon fixation; however, it remains unclear how the system tunes the relative levels of linear and cyclic flow. Here, we show that PETO, a transmembrane thylakoid phosphoprotein specific of green algae, contributes to the stimulation of CEF when cells are placed in anoxia. In oxic conditions, PETO co-fractionates with other thylakoid proteins involved in CEF （ANR1, PGRL1, FNR）. In PETO-knock- down strains, interactions between these CEF proteins are affected. Anoxia triggers a reorganization of the membrane, so that a subpopulation of PSi and cytochrome bsf now co-fractionates with the CEF effectors in sucrose gradients. The absence of PETO impairs this reorganization. Affinity purification identifies ANR1 as a major interactant of PETO. ANR1 contains two ANR domains, which are also found in the N-terminal region of NdhS, the ferredoxin-binding subunit of the plant ferredoxin-plastoquinone oxidoreductase （NDH）. We propose that the ANR domain was co-opted by two unrelated CEF systems （PGR and NDH）, possibly as a sensor of the redox state of the membrane.

关键词： time-resolved spectroscopy chlorophyll fluorescence tridecyl-maltoside sucrose gradient ultracen-trifugation state transition STT7

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Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes

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World Journal of Stem Cells 2019年第9期11卷 650-665页

作者： Jian-Yun Ge Yun-Wen Zheng Li-Ping Liu hiroko Isoda Tatsuya Oda Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukubaIbaraki 305-8575Japan Institute of Regenerative Medicine and Affiliated Hospital Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Regenerative Medicine School of MedicineYokohama City UniversityYokohama 236-0004Japan Faculty of Life and Environmental Sciences University of TsukubaTsukubaIbaraki 305-8572Japan

In the field of regenerative medicine,generating numerous transplantable functional cells in the laboratory setting on a large scale is a major ***,the in vitro maintenance and expansion of terminally differentiated cells are challenging because of the lack of specific environmental and intercellular signal stimulations,markedly hindering their therapeutic ***,the generation of stem/progenitor cells or functional cells with effective proliferative potential is markedly in demand for disease modeling,cell-based transplantation,and drug *** the potent genetic manipulation of transcription factors,integration-free chemically defined approaches for the conversion of somatic cell fate have garnered considerable attention in recent *** review aims to summarize the progress thus far and discuss the advantages,limitations,and challenges of the impact of full chemicals on the stepwise reprogramming of pluripotency,direct lineage conversion,and direct lineage expansion on somatic *** to the current chemical-mediated induction,reprogrammed pluripotent stem cells with reproducibility difficulties,and direct lineage converted cells with marked functional deficiency,it is imperative to generate the desired cell types directly by chemically inducing their potent proliferation ability through a lineagecommitted progenitor state,while upholding the maturation and engraftment capacity posttransplantation in *** with the comprehensive understanding of the mechanism of chemical drives,as well as the elucidation of specificity and commonalities,the precise manipulation of the expansion for diverse functional cell types could broaden the available cell sources and enhance the cellular function for clinical application in future.

关键词： Chemical induction Pluripotent reprogramming Direct lineage conversion Direct lineage expansion Hepatocyte expansion Cell fate specificity Transcriptional memory In vivo induction

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Accelerated biodegradation of nitrophenols in the rhizosphere of Spirodela polyrrhiza

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Journal of Environmental Sciences 2012年第5期24卷 800-807页

作者： Risky Ayu Kristanti Masahiro Kanbe Tadashi Toyama Yasuhiro Tanaka Kazuhiro mori Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 4-3-11 Takeda Kofu Yamanashi 400-8511 Japan

We investigated the biodegradation of 2-nitrophenol （2-NP）, 4-nitrophenol （4-NP）, and 2,4-dinitrophenol （2,4-DNP） in the rhizosphere of Spirodela polyrrhiza plants by conducting degradation experiments with three river water samples supplemented with each nitrophenol （NP）. We then isolated NP-degrading bacteria both from the S. polyrrhiza roots and from the river water. In the river water samples, removal of the three NP was accelerated in the presence of S. polyrrhiza plants. The three NPs persisted in an autoclaved solution with sterile plants suggests that NP removal was accelerated largely by bacterial NP biodegradation rather than by adsorption and uptake by the plants. We isolated 8 strains of NP-degrading bacteria： 6 strains from the S. polyrrhiza roots and 2 strains from river water without the plants. The 2-NP- and 2,4-DNP-degrading bacteria were isolated only from the S. polyrrhiza roots. The 4-NP- degrading bacteria different from those isolated from the river water samples were also found on S. polyrrhiza roots. The 2-NP- and 4-NP-degrading strains isolated from the roots utilized the corresponding NP （0.5 mmol/L） as the sole carbon and energy source. The 2,4-DNP-degrading strains isolated from the roots showed substantial 2,4-DNP-degrading activity, but the presence of other carbon and energy sources was required for their growth. The isolated NP-degrading bacteria from the roots must have contributed to the accelerated degradation of the three NPs in the rhizosphere of S. polyrrhiza. Our results suggested that rhizoremediation with S. polyrrhiza may be effective for NP-contaminated surface water.

关键词： Spirodela polyrrhiza rhizosphere nitrophenol biodegradation

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Machine learning adaptation of intraocular lens power calculation for a patient group

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Eye and Vision 2021年第5期8卷 422-430页

作者： Yosai mori Tomofusa Yamauchi Shota Tokuda Keiichiro Minami Hitoshi Tabuchi Kazunori Miyata Miyata Eye Hospital 6‑3 Kurahara‑choMiyakonojoMiyazaki 885‑0051Japan Department of Ophthalmology Tsukazaki Hospital68‑1 WakuAboshi‑kuHimejiHyogo 671‑1227Japan Department of Technology and Design Thinking for Medicine Hiroshima University1‑2‑3 KasumiMinami‑kuHiroshima 734‑8553Japan

Background:To examine the effectiveness of the use of machine learning for adapting an intraocular lens(IOL)power calculation for a patient ***:In this retrospective study,the clinical records of 1,611 eyes of 1,169 Japanese patients who received a single model of monofocal IOL(SN60WF,Alcon)at Miyata Eye Hospital were reviewed and *** biometric metrics and postoperative refractions of 1211 eyes of 769 patients,constants of the SRK/T and Haigis formulas were *** SRK/T formula was adapted using a support vector *** errors in the use of adapted formulas as well as the SRK/T,Haigis,Hill-RBF and Barrett Universal II formulas were evaluated with data from 395 eyes of 395 distinct *** prediction errors,median absolute errors,and percentages of eyes within±0.25 D,±0.50 D,and±1.00 D,and over+0.50 D of errors were compared among ***:The mean prediction errors in the use of the SRT/K and adapted formulas were smaller than the use of other formulas(P<0.001).In the absolute errors,the Hill-RBF and adapted methods were better than *** performance of the Barrett Universal II was not better than the others for the patient *** were the least eyes with hyperopic refractive errors(16.5%)in the use of the adapted ***:Adapting IOL power calculations using machine learning technology with data from a particular patient group was effective and promising.

关键词： Machine learning Adaptation Intraocular lens power calculation Patient ethnicity Patient race Region of patient SRK/T formula

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High-Density Polyethylene(HDPE) Surface Treatment Using an RF Capacitive Atmospheric Pressure Cold Ar Plasma Jet

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Plasma Science and Technology 2013年第6期15卷 577-581页

作者：费小猛 Shin-ichi KURODA Tamio mori Katsuhiko HOSOI School of Materials Science and Engineering Wuhan Institute of Technology Department of Advanced Production Science and Technology Graduate School of EngineeringGunma University Department of Advanced Production Science and Technology Graduate School of EngineeringGunma University29-1HontyoOta 373-0057GunmaJapan Cresur Corporation 15-305 Kanda SudaChiyoda 101-0041TokyoJapan

In this study,a high-density polyethylene（HDPE,5-mm-thick,0.95 g/cm3） surface was treated using an RF capacitive atmospheric pressure cold Ar plasma *** using this Ar plasma jet,a hydrophilic HDPE surface was formed during the plasma *** particular, the effects of an additive gas（N;or O2） on the HDPE surface treatment were investigated in *** was shown that the addition of N2 or O2 gas had an important influence on the HDPE surface *** to pure Ar plasma treatment,a lower value of water contact angle （WCA） was obtained when a trace of N2 or O2 gas was *** was also found that besides the quantities of active species in the plasma jet,the treatment temperature played an important role in the HDPE surface *** is because surface molecular motion is not negligible when the treatment temperature is close to the melting point of the polymer.

关键词： atmospheric pressure Ar plasma jet additive gas HDPE surface treatment

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Anti-oxidation activity of ethanol extracts from natural thalli of lichens

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菌物学报 2011年第6期30卷 950-954页

作者： Kojiro HARA Marie ENDO hiroko KAWAKAMI Masashi KOMINE Yoshikazu YAMAMOTO Faculty of Bioresource Sciences Akita Prefectural University241-438 Kaidobata-NishiShimoshinjo-NakanoAkita City 010-0195Japan

Screening test on anti-oxidation activity using 1,1-diphenyl-2-picrylhydrazyl(DPPH) was performed for 99 ethanol extracts of 85 species of natural thalli of lichens in order to find novel anti-oxidation *** 17 extracts of natural thalli showed high anti-oxidation *** them,the activities of extracts from Hypogymnia vittata,Peltigera aphthosa,Nephromopsis ornata,Pseudevernia furfuracea,Cladonia vulcani and Peltigera elizabethae were *** of Peltigera *** higher activity than those of other *** ethanol extract of *** had been separated into ethyl acetate-soluble and water-soluble *** anti-oxidative spots were found only in the water-soluble fractions by thin-layer *** compound in the lower spot had the same Rf value,UV spectrum,and color as authentic solorinine that was previously found as a unique quaternary ammonium compound from Peltigera *** now report that the hydrophilic lichen substance,solorinine showed a nearly same anti-oxidation activity(EC50=120?mol/Lol/L) as standard antioxidant Trolox(EC50=150?mol/L).

关键词：青苔 DPPH 菌物学乙醇

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Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 202-204页

作者： Shinji Itoh Tomoharu Yoshizumi Masaki mori Department of Surgery and Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

The most common primary cancer derived from the liver is hepatocellular carcinoma(HCC),and its incidence is increasing globally(1).Hepatic resection has been established as a safe and effective treatment in patients with ***,the number of patients who develop recurrence after hepatic resection remains high(2).The body composition,which consists of the skeletal muscle mass and fat area,is an important used to determine the perioperative risk and prognosis in patients with cancer.

关键词： patients resection hepatic

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