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Computer-controlled ultra high voltage amplifier for dielectric elastomer actuators

Biomimetic Intelligence & Robotics 2024年第1期4卷 14-23页

作者： Ardi Wiranata Zebing Mao Yu Kuwajima Yuya yamaguchi Muhammad Akhsin Muflikhun hiroki Shigemune Naoki Hosoya Shingo Maeda Department of Mechanical and Industrial Engineering University of Gadjah MadaYogyakarta 55281Indonesia Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Department of Engineering and Science Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Electrical Engineering Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Living Systems Materialogy(LiSM)Research Group International Research Frontiers Initiative(IRFI)Tokyo Institute of TechnologyYokohama 226-8501Japan

Soft robotics is a breakthrough technology to support human-robot *** soft structure of a soft robot can increase safety during human and robot *** of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy *** simple structure of DEAs leads to the easy fabrication of soft *** simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics *** actuation follows the Maxwell-pressure *** pressure produced in the DEAs actuation depends much on the voltage *** DEAs requires high voltage to gain an *** the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be *** commercially available DC-DC converters can convert the volt range to the kV *** order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each *** problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric *** paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft ***-Amp can amplify 12 V to at a maximum of 4 kV *** a demonstration,we used this UHV-Amp to test a single layer of powdered-based *** strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV *** its current state,the UHV-Amp has the potential to achieve approximately 4 *** created a simple platform to control the UHV-Amp from a personal *** near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.

关键词： Dielectric elastomer actuators Electric amplifier Soft actuators Soft robotics Soft actuator education

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ULF seismo-electromagnetic studies in Kanto, Japan

ULF seismo-electromagnetic studies in Kanto, Japan

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2014年中国地球科学联合学术年会——专题2：电磁地球物理学研究应用及其新进展

作者： Peng Han Katsumi Hattori Qinghua Huang Febty Febriani hiroki yamaguchi Chie Yoshino Graduate School of Science Chiba University Department of Geophysics School of Earth and Space Sciences Peking University

In order to clarify the ULF seismo-magnetic phenomena,a sensitive geomagnetic network has been installed in Kanto,*** this study,we have analyzed geomagnetic data observed during the past decade in Izu,Boso,and Kakioka(KAK)*** verify the relation between ULF geomagnetic anomalies and local seismicity,statistical studies by superposed epoch analysis(SEA)have been carried *** results have indicated that before a sizeable earthquake there are clearly higher probabilities of ULF anomalies than after the earthquake:for Seikoshi(SKS)station in Izu,about 200 days before,one week and few days before,and

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On the precursory phenomena of the 2011 off the Pacific coast of Tohoku earthquake(Mw9.0):insight from GPS measurements and geomagnetic observations

On the precursory phenomena of the 2011 off the Pacific coas...

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2014年中国地球科学联合学术年会——专题2：电磁地球物理学研究应用及其新进展

作者： Katsumi Hattori Qinghua Huang Peng Han Guangjing Xu Febty Febriani hiroki yamaguchi Graduate School of Science Chiba University Department of Geophysics School of Earth and Space Sciences Peking University

At present,using a unique physical model to qualitatively interpret an earthquake precursor is considerably difficult,since the earthquake process is rather *** the other hand,although many different kinds of precursors have been claimed,none of them can be always detected before all large earthquakes nor always followed by large *** facts have led to active debates on the earthquake prediction(Geller,1997)and put the studies of pre-earthquake phenomena into a rather difficult situation(Uyeda,2013).To improve the reliability of earthquake forecasting,we could attempt to

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Linking of Chemical Reactions and Silica Nanoparticle Contact Using Synthetic Helical Molecules

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Chinese Journal of Chemistry 2024年第15期42卷 1781-1796页

作者： Sheng Zhang Ming Bao Mieko Arisawa Masahiko yamaguchi state Key Laboratory of Fine Chemicals Dalian University of TechnologyDalianLiaoning 116024China Department of Bioscience and Biotechnology Graduate Schoolof Bioresource and Bioenvironmental SciencesKyushu UniversityFukuoka 819-0395Japan

Biological cells exhibit diverse phenomena induced through linking of chemical reactions of molecules and solid surface *** is then a significant topic in the field of chemistry to study phenomena induced through this linking using synthetic systems,which can promote our understanding of biological phenomena and can be applied to the development of novel *** nanoparticles(sNPs),which are synthetic inorganic materials,are attractive for such purposes,because of their following characteristics:they can adsorb large amounts of molecules on their surfaces,they can aggregate through contact between SNPs as well as contact between molecules and SNPs,and the molecules can be easily removed from solutions by *** contact of sNP surfaces with molecules then affects chemical reactions of molecules and also behaviors of *** article describes systems derived from synthetic helical molecules and sNPs,which exhibit notable phenomena including selective adsorption and molecular recognition,equilibrium shift,step kinetics with induction period,precipitation with flow and sweeping,and disaggregation and desorption by sonication,in which the high affinity of helical molecules with sNP surfaces plays important *** models that explain the phenomena are *** applications are also discussed,including the separation of molecules,capture of intermediates,the storage and release of molecules,equilibrium shift,clocking,and the translation of mechanical stimulations into chemical reactions.

关键词： Silica nanoparticles Chemical reactions Molecular recognition Linking Nanoparticles Adsorption Chirality Precipitation

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关于大跨度钢斜拉桥极限承载力特性的研究

关于大跨度钢斜拉桥极限承载力特性的研究

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中国土木工程学会桥梁及结构工程学会第十三届年会

作者：谢旭 hiroki yamaguchi 黄剑源埼玉大学埼玉大学宁波大学

斜拉桥随着跨度的增大,主梁及塔断内产生的轴向压缩力也同时随之增加,精确地评价它的极限稳定强度,已成了建立长大斜拉桥合理设计方法的重要课题之一．通常,长大斜拉桥的几何非线性性状并不显著,结构破坏主要是由于轴力作用下断面内大... 详细信息

斜拉桥随着跨度的增大,主梁及塔断内产生的轴向压缩力也同时随之增加,精确地评价它的极限稳定强度,已成了建立长大斜拉桥合理设计方法的重要课题之一．通常,长大斜拉桥的几何非线性性状并不显著,结构破坏主要是由于轴力作用下断面内大范围塑性域开展所致,作为合理的结构极限强度分析方法,应当考虑塑性域开展过程的影响．本文中,作者以主跨度600m 的钢斜拉桥为例,用3维弹塑性大变位解析方法,对长大斜拉桥的极限稳定特性进行了考察和分析．结果表明,主跨度600m 的钢斜拉桥具有足够的安全系数以确保结构稳定强度,在工程设计时,对这一等级跨度的钢斜拉桥,失稳强度一般不成会控制主梁断面选定的主要因素．

关键词：斜拉桥极限承载力

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A plant growth chamber system equipped with aerosol generators for studying aerosol-vegetation interactions

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Particuology 2024年第2期85卷 122-132页

作者： Masao Gen Seiji Ikawa Masahiro yamaguchi Fong Zyin Lim Takeshi Izuta I.Wuled Lenggoro Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan Faculty of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509 Japan Department of Applied Physics and Chemical Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan

Understanding aerosol-vegetation interactions is vital in ***,the interactions remain elusive partly due to the lack of suitable plant growth chamber ***,deposition of submicron particles on leaf surfaces is challenging due to its low deposition velocities compared to larger *** this work,we present a plant-growth chamber that was used to study the effect of sub-micron black carbon(BC)particles on the growth and photosynthesis of *** chamber system simultaneously enables the growth of multiple plants in pots and the deposition of submicron particles onto *** spraying methods assisted by ultrasonic and electrostatic forces were employed as aerosol generators to realize the particle *** flow regime inside the chamber was numeri-cally calculated to predict the transportation of aerosol particles,suggesting the optimal operating conditions of the *** gas-phase particle size distribution measurements showed that gener-ated BC particles were suspended in submicron diameter *** aerosol generators were examined in the chamber using three conductor and insulator substrates as a model of plant *** observations and spectroscopic analysis ascertained that submicron BC particles generated from our generators were deposited on all substrate *** the developed chamber system,systematic studies can be performed to advance the fundamental understanding of aerosol-vegetation interactions.

关键词： Aerosol Exposure chamber Spray drying Black carbon

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Edge enhanced depth perception with binocular meta-lens

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Opto-Electronic Science 2024年第9期3卷 4-13页

作者： Xiaoyuan Liu Jingcheng Zhang Borui Leng Yin Zhou Jialuo Cheng Takeshi yamaguchi Takuo Tanaka Mu Ku Chen Department of Electrical Engineering City University of Hong KongHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongHong Kong SAR 999077China The State Key Laboratory of Terahertz and Millimeter Waves and NanotechnologyCity University of Hong KongHong Kong SAR 999077China Innovative Photon Manipulation Research Team RIKEN Center for Advanced Photonics351-0198Japan Metamaterial Laboratory RIKEN Cluster for Pioneering Research351-0198Japan Institute of Post-LED Photonics Tokushima University770-8506Japan

The increasing popularity of the metaverse has led to a growing interest and market size in spatial computing from both academia and *** portable and accurate imaging and depth sensing systems is crucial for advancing next-generation virtual reality *** work demonstrates an intelligent,lightweight,and compact edge-enhanced depth perception system that utilizes a binocular meta-lens for spatial *** miniaturized system comprises a binocular meta-lens,a 532 nm filter,and a CMOS *** disparity computation,we propose a stereo-matching neural network with a novel *** H-Module incorporates an attention mechanism into the Siamese *** symmetric architecture,with cross-pixel interaction and cross-view interaction,enables a more comprehensive analysis of contextual information in stereo *** on spatial intensity discontinuity,the edge enhancement eliminates illposed regions in the image where ambiguous depth predictions may occur due to a lack of *** the assistance of deep learning,our edge-enhanced system provides prompt responses in less than 0.15 *** edge-enhanced depth perception meta-lens imaging system will significantly contribute to accurate 3D scene modeling,machine vision,autonomous driving,and robotics development.

关键词： metasurfaces meta-lenses deep learning depth perception edge detection

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Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi yamaguchi Kazuya Kuraoka Shinya Takahashi Hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

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The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

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Static Stretching Combined with Conscious Slower Breathing May Increase Parasympathetic Activity and Reduce Stress in Adult Women

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Health 2024年第3期16卷 242-256页

作者： Mami Sakurai Yasushi Ikarashi Masahiro Tabuchi Ailing Hu Takuji yamaguchi Hiroyuki Kobayashi Department of Hospital Administration Juntendo University Graduate School of Medicine Tokyo Japan Department of Beauty & Wellness Professional University of Beauty & Wellness Yokohama Japan Department of Personalized Kampo Medicine Juntendo University Graduate School of Medicine Tokyo Japan

Background: Women are thought to be more susceptible to stress than men in a stressful society, and reducing stress is crucial for women to maintain their health. Static stretching (SST) is applied in various fields to not only increase muscle flexibility but also reduce stress. Additionally, conscious slower breathing (CSB) predominates parasympathetic activity, causing a relaxing effect. These results indicate that combining SST and CSB may be more useful in reducing stress. However, to the best of our knowledge, the effect of this combination remains unclear. Objective: This study aimed to elucidate the effects of the combination of SST and CSB on autonomic activity and stress in adult women. Methods: Eleven healthy Japanese adult female participants performed SST with nonconscious natural breathing for 20 min. The same participants performed SST in combination with CSB (2 s inspiratory and 4 s expiratory) for 20 min on another day. Salivary cortisol and chromogranin A levels were measured before and after stretching as stress markers of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system. The coefficient of variation of the R-R interval (CVR-R) and high-frequency component (HF), which reflect parasympathetic nerve activity, and heart rate and low-frequency component (LF)/HF ratio, which reflect sympathetic nerve activity, were measured before, during, and after stretching. Results: SST decreased cortisol levels but with no significant changes in chromogranin A, heart rate, CVR-R, HF, or LF/HF ratio. The combination of SST and CSB increased CVR-R and HF levels in addition to decreasing cortisol levels but with no significant changes in chromogranin A, heart rate, or LF/HF levels. Conclusion: These results indicate that the combination of SST and CSB may increase parasympathetic activity and reduce stress. However, future randomized controlled trials with larger sample sizes should support this conclusion.

关键词： Static Stretching Conscious Slower Breathing Autonomic Activity Heart Rate Variability Stress

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