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Tropifexor,a selective non-acid farnesoid X receptor agonist,improved nonalcoholic steatohepatitis in a phase 2 trial,but several issues remain to be resolved

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 759-762页

作者： Masato Yoneda Takashi Kobayashi Naohiro wada Tomohiro Otani Asako Nogami Michihiro Iwaki Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University HospitalYokohamaJapan

As obesity continues to escalate worldwide,nonalcoholic fatty liver disease(NAFLD)has emerged as the most prevalent form of liver disease,with a reported global prevalence of 30.1%(1).The prevalence of NAFLD,which was around 25%in the 1990s,has been increasing year by year in recent years and has exceeded 35%in the past few years(1).The spectrum of disease includes nonalcoholic fatty liver(NAFL),characterized by macrovesicular hepatic steatosis that may be accompanied by mild inflammation,and nonalcoholic steatohepatitis(NASH),which is additionally characterized by the presence of inflammation and cellular injury(2).

关键词： Nonalcoholic fatty liver disease(NAFLD) obesity nonalcoholic steatohepatitis(NASH) tropifexor selective non-acid farnesoid X receptor agonists(selective non-acid FXR agonists)

Angular distribution measurement for ^12C fragmentation via ^12C ＋ ^12C scattering at 100 MeV/u

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Chinese Physics C 2018年第7期42卷 30-36页

作者： Wei-Wei Qu Gao-Long Zhang Guo-Yu Tian Zhi-Qiang Chen Shou-Ping Xu Royichi wada State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China School of Physics and Nuclear Energy Engineering Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data-based Precision Medicine Beihang UniversityBeijing100083China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Department of Radiation Oncology PLA General HospitalBeijing 100853China Cyclotron Institute Texas A&M UniversityCollege StationTexas 77843USA

The angular distributions and energy spectra of 11B, 10B, and 9Be fragments of 12C in the angular range from 1.0° to 7.5° at 100 MeV/u were obtained via 12C ＋ 12C scattering. Detailed comparisons are presented between the experimental data and the modified antisymmetrized molecular dynamics （AMD-FM）, binary intranuclear cascade model （BIC） and Liège intranuclear cascade model （INCL＋＋）. The experimental angular distributions and energy spectra are well reproduced by the AMD-FM calculations but fail to be reproduced by the physical models installed in the Geant4 program, including the BIC and INCL＋＋ models.

关键词： breakup angular distribution AMD Geant4 simulation

STEREOCONTROLLED SYNTHESIS OF PHSOPHOROTHIOATE DNA AND RNA BY THE OXAZAPHOSPHOLIDINE APPROACH

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STEREOCONTROLLED SYNTHESIS OF PHSOPHOROTHIOATE DNA AND RNA B...

A universal slow Rl-beam facility at RIKEN RIBF

第17届国际磷化学大会

作者： Takeshi wada Department of Medical Genome Sciences Graduate School of Frontier SciencesThe University of TokyoBioscience Building 7025-1-5 KashiwanohaKashiwa 277-8562Japan

＜正＞In recent years, a great deal of attention has been focused on small DNA and RNA molecules as therapeutic agents for selective inhibition of gene expression.[1] Oligonucleotide therapeutic agents,

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A universal slow Rl-beam facility at RIKEN RIBF

A universal slow RI-beam facllity at RIKEN RIBF

The 6th China-Nuclear Physics Symposium

作者： Michiharu wada RIKEN 2-1 HirosawaWakoSaitama 351-0198 Japan

A next-generation slow radioactive nuclear ion beam facility (SLOWRI) which provides slow, high-purity and small emittance ion beams of all elements has been proposed as one of the major experimental facilities at the RIKEN RI-beam factory (RIBF). High energy radioactive ion beams from the projectile fragment separator BigRIPS are thermalized in a large gas catcher cell. The thermalized ions in the gas cell are guided and extracted to vacuum by a combination of DC electric fields and inhomogeneous RF

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A universal slow RI-beam facllity at RIKEN RIBF

Effects of In-Medium Nucleon-Nucleon Cross Section and Nuclear Density Distribution on the Proton-Nucleus Total Reaction Cross Section

6th China-Japan Nuclear Physics Symposium

作者： Michiharu wada RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

＜正＞A next-generation slow radioactive nuclear ion beam facility （SLOWRI） which provides slow, high-purity and small emittance ion beams of all elements has been proposed as one of the major experimental facilities at the RIKLEN RI-beam factory （RIBF）. High energy radioactive ion beams from the projectile fragment separator BigRIPS are thermalized in a large gas catcher cell. The thermalized ions in the gas cell are guided

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Chinese Physics Letters 2013年第12期30卷 25-29页

作者： HAN Rui CHEN Zhi-Qiang R.wada ZHANG Su-Ya-La-Tu LIU Xing-Quan LIN Wei-Ping JIN Zeng-Xue HU Bi-Tao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000 University of Chinese Academy of Sciences Beijing 100049

We present the proton-total reaction cross sectionsσR by comparing the experimental data with the Glauber model calculation using four sets of nucleon-nucleon cross sections used in literature(free nucleon-nucleon cross sections(NNCS),phenomenological NNCS,Bruckner-type NNCS and Pauli NNCS)and different nuclear densities for symmetric and asymmetric *** light symmetric target nuclei,the experimentalσR data are well reproduced by the former three NNCS with the ground state density distributions of relativistic mean-field *** the other hand,for asymmetry heavier target nuclei,the calculations of theσR data depend significantly on the nuclear density distribution at large radius in the low energy *** experimentalσR of these nuclei are well reproduced by the empirical 3 pF density distribution and the in-medium *** neutron surface distributions are also discussed based on the 3 pF nuclear charge distributions.

关键词： theory symmetric radius

SEPARATED FLOW AROUND BENT-NOSE BICONIC IN HYPERSONIC FLOW

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Chinese Journal of Aeronautics 1991年第2期6卷 126-132页

作者： N.Arai S.Sakaguchi Y.wada S.Ogawa Depurtment of Mechunical Systems Engineering Tokyo Noko University Depurtment of Mechunical Systems Engineering Tokyo Noko UniversityComputational Sciences Division National Aerospace Laboratory Chofu Tokyo 182 JAPANComputational Sciences Division National Aerospace Laboratory Chofu Tokyo 182 JAPAN

This article investigates the separated flow around the bent-nose biconic, in which the second ordered TVD(Total Variation Diminishing) method is applied. The governing cqua-tion is a thin layer Navier-Stokes equation. The surface pressure distribution at the leeward side is a little higher in the vicinity of the symmetrical plane. This seems to be caused by the development of the vortex at the leeward side due to the separated flow. The location of a separation line and the size are in very good agreement with the experiment. Also the secondary separation is captured very clearly.

关键词： AOTV SEPARATED FLOW AROUND BENT-NOSE BICONIC IN HYPERSONIC FLOW line very

Major Outcomes through Recent ROSA/LSTF Experiments and Future Plans

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World Journal of Nuclear Science and Technology 2021年第1期11卷 17-42页

作者： Takeshi Takeda Yuki wada Yasuteru Sibamoto Nuclear Safety Research Center Japan Atomic Energy Agency Ibaraki Japan

Many experiments have been conducted on accidents and transients of pressurized water reactor (PWR) employing the rig of safety assessment/large-scale test facility (ROSA/LSTF). Recent research activities concerned with the OECD/NEA international joint projects included experimental investigation via the ROSA and ROSA-2 Projects, and counterpart testing with thermal-hydraulic integral test facilities under collaboration of the PKL-2, PKL-3, ATLAS, and ATLAS-2 Projects. Major results of the related integral effect tests (IETs) with the LSTF were reviewed to experimentally identify thermal-hydraulic phenomena involved, regarding the PWR accident sequences in accordance with the new regulatory requirements for the Japanese light-water nuclear power plants. Future separate effect test using the LSTF is planned to simulate loss of emergency core cooling system (ECCS) recirculation functions in a large-break loss-of-coolant accident (LOCA). Key results of the recent IETs utilizing the LSTF and future plans were presented relevant to multiple steam generator tube rupture accident with recovery operation, small-break LOCA with accident management measure on core exit temperature reliability, and small-break LOCA with thermal stratification under cold water injection from ECCS into cold legs. Also, main outcomes of the LSTF IETs were indicated for wide spectrum LOCA with core uncovery and anticipated transient without scram following small-break LOCA under totally failed high-pressure injection system.

关键词： PWR ROSA/LSTF LOCA ECCS Integral Effect Test

Analysis of the Relationship between Image and Blood Examinations in an Artificial Intelligence System for the Molecular Diagnosis of Breast Cancer

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Open Journal of Applied Sciences 2021年第9期11卷 1016-1027页

作者： Natsumi wada Maoko Nakashima Yoshikazu Uchiyama Graduate School of Health Sciences Kumamoto University Kumamoto Japan Department of Medical Image Sciences Faculty of Life Sciences Kumamoto University Kumamoto Japan

Molecular subtype classification based on tumor genotype has recently been used for differential diagnosis of breast cancer. The shift from conventional tissue classification to molecular genetics-based classification is primarily because objective genetic information can ensure a biologically clear classification system and patient groups may be created for a given set of diagnoses and suitable treatments. Given the stressful nature of biopsy, radiomic studies are conducted to determine breast cancer subtypes using non-invasive imaging tests. Minimally invasive blood tests using microRNAs (miRNAs) contained in exosomes have been developed. We investigated the usefulness of radiomic features and miRNAs in distinguishing triple-negative breast cancer (TNBC) from other cancer types. Fat suppression T2-weighted magnetic resonance images and miRNAs of 60 cases (9 TNBC and 51 others) were retrieved from the Cancer Genome Atlas Breast Invasive Carcinoma. Six radiomic features and six miRNAs were selected by least absolute shrinkage and selection operator. Linear discriminant analysis was employed to distinguish between TNBC and others. With miRNAs, TNBC and others were completely separated, whereas with radiomic features, TNBC overlapped with other types of breast cancer. Receiver operating characteristic curve analysis results showed that the area under the curve of radiomic features and miRNAs was 0.85 and 1.0, respectively. miRNAs showed a higher discrimination performance than radiomic features. Although gene analysis is expensive and facilities for performing it are limited, miRNAs for blood tests may be useful in artificial intelligence systems for the molecular diagnosis of breast cancer.

关键词： Radiomic Feature microRNA Breast Cancer Artificial Intelligence Characterization