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Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse

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World Journal of Gastroenterology 2007年第16期13卷 2289-2297页

作者： Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan

AIM： To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS： The multi-herbal medicine Juzentaihoto （JTX） was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins （HSPs） 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite （SA） was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism （T-RFLP） method was used. To identify the changed bacteria, DNA sequencing was *** by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene ***： Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver.

关键词： Herbal medicine Juzentaihoto Intestinal microflora Terminal restriction fragment length polymorphism Heat shock protein

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Endoscopic resection for residual lesion of metastatic gastric cancer:A case report

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World Journal of Clinical Cases 2019年第4期7卷 482-488页

作者： Kaori Hayashi Sho Suzuki Hisatomo Ikehara Hiroaki Okuno Akira irie Mitsuru Esaki Chika Kusano Takuji Gotoda Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

BACKGROUND Chemotherapy is a standard strategy for stage IV gastric cancer ***, some cases cannot undergo conversion surgery because of their frailty,even if the patients had response to chemotherapy. For these patients, local tumor progression is a problem. We report here the case of a patient whose residual gastric cancer was resected through endoscopic submucosal dissection(ESD)after concomitant chemotherapy for metastatic gastric *** SUMMARY An 85-year-old male complained of difficulty swallowing, and examination revealed gastric cancer with multiple liver metastases. Although he received concomitant chemotherapy, a residual tumor was observed in the primary lesion while the metastatic lesions disappeared completely. Conversion surgery was considered optional treatment; however, he could not undergo that because of advanced age and comorbidities. Thus, we performed ESD to treat the residual tumor. As a result, we resected the residual lesion completely. The patient has been alive for 29 mo since ESD, without *** We achieved local control using ESD, and these findings may provide therapeutic improvements both in local control and patient survival outcomes.

关键词： Gastric cancer Liver metastases Conversion Endoscopic submucosal dissection Chemotherapy Case report

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Development of APEC Low-Carbon Town Indicator（LCT-I） System

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Journal of Civil Engineering and Architecture 2017年第11期11卷 979-992页

作者： Yuko Tanaka Kazutomo irie Asia Pacific Energy Research Centre (APERC) The Institute of Energy Economics Japan (IEEJ) Inui Bldg. Kachidol~" 1 IF 1-13-1Kaehidoki Chuo-ku Tokyo 104-0054 Japan

The APEC （Asia-Pacific Economic Cooperation） LCMT （Low-Carbon Model Town） project was initiated in 2011 as apart of APEC＇s energy cooperation scheme in response to the rapid urbanization and growing fossil energy use in the developingeconomies of the APEC region. The LCMT project has conducted feasibility studies and policy reviews for a case town eachyear and developed and refined the ＂Concept of Low-Carbon Town in the APEC region （Concept）＂. The Concept is a guidebookfor city planners and developers who wish to implement low-carbon town design. In tandem with the Concept, the ＂APECLow-Carbon Town Indicator （LCT-I） System＂ has been developed since 2013. The LCT-I System is a self-assessment tool to assessand monitor the progress of each low-carbon town development project in the APEC region. The first edition of the LCT-I SystemGuideline and its evaluation sheet were published together with the final edition of the Concept in 2016. The LCMT project ismoving into the dissemination stage beginning in 2017 through the utilization of the LCT-I System. This paper explains the processof the development of the LCT-I System, provides a brief summary and discusses its expected role in the spread of low-carbontowns.

关键词： Sustainable cities, low-carbon towns, indicator system.

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Thermoelectric Properties of Misfit Layered Bismuth-Based Rhodium Oxides, (Bi,Pb)2Sr2Rh2Oy

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Journal of Materials Science and Chemical Engineering 2018年第7期6卷 97-103页

作者： Takuya Watanabe Hiroshi irie Special Doctoral Program for Green Energy Conversion Science and Technology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan Clean Energy Research Center University of Yamanashi Yamanashi Japan

Rhodium oxides, including a misfitlayered structure with alternate stacking of a rock salttype layer and a hexagonal RhO2 layer, are expected to have good thermoelectric properties. Among them, the thermoelectric properties (electrical conductivity (σ), Seebeck coefficient (S), Figure of merit (ZT) and calculated thermal conductivity (κ) by S, σ, ZT, and absolute temperature (T)) of bismuth-based rhodium oxides ((Bi1-x,Pbx) 2Sr2Rh2Oy, x = 0 and 0.02, hereafter BSR and BPSR, respectively) were investigated. In comparison with Bi2Sr2Co2Oy (BSC) at 700°C, S and κ enhanced (increased S, 110 (BSR) and 105 μV K-1 (BPSR) from 85 μV K-1 (BSC) and decreased κ, 0.32 (BSR) and 0.50 W m-1 K-1 (BPSR) from 1.75 W m-1 K-1 (BSC)), whereas σ decreased (15 (BSR) and 31 S cm-1 (BPSR) from 70 S cm-1 (BSC)). BPSR reached the highest ZT value of 0.067 at 700°C, compared to those of 0.056 (BSR) and 0.027 (BSC).

关键词： Electroceramics Layered Rhodium Oxide Misfit Layer Structure Thermoe-lectric Material Harman Method

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Immunohistochemical Analysis of the Acid Secretion Potency in Gastric Parietal Cells

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CellBio 2013年第4期2卷 179-185页

作者： Rie irie-Maezono Shinichiro Tsuyama Department of Gene Therapy and Regenerative Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Laboratory for Neuroanatomy Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan

Gastric parietal cells are important in acid secretion, but it is unclear which cells throughout the gastric gland have the highest secretion potency. Here, we used immunohistochemical methods with anti-H+, K+-ATPase, phosphoryl ezrin and CD44 antibodies to study the distribution of gastric acid secretion activity. Stomach tissues from freely fed and starved rats were cryofixed for light microscopy or fixed by high-pressure freezing for electron microscopy. Parietal cells from freely fed animals corresponded to the active secretion phase and to the inactive resting phase from starved rats. Anti-H+, K+-ATPase and anti-phosphoryl ezrin labeling were observed on the membrane of the intracellular canaliculi and the tubulovesicle from freely fed rats, while cells from starved animals showed weak labeling with anti-phosphoryl ezrin antibody staining. Morphometrical analysis at the electron microscopic level was performed on active and inactive acid secretory phases between the upper and base regions of the gland. H+, K+-ATPase and CD44 were distributed on both sites of the microvillous and tubulovesicle membrane in the same cells, but phosphoryl ezrin localized predominantly on the microvillous membrane in active cells of the glandular neck and upper base. Therefore, the highest secreting potency appeared to be in cells of the glandular neck and upper base.

关键词： Gastric Parietal Cells Secretory Potency Phosphoryl Ezrin Histochemical Morphometry

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Nonequilibrium Effect in Ferromagnet-Insulator-Superconductor Tunneling Junction Currents

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World Journal of Condensed Matter Physics 2016年第3期6卷 169-176页

作者： Michihide Kitamura Kazuhiro Yamaki Akinobu irie Department of Electrical and Electronic System Engineering Utsunomiya University Utsunomiya Japan

Nonequilibrium effect due to the imbalance in the number of the ? and ? spin electrons has been studied for the tunneling currents in the ferromagnet-insulator-superconductor (FIS) tunneling junctions within a phenomenological manner. It has been stated how the nonequilibrium effect should be observed in the spin-polarized quasiparticle tunneling currents, and pointed out that the detectable nonequilibrium effect could be found in the FIS tunneling junction at 77 K using HgBa2Ca2Cu3O8+? (Hg-1223) high-Tc superconductor rather than Bi2Sr2CaCu2O8+? (Bi-2212) one.

关键词： Nonequilibrium Effect Ferromagnet-Insulator-Superconductor Tunneling Junction Hg-1223 Bi-2212 Spin-Polarized Quasiparticle Tunneling

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Thermoelectric Properties of Silver Antimonate with Mixed Valency of Antimony

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Journal of Materials Science and Chemical Engineering 2017年第1期5卷 121-128页

作者： Kensuke Ozawa Hirofumi Kakemoto Hiroshi irie Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan Clean Energy Research Center University of Yamanashi Yamanashi Japan

Silver (Ag) and silver antimonate (AgSbO3) composites with different amounts of Sb3+ were synthesized by normal sintering with the aim of realizing a thermoelectric material. The electrical conductivity (σ) increased in the sample containing larger amount of Sb3+, whereas Seebeck coefficient (S) decreased. Producing Sb3+ caused the generation of oxygen vacancies in the material, and thus the corresponding donor levels are created in the bandgap, providing more conduction electrons. The conductive Ag particles would contribute to the conduction path as bypasses for carrier transport. The thermal conductivity (κ) was slightly lower in the presence of Ag defects in AgSbO3.

关键词： Thermoelectric Material Silver Antimonate Seebeck Coefficient Electrical Conductivity Thermal Conductivity

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Enhancement of Oxygen Evolution Activity of Ruddlesden-Popper-Type Strontium Ferrite by Stabilizing Fe4+

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Journal of Materials Science and Chemical Engineering 2017年第4期5卷 45-55页

作者： Toshihiro Takashima Koki Ishikawa Hiroshi irie Clean Energy Research Center University of Yamanashi Yamanashi Japan Special Doctoral Program for Green Energy Conversion Science and Technology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan

Development of active iron based water oxidation for designing an ideal artificial photosynthesis devices operating under benign neutral pH is highly demanded. We investigated the electrocatalytic activity of Ruddlesden-Pop-per-type strontium ferrite (Sr3Fe2O7) toward the oxygen evolution reaction (OER). Owing to the temperature-dependent efficiency of the charge disproportionation of Fe4+, the OER activity of Sr3Fe2O7 varied with the temperature, and the onset potential for the OER at a neutral pH underwent a negative shift of approximately 200 mV by increasing the temperature for the stabilization of Fe4+. When metal substitution was made to Sr3Fe2O7 for stabilizing Fe4+ at room temperature, the temperature dependence of the OER activity disappeared and the OER was driven at a small overpotential without increasing the temperature, indicating that the stabilization of Fe4+ is substantially important for achieving high OER activity.

关键词： Oxygen Evolution Charge Disproportionation Water-Splitting Sr3Fe2O7

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Ohmic Hetero-Junction of n-Type Silicon and Tungsten Trioxide for Visible-Light Sensitive Photocatalyst

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Journal of Materials Science and Chemical Engineering 2017年第8期5卷 33-43页

作者： Masaharu Yoshimizu Yuki Hotori Hiroshi irie Special Doctoral Program for Green Energy Conversion Science and Technology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan Special Doctoral Program on Clean Energy Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan Clean Energy Research Center University of Yamanashi Yamanashi Japan

Visible light-sensitive photocatalyst was developed by combining n-type silicon (n-Si) and tungsten trioxide (WO3, n-Si/WO3), yielding an ohmic contact in between. In this system, the ohmic contact acted as an electron-and-hole mediator for the transfer of electrons and holes in the conduction band (CB) of WO3 and in the valence band (VB) of n-Si, respectively. Utilizing thus- constructed n-Si/WO3, the decomposition of 2-propanolto CO2 via acetone was achieved under visible light irradiation, by the contribution of holes in the VB of WO3 to decompose 2-propanol and the consumption of electrons in the CB of n-Si to reduce O2. The combination of p-type Si (p-Si) and WO3 (p-Si/ WO3), not the ohmic contact but the rectifying contact, was much less effective, compared to n-Si/WO3.

关键词： Ohmic Contact Silicon Tungsten Trioxide Visible Light Oxidative Decomposition Two-Step Excitation

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Enhanced Visible-Light-Sensitive Two-Step Overall Water-Splitting Based on Band Structure Controls of Titanium Dioxide and Strontium Titanate

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Journal of Materials Science and Chemical Engineering 2017年第1期5卷 129-141页

作者： Satoshi Tanigawa Toshihiro Takashima Hiroshi irie Special Doctoral Program for Green Energy Conversion Science and Technology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan Clean Energy Research Center University of Yamanashi Yamanashi Japan

Visible light-induced two-step overall water-splitting was achieved by combining two types of photocatalysts, which were prepared by introducing foreign elements into rutile titanium dioxide (TiO2) and strontium titanate (SrTiO3) with a controlled electronic band structure. Rutile TiO2 and SrTiO3 were doped with chromium and tantalum (Cr,Ta-TiO2) and with rhodium (Rh-SrTiO3), respectively, to introduce visible-light sensitivity. Under irradiation with only visible light from a 420-nm LED lamp, the simultaneous liberation of hydrogen and oxygen with a molar ratio of ~2:1 was achieved with these two types of photocatalysts in the presence of iodate ion/iodide ion as a redox mediator.

关键词： Titanium Dioxide Strontium Titanate Visible Light Overall Water-Splitting Two-Step Excitation

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