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Asian Journal of Andrology 2016年第3期18卷 500-500页

作者： hiroki watanabe Director Watanabe Memorial Choumei Research Laboratory Shiga Japan Honorary Professor Kyoto Prefectural University of Medicine and Meiji University otIntegrated Medicine Kyoto Japan.

In published paper by watanabe, the Figure 3 on page 905 is incorrect, because of a mistake on computer processing. The correct Figure 3 is as follows.

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Relapse of prostate cancer from the viewpoint of total gland volume kinetics theory

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Asian Journal of Andrology 2015年第6期17卷 904-907页

作者： hiroki watanabe Director Watanabe Memorial Choumei ResearchLaboratory Shiga Japan Honorary Professor KyotoPrefectural University of Medicine and Meiji Universityof Integrated Medicine Kyoto Japan.

In many cases of prostate cancer, changes of prostate volume were measured very frequently after castration by means of transrectal ultrasound. For short-term observations, a factor called as ＂reduction time （tau [τ]）,＂ which means the time required for the volume of ＂effective portion＂（volume responded to castration） to be reduced to one-tenth of its original value, correlated very well with patients＇ prognosis. For long-term observations for relapse, changes of prostate volume could be divided clearly into two types, namely, ＂metastatic progressive type＂ with metastasis without volume increase and ＂local progressive type＂ with remarkable volume increase without metastasis. ＂τ＂ in the ＂local progressive type＂ was far shorter than that in the ＂metastatic progressive type.＂ Much longer survival was obtained when the patient belonged to the ＂local progressive type＂ than to the ＂metastatic progressive type.＂ Thus, ＂τ＂ was the most important and the most reliable factor to predict the prognosis. Based upon these observations, a schematic analysis of prostate cancer relapse was shown.

关键词： Relapse prostate theory

The International Prostate Forum introduction and history

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Asian Journal of Andrology 2015年第6期17卷 863-863,I0006页

作者： John W Davis Tsuneharu Miki Atif Akdas hiroki watanabe Ziya Kirkali Run Wang R Joseph Babaian Department of Urology The University of Texas MDAnderson Cancer Center Houston Texas 77030 USA Department of Urology Kyoto Prefectural University ofMedicine Kyoto Japan Department of Urology Schoolof Medicine Marmara University Istanbul Turkey watanabe Memorial Choumei Research Laboratory Shiga Japan Dokuz EylOI University School ofMedicine Department of Urology Izmir Turkey Division of Urology University of Texas Medical Schoolat Houston Department of Urology Houston TexasUSA Department of Urology University of Texas MDAnderson Cancer Center Houston Texas 77030 USA

The International Prostate Forum （IPF） originally started with three urology departments in Japan, Turkey, and the United States. The forum emphasized discussions and presentations of new knowledge in all areas of prostate diseases with an early emphasis on ultrasound and diagnostics. The meeting has generally run every 2 years and rotated through the three sites with new leadersjoining the effort. Over the years, the meeting has enjoyed a diverse locale and points of emphasis. The latter agendas now cover all aspects of the benign prostate disease, prostate cancer screening, prostate cancer diagnosis and staging, and therapies. Table 1 summarizes the dates of the meetings, locations, and chairman.

关键词： International Prostate history

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膀胱内微型爆炸碎石术

国际泌尿系统杂志 1984年第3期 129-130页

作者： hiroki watanabe 顾金罕

作者在1977年首先报道了微型爆炸的概念。此后在技术上开展了系统的研究。本文报道了根据上述微型爆炸碎石术所发明的一种膀胱碎石器的动物实验和临床应用。这种碎石器有一根爆炸用的导管,其尖端装有叠氮化铅(lead azide)炸药。选用叠... 详细信息

作者在1977年首先报道了微型爆炸的概念。此后在技术上开展了系统的研究。本文报道了根据上述微型爆炸碎石术所发明的一种膀胱碎石器的动物实验和临床应用。这种碎石器有一根爆炸用的导管,其尖端装有叠氮化铅(lead azide)炸药。选用叠氮化铅是因它点燃时灵敏,即使少量时亦易于点燃。其产生的能量与通常工业用的甘油炸药(dynamite)等相同。在常温下不会有意外的爆炸。

关键词：结石钳子碎石术

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

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VISUALIZATION OF TURBULENT REACTIVE JET BY USING DIRECT NUMERICAL SIMULATION

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S01期4卷 70-85页

作者： TOMOAKI watanabe YASUHIKO SAKAI KOUJI NAGATA OSAMU TERASHIMA hiroki SUZUKI TOSHIYUKI HAYASE YASUMASA ITO Department of Mechanical Science and Engineering Nagoya University Nagoya Aichi464-8603Japan Department of Engineering Physics Nagoya Institute of Technology Nagoya Aichi466-8555Japan Institute of Fluid Science Tohoku University SendaiMiyagi980-8577Japan

Direct numerical simulation(DNS)of turbulent planar jet with a second-order chemical reaction(A+B→R)is performed to investigate the processes of mixing and chemical reactions in spatially developing turbulent free shear *** A is premixed into the jet flow,and reactant B is premixed into the ambient *** is performed at three different Damk¨ohler numbers(Da=0.1,1,and 10).Damk¨ohler number is a ratio of a time scale of a flow to that of chemical reactions,and in this study,the large Da means a fast chemical reaction,and the small Da means a slow chemical *** visualization of velocity field shows that the jet flow is developed by entraining the ambient *** visualization of concentration of reactant A shows that concentration of reactant A for Da=1 and 10 becomes very small in the downstream region because the chemical reaction consumes the reactants and reactant A is diffused with the jet *** comparison of the profiles of chemical reaction rate and concentration of product R,it is found that product R for Da=10 is produced by the chemical reaction at the interface between the jet and the ambient fluids and is diffused into the jet flow,whereas product R for Da=0.1 is produced in the jet flow after reactants A and B are well mixed.

关键词： Turbulent flow direct numerical simulation jet.

Benefit of laparoscopic liver resection in high body mass index patients

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World Journal of Gastroenterology 2016年第10期22卷 3015-3022页

作者： hiroki Uchida Yukio Iwashita Kunihiro Saga Hiroomi Takayama Kiminori watanabe Yuichi Endo Kazuhiro Yada Masayuki Ohta Masafumi Inomata Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine

AIM: To explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).METHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical ***: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. There were no signi ficant di fferences in mortali ty and morbidity in two groups. Twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. The operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate ***: The present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients.

关键词： Laparoscopic liver resection Obesity Body mass index Prolonged operation time Increased blood loss

Surface modification and characterization of F-Co doped spinel LiMn_2O_4

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Rare Metals 2006年第z1期25卷 33-38页

作者： watanabe Takayuki Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 Nagatsuta Yokomaha 226-8502 Japan

Spinel LiCo0.09Mn1.91O3.92F0.08 as cathode material was modified with LiCoO2 by the sol-gel method, and the crystal structure, morphology and electrochemical performance were characterized with XRD, SEM, EDS, AAS and charge-discharge test in this paper. The results show that a good clad coated on parent material can be synthesized by the sol-gel method, and the materials with modification have perfect spinel structure. LiCo0.09Mn1.91O3.92F0.08 materials coated by LiCoO2 improve the stability of crystal structure and decrease the dissolution of Mn into electrolyte. With the LiCoO2 content increasing, the specific capacity and cycle performance of samples are improved. The capacity loss is also suppressed distinctly even at 55 ℃.

关键词： lithium ion batteries spinel LiMn2O4 ion doping surface coating

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Protein-losing enteropathy caused by a jejunal ulcer after an internal hernia in Petersen's space: A case report

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World Journal of Clinical Cases 2022年第1期10卷 323-330页

作者： Tomohiko Yasuda Nobuyuki Sakurazawa Komei Kuge Jun Omori hiroki Arai Daisuke Kakinuma Masanori watanabe Hideyuki Suzuki Katsuhiko Iwakiri Hiroshi Yoshida Department of Gastrointestinal Surgery Nippon Medical School Chiba Hokusoh HospitalChiba 270-1694Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8603Japan Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan

BACKGROUND The incidence of internal hernias has recently increased in concordance with the popularization of laparoscopic *** particular concern are internal hernias occurring in Petersen's space,a space that is surgically created after treatment for gastric cancer and *** hernias cause devastating sequelae,such as massive intestinal necrosis,fatal Roux limb necrosis,and superior mesenteric vein *** addition,protein-losing enteropathy(PLE)is a rare syndrome involving gastrointestinal protein loss,although its relationship with internal Petersen’s hernias remains *** SUMMARY A 75-year-old man with a history of laparotomy for early gastric cancer developed Petersen's hernia 1 year and 5 mo after *** was successfully treated by reducing the incarcerated small intestine and closure of Petersen’s defect without resection of the small *** 3 mo after his surgery for Petersen’s hernia,he developed bilateral leg edema and *** was diagnosed with PLE with an alpha-1 antitrypsin clearance of 733 mL/24 ***-balloon enteroscopy revealed extensive jejunal ulceration as the etiology,and it facilitated minimum bowel *** analysis showed extensive jejunal ulceration and collagen hyperplasia with nonspecific inflammation of all layers without lymphangiectasia,lymphoma,or vascular *** postoperative course was unremarkable,and his bilateral leg edema and hypoalbuminemia improved after 1 *** was no relapse over the 5-year follow-up *** PLE and extensive jejunal ulceration may occur after Petersen's *** enteroscopy helps identify and resect these lesions.

关键词： Internal hernia Ulcer Protein-losing enteropathy Double-balloon enteroscopy Ischemia-reperfusion injury Case report

The Theaflavin Monomers Inhibit the Cancer Cells Growth in Vitro

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 508-512页

作者： Naoharu watanabe Department of Applied Biological Chemistry 836 Ohya Shizuoka 422-8529 Shizuoka University Japan

The inhibition effects of tea theaflavins complex (TFs), theaflavin-3-3’-digallate (TFDG), theaflavin-3’-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells were investigated. TFs was obtained through the catalysis of catechins with immobilized polyphenols oxidase. TFDG, TF2B and UC were isolated from TFs with high speed countercurrent chromatography (HSCCC). The results showed that TF2B significantly inhibited the growth of all three kinds of cancer cells, TFs, TFDG and UC had some effect on BEL-7402 and MKN-28, but little activity on LH-60. The inhibition effects of TF2B, TFDG, and UC on BEL-7402 and MKN-28 were stronger than TFs. The relationship coefficients between monomer concentration and its inhibition rate against MKN-28 and BEL-7402 were 0.87 and 0.98 for TF2B, 0.96 and 0.98 for UC, respectively. The IC50 values of TFs, TF2B, and TFDG were 0.18, 0.11, and 0.16 mM on BEL-7402 cells, and 1.11, 0.22, and 0.25 mM on MKN-28 cells respectively.

关键词： theaflavin monomer separation cancer cells inhibition