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Analysis of Electrogastrograms of Elderly Gastrectomized Subjects by Using Maximum Lyapunov Exponent

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Computer Technology and Application 2011年第12期2卷 985-990页

作者： hiroki takada Yasuyuki Matsuura Masaru Miyao Graduate School of Engineering University of Fukui Fukui City 910-8507 Japan Headquarters for Innovative Society-Academia Cooperation University of Fukui Fukui City 910-8507 Japan Graduate School of lnformation Science Nagoya University Nagoya City 464-8601 Japan

Not much data are available regarding the electrical activity in the stomachs and intestines of elderly gastrectomized patients The purpose of this study was to determine the feasibility of using a complex dynamic method to analyze the electrogastrograms （EGGs） of healthy young, healthy elderly, and gastrectomized elderly male individuals. The authors analyzed the EGGs by using the maximum Lyapunov exponent （MLE）, which is one of the indices of the chaotic characteristics of time series. Significant differences were observed between the MLEs estimated from the, EGGs of the young and elderly individuals for most of the temporal intervals. The authors＇ data indicate that the EGGs of elderly gastrectomized subjects might be distinguished from the EGGs of healthy elderly individuals on the basis of the MLE distribution.

关键词： Electrogastrogram (EGG) gastrectomized attractor maximum Lyapunov exponent (MLE).

Stochastic Resonance as a Mathematical Model of an Electrogastrogram

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Journal of Physical Science and Application 2012年第6期2卷 186-194页

作者： Matsuura Yasuyuki Miyao Masaru takada hiroki Headquarters for Innovative Society-Academia Cooperation University of Fukui Fukui 910-8507 Japan Graduate School of Information Science Nagoya University Nagoya 464-8603 Japan Graduate School of Engineering University of FukuL Fukui 910-8507 Japan

An electrogastrogram （EGG） is a recording of the electrical activity in the stomach, as measured on the abdominal surface. In this study, the goal is to obtain a mathematical model of an EGG; to achieve this, the EGG of 14 subjects （seven males and seven females） will be obtained. Initially, the Wayland algorithm to the EGG to measure the degree of determinism is applied. However, it could not be determined whether the EGG could be generated by a chaotic process. In addition, the waveform of the electric potential in the interstitial cells of Cajal is similar to the graphs of the numerical solutions to the Van der Pol equation. Therefore, the Van der Pol equation to a periodic function was added, and random white noise was used to represent the intestinal motility and other biosignals. The EGG and numerical solutions were compared and evaluated on the basis of the translation error （Etrans） in the Wayland algorithm and the maximum Lyapunov exponent （2） in Rosenstein＇s algorithm. By projecting the data from an obtained stationary EGG from the subjects, along with the numerical solutions, onto the Etrans-λ plane, the affinity between them was qualitatively evaluated. The EGG was well described by stochastic resonance from the stochastic differential equations.

关键词： Electrogastrography numerical solution Wayland algorithm maximum Lyapunov exponent stochastic resonance.

System to Control Upright Posture with Alcoholic Intake

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Journal of Mathematics and System Science 2012年第7期2卷 447-453页

作者： hiroki takada Shinichi Taniguchi Yuuki Shimizu Takayuki Hirata Graduate School of Engineering University of Fukui Fukui 910-8507 Japan Department of Physiology Aichi Medical University School of Medicine Aichi 480-1195 Japan

Equilibrium function in the cerebellum （vestibulo-cerebellar system） can deteriorate under the influence of alcohol. In the Romberg posture, the center of gravity, which was measured every 50 ms by stabilometry, appeared to shift with alcohol ingestion. In the previous study, a locus in the center of gravity （stabilogram） was converted to values of statistical indices such as area of sway, total locus length, sparse density, and locus length per unit area, although these indices could not always distinguish between the stabilograms sampled from seven healthy young males in sober and intoxicated states. This measurement was made with an AMTI force plate. In this study, ＂translation error＂ was estimated in a d-dimensional embedding space in order to compare stabilograms recorded before and after the ingestion of doubly diluted brandy in 30 s （1 ≤ d ≤ 10）. The authors succeeded in validating stochastic differential equations as a mathematical model of the body sway. Although the postural control system shows different patterns in the lateral and anterior-posterior directions, the randomness in the model was preserved after alcohol intake and significantly increased in the medial/lateral direction. Visual information referred by the postural conlrol system when standing might be interfered by the effects of intoxication, which was regarded as disturbance. The possibility of detecting alcohol-ingestion-induced reduction of the equilibrium function and its recovery process are also suggested in this paper. This method is considered to be useful to diagnose the disorders of the vestibulo-cerebellar system.

关键词： Stabilogram alcoholic intake SPD (sparse density) translation error SDE (stochastic differential equation).

Effects of dry and mist saunas on circulatory and thermoregulatory functions in humans

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Health 2013年第2期5卷 267-273页

作者： Satoshi Iwase Yuko Kawahara Naoki Nishimura hiroki takada Mayumi Nagata Yuki Niimi Chihiro Miwa Aichi Medical College for Physical Therapy and Occupational Therapy Kiyosu Japan Department of Human & Artificial Intelligent Systems Graduate School of Engineering University of Fukui Fukui Japan Department of Neurology Tsushima Municipal Hospital Tsushima Japan Department of Physiology Aichi Medical University Nagakute Japan Group of Home Systems & Appliance R&D Department of Home Systems & Appliance Sales Toho Gas Co. Ltd. Nagoya Japan Plumbing Fixtures Technology Research Institute Kitchen & Plumbing Fixtures Company LIXIL Corporation Tokoname Japan

To test the hypothesis that mist sauna is a safer way of bathing than dry sauna, we compared changes in circulatory and thermoregulatory functions during 10 min sauna bathing in mist sauna at 40℃ with relative humidity of 100%, and in dry sauna by infrared ray at 70℃ with relative humidity of 15%. Subjects were seven healthy young men aged 29 ± 6 yrs (mean ± SD). We measured blood pressure, heart rate, skin temperatures at chest, forearm, thigh, and leg, tympanic temperature (Tty) by thermistors, skin blood flow at forearm by laser Doppler flowmetry, and sweat rate by ventilated capsule method at 1 min intervals throughout the experiment. Total sweating and change of hematocrit were also measured for dehydration analysis. Blood pressure was elevated more and changes in heart rate and total sweating were larger in dry sauna than mist. A significant hematocrit increase was observed in dry sauna bathing only. Mean skin temperature and Tty in dry sauna were elevated higher than those in mist. Heat stress of the dry sauna may be stronger than that of the mist, leading to dehydration and hypovolemia by sweating. Percent plasma volume loss was significantly larger in the dry than mist sauna. Changes in skin blood flow and sweat rate/Tty during mist sauna were significantly larger than those during dry sauna bathing despite heat stress of the mist sauna. The mist sauna bathing may thus be safer physiologically, and provide more effective vascular dilatation and sweating than the dry sauna bathing.

关键词： Sauna Bathing Mist Sauna Dry Sauna Heat Stress Hemodynamic Change Thermoregulatory Function

Isolated intrapancreatic Ig G4-related sclerosing cholangitis

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World Journal of Gastroenterology 2015年第4期21卷 1334-1343页

作者： Takahiro Nakazawa Yushi Ikeda Yoshiaki Kawaguchi Hirohisa Kitagawa hiroki takada Yutaka Takeda Isamu Makino Naohiko Makino Itaru Naitoh Atsushi Tanaka Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan Department of Gastroenterology Yamagata University Faculty of MedicineYamagata 990-9585Japan Department of Gastroenterology Tokai University School of MedicineKanagawa 259-1153Japan Gastroenterologic Surgery Division of Cancer Medicine Graduate School of Medical ScienceKanazawa UniversityKanazawa 920-8640Japan Department of Gastroenterology Kasugai Municipal HospitalKasugai 486-8510Japan Department of Surgery Kansai Rosai HospitalOsaka 660-8511Japan Department of Medicine Teikyo University School of MedicineTokyo 173-8606Japan

Immunoglobulin G4-related sclerosing cholangitis(Ig G4-SC) is frequently associated with type 1 autoimmune pancreatitis(AIP). Association with AIP can be utilized in the diagnosis of Ig G4-SC. However, some cases of Ig G4-SC are isolated from AIP, which complicates the diagnosis. Most of the reported cases of isolated Ig G4-SC displayed hilar biliary strictures, whereas isolated Ig G4-SC with intrapancreatic biliary stricture is very rare. Recently, we have encountered 5 isolated intrapancreatic Ig G4-SC cases that were not associated with AIP, three of which were pathologically investigated after surgical operation. They all were males with a mean age of 74.2 years. The pancreas was not enlarged in any of these cases. No irregular narrowing of the main pancreatic duct was found. Bile duct wall thickening in lesions without luminal stenosis was detected by abdominal computed tomography in all five cases, by endoscopic ultrasonography in two out of four cases and by intraductal ultrasonography in all three cases. In three cases, serum Ig G4 levels were within the normal limits. The mean serum Ig G4 level measured before surgery was 202.1 mg/d L(4 cases). Isolated intrapancreatic Ig G4-SC is difficult to diagnose, especially if the Ig G4 level remains normal. Thus, this type of Ig G4-SC should be suspected in addition to cholangiocarcinoma and pancreatic cancer if stenosis of intrapancreatic bile duct is present.

关键词： Immunoglobulin G4-related sclerosing cholangitis I

Characterization of Electrical Tree Degradation of Epoxy Resin under Thermal and Temperature Stresses by Photoelastic Effect

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Chinese Journal of Electrical Engineering 2024年第1期10卷 12-20页

作者： Hein Htet Aung Yuhuai Wang Jin Li Ying Zhang Tatsuo takada School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Department of Power Generation and Transformation Engineering Baoding Technical College of Electric PowerBaoding 071051China Measurement and Electric Machine Control Laboratory Tokyo City UniversityTokyo 158-8557Japan

Epoxy resin is widely used in the support,insulation,and packaging components of electrical equipment owing to their excellent insulation,thermal,and mechanical ***,epoxy-resin insulation often suffers from thermal and mechanical stresses under extreme environmental conditions and a compact design,which can induce electrical tree degradation and insulation failure in electrical *** this study,the photoelastic method is employed to investigate the thermal-mechanical coupling stress dependence of the electrical treeing behavior of epoxy *** electrical tree growth morphology and stress distribution were observed using the photoelastic *** correlation between the tree length and overall accumulated damage with an increase in mechanical stress is *** results show that compressive stress retards the growth of electrical trees along the electric field,while tensile stress has accelerating *** proves that the presence of thermal stress can induce more severe accumulated damage.

关键词： Epoxy resin electrical tree degradation thermal stress mechanical stress photoelastic effects

The Role of Jasmonates as Antibulbing Substances in the Bulb Formation of Onion

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Agricultural Biotechnology 2024年第1期13卷 1-4,8页

作者： Noboru takada Atsushi Saito Yuuki Matsuzuka Tatsushi Mochiduki Eriko Wakita Meng WANG Yasunori Koda Faculty of Agriculture and Life Science Hirosaki University3Bunkyo-choHirosaki 036-8561Japan The United Graduate School of Agricultural Science Iwate UniversityMoriokaIwate 020-8550Japan National Institute of Vegitable and Tea Science National Agriculture and Food Research Organization360 KusawaAnoTsu 514-2392Japan Research Faculty of Agriculture Hokkaido UniversityKita-9 Nishi-9Kita-kuSapporo 060-8589Japan

Onion plants form spherical bulbs under long-day *** regulating bulb formation remain *** the course of chemical studies on the bulb formation,α-linolenic acid was isolated from onion extracts as an antibulbing substance,the amount of which was synchronized with the bulb *** allene oxide synthase inhibitor canceled the antibulbing activity ofα-linolenic acid,it was disclosed that jasmonic acid concerns this ***-activity-relationship study revealed that its(3R,7S)stereochemistry is necessary for showing its antibulbing *** is concluded that(3R,7S)-jasmonate derived fromα-linolenic acid actually participates in the regulation of bulb formation.

关键词： Onion(Allim cepa L.cv.Higuma) Isolation Bulb formation Antibulbing substance α-Linolenic acid Methyl jasmonate

Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators

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Asian Journal of Andrology 2023年第2期25卷 158-165页

作者： Sayuri Takahashi Ichiro takada Department of Urology The Institute of Medical ScienceThe University of TokyoShirokanedaiMinato-kuTokyo 108-8639Japan Department of Urology The Faculty of MedicineThe University of TokyoHongoBunkyo-kuTokyo 113-8655Japan

Prostate cancer is one of the most common diseases in men ***,radiation therapy,and hormonal therapy are effective treatments for early-stage prostate ***,the development of castration-resistant prostate cancer has increased the mortality rate of prostate *** develop novel drugs for castration-resistant prostate cancer,the molecular mechanisms of prostate cancer progression must be *** the signaling pathways regulating prostate cancer development,recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family(WNT)signaling pathways,mainly that involving WNT5A,in prostate cancer progression and metastasis;however,its role remains ***,chromatin remodelers such as the switch/sucrose nonfermentable(SWI/SNF)complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression ***,we review the roles of noncanonical WNT signaling pathways,chromatin remodelers,and epigenetic enzymes in the development and progression of prostate cancer.

关键词： chromatin remodeling histone-modifying enzymes prostate cancer WNT5A

Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury

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Neural Regeneration Research 2018年第6期13卷 981-982页

作者： Hiroshi Nakagawa Masahiko takada Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology University College London Systems Neuroscience Section Primate Research Institute Kyoto University

Spinal cord injury（SCI）leads to permanent disability with motor and sensory *** mature mammalian central nervous system（CNS）possesses a limited capacity to regenerate/regrow after injury.

关键词： Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury SCI