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Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion

International Journal of Ophthalmology(English edition) 2019年第1期12卷 94-99页

作者： Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi hiroki masumoto hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura Department of Ophthalmology Saneikai Tsukazaki Hospital Rist Inc Department of Ophthalmology Institute of Biomedical SciencesTokushima University Graduate School

AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center.

关键词： automatic diagnosis branch retinal vein occlusion deep learning machine-learning technology ultrawide-field fundus ophthalmoscopy

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Multicentric recurrence of intraductal papillary neoplasm of bile duct after spontaneous detachment of primary tumor:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1000-1007页

作者： hiroki Fukuya Akifumi Kuwano Shigehiro Nagasawa Yusuke Morita Kosuke Tanaka Masayoshi Yada Akihide masumoto Kenta Motomura Department of Hepatology Iizuka HospitalIizuka 820-8505FukuokaJapan

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)rarely recurs in a multicentric *** encountered a patient with multiple recurrences of the gastric subtype of IPNB one year after spontaneous detachment of the primary tumor during peroral cholangioscopy(POCS).CASE SUMMARY A 68-year-old woman on maintenance hemodialysis because of lupus nephritis had several cardiovascular diseases and a pancreatic intraductal papillary mucinous neoplasm(IPMN).She was referred to our department for dilation of the common bile duct(CBD)and a tumor in the lumen,detected using *** had no complaints,and blood tests of hepatobiliary enzymes were *** resonance cholangiopancreatography(MRCP)showed a papillary tumor in the CBD with a filling defect detected using endoscopic retrograde cholangiography(ERC).Intraductal ultrasonography revealed a papillary tumor and stalk at the *** POCS,the tumor spontaneously detached with its stalk into the *** showed low-intermediate nuclear atypia of the gastric subtype of *** 1 year,follow-up MRCP showed multiple tumors distributed from the left hepatic duct to the *** and POCS showed multicentric *** was alive without hepatobiliary symptoms at least two years after initial diagnosis of *** The patient experienced gastric subtype of IPNB without curative *** may be reasonable for patients with this subtype.

关键词： Bile duct neoplasm Neoplasm Recurrence Pancreatic intraductal neoplasms Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiography Peroral cholangioscopy Case report

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Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： Atsuko NONOMURA Shuichi HASEGAWA Hideo MATSUMOTO Mari TAKAHASHI Mina masumoto Kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

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Hepatocellular carcinoma or interferon-based therapy history attenuates sofosbuvir/ribavirin for Japanese genotype 2 hepatitis C virus

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World Journal of Gastroenterology 2018年第13期24卷 1478-1485页

作者： Masayoshi Yada Masayuki Miyazaki Kosuke Tanaka Akihide masumoto Kenta Motomura Department of Hepatology Iizuka Hospital

AIM To investigate the real-world efficacy and safety of sofosbuvir/ribavirin(SOF/RBV) therapy for Japanese patients with genotype 2 hepatitis C virus(GT2-HCV).METHODS A total of 182 patients with GT2-HCV infection who received SOF/RBV therapy for 12 wk at our hospital were enrolled. The patients comprised 122 men and 60 women(age range: 17-84 years; mean age ± SD: 60.1 ± 12.1 years). Relationships between virological response and clinical data were examined by logistic regression analyses. RESULTS The proportions of patients with liver cirrhosis and history of hepatocellular carcinoma(HCC) were 29.0% and 17.3%, respectively. The proportion of patients with prior interferon(IFN)-based therapy was 25.6%. SOF/RBV therapy rapidly decreased HCV RNA levels. Several patients required RBV dose reduction because of anemia or fatigue. Four patients discontinued the therapy. The rates of sustained virological response at 12 wk after the end of treatment were 87.9%(intention to treat: 160/182) and 94.1%(per protocol: 159/169). Multivariate analyses showed that history of HCC or IFN-based therapy independently reduced the efficacy of SOF/RBV therapy. CONCLUSION SOF/RBV therapy for GT2-HCV is safe, highly tolerated, and effective. History of HCC or IFN-based therapy independently reduces the efficacy of this treatment.

关键词： Sofosbuvir Ribavirin Genotype 2 Hepatitis C virus Interferon-based therapy Hepatocellular carcinoma

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The IOD-ENSO precursory teleconnection over the tropical Indo-Pacific Ocean:dynamics and long-term trends under global warming

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Journal of Oceanology and Limnology 2018年第1期36卷 4-19页

作者：袁东亮胡晓悦徐鹏赵霞 Yukio masumoto 韩卫清 Key Laboratory of Ocean Circulation and Waves(KLOCW) and Institute of OceanologyChinese Academy of Sciencesand Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Qingdao Collaborative Innovation Center of Marine Science and Technology Qingdao 266071China University of Tokyo TokyoJapan Department of Atmospheric and Oceanic Sciences University of ColoradoBoulderColoradoUSA

The dynamics of the teleconnection between the Indian Ocean Dipole(IOD) in the tropical Indian Ocean and El Ni?o-Southern Oscillation(ENSO) in the tropical Pacific Ocean at the time lag of one year are investigated using lag correlations between the oceanic anomalies in the southeastern tropical Indian Ocean in fall and those in the tropical Indo-Pacific Ocean in the following winter-fall seasons in the observations and in high-resolution global ocean model simulations. The lag correlations suggest that the IOD-forced interannual transport anomalies of the Indonesian Throughflow generate thermocline anomalies in the western equatorial Pacific Ocean, which propagate to the east to induce ocean-atmosphere coupled evolution leading to ENSO. In comparison, lag correlations between the surface zonal wind anomalies over the western equatorial Pacific in fall and the Indo-Pacific oceanic anomalies at time lags longer than a season are all insignificant, suggesting the short memory of the atmospheric bridge. A linear continuously stratified model is used to investigate the dynamics of the oceanic connection between the tropical Indian and Pacific Oceans. The experiments suggest that interannual equatorial Kelvin waves from the Indian Ocean propagate into the equatorial Pacific Ocean through the Makassar Strait and the eastern Indonesian seas with a penetration rate of about 10%–15% depending on the baroclinic modes. The IOD-ENSO teleconnection is found to get stronger in the past century or so. Diagnoses of the CMIP5 model simulations suggest that the increased teleconnection is associated with decreased Indonesian Throughflow transports in the recent century, which is found sensitive to the global warming *** dynamics of the teleconnection between the Indian Ocean Dipole(IOD)in the tropical Indian Ocean and El Ni?o-Southern Oscillation(ENSO)in the tropical Pacific Ocean at the time lag of one year are investigated using lag correlations between the oceanic anomalie

关键词： Indian Ocean Dipole(IOD) El Nino-Southern Oscillation(ENSO) oceanic channel Indonesian Throughflow ENSO predictability

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Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding

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World Journal of Gastroenterology 2017年第3期23卷 496-504页

作者： Keishi Komori Masaru Kubokawa Eikichi Ihara Kazuya Akahoshi Kazuhiko Nakamura Kenta Motomura Akihide masumoto Department of Gastroenterology Aso Iizuka HospitalIizuka 820-8505Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityHigashi-kuFukuoka 812-8582Japan Department of Hepatology Aso Iizuka HospitalIizuka 820-8505Japan

AIM To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) *** In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results(hemoglobin, albumin, and bilirubin concentrations), and imaging results(including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality(up to 90 d) and long-term mortality in all *** Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and longterm mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in shortterm mortality(HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI(P = 0.0074).CONCLUSION Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

关键词： Antibiotics Gastric varices Gastric fundus Proton pump inhibitors Hemorrhage

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Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第35期20卷 12581-12587页

作者： Masayoshi Yada Akihide masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita Hideo Suzuki Takeshi Senju Toshimasa Koyanagi Department of Hepatology Iizuka Hospital

AIM: To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma (HCC).

关键词： Hand-foot syndrome Hepatocellular carcinoma Indicator of efficacy Sorafenib Time to progression

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The New Olympic Peace Culture?:The Olympic Message Relay for Peace and the Environment

The New Olympic Peace Culture?:The Olympic Message Relay for...

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北京论坛（2006）文明的和谐与共同繁荣—对人类文明方式的思考

作者： Naofumi masumoto Tokyo Metropolitan University

Introduction On the occasion of the 2006 Torino Winter Olympic Games,many Olympic medalists signed the"Olympic truce book"at the medal plaza in central ***,the IOC president, Jack Rogge,asked the athletes to sign the Olympic truce on the wall of the three Olympic *** could be said that the 2006 Turin Games was commemorated as the Olympic Truce Games.

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使用活化探测器和成像盘技术相结合的方法测量混凝土屏蔽体内中子空间分布

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原子能科学技术 2006年第6期40卷 650-653页

作者：王庆斌李铁辉 masumoto K Matsumura H Shibta T 中国科学院高能物理研究所北京100049 High Energy Accelerator Research Organization(KEK)

描述了1种联合使用活化探测器和成像盘技术(IP)探测中子注量的方法。利用这种方法,测量了高能中子束线装置KENS(KEK spallation neutron source facility)中混凝土屏蔽体内中子的空间分布。高能中子注量衰减的实验结果与使用蒙特卡罗程... 详细信息

描述了1种联合使用活化探测器和成像盘技术(IP)探测中子注量的方法。利用这种方法,测量了高能中子束线装置KENS(KEK spallation neutron source facility)中混凝土屏蔽体内中子的空间分布。高能中子注量衰减的实验结果与使用蒙特卡罗程序MARS14模拟计算的结果符合很好。结果表明,联合使用活化探测器和成像盘技术可以同时测量多个位置的中子注量,直观展现出混凝土屏蔽体内中子强度的分布。

关键词：活化探测器成像盘技术中子注量屏蔽混凝土空间分布

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Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第29期23卷 5379-5385页

作者： Masayuki Miyazaki Masayoshi Yada Kosuke Tanaka Takeshi Senjyu Takeshi Goya Kenta Motomura Motoyuki Kohjima Masaki Kato Akihide masumoto Kazuhiro Kotoh Department of Hepatology Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University Department of Hepatology Harasanshin Hospital

To investigate the factors influenced the efficacy of tolvaptan (TLV) in liver cirrhosis. METHODSWe retrospectively enrolled 61 consecutive patients with refractory hepatic ascites. All of them had been treated with furosemide and spironolactone before admission, and treated with TLV for 7 d in our hospital. The effect of TLV was defined by the rate of body weight loss, and the factors that influenced TLV efficacy were analyzed using multiple regression. RESULTSCoexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV. In stratified analysis, high doses of furosemide decreased the efficacy of TLV in patients with HCC, and increased efficacy in those without HCC. In the latter, a high Child-Pugh-Turcotte score had a positive influence and a high concentration of lactate dehydrogenase had a negative influence on the effectiveness of TLV. CONCLUSIONDevelopment of ascites may differ between patients with liver failure and those with HCC progression. A sufficient preceding dose of furosemide decreases diuretic effect of TLV.

关键词： Ascites Tolvaptan Furosemide Cirrhosis Hepatocellular carcinoma

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