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Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review

World Journal of Gastroenterology 2020年第3期26卷 353-365页

作者： Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto Division of Medicine and Clinical Science Department of Multidisciplinary Internal MedicineFaculty of MedicineTottori UniversityTottori prefecture 683-8504Japan Internal Medicine Irisawa Medical ClinicShimane prefecture 690-0025Japan

BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of ***,these inhibitors also cause immune-related adverse *** disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 *** studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are *** To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the *** The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in *** scanned the references of the selected literature to identify any further relevant *** cases previously studied by us,including three that have not yet been published,were included in this *** Thirty-one PD-1 inhibitor-related SC cases were *** age of patients was 67 years(range,43–89),with a male to female ratio of 21:*** main disease requiring PD-1 inhibitor treatment was non-small cell lung *** that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent *** serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin *** dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were *** 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells i

关键词： Nivolumab Pembrolizumab Avelumab Durvalumab Atezolizumab Programmed cell death-1 inhibitor Immune-related adverse events Cholangitis

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Advanced analysis of laser-driven pulsed magnetic diffusion based on quantum molecular dynamics simulation

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Matter and Radiation at Extremes 2021年第6期6卷 26-35页

作者： hiroki Morita Tadashi Ogitsu Frank R.Graziani Shinsuke Fujioka Institute of Laser Engineering Osaka University2-6 Yamada-OkaSuitaOsaka 565-0871Japan Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA

Magnetic diffusion plays an important role in inertial confinement fusion with strong magnetic *** this paper,we improve a previous analysis of the generation and diffusion of the magnetic field[Morita et al.,*** 25,094505(2018)].For the generation process,we calculate the temporal evolution of the coil current using a self-consistent circuit *** results show that the peak of the calculated magnetic field is delayed by 1.2 ns compared with that of the incident laser *** the diffusion process,we evaluate the electrical conductivity of warm dense gold over a wide temperature range(300K–100 eV)by combining the Kubo–Greenwood formula based on a quantum molecular dynamics simulation with the modified Spitzer *** simulation shows that the maximum magnetic field(530 T)that penetrates the cone is delayed by 2.5 ns compared with the laser *** result is consistent with experiments[Sakata et al.,***.9,3937(2018)]that showed that applying a strong magnetic field improved the heating efficiency of fusion fuel.

关键词： diffusion magnetic dynamics

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Model-based Comparative Prediction of Transcription-Factor Binding Motifs in Anabolic Responses in Bone

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Genomics, Proteomics & Bioinformatics 2007年第3期5卷 158-165页

作者： Andy B. Chen Kazunori Hamamura Guohua Wang Weirong Xing Subburaman Mohan hiroki Yokota Yunlong Liu Departments of Biomedical Engineering/Anatomy and Cell Biology Indiana University-Purdue University Indianapolis Indianapolis IN 45202 USA Division of Biostatistics Department of Medicine Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis IN 46202 USA School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Musculoskeletal Disease Center JP Pettis Memorial Veterans Administration Medical Center Loma Linda CA 92357 USA

Understanding the regulatory mechanism that controls the alteration of global gene expression patterns continues to be a challenging task in computational biology. We previously developed an ant algorithm, a biologically-inspired computational technique for microarray data, and predicted putative transcription-factor binding motifs （TFBMs） through mimicking interactive behaviors of natural ants. Here we extended the algorithm into a set of web-based software, Ant Modeler, and applied it to investigate the transcriptional mechanism underlying bone formation. Mechanical loading and administration of bone morphogenic proteins （BMPs） are two known treatments to strengthen bone. We addressed a question： Is there any TFBM that stimulates both ＂anabolic responses of mechanical loading＂ and ＂BMP-mediated osteogenic signaling＂？ Although there is no significant overlap among genes in the two responses, a comparative model-based analysis suggests that the two independent osteogenic processes employ common TFBMs, such as a stress responsive element and a motif for peroxisome proliferator-activated receptor （PPAR）. The post-modeling in vitro analysis using mouse osteoblast cells supported involvements of the predicted TFBMs such as PPAR, Ikaros 3, and LMO2 in response to mechanical loading. Taken together, the results would be useful to derive a set of testable hypotheses and examine the role of specific regulators in complex transcriptional control of bone formation.

关键词： microarray transcription-factor binding motif mechanical loading bone morphogenic protein ant algorithm

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Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy

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Chinese Neurosurgical Journal 2023年第3期9卷 159-165页

作者： Taro Yanagawa hiroki Sato Kaima Suzuki Hidetoshi Ooigawa Masaki Takao hiroki Kurita Department of Cerebrovascular Surgery International Medical CenterSaitama Medical University1397-1 YamaneHidaka CitySaitama 350-1298Japan Stroke Center Sagamihara Kyodo Hospital4-3-1 HashimotodaiMidori-KuSagamihara CityKanagawa-Pref 252-5188Japan Department of Clinical Laboratory National Center of Neurology and PsychiatryNational Center Hospital4-1-1Ogawa-HigashiKodairaTokyo 187-8502Japan

Background Cerebral amyloid angiopathy is a common cause of subcortical hemorrhage in older *** open hematoma removal may be performed for severe subcortical hemorrhage,its safety in patients with cerebral amyloid angiopathy has not been established,and postoperative rebleeding may ***,this study aimed to investigate factors associated with postoperative *** Out of 145 consecutive patients who had undergone craniotomy for surgical removal of subcortical intracerebral hemorrhage between April 2010 and August 2019 at a single institution in Japan,we examined 109 patients with subcortical hemorrhage who met the inclusion *** excluding 30 patients whose tissue samples were unsuitable for the study,the final study cohort comprised 79 *** Of the 79 patients,50(63%)were diagnosed with cerebral amyloid angiopathy(cerebral amyloid angiopathy group)and 29(37%)were not diagnosed with noncerebral amyloid angiopathy(noncerebral amyloid angiopathy group).Postoperative rebleeding occurred in 12 patients(24%)in the cerebral amyloid angiopathy group and in 2 patients(7%)in the noncerebral amyloid angiopathy *** prothrombin time-international normalized ratio and intraoperative bleeding volume were significantly associated with postoperative rebleeding in the cerebral amyloid angiopathy group(odds ratio=42.4,95%confidence interval=1.14-1578;p=0.042 and odds ratio=1.005,95%confidence interval=1.001-1.008;p=0.007,respectively).Conclusions Patients with cerebral amyloid angiopathy-related cerebral hemorrhage who are receiving antithrombotic therapy,particularly warfarin therapy,are at a high risk of postoperative *** registration Registry and Registration Number of the study:19-220,2019/12/23,retrospectively registered.

关键词： Amyloid-β Antithrombotic therapy Cerebral amyloid angiopathy Postoperative rebleeding Subcortical hemorrhage

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Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing

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Molecular Plant 2013年第3期6卷 790-801页

作者： Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka Division of Agronomy and Horticulture Science Graduate School of Agriculture Kyoto University Kitashirakawa Sakyo Kyoto 606-8502 Japan Faculty of Biology-Oriented Science and Technology Kinki University Kinokawa Wakayama 649-6433 Japan

Miniature inverted-repeat transposable elements （MITEs） are widespread in both prokaryotic and eukaryotic genomes, where their copy numbers can attain several thousands. Little is known, however, about the genetic factor（s） affecting their transpositions. Here, we show that disruption of a gene encoding ubiquitin-like protein markedly enhances the transposition activity of a MITE roPing in intact rice plants without any exogenous stresses. We found that the transposition activity of roPing is far higher in the lines harboring a non-functional allele at the Rurml （Rice ubiquitin-related modifier-I） locus than in the wild-type line. Although the alteration of cytosine methylation pattern triggers the activation of transposable elements under exogenous stress conditions, the methylation degrees in the whole genome, the roPing-body region, and the roPing-flanking regions of the non-functional Rurml line were unchanged. This study provides experimental evidence for one of the models of genome shock theory that genetic accidents within cells enhance the transposition activities of transposable elements.

关键词： Oryza sativa MITE mPing ubiquitin-related modifier methylation genome shock theory.

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A Case of Pyogenic Spondylitis after Surgery for Oral Floor Cancer

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Open Journal of Stomatology 2014年第5期4卷 258-262页

作者： Takamitsu mano Ryota Yamanouchi Jutaro Miyamoto Hirotsugu Umeda Yoshiya Ueyama Department of Oral and Maxillofacial Surgery Yamaguchi University Graduate School of Medicine Yamaguchi Japan

We report the case of a patient who developed pyogenic spondylitis after surgery for oral floor cancer. This 85-year-old man was evaluated at our hospital for a mass in the left floor of the mouth. Oral floor cancer (T2N0M0) was diagnosed. Surgical resection of the tumor was performed twice. On postoperative day 14, he developed sudden neck pain, followed by fever the next day and a gradual decrease in blood pressure. Septic shock was diagnosed, and echocardiography was performed, but no evidence of infective endocarditis was found. Findings on neck magnetic resonance imaging suggested pyogenic spondylitis, and ultimately pyogenic spondylitis causing septic shock was diagnosed. In patients with a compromised immune system after surgery who develop neck pain and fever, the possibility of pyogenic spondylitis as a complication should be kept in mind.

关键词： Pyogenic Spondylitis Oral Cancer Sepsis

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The Fish Fauna of the Future Large Size Reservoir of Ouessa, on the Mouhoun River, Burkina Faso

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Advances in Bioscience and Biotechnology 2021年第10期12卷 309-322页

作者： Raymond Ouedraogo Florent M. Y. Sawadogo Nomwine Da Komandan mano INERA-Institut de l’Environnement et de Recherches Agricoles Ouagadougou Burkina Faso Laboratoire de Biologie et d’Ecologie Animales Université Joseph KI-ZERBO Ouagadougou Burkina Faso Université de Dédougou Dédougou Burkina Faso

Reliable and basic information on fish are required for the sustainable management of a fishery. For this reason, the fish fauna of the future reservoir of Ouessa in the low section of the Mouhoun River, Burkina Faso is studied. In order to describe the fish community, the fish were sampled in March 2020 thanks to cast nets and gill nets. They were sorted into species and each fish was weighted at the nearest 0.1 g and its total length measured at the nearest mm. The landings of commercial fishermen were also observed. In total, 1059 fishes were collected and grouped into 42 species, 27 generas and 16 families. The dominant species were Synodontis nigrita, Synodontis schall, Marcusenius senegalensis, Schilbe intermedius, Brycinus nurse and Alestes baremoze. However, the compilation of diverse sources suggests the presence of nearly 70 species. The index of Shannon-Weaver (3.97), the values of the condition factor, the fish size and the presence of intolerant species indicate the relatively good conditions of the aquatic ecosystem. Among the 24 dominant species, 54% have a positive allometric growth, 42% a negative allometric growth and 0.04 an isometric growth. This study builds the basis of sustainable management of the future reservoir of Ouessa that is planned to be the largest one of the country (40,000 ha large).

关键词： Ichthyofauna Reservoir Ouessa Mouhoun River Burkina Faso

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Circulating immunocompetent cell profiles during oral cyclosporin therapy for immunoglobulin-resistant Kawasaki disease

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World Journal of Pediatrics 2021年第6期17卷 671-673页

作者： Seigo Okada Yuji OhnishiTakashi Furuta Yasuo Suzuki Akiko Kawakami-Miyake Chie Matsuguma Takako Waniishi hiroki Yasudo Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi 755-8505Japan

Although the standard treatment for Kawasaki disease(KD)is intravenous immunoglobulin(IVIG)combined with oral aspirin,18%of 1st IVIG is refractory[1].Recently,the efficacy of immunomodulatory drugs for IVIG-resistant KD,such as prednisolone,infliximab(IFX),and cyclosporine(CsA),has been reported[2-5].However,optimal immunomodulatory therapy for IVIG-resistant KD has not yet been established.

关键词： immuno drugs immunoglobulin

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Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report

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世界临床病例杂志 2023年第26期11卷 6262-6267页

作者： Mari Mori Satoru Takeshita Nami Nakamura Yuki Mizuno Akiko Tomita Mineyoshi Aoyama hiroki Kakita Yasumasa Yamada Department of Perinatal and Neonatal Medicine Aichi Medical UniversityNagakute 480-1195Japan Department of Pathobiology Nagoya City University Graduate School of Pharmaceutical SciencesNagoya 467-8603Japan Department of Pediatrics Aichi Medical UniversityNagakute 480-1195Japan Department of Pharmacy Aichi Medical UniversityNagakute 480-1195Japan

BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the *** HPE with diabetes insipidus due to associated pituitary dysfunction has been reported,HPE with the syndrome of inappropriate antidiuretic hormone secretion(SIADH)is very ***,a vasopressin V2 receptor antagonist,is effective in adults with ***,there is no report of its efficacy in infants with *** purpose of this report is to demonstrate that tolvaptan is effective for SIADH in infants and that administration of tolvaptan eliminates the need for restriction of water intake and sodium *** SUMMARY A 2414-g female infant was born at 38 wk by normal vaginal *** anomalies and head magnetic resonance imaging indicated semilobar *** birth,she had hyponatremia due to SIADH and was treated using water and sodium ***,she developed an exaggerated response to the fluid restrictions,resulting in large fluctuations in serum sodium *** administration of tolvaptan improved the fluctuations in serum sodium levels without the need for adjustment of water or sodium *** sodium was maintained within the normal range after discontinuation of tolvaptan at 80 d of *** were no side effects,such as hypernatremia or liver dysfunction,during the administration of *** This is the first report on the safety and efficacy of tolvaptan in an infant with SIADH associated with HPE.

关键词： Tolvaptan Holoprosencephaly Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Case report

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两例具有大磁滞的氰根桥联{Fe^(Ⅲ)_(2)Ni^(Ⅱ)}单链磁体

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无机化学学报 2023年第9期39卷 1775-1781页

作者：管雅慧赵亮姚念涛 hiroki Oshio 刘涛大连理工大学精细化工国家重点实验室大连116024

我们利用具有不同对称性的同分异构体,通过改变分子间氢键网络,操控单链磁体行为,成功合成了2例化合物:[Ni^(Ⅱ)(L1)][Fe^(Ⅲ)(Tp)(CN)_(3)]_(2)·3.5H_(2)O(1)和[Ni^(Ⅱ)(L2)][Fe^(Ⅲ)(Tp)(CN)_(3)]_(2)·3H_(2)O(2),其中Tp=hydrotris(pyrazolyl)borate,L1=3,4-bis(1H-imidazol-1-yl)thiophen,L2=1,2-bis(1H-imidazol-1-yl)thiophen)。磁性研究表明,1和2表现为具有不同矫顽场的单链磁体行为。1的矫顽场为8.41 kOe,而2的矫顽场为3.84 kOe。

关键词：单链磁体氰基桥联氢键矫顽场

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