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Regulation of CTNNB1 signaling in gastric cancer and stem cells

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 592-598页

作者： Shihori Tanabe Kazuhiko Aoyagi Hiroshi Yokozaki hiroki Sasaki Division of Risk Assessment Biological Safety Re-search Center National Institute of Health ScienceTokyo Department of Translational Oncology National Cancer Center Research InstituteTokyo Department of Pathology Kobe University of Graduate School of Medicine

Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinal-type gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1 (CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.

关键词： CTNNB1 signaling &beta -catenin Epithelial-mesenchymal transition Gastric cancer Stem cell

Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada Tomoshige Umeyama Yumi Kudo hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe Yasushi Hasegawa Kentaro Matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation Chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

Potential antioxidant bioactive peptides from camel milk proteins

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Animal Nutrition 2018年第3期4卷 273-280页

作者： Hisham R.Ibrahim hiroki Isono Takeshi Miyata Department of Biochemistry and Biotechnology Faculty of Agriculture Kagoshima University

Camel milk is traditionally considered to have medicinal characteristics that it has potential health benefits and could help to treat several illnesses. Particularly, it is closest to human breast milk and has high levels of nutrients and bioactive components. The aim of this study was to explore the antioxidant peptides derived from protein fractions of camel milk. Camel milk proteins(CMP) were fractionated into camel casein protein(CCP) and camel whey protein(CWP), which were hydrolyzed with pepsin to produce peptic digests P-CCP and P-CWP, respectively. RP-HPLC was used for fractionation of the peptides from the P-CCP and P-CWP. The antioxidant activities were evaluated using superoxide anion generating system of xanthine oxidase(XOD)and 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. Active peptides were analyzed using matrixassisted laser desorption ionization time of flight mass spectrometry(MALDI-TOF-MS) whereas a number of antioxidant peptides, with masses ranging from 913 to 2,951 Da, derived mainly from alpha-casein, lactophorin and lactoferrin, were identified. When yeast cells are used as a system for modeling mitochondrial disease, the peptides in caseins and whey fractions significantly enhanced the tolerance of yeast cells against peroxide-induced oxidative stress. The results show that both caseins and whey proteins of camel milk possess bioactive peptides with significant radical-scavenging activities and thus herald a fascinating opportunity for their potential as nutraceuticals or therapeutic peptides for prevention and treatment of oxidative stress-associated diseases.

关键词： Camel milk proteins Antioxidant Bioactive peptides Superoxide scavenging Yeast tolerance

Genotype-Phenotype Correlations in Ornithine Transcarbamylase Deficiency: A Mutation Update

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Journal of Genetics and Genomics 2015年第5期42卷 181-194页

作者： Ljubica Caldovic Iman Abdikarim Sahas Narain Mendel Tuchman hiroki Morizono Department of Integrative Systems Biology Center for Genetic Medicine Research Children's National Health System Department of Anthropology College of Arts and Sciences Washington University Graduate School of Biomedical Sciences and Professional Studies College of Medicine Drexel University

Ornithine transcarbamylase （OTC） deficiency is an X-linked trait that accounts for nearly half of all inherited disorders of the urea cycle. OTC is one of the enzymes common to both the urea cycle and the bacterial arginine biosynthesis pathway; however, the role of OTC has changed over evolution. For animals with a urea cycle, defects in OTC can trigger hyperammonemic episodes that can lead to brain damage and death. This is the fifth mutation update for human OTC with previous updates reported in 1993, 1995, 2002, and 2006. In the 2006 update, 341 mutations were reported. This current update contains 417 disease-causing mutations, and also is the first report of this series to incorporate information about natural variation of the OTC gene in the general population through examination of publicly available genomic data and examination of phenotype/genotype correlations from patients participating in the Urea Cycle Disorders Consortium Longitudinal Study and the first to evaluate the suitability of systematic computational approaches to predict severity of disease associated with different types of OTC mutations.

关键词： Ornithine transcarbamylase Mutation Ornithine transcarbamylase deficiency Urea cycle Hyperammonemia

Synthesis of Large Area, Homogeneous, Single Layer Graphene Films by Annealing Amorphous Carbon on Co and Ni

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Nano Research 2011年第6期4卷 531-540页

作者： Carlo M. Orofeo hiroki Ago Baoshan Hu Masaharu Tsuji Graduate School of Engineering Sciences Kyushu University Kasuga Fukuoka 816-8580 Japan Institute for Materials Chemistry and Engineering Kyushu University Kasuga Fukuoka 816-8580 Japan

The synthesis of large area, homogenous, single layer graphene on cobalt （Co） and nickel （Ni） is reported. The process involves vacuum annealing of sputtered amorphous carbon （a-C） deposited on Co/sapphire or Ni/sapphire substrates. The improved crystallinity of the metal film, assisted by the sapphire substrate, proves to be the key to the quality of as-grown graphene film. The crystallinity of the Co and Ni metal films was improved by sputtering the metal at elevated temperature as was verified by X-ray diffraction （XRD）. After sputtering of a-C and annealing, large area, single layer graphene that occupies almost the entire area of the substrate was produced. With this method, 100 mm2-area single layer graphene can be synthesized and is limited only by the substrate and vacuum chamber size. The homogeneity of the graphene film is not dependent on the cooling rate, in contrast to syntheses using polycrystalline metal films and conventional chemical vapor deposition （CVD） growth. Our facile method of producing single layer graphene on Co and Ni metal films should lead to large scale graphene-based applications.

关键词： Single layer graphene amorphous carbon epitaxial metal annealing

Best C^(4+) and C^(5+) Beams of the Kei2 ECR Ion Source

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Chinese Physics C 2007年第S1期31卷 94-96页

作者： A.G.Drentje M.Muramatsu A.kitagawa National Institute of Radiological Sciences Chiba 263-8555Japan

With the prototype ECR ion source for the next carbon therapy facility in Japan a new series of measurements has been performed in order(a)to find the highest beam currents of C^(4+) ions,and(b)to study the effect of'special'gas-mixing by using a chemical compound as a feed *** isotopic effect has been found in a previous experiment:with deuterated methane(CD_4 gas) the C^(5+) beam currents are about 10% higher than with regular methane(CH_4 gas).For butane gases(C_4D_(10) and C_4H_(10) respectively)the isotopic effect for C^(5+) production is even stronger(>15%).For production of C^(4+) ions the isotopic effect appears to be *** turns out that the relative amount of carbon is much more important:acetylene gives 15% higher C^(4+) current than butane,which in turn gives about 10% higher C^(4+) ion currents than methane.

关键词： carbon ions ECR ion source isotopic effect gas-mixing

The new era of precision medicine in hepatocellular carcinoma:the urgent need for promising biomarkers

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 490-491页

作者： Haruhiko Takeda hiroki Nishikawa Yukio Osaki Department of Gastroenterology and Hepatology Graduate School of MedicineKyoto UniversityKyotoJapan Department of Gastroenterology and Hepatology Osaka Red Cross HospitalOsakaJapan Department of Gastroenterology and Hepatology Hyogo College of MedicineNishinomiyaJapan Department of Gastroenterology and Hepatology Meiwa HospitalNishinomiyaJapan

Hepatocellular carcinoma(HCC)is the second most lethal malignancy worldwide,and the prognosis of advanced HCC is especially *** the SHARP trial reported in 2007,a number of phase III trials of molecular targeting agents for advanced HCC have been conducted,but most of them have failed to achieve their primary endpoint,and sorafenib has been the only first-line systemic therapy approved for HCC in this decade(1).

关键词： prognosis carcinoma hepatocellular

Endoscopic ultrasound-guided fine-needle aspiration biopsy-Recent topics and technical tips

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World Journal of Clinical Cases 2019年第14期7卷 1775-1783页

作者： Kazuya Matsumoto Yohei Takeda Takumi Onoyama Soichiro Kawata hiroki Kurumi hiroki Koda Taro Yamashita Hajime Isomoto Division of Internal Medicine Irisawa Medical ClinicMatsue 690-0025Japan Department of Multidisciplinary Internal Medicine Tottori UniversityYonago 683-8504Japan

Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) is a useful procedure that enables reliable pathological diagnoses of pancreatobiliary diseases, subepithelial lesions, and swollen lymph nodes. In recent years, a pathological diagnosis based on EUS-FNA has made it possible to provide accurate treatment methods not only in these fields, but also in respiratory organs and otorhinolaryngology. This review discusses the latest topics pertaining to EUS-FNA as well as procedural tips.

关键词： Endoscopic ultrasound-guided fine-needle aspiration biopsy Cytology Pathology Pancreatobiliary diseases Subepithelial lesions Lymph nodes

Genomics in Space Life Sciences

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Genomics, Proteomics & Bioinformatics 2008年第1期6卷 1-3页

作者： Jade Q. Clement hiroki Yokota Department of Chemistry and NASA University Research Center for Biotechnology and Environmental Health Texas Southern UniversityHouston TX 77004 USA Department of Biomedical Engineering / Department of Anatomy and Cell Biology Indiana University-Purdue University IndianapolisIndianapolis IN 46202 USA

Since the early days of manned spaceflight, hazardous effects of the space environment on living organisms have been disputed. With the continuous manning of the International Space Station, the planned Chinese space station, and renewed interest in returning to the Moon and sending manned flights to Mars, identifying and addressing the potential outcomes of long-term space exposures is critically important.

关键词： gene Genomics in Space Life Sciences