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NF-κB反义寡核苷酸对博莱霉素致小鼠急性肺损伤的保护作用

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中国医科大学学报 2008年第2期37卷 158-161页

作者：张晓晔焦光宇朱敏刘卫青志村早苗增田辙齐藤宏树中国医科大学附属盛京医院呼吸内科沈阳110004 东北大学医学部第一内科日本仙台

目的研究转录因子NF-κB在博莱霉素(BLM)致小鼠急性肺损伤病理过程中的重要作用,及其反义寡核苷酸对肺损伤的防治作用。方法小鼠随机分为5组,于0d经小鼠尾静脉分别注射150mg/kg或300mg/kgBLM,在注射前6h和注射后第5d,150组和300组分别... 详细信息

目的研究转录因子NF-κB在博莱霉素(BLM)致小鼠急性肺损伤病理过程中的重要作用,及其反义寡核苷酸对肺损伤的防治作用。方法小鼠随机分为5组,于0d经小鼠尾静脉分别注射150mg/kg或300mg/kgBLM,在注射前6h和注射后第5d,150组和300组分别注射生理盐水(NS);anti150组和anti300组分别注射p65的硫甙反义寡核苷酸(900μg/只);同时设立正常对照组,分别在3个时间点(注射前6h、0d、第5d),经尾静脉注射NS,观察各组小鼠体质量变化、死亡情况和肺组织病理改变。结果(1)150组和anti150组死亡率分别为53%和0%(P<0.05);而300组和anti300组死亡率分别为100%和60%(P<0.05)。p65反义寡核苷酸抑制了BLM所致小鼠死亡;(2)150组和anti150组小鼠的最低体质量分别减轻至原来的(65.5±7.8)%和(82.1±3.4)%(P<0.01)。p65反义寡核苷酸改善了BLM所致小鼠体质量减轻;(3)肺组织HE染色显示,BLM致死的150组小鼠,可见肺组织血管结构丧失,出血性水肿,肺泡腔内大量炎性渗出;非BLM致死小鼠注射BLM后14d,可见肺组织大片实变,肺泡结构丧失。而anti150组14d明显减轻了BLM导致的肺组织损伤。结论NF-κB可能在BLM致小鼠急性肺损伤过程中具有重要作用。NF-κB反义寡核苷酸对BLM所致小鼠急性肺损伤具有保护作用。

关键词：核因子κB 博莱霉素反义寡核苷酸急性肺损伤

双能CT虚拟单能成像替代单能成像:不同采集技术可检测性参数的比较

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国际医学放射学杂志 2023年第5期 627-627页

作者： K.hiroki I.Katsuhiro U.Hiroshi T.Tadanori M.Wataru N.Hiroji 耿广

摘要目的比较5种双能（DE）成像的虚拟单能（VM）影像与相同剂量、碘浓度单能（SE）影像的效能，包括2代瞬时管电压切换（FKS）CT、2代双源（DS）CT和一种分离滤波器

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Hand-assisted laparoscopic restorative proctocolectomy for ulcerative colitis

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World Journal of Gastrointestinal Surgery 2016年第8期8卷 578-582页

作者： Norimitsu Shimada hiroki Ohge Raita Yano Naoki Murao Norifumi Shigemoto Shinnosuke Uegami Yusuke Watadani Kenichiro Uemura Yoshiaki Murakami Taijiro Sueda Depart-ment of Surgery Hiroshima University Graduate School of Biomedical and Health Sciences

AIM To evaluate the utility of hand-assisted laparoscopic restorative proctocolectomy(HALS-RP) compared with the conventional open procedure(OPEN-RP).METHODS Fifty-one patients who underwent restorative total proctocolectomy with rectal mucosectomy and ileal pouch anal anastomosis between January 2008 and July 2015 were retrospectively *** patients in the HALS-RP group and twentyfour patients in the OPEN-RP group were *** patients who had purely laparoscopic surgery were *** total proctocolectomy was performed with mucosectomy and a hand-sewn ilealpouch-anal *** comorbidities,intraoperative factors such as blood loss and operative time,postoperative complications,and postoperative course were compared between two *** Patients in both groups were matched with regards to patient age,gender,and American Society of Anesthesiologists *** were no significant differences in extent of colitis,indications for surgery,preoperative comorbidities,and preoperative medications in the two *** median operative time for the HALS-RP group was 369(320-420) min,slightly longer than the OPEN-RP group at 355(318-421) min; this was not statistically *** loss was significantly less in HALS-RP [300(230-402) m L] compared to OPEN-RP [512(401-1162) m L,P = 0.003].Anastomotic leakage was noted in 3 patients in the HALS-RP group and 2 patients in the OPEN-RP group(13% vs 8.3%,NS).The rates of other postoperative complications and the length of hospital stay were not different between the two *** HALS-RP can be performed with less blood loss and smaller skin *** procedure is a feasible technique for total proctocolectomy for ulcerative colitis.

关键词： Hand-assisted laparoscopic surgery Ulcerative colitis Laparoscopic surgery Proctocolectomy

Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma

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World Journal of Gastroenterology 2015年第2期21卷 549-555页

作者： Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae hiroki Shimizu Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Surgical Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric ***: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P < 0.0001), more aggressive lymphatic invasion(P = 0.0011), and deeper tumor invasion(P < 0.0001). In addition, they exhibited significantly worse overall survival rates than did patients with non-mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer.

关键词： Mixed-type gastric cancer Histological type Progno

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北京乐成四合院幼儿园

现代装饰 2020年第12期 36-43页

作者：马岩松党群早野洋介何威傅昌瑞肖莹傅晓毅陈竑宾尹建峰赵孟杨雪兵 Kazushi Miyamoto Dmitry Seregin 张龙贲禹强曹溪马悦 hiroki Fujino MAD

2017年,围绕"一老一小"的"代际融合"布局,乐成集团委托MAD建筑事务所在北京一处养老社区旁设计一座幼儿园。项目占地9275平方米,原址上有一座三进四合院,一座上世纪90年代兴建的仿四合院及一栋现代四层建筑。2019年底,幼儿园建成,成为... 详细信息

2017年,围绕"一老一小"的"代际融合"布局,乐成集团委托MAD建筑事务所在北京一处养老社区旁设计一座幼儿园。项目占地9275平方米,原址上有一座三进四合院,一座上世纪90年代兴建的仿四合院及一栋现代四层建筑。2019年底,幼儿园建成,成为一所可容纳390位1.5至6岁学童的幼儿园。"我回想小时候上的幼儿园,和后面看到的幼儿园,都在想孩子们最心心念念的是什么。"马岩松说,"我想是自由与大爱。幼儿园不一定要在硬件上有多大的给予性,但必须让孩子们感受到自由与爱——它们让孩子们的发展有无限的可能性。"

关键词：建筑事务所养老社区四合院幼儿园一所给予性

Interventional endoscopic ultrasonography for pancreatic cancer

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World Journal of Clinical Oncology 2011年第2期2卷 108-114页

作者： Kazuo Hara Kenji Yamao Nobumasa Mizuno Susumu Hijioka Akira Sawaki Masahiro Tajika hiroki Kawai Shinya Kondo Yasuhiro Shimizu Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastrointestinal Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

Endoscopic ultrasonography(EUS)represents the combination of endoscopy and intraluminal *** allows use of a high-frequency transducer(5-20 MHz)that,due to the short distance to the target lesion,provides ultrasonographic images of higher resolution than those obtained from other imaging modalities,including multiple-detector-row-computed tomography,magnetic resonance imaging,and positron emission *** is now a widely accepted modality for diagnosing pancreatic ***,the most important limitation of EUS has been the lack of specificity in differentiating between benign and malignant *** 1992,EUS-guided fine needle aspiration(FNA)of lesions in the pancreas head was introduced into clinical practice,using a curved linear-array *** then,EUS has evolved from EUS imaging to EUSFNA and wider *** EUS for pancreatic cancer includes EUS-FNA,EUS-guided fine needle injection,EUS-guided biliary drainage and anastomosis,EUS-guided celiac neurolysis,radiofrequency ablation,brachytherapy,and delivery of a growing number of anti-tumor *** review focuses on interventional EUS,including EUS-FNA and therapeutic EUS for pancreatic cancer.

关键词： Endoscopic ultrasonography-biliary drainage Endoscopic ultrasonography-choledochoduodenostomy Endoscopic ultrasonography-fine needle aspiration Endoscopic ultrasonography-guided biliary drainage Interventional endoscopic ultrasonography

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中国中药材市场流通的蝉蜕种类调查

天然产物研究与开发 2013年第3期25卷 421-429页

作者：刘宪伟近藤健儿司马真央山路弘树桥本和则武田修已郭济贤中国科学院上海昆虫博物馆上海200032 日本株式会社津村复旦大学药学院上海201203

蝉作为中药材,在中国已有悠久的应用历史。中国国内市场流通的蝉蜕基源动物常见为10种。在种类部分提供了各分类阶元的鉴别特征。绘制了蝉蜕的触角和前足的特征图。

关键词：蝉蜕中药材种类中国

Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development

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World Journal of Hepatology 2015年第19期7卷 2220-2228页

作者： Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Molecular Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Internal Medicine Okayama Saiseikai General Hospital Department of Internal Medicine Hiroshima City Hospital Department of Internal Medicine Kagawa Prefectural Central Hospital Department of Internal Medicine Kurashiki Central Hospital Department of Internal Medicine Mihara Red Cross hospital Department of Internal Medicine Fukuyama City Hospital Department of Internal Medicine National Hospital Organization Fukuyama Clinical Center Department of Internal Medicine Mitoyo General Hospital Department of Gastroenterology National Hospital Organization Iwakuni Clinical Center Department of Internal Medicine Sumitomo Besshi Hospital Department of Gastroenterology Tsuyama Central Hospital Health Service Center Okayama University

AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m ***: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients.

关键词： Hepatitis C virus Interferon Hepatocellular carcin

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大连王家村遗址出土陶器印痕分析

东方考古 2019年第1期 -页

作者：小田弘己王强齐藤希宫本一夫栾丰实熊本大学大学人文社会科学研究院山东大学历史文化学院橿原考古研究所九州大学人文科学研究院

通过对王家村遗址陶器进行的印痕分析,我们在不同时期的陶片中发现了粟、黍、水稻、小麦族、紫苏属、大豆属及其他豆科种属、薏苡属等植物。在小珠山第三期文化中,发现了薏苡属、黍、粟的主要植物种属组合,其中薏苡属植物可能已经人工... 详细信息

通过对王家村遗址陶器进行的印痕分析,我们在不同时期的陶片中发现了粟、黍、水稻、小麦族、紫苏属、大豆属及其他豆科种属、薏苡属等植物。在小珠山第三期文化中,发现了薏苡属、黍、粟的主要植物种属组合,其中薏苡属植物可能已经人工栽培。在小珠山第五期文化中,则主要是黍、粟类作物,此外还发现有水稻和小麦族植物,但不见薏苡属植物。这与浮选结果基本吻合。印痕分析中杂草种子发现较少,并且很可能也不是古人的食物来源,这与浮选结果不同。此外,通过分析,我们认为陶器制作和谷物生产活动的作业场所具有相关性。

关键词：王家村遗址陶器印痕植食性食谱