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Genomics in Space Life Sciences

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Genomics, Proteomics & Bioinformatics 2008年第1期6卷 1-3页

作者： Jade Q. Clement hiroki Yokota Department of Chemistry and NASA University Research Center for Biotechnology and Environmental Health Texas Southern UniversityHouston TX 77004 USA Department of Biomedical Engineering / Department of Anatomy and Cell Biology Indiana University-Purdue University IndianapolisIndianapolis IN 46202 USA

Since the early days of manned spaceflight, hazardous effects of the space environment on living organisms have been disputed. With the continuous manning of the International Space Station, the planned Chinese space station, and renewed interest in returning to the Moon and sending manned flights to Mars, identifying and addressing the potential outcomes of long-term space exposures is critically important.

关键词： gene Genomics in Space Life Sciences

The right hepatic artery syndrome

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World Journal of Gastroenterology 2005年第19期11卷 3008-3009页

作者： Kazumi Miyashita Katsuya Shiraki Takeshi Ito hiroki Taoka Takeshi Nakano First Department of Internal Medicine Mie University School of Medicine TsuMie 514-8507Japan First Department of Surgery Mie University School of Medicine TsuMie 514-8507Japan

Various benign and malignant conditions could cause biliary obstruction. Compression of extrahepatic bile duct (EBD) by right hepatic artery was reported as a right hepatic artery syndrome but all cases were compressed EBD from stomach side. Our case compressed from dorsum was not yet reported, so it was thought to be a very rare case. We present here the first case of bile duct obstruction due to the compression of EBD from dorsum by right hepatic artery.

关键词： Right hepatic artery syndrome Obstructive jaundice Extrahepatic bile duct Right hepatic artery Endoscopic retrograde cholangiography Cholangioen-terostomy

Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 94-99页

作者： Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi hiroki Masumoto hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura Department of Ophthalmology Saneikai Tsukazaki Hospital Rist Inc Department of Ophthalmology Institute of Biomedical SciencesTokushima University Graduate School

AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center.

关键词： automatic diagnosis branch retinal vein occlusion deep learning machine-learning technology ultrawide-field fundus ophthalmoscopy

Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes

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World Journal of Gastroenterology 2022年第27期28卷 3383-3397页

作者： Birte Purschke Louisa Bolm Max Nikolaus Meyer hiroki Sato Department of Gastrointestinal Surgery Massachusetts General HospitalBostonMA 02114United States Department of Radiation Oncology Massachusetts General HospitalBostonMA 02114United States Department of Medicine Asahikawa Medical UniversityAsahikawa 0788510HokkaidoJapan Department of Gastroenterology Asahikawa Kosei HospitalAsahikawa 0788211HokkaidoJapan

Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening *** AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient *** emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if *** showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional ***,the optimal interventional sequence and timing of interventional procedures remain *** review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making.

关键词： Pancreatitis Acute necrotizing pancreatitis Necrosis Superinfection Endoscopy Surgery

MnO/N—C anode materials for lithium-ion batteries prepared by cotton-templated combustion synthesis

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Green Energy & Environment 2017年第4期2卷 377-386页

作者： Cheng-Gong Han Chunyu Zhu Yoshitaka Aoki hiroki Habazaki Tomohiro Akiyama Faculty of Engineering Hokkaido University

We herein report a facile one-pot synthesis of MnO/N-doped carbon(N—C) composites via a sustainable cotton-template glycineenitrate combustion synthesis to yield superior anode materials for Li ion batteries. MnO nanoparticles with several nanometers were well-embedded in a porous N-doped carbon matrix. It displays the unique characteristics, including the shortened Li^+-ion transport path, increased contact areas with the electrolyte solution, inhibited volume changes and agglomeration of nanoparticles, as well as good conductivity and structural stability during the cycling process, thereby benefiting the superior cycling performance and rate capability. This favorable electrochemical performance of obtained MnO/N—C composites via a one-pot biomass-templated glycine/nitrate combustion synthesis renders the suitability as anode materials for Li-ion batteries.

关键词： Biomass Cotton Manganese oxide Lithium ion battery Porous carbon

Energy reduction of a submerged membrane bioreactor using a polytetrafluoroethylene （PTFE） hollow-fiber membrane

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Frontiers of Environmental Science & Engineering 2018年第3期12卷 45-54页

作者： Taro Miyoshi Thanh Phong Nguyen Terumi Tsumuraya Hiromu Tanaka hiroki Itokawa Toshikazu Hashimoto Maezawa Industries Inc. 5-11 Naka-cho Kawaguchi City Saitama 332-8556 Japan Sumitomo Electric Industries LTD. 1-950 Asashironishi Kumatori-cho Sennan-gun Osaka 590-0458 Japan Japan Sewage Works Agency 2-31-27 Yushima Bunkyo City Tokyo 113-0034 Japan

In this study, we modified a polytetrafluoroethylene （PTFE） hollow-fiber membrane element used for submerged membrane bioreactors （MBRs） to reduce the energy consumption during MBR processes. The high mechanical strength of the PTFE membrane made it possible to increase the effective length of the membrane fiber from 2 to 3 m. In addition, the packing density was increased by 20% by optimizing the membrane element configuration. These modifications improve the efficiency of membrane cleaning associated with aeration. The target of specific energy consumption was less than 0.4 kWh·m^-3 in this study. The continuous operation of a pilot MBR treating real municipal wastewater revealed that the MBR utilizing the modified membrane element can be stably operated under a specific air demand per membrane surface area （SADm） of 0.13 m^3·m^-2. hr I when the daily- averaged membrane fluxes for the constant flow rate and flow rate fluctuating modes of operation were set to 0,6 and 0.5m^3·m^-2·d^-1 respectively. The specific energy consumption under these operating conditions was estimated to be less than 0.37 kWh.m^-3. These results strongly suggest that operating an MBR equipped with the modified membrane element with a specific energy consumption of less than 0.4 kWh·m^-3 is highly possible.

关键词： Energy-saving Membrane bioreactor Polytetrafluoroethylene (PTFE) membrane Hollow fiber Power consumption

Metachronous penile metastasis from rectal cancer after total pelvic exenteration

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World Journal of Gastroenterology 2012年第38期18卷 5476-5478页

作者： Yuta Kimura Keiichi Nasu hiroki Matsunaga Masahiro Warabi Satoru Inoue Department of Surgery Tokyo Metropolitan Bokutoh Hospital 4-23-15 Koto-bashi Sumida-ku Tokyo 1308575 Japan Department of Pathology Tokyo Metropolitan Bokutoh Hospital 4-23-15 Koto-bashi Sumida-ku Tokyo 1308575 Japan

Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal cancer sixteen months earlier, demonstrated an abnormal uptake within his penis by positron emission tomography/computed tomography. A single elastic nodule of the middle penis shaft was noted deep within Bucks fascia. No other obvious recurrent site was noted except the penile lesion. Total penectomy was performed as a curative resection based on a diagnosis of isolated penile metastasis from rectal cancer. A histopathological examination revealed an increase of well differentiated adenocarcinoma in the corpus spongiosum consistent with his primary rectal tumor. The immunohistochemistry of the tumor cells demonstrated positive staining for cytokeratin 20 and negative staining for cytokeratin 7, which strongly supported a diagnosis of penile metastasis from the rectum. The patient is alive more than two years without any recurrence.

关键词： Penile metastasis Rectal cancer Corpus spongiosum

Exploration of organic superionic glassy conductors by process and materials informatics with lossless graph database

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npj Computational Materials 2022年第1期8卷 1622-1629页

作者： Kan Hatakeyama-Sato Momoka Umeki hiroki Adachi Naoaki Kuwata Gen Hasegawa Kenichi Oyaizu Department of Applied Chemistry Waseda University3-4-1 OkuboShinjukuTokyo169-8555Japan National Institute for Materials Science(NIMS) 1-1 NamikiTsukuba305-0044Japan

Data-driven material exploration is a ground-breaking research style;however,daily experimental results are difficult to record,analyze,and *** report a data platform that losslessly describes the relationships of structures,properties,and processes as graphs in electronic laboratory *** a model project,organic superionic glassy conductors were explored by recording over 500 different *** data analysis revealed the essential factors for a remarkable room temperature ionic conductivity of 10^(−4)–10^(−3) S cm^(−1) and a Li^(+) transference number of around *** contrast to previous materials research,everyone can access all the experimental results,including graphs,raw measurement data,and data processing systems,at a public *** data sharing will improve scientific communication and accelerate integration of material knowledge.

关键词： ionic glassy breaking

Stochastic model predictive braking control for heavy-duty commercial vehicles during uncertain brake pressure and road profile conditions

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Control Theory and Technology 2022年第2期20卷 248-262页

作者： Ryota Nakahara Kazuma Sekiguchi Kenichiro Nonaka Masahiro Takasugi hiroki Hasebe Kenichi Matsubara Graduate School of Integrative Science and Engineering Tokyo City UniversityTamazutsumiSetagaya-kuTokyo 1588557Japan Nabtesco Automotive Co. Ltd.HirakawachoChiyoda-kuTokyo 1020093Japan

When heavy-duty commercial vehicles(HDCVs)must engage in emergency braking,uncertain conditions such as the brake pressure and road profile variations will inevitably affect braking *** minimize these uncertainties,we propose a combined longitudinal and lateral controller method based on stochastic model predictive control(SMPC)that is achieved via Chebyshev–Cantelli *** our method,SMPC calculates braking control inputs based on a finite time prediction that is achieved by solving stochastic programming elements,including chance *** accomplish this,SMPC explicitly describes the probabilistic uncertainties to be used when designing a robust control *** main contribution of this paper is the proposal of a braking control formulation that is robust against probabilistic friction circle uncertainty *** specifically,the use of Chebyshev–Cantelli inequality suppresses road profile influences,which have characteristics that are different from the Gaussian distribution,thereby improving both braking robustness and control performance against statistical ***,since the Kalman filtering(KF)algorithm is used to obtain the expectation and covariance used for calculating deterministic transformed chance constraints,the SMPC is reformulated as a KF embedded deterministic ***,the effectiveness of our proposed method is verified via a MATLAB/Simulink and TruckSim co-simulation.

关键词： Heavy-duty commercial vehicle Brake system Stochastic model predictive control Road profile