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Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

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World Journal of Gastroenterology 2012年第38期18卷 5360-5368页

作者： Kunihiro Hosono Eiji Yamada Hiroki Endo hirokazu Takahashi Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima Division of Gas-troenterology Yokohama City University School of Medicine Yokohama 2360004 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 1040045 Japan

AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis.

关键词： Tumor necrosis factor-α Tumor necrosis factor receptor 1 c-Jun N-terminal kinase Colorectal adenoma Biomarker

Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

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World Journal of Gastroenterology 2011年第7期17卷 914-921页

作者： Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto Department of Internal Medicine Saga Medical School Department of Hepatology Saga Prefectural Hospital Department of Hepatology Saga Prefectural Hospital Saga 8408571 Japan

AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: 60 years old were lower and mean BMI values of female patients 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis.

关键词： Age-at-onset Hepatocellular carcinoma Hepatitis C virus Body mass index Alcohol consumption Sex difference

Development of underground mine monitoring and communication system integrated ZigBee and GIS

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International Journal of Mining Science and Technology 2015年第5期25卷 811-818页

作者： Moridi Mohammad Ali Kawamura Youhei Sharifzadeh Mostafa Chanda Emmanuel Knox Wagner Markus Jang Hyongdoo Okawa hirokazu Department of Mining Engineering and Metallurgy Engineering Western Australian School of MinesCurtin University School of Civil Environment and Mining EngineeringThe University of Adelaide School of Computer Science The University of Adelaide Graduate School of Engineering and Resource Science Department of Materials-Process Engineering and Applied Chemistry EnvironmentAkita University

An automated underground mine monitoring and communication system based on the integration of new technologies is introduced to promote safety and health,operational management and *** proposed system integration considering Wireless Sensor Network(WSN) assisted Geographic Information System(GIS) enables to monitor and control underground mining applications from surface *** on the capabilities of WSNs,ZigBee network is adapted for near real-time monitoring,ventilation system control and emergency communication in underground *** nodes were developed to sense environmental attributes such as temperature,humidity and gases concentration;switching ON and OFF ventilation fans;and texting emergency messages.A trigger action plan for monitored attributes above normal and threshold value limits is programmed in the surface GIS management *** is designed to turn the auxiliary fans on remotely or automatically in orange condition and sending evacuation messages for underground miners in unsafe(red) ***-users operation and 3D visualisations are other successful achievements of the proposed system for the underground monitoring and communication.

关键词： Wireless sensor networks ZigBee Underground mine safety Ventilation Mine monitoring

Design and Implementation of an Extended Collectives Library for Unified Parallel C

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Journal of Computer Science & Technology 2013年第1期28卷 72-89页

作者： Carlos Teijeiro Guillermo L.Taboada Juan Tourio Ramón Doallo Jos C.mourio Damivn A.Mallón Brian Wibecan Computer Architecture Group University of A Corua Galicia Supercomputing Center Jlich Supercomputing Centre Institute for Advanced SimulationForschungszentrum Jlich Industry Standard Servers Group Hewlett-Packard Company

Unified Parallel C （UPC） is a parallel extension of ANSI C based on the Partitioned Global Address Space （PGAS） programming model, which provides a shared memory view that simplifies code development while it can take advantage of the scalability of distributed memory architectures. Therefore, UPC allows programmers to write parallel applications on hybrid shared/distributed memory architectures, such as multi-core clusters, in a more productive way, accessing remote memory by means of different high-level language constructs, such as assignments to shared variables or collective primitives. However, the standard UPC collectives library includes a reduced set of eight basic primitives with quite limited functionality. This work presents the design and implementation of extended UPC collective functions that overcome the limitations of the standard collectives library, allowing, for example, the use of a specific source and destination thread or defining the amount of data transferred by each particular thread. This library fulfills the demands made by the UPC developers community and implements portable algorithms, independent of the specific UPC compiler/runtime being used. The use of a representative set of these extended collectives has been evaluated using two applications and four kernels as case studies. The results obtained confirm the suitability of the new library to provide easier programming without trading off performance, thus achieving high productivity in parallel programming to harness the performance of hybrid shared/distributed memory architectures in high performance computing.

关键词： Unified Parallel C collective operation programmability partitioned global address space high performance computing

Formalin fixation on HER-2 and PD-L1 expression in gastric cancer:A pilot analysis using the same surgical specimens with different fixation times

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World Journal of Clinical Cases 2019年第4期7卷 419-430页

作者： Keita Kai Yukie Yoda Atsushi Kawaguchi Akimichi Minesaki Hironori Iwasaki Shinichi Aishima hirokazu Noshiro Department of Pathology Saga University Hospital Department of Surgery Saga University Faculty of Medicine Center for Comprehensive Community Medicine Saga University Faculty of Medicine Department of Pathology and Microbiology Saga University Faculty of Medicine Department of Otolaryngology - Head and Neck Surgery Saga University Faculty of Medicine

BACKGROUND The needs for human epidermal growth factor receptor 2(HER-2) and/or programmed death-ligand 1(PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized, most of the evidence regarding the fixation duration or type of fixing solution are based on breast *** To investigate the real effects of fixation conditions on HER-2 testing or PD-L1 testing for gastric cancer using gastrectomy *** Thirty-two patients who underwent gastrectomy for gastric cancer were *** resected specimens were each divided into four pieces and fixed in four strictly controlled different durations(6 h, 24 h, and 48 h, and 1 wk) by 10%formalin(n = 22) or 10% neutral buffered formalin(NBF)(n = 10).Immunohistochemistry(IHC) of HER-2 and PD-1 was performed, and a pathology examination was conducted. In the HER-2-immunoreactive cases, all four specimens were subjected to dual-color in situ hybridization(DISH). Five cases were assessed as HER-2-positive by IHC and DISH. We used the cut-off values of 1%, 10%, and 50% to assess the IHC findings of *** No significant difference was observed in comparisons between the shorter fixation period groups(6 h, 24 h, and 48 h) and the prolonged fixation period(1 wk) group in the HER-2 and PD-L1 analyses. Although no significant difference was observed between 10% formalin and 10% NBF within 1 wk of fixation, the superiority of 10% NBF was confirmed in a long-term(> 3 mo) fixation in both the HER-2 and PD-L1 *** In this small-numbered pilot study, prolonged fixation within 1 wk showed no inferiority in HER-2 or PD-L1 testing. However, a large-numbered prospective study is needed to obtain conclusive results.

关键词： Gastric cancer Programmed death-ligand1 Human epidermal growth factor receptor2 Neutral buffered formalin Fixation time

Preparation of hemicellulolic oligosaccharides from Chamaecyparis obtuse （Hinoki） slurry using commercial enzymes

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 224-231页

作者： Yuya KUMAGAI hirokazu USUKI Yukihiro YAMAMOTO Akihiro YAMASATO Takafumi MUKAIHARA Tadashi HATANAKA Okayama Prefectural Technology Center for Agriculture Forestry and FisheriesResearch Institute for Biological Sciences(RIBS)Okayama 716-1241Japan Research Fellow of the Japan Society for the Promotion of Science(JSPS) Japan Nagoya University Nagoya 464-8601Japan

Wood biomass is anticipated to serve as a substitute for carbon source, which has no feedstock competition with foods. Biomass is commonly used for the production of bio-ethanol by a series of processes such as pretreatment, enzymatic degradation, and fermentation. Hemicellulose, constituting 20 wt-% - 40 wt-% ofbiomass materials, contains various kinds of saccharides known to be bioactive substrates. Practical usage of hemicellulose is generally limited to its conversion to bio-ethanol. Here, we aimed to prepare hemicellulolic oligosaccharides, more valuable products other than ethanol. Therefore, the Hinoki slurry was treated with lime at room temperature for 3 h, and then neutralized with HCI. The resulting sample was treated with 13 types of commercial enzymes, and the saccharides produced in the supernatant were evaluated. The result showed that the commercial enzyme Cellulase SS （Nagase ＆ Co., LTD.） effectively degraded the slurry to produce disaccharides and trisaccharides. Analysis of sugar components by liquid chromatography/mass spectrography （LC/MS） after the derivation with ethyl 4- aminobenzoate （ABEE） showed that mannobiose, manno- Nose, and cellobiose were the major oligosaccharides. These results indicate valuable oligosaccharides can be successfully produced from Hinoki softwood slurry.

关键词： hemicellulolic oligosaccharides Chamaecyparis obtuse (Hinoki) commercial enzyme manno-oligosaccharide cello-oligosaccharide

Effective Life and Area Based Data Storing and Deployment in Vehicular Ad-Hoc Networks

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Communications and Network 2015年第3期7卷 146-157页

作者： hirokazu Miura Hideki Tode hirokazu Taki Faculty of Systems Engineering Wakayama University Wakayama Japan Department of Computer Science and Intelligent Systems Osaka Prefecture University Sakai Japan

In vehicular ad-hoc networks (VANETs), store-carry-forward approach may be used for data sharing, where moving vehicles carry and exchange data when they go by each other. In this approach, storage resource in a vehicle is generally limited. Therefore, attributes of data that have to be stored in vehicles are an important factor in order to efficiently distribute desired data. In VANETs, there are different types of data which depend on the time and location. Such kind of data cannot be deployed adequately to the requesting vehicles only by popularity-based rule. In this paper, we propose a data distribution method that takes into account the effective life and area in addition to popularity of data. Our extensive simulation results demonstrate drastic improvements on acquisition performance of the time and area specific data.

关键词： Vehicular Ad-Hoc Networks (VANETs) Popularity Effective Life Effective Area Data Deployment

New Insights into the Growth Mechanism and Surface Structure of Palladium Nanocrystals

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Nano Research 2010年第3期3卷 180-188页

作者： Byungkwon Lim hirokazu Kobayashi Pedro H.G.Camargo Lawrence F.Allard Jingyue Liu Younan Xia Department of Biomedical Engineering Washington UniversitySt.LouisMissouri 63130USA Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Center for Nanoscience and Department of Chemistry and Biochemistry University of Missouri-St.LouisSt.LouisMissouri 63121USA

This paper presents a systematic study of the growth mechanism for Pd nanobars synthesized by reducing Na_(2)PdCl_(4) with L-ascorbic acid in an aqueous solution in the presence of bromide ions as a capping *** electron microscopy(TEM)and high-resolution TEM analyses revealed that the growth at early stages of the synthesis was dominated by particle coalescence,followed by shape focusing via recrystallization and further growth via atomic *** also investigated the detailed surface structure of the nanobars using aberration-corrected scanning TEM and found that the exposed{100}surfaces contained several types of defects such as an adatom island,a vacancy pit,and atomic *** thermal annealing,the nanobars evolved into a more thermodynamically favored shape with enhanced truncation at the corners.

关键词： Palladium nanocrystals growth coalescence surface evolution

Axiomatic Differential Geometry III-3-Its Landscape-Chapter 3: The Old Kingdom of Differential Geometers

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Applied Mathematics 2017年第6期8卷 835-845页

作者： hirokazu Nishimura Institute of Mathematics University of Tsukuba Tsukuba Japan

The principal objective of this paper is to study the relationship between the old kingdom of differential geometry (the category of smooth manifolds) and its new kingdom (the category of functors on the category of Weil algebras to some smooth category). It is shown that the canonical embedding of the old kingdom into the new kingdom preserves Weil functors.

关键词： Axiomatic Differential Geometry Synthetic Differential Geometry Weil Algebra Weil Functor