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Bone metastasis from early gastric cancer following non-curative endoscopic submucosal dissection

World Journal of Gastroenterology 2013年第30期19卷 5016-5020页

作者： Hiroyuki Kawabata Ichiro Oda Haruhisa suzuki Satoru Nonaka Shigetaka Yoshinaga Hitoshi Katai hirokazu Taniguchi Ryoji Kushima Yutaka Saito Endoscopy Division National Cancer Center Hospital Department of Internal Medicine Saiseikai Matsusaka General Hospital Gastric Surgery Division National Cancer Center Hospital Pathology Division National Cancer Center Hospital

A 67-year-old male underwent endoscopic submucosal dissection(ESD)to treat early gastric cancer(EGC)in *** lesion(50 mm × 25 mm diameter)was histologically diagnosed as poorly differentiated adenocarcinoma,with an ulcer *** the tumor was confined to the mucosa with no evidence of lymphovascular involvement,the ESD was regarded as a noncurative resection due to the histological type,tumor size,and existence of an ulcer finding(as indicated by the 2010 Japanese gastric cancer treatment guidelines,ver.3).Despite strong recommendation for subsequent gastrectomy,the patient refused *** alternative follow-up routine was designed,which included five years of biannual clinical examinations to detect and measure serum tumor markers and perform visual assessment of recurrence by endoscopy and computed tomography scan after which the examinations were performed *** patient's condition remained stable for eight years,until a complaint of back pain in 2010 prompted further clinical *** scintigraphy indicated increased *** examination of biopsy specimens taken from the lumbar spine revealed adenocarcinoma resembling the carcinoma cells from the EGC that had been treated previously by ESD,and which was consistent with immunohistochemical findings of gastrointestinal tract ***,the diagnosis of bone metastasis from EGC was *** reported rates of EGC recurrence in surgically resected cases range 1.4%-3.4%,but among these bone metastasis is very *** our knowledge,this is the first reported case of bone metastasis from EGC following a non-curative ESD and occurring after an eight-year disease-free interval.

关键词： Endoscopic submucosal dissection Early gastric cancer Non-curative resection Bone metastasis Late recurrence

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Energy calibration of tagged photons by the d(γ,π^-pp) reaction

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Chinese Physics C 2010年第1期34卷 35-38页

作者：韩运成 Nobuyuki Chiga Yu Fujii Kenta Futatsukawa Osamu Hashimoto Kentaro Hirose Takatsugu Ishikawa Hiroki Kanda Masashi Kaneta Daisuke Kawama Kazushige Maeda Tomofumi Maruta Nayuta Maruyama Akihiko Matsumura Youhei Miyagi Koji Miwa Satoshi N. Nakamura Hajime Shimizu Koutarou Shirotori Koutaku suzuki Tadaaki Tamae hirokazu Tamura Kyo Tsukada 王铁山 Hirohito Yamazaki School of Nuclear Science and Technology Lanzhou University Department of Physics Tohoku University Laboratory of Nuclear Science Tohoku University

The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d（γ,π-pp） reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer （NKS2）. Photon energies were obtained from the reaction of d（γ,π-pp）. The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d（γ,π-pp）.

关键词： deuteron pion photoproduction tagged photon

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Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids

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World Journal of Gastroenterology 2013年第11期19卷 1718-1727页

作者： Norihiro Kato Hiroyuki Yamamoto Yasushi Adachi hirokazu Ohashi Hiroaki Taniguchi Hiromu suzuki Mayumi Nakazawa Hiroyuki Kaneto Shigeru Sasaki Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 060-8543Japan The Section of Antibody Vaccine and Molecular Targeted Therapy ResearchThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan Department of Molecular Biology Sapporo Medical University School of MedicineSapporo 060-8556Japan Division of Gastroenterology Muroran City General HospitalMuroran 051-8512Japan

AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary ***:DNA was extracted from undiluted pancreatic and biliary *** a surrogate for a genomewide hypomethylation assay,levels of long interspersed nuclear element-1(LINE-1) methylation were analyzed using bisulfite *** island hypermethylation of 10 tumor-associated genes,aryl-hydrocarbon receptor repressor,adenomatous polyposis coli,calcium channel,voltage dependent,T type α1G subunit,insulin-like growth factor 2,O-6-methyl-guanine-DNA methyltransferase,neurogenin 1,CDKN2A,runt-related transcription factor 3(RUNX3),secreted frizzled-related protein 1,and ubiquitin carboxyl-terminal esterase L1(UCHL1),was analyzed using *** examine the role of CpG methylation and histone deacetylation in the silencing of UCHL1,human gallbladder carcinoma cell lines and pancreatic carcinoma cell lines were treated with 2 or 5 μmol/L 5-AZA-dC for 72 h or 100 nmol/L Trichostatin A for 24 *** the treatment,UCHL1 expression was analyzed by real-time reverse transcription-polymerase chain ***:Pancreatobiliary cancers exhibited significantly lower LINE-1 methylation levels in pancreatic and biliary fluids than did noncancerous pancreatobiliary disease(58.7% ± 4.3% vs 61.7% ± 2.2%,P = 0.027;53.8% ± 6.6% vs 57.5% ± 1.7%,P = 0.007);however,LINE-1 hypomethylation was more evident in pancreatic cancer tissues than in pancreatic fluids(45.4% ± 5.5% vs 58.7% ± 4.3%,P < 0.001).CpG island hypermethylation of tumor-associated genes was detected at various frequencies,but it was not correlated with LINE-1 *** of the UCHL1 gene was cancer-specific and most frequently detected in pancreatic(67%) or biliary(70%) fluids from patients with pancreatobiliary *** a single marker,hypermethylation of the UCHL1 gene in pancreatic and biliary fluids was most useful for the de

关键词： Pancreatobiliary cancers DNA methylation Pancreatobiliary fluids Ubiquitin carboxyl-terminal esterase L1 Runt-related transcription factor 3

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The 3rd Global Summit of Research Institutes for Disaster Risk Reduction:Expanding the Platform for Bridging Science and Policy Making

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International Journal of Disaster Risk Science 2017年第2期8卷 224-230页

作者： Andrew Collins hirokazu Tatano Wilma James Chadia Wannous Kaoru Takara Virginia Murray Charles Scawthorn Jim Mori Sarah Aziz Khalid M.Mosalam Stefan Hochrainer-Stigler Irasema Alcántara-Ayala Elisabeth Krausmann Wei-Sen Li Ana Maria Cruz Subhajyoti Samaddar Tom De Groeve Yuichi Ono Kelvin Berryman Koji suzuki Mark Ashley Parry Peter McGowran John G.Rees Department of Geography/Disaster and Development Network (DDN) Northumbria University Disaster Prevention Research Institute (DPRI) Kyoto University United Nations Office for Disaster Risk Reduction (UNISDR) Public Health England United Nations Office for Disaster Reduction (UNISDR) Scientific and Technical Advisory Group and Integrated Research on Disaster Risk (IRDR) Scientific Committee Pacific Earthquake Engineering Research Center (PEER) University of CaliforniaBerkeley Centre for Southeast Asia Disaster Prevention Research Initiative (SEADPRI) Universiti Kebangsaan Malaysia Department of Civil and Environmental Engineering Pacific Earthquake Engineering CenterUniversity of CaliforniaBerkeley International Institute for Applied Systems Analysis (IIASA) Institute of Geography National Autonomous University of Mexico (UNAM) European Commission Joint Research Centre (JRC) APEC Emergency Preparedness Capacity Building Center (EPCC) International Research Institute of Disaster Science Tohoku University Natural Hazards Division GNS Science National Research Institute for Earth Science and Disaster Resilience (NIED) British Geological Survey and Research Councils UK

The Global Alliance of Disaster Research Institutes held its 3rd Global Summit of Research Institutes for Disaster Risk Reduction at the Disaster Prevention Research Institute,Kyoto University,Japan,19–21 March,*** Global Alliance seeks to contribute to enhancing disaster risk reduction(DRR) and disaster resilience through the collaboration of research organizations around the *** summit aim was to expand the platform for bridging science and policy making by evaluating the evidence base needed to meet the expected outcomes and actions of the Sendai Framework for Disaster RiskReduction 2015–2030 and its Science and Technology *** summit reflected the international nature of collaborative research and action.A pre-conference questionnaire filled out by Global Alliance members identified323 research projects that are indicative of current *** were categorized to support seven parallel discussion sessions related to the Sendai Framework priorities for *** discussion sessions focused on research that aims to deepen the understanding of disaster *** cross-cutting sessions focused on research that is aimed at the priorities for action on governance,resilience,and *** summaries were presentedin plenary sessions in support of outcomes for widely enhancing the science and policy of DRR.

关键词： Disaster risk reduction research GADRI global summit Policy Science

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Morphological and functional evaluation of chronic kidney disease using magnetic resonance imaging

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World Journal of Clinical Urology 2014年第3期3卷 325-329页

作者： Tsutomu Inoue Eito Kozawa hirokazu Okada Hiromichi suzuki Department of Nephrology Faculty of Medicine Saitama Medical UniversitySaitama 350-0495 Japan Department of Diagnostic Radiology Saitama Medical University International Medical CenterSaitama 350-1298 Japan

X-ray computed tomography(CT),ultrasonography(US)and radionuclide scanning are important clinical methods for evaluating morphology of the *** modalities are also applicable for estimating kidney function with time lapse analysis using proper contrastmedia as may be *** the case of US,it can estimate kidney function based on the measurement of blood flow using the Doppler ***,magnetic resonance imaging(MRI)was an inappropriate diagnostic imaging technique for abdominal organs because of their respiratory ***,MRI is now actively used for kidney as well as liver or other parenchymal organs,in tandem with the technological *** unenhanced X-ray CT,"conventional"MRI can distinguish the border between cortex and medulla in T1 or T2 weighted *** was known that the border blurred with decreasing kidney ***,several other particular imaging methods were introduced in recent years,and these could be called"functional"*** this review,the following are discussed:functional MRI for chronic kidney disease,which include blood oxygenation level-dependent MRI for evaluation of hypoxia,diffusion-weighted imagingfor evaluation of fibrosis,diffusion tensor imaging for evaluation of microstructure,and arterial spin labeling to evaluate the amount of organ perfusion,accompanied with several related *** ultimate goal of functional MRI is to provide useful in vivo information repeatedly for daily medical treatment non-invasively.

关键词： Magnetic resonance imaging Chronic kidney disease Blood oxygenation level-dependent effect Diffusion-weighted imaging Diffusion tensor imaging Arterial spin labeling Fibrosis Hypoxia Functional magnetic resonance imaging

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Evaluation of the margins of differentiated early gastric cancer by using conventional endoscopy

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World Journal of Gastrointestinal Endoscopy 2015年第6期7卷 659-664页

作者： Shigetaka Yoshinaga Ichiro Oda Seiichiro Abe Satoru Nonaka Haruhisa suzuki Hajime Takisawa hirokazu Taniguchi Yutaka Saito Endoscopy Division National Cancer Center Hospital Pathology Division National Cancer Center Hospital

AIM: To evaluate the determination of the margin of differentiated-type early gastric cancers by using conventional ***: We retrospectively evaluated 364 differentiated early gastric cancers that were endoscopically resected as en-bloc specimens and diagnosed pathologically in detail between November 2007 and October 2008. All procedures were done with conventional endoscopes and all endoscopic samples, before and after indigo carmine dye, were re-evaluated using a digital filing system by one endoscopist. We analyzed the incidence of lesions with unclear margins and the relationship between unclear margins and relevant clinicopathological findings. RESULTS: The rate of lesions with unclear margins was 20.6%(75/364). Multivariate regression analysis suggested that the factors that make the determination of the margin difficult were normal color, presence of components of flat area(0-IIb), a diameter ≥ 21 mm, ulceration, and components of poorly differentiated adenocarcinoma in the mucosal ***: As many as 20% of differentiated early gastric cancers show unclear margins. Consideration of the factors associated with unclear margins may help endoscopists to accurately determine the margins of the lesion.

关键词： Early gastric cancer Conventional endoscopy Determination of the margin

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