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Arteriovenous malformation of the vestibulocochlear nerve

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World Journal of Clinical Cases 2015年第7期3卷 661-670页

作者： Adam Tucker Masao Tsuji Yoshitaka Yamada Kenichiro Hanabusa Tohru Ukita hiroji Miyake Takehisa Ohmura Department of Neurosurgery Nishinomiya Kyoritsu Neurosurgical Hospital

We describe a rare case of an arteriovenous malformation(AVM) embedded in the vestibulocochlear nerve presenting with subarachnoid hemorrhage(SAH) treated by microsurgical elimination of the main feeding artery and partial nidus volume reduction with no permanent deficits. This 70-year-old woman was incidentally diagnosed 4 years previously with two small unruptured tandem aneurysms(ANs) on the right anterior inferior cerebral artery feeding a small right cerebellopontine angle AVM. The patient was followed conservatively until she developed sudden headache, nausea and vomiting and presented to our outpatient clinic after several days. Magnetic resonance imaging demonstrated findings suggestive of early subacute SAH in the quadrigeminal cistern. A microsurgical flow reduction technique via clipping between the two ANs and partial electrocoagulation of the nidus buried within the eighth cranial nerve provided radiographical devascularization of the ANs with residual AVM shunt flow and no major deficits during the 2.5 year follow-up. This is only the second report of an auditory nerve AVM. In the event of recurrence, reoperation or application of alternative therapies may be considered.

关键词： Arteriovenous malformation Flow reduction Microsurgery Subarachnoid hemorrhage Vestibulocochlear nerve

A Multi-Section Quantum-Dot Semiconductor Optical Amplifier for Ultrabroad-Band Gain-Flattened Low-Noise Amplification

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光学学报 2003年第S1期23卷 459-460页

作者： Tomoyuki Akiyama Mitsuru Sugawara Koji Otsubo hiroji Ebe Nobuaki Hatori Yasuhiko Arakawa Fujitsu Ltd. Kanagawa JapanUniversity of Tokyo Tokyo JapanFujitsu Ltd. Kanagawa JapanUniversity of Tokyo Tokyo JapanUniversity of Tokyo Tokyo JapanUniversity of Tokyo Tokyo Japan

We propose an ultrabroad-band 1R regenerator utilizing a multi-section quantum-dot semiconductor optical amplifier. Due to the reduced electron states, quantum dot is beneficial in broadening the gain spectrum and lowering the noise figure. Combining this with a multi-section structure drastically improves the gain equality among the different bound states, leading to an increase in the maximum output power and an improvement of the noise figure.

关键词： for in of be it A Multi-Section Quantum-Dot Semiconductor Optical Amplifier for Ultrabroad-Band Gain-Flattened Low-Noise Amplification MOP SOA NF dBm QDs

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Hepatitis B virus infection in Indonesia

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World Journal of Gastroenterology 2015年第38期21卷 10714-10720页

作者： Shoji Kubo Shigekazu Takemura Shogo Tanaka hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata Department of Hepato-Biliary-Pancreatic Surgery Osaka City University Graduate School of Medicine

Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia.

关键词： Hepatitis B virus Epidemiology Prevention Clinical

The neutrophil-to-lymphocyte ratio at the prostate-specific antigen nadir predicts the time to castration-resistant prostate cancer

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Asian Journal of Urology 2021年第3期8卷 332-334页

作者： Genta Iwamoto Takashi Kawahara Yumiko Yokomizo Yasuhide Miyoshi Masahiro Yao hiroji Uemura Department of Urology and Renal Transportation Yokohama City University Medical CenterYokohamaKanagawaJapan Department of Urology Yokohama City University Graduate School of MedicineYokohamaKanagawaJapan

Dear editor,With the spread of prostate-specific antigen(PSA)screening,an increasing number of early-stage prostate cancers have been diagnosed recently,although many patients are still diagnosed in the advanced stage[1].Although most prostate cancers with metastatic lesions respond to initial androgen ablation therapy,responders ultimately develop progressive disease due to hormone-refractory cancer.

关键词： editor prostate specific

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Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1219-1229页

作者： Kohei Nishio Kenjiro Kimura Akihiro Murata Go Ohira hiroji Shinkawa Shintaro Kodai Ryosuke Amano Shogo Tanaka Sadatoshi Shimizu Shigekazu Takemura Akishige Kanazawa Shoji Kubo Takeaki Ishizawa Department of Hepato-Biliary-Pancreatic Surgery Osaka Metropolitan UniversityOsaka 5458585Japan Department of HepatoBiliary-Pancreatic Surgery Osaka City General HospitalOsaka 5340021Japan

BACKGROUND Few studies compared the oncological and biological characteristics between ampullary carcinoma(AC) and cancer of the second portion of the duodenum(DC-Ⅱ), although both tumors arise from anatomically close *** To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis(LNM), between AC and DC-Ⅱ.METHODS This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-Ⅱ who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two *** The patients with AC and DC-Ⅱ did not exhibit significant differences in 5-year overall survival(66.0% and 67.1%, respectively) and 5-year relapse-free survival(63.5% and 62.2%, respectively). Compared to the patients with DC-Ⅱ, the rate of preoperative biliary drainage was higher(P = 0.042) and the rates of digestive symptoms(P = 0.0158), ulcerative-type cancer(P < 0.0001), large tumor diameter(P < 0.0001), and advanced tumor stage(P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-Ⅱ,respectively, without significant difference(P = 0.23). The rates of LNM to hepatic nodes(N-He)and pyloric nodes(N-Py) were significantly higher in patients with DC-Ⅱ than in those with AC(metastasis to N-HE: 18.5% and 5% in patients with DC-Ⅱ and AC, respectively;P = 0.0432;metastasis to N-Py: 11.1% and 0% in patients with DC-Ⅱ and AC, respectively;P = 0.0186)CONCLUSION Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-Ⅱ than in those with AC.

关键词： Ampulla of Vater Duodenum Lymphatic metastasis pattern Lymphatic metastasis station Lymph node excision Neoplasm Pancreaticoduodenectomy

全球环境变化的走向与掌握其关键的中国——基于环境经济社会学的考察

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中央民族大学学报（哲学社会科学版） 2018年第1期45卷 5-11页

作者：池田宽二日本法政大学社会学部

在以气候变化为中心的全球环境问题和环境政策中,中国已经成为关键性主角。这不仅体现在中国已超过美国成为世界上最大的二氧化碳排放国这一事实上,同时也体现在《巴黎协定》(Paris Agreement)的签署生效过程中中国所表现出来的积极态... 详细信息

在以气候变化为中心的全球环境问题和环境政策中,中国已经成为关键性主角。这不仅体现在中国已超过美国成为世界上最大的二氧化碳排放国这一事实上,同时也体现在《巴黎协定》(Paris Agreement)的签署生效过程中中国所表现出来的积极态度及实质性的参与。就"环境经济社会学"的角度而言,环境问题因人类的经济活动而出现,故而环境问题的解决也应该属于经济活动。因此,也应该存在着两种相应的环境政策。通过对汽车拆解业A企业和食品加工业I企业两个案例的分析,认为中国企业应该通过将动脉产业与静脉产业相结合的方式来实现可持续的增长。同时,中国的环境政策也应给经济活动中所嵌入的各种社会关系予以充分的考量。

关键词：环境问题气候变化环境经济社会学环境政策

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ApoE isoforms,treatment of diabetes and the risk of coronary heart disease

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World Journal of Diabetes 2012年第3期3卷 54-59页

作者： Hideki Ehara Ritsuko Yamamoto-Honda hiroji Kitazato Yoshihiko Takahashi Shoji Kawazu Yasuo Akanuma Mitsuhiko Noda the Institute for Adult Diseases Asahi Life Foundation2-2-6Nihonbashi-bakurochoChuo-kuTokyo 103-0002Japan Ehara Medical Clinic 1-10 Shouwa-choTuyamacityOkayama 708-0886Japan Department of Diabetes and Metabolic Medicine and Diabetes Research Center National Center for Global Health and Medicine1-21-1 ToyamaShinjuku-kuTokyo 162-8655Japan Department of Diabetes and Endocrinology Oomori Red Cross Hospital 4-30-11 ChuoOota-kuTokyo 143-8527Japan

AIM:To analyze the risk of coronary heart disease in patients with type 2 diabetes mellitus(T2DM)receiving standard medical ***:We performed a retrospective chart analysis of 269 middle-aged patients(age 45-64 years,mean age,53.9±5.5 years)with T2DM and without atherosclerotic cardiovascular events who underwent typing to determine their apolipoprotein E(apoE)*** apoE isoforms were determined using isoelectric focusing,followed by *** retrospectively evaluated the charts of the 269 patients,recorded between their first visit to the hospital(the study's start point,between 1987 and 1992)and the occurrence of an atherosclerotic cardiovascular event(the study's endpoint)or January 2004,whichever came *** age-adjusted mean values and the prevalences of covariates were calculated to compare the laboratory data among the apoE *** investigate the association of risk factors with the incidence of coronary heart disease during the follow-up period,monovariate and multivariate Cox regression models were ***:At enrollment,the mean serum low density lipoprotein(LDL)cholesterol levels were lowest(2.92± 0.89 mmol/L)among the subjects with apoE2(apoE2/2 or apoE2/3)and highest(3.52±0.77 mmol/L)among the subjects with apoE4(apoE3/4 or apoE4/4).No significant differences in mean age or the percentage of smokers were observed among the three ***,no significant differences were observed in the systolic and diastolic blood pressures,body mass index,HbA1c level or serum triglyceride levels among the three *** were 47 cases of coronary heart disease over 3285 person-years of *** age-adjusted multivariate Cox proportional model identified diabetic retinopathy(hazard ratio,2.38,95% CI:1.28-4.43,P=0.006),a high systolic blood pressure(hazard ratio,1.04,95%CI:1.02-1.06,P<0.001) and high HbA1c values(hazard ratio,1.19,95%CI:1.02-1.38,P=0.0029),but not the LDL cholesterol value at enrollment(hazard ra

关键词： Type 2 diabetes Atherosclerosis Apolipoprotein E isoform

Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第27期21卷 8249-8255页

Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC.

关键词： Chronic hepatitis B Liver resection Hepatocellularcarcinoma Antiviral therapy Nucleos(t)ide analogs