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Hepatitis B virus infection in Indonesia

World Journal of Gastroenterology 2015年第38期21卷 10714-10720页

作者： Shoji Kubo Shigekazu Takemura Shogo Tanaka hiroj. shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata Department of Hepato-Biliary-Pancreatic Surgery Osaka City University Graduate School of Medicine

Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia.

关键词： Hepatitis B virus Epidemiology Prevention Clinical

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Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第27期21卷 8249-8255页

Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC.

关键词： Chronic hepatitis B Liver resection Hepatocellularcarcinoma Antiviral therapy Nucleos(t)ide analogs

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高温培养灰色链霉菌引起链霉素6-磷酸转移酶基因的沉默

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国外医药（抗生素分册） 1992年第6期13卷 401-402,434页

作者： shinkawa H 张征

链霉菌的遗传研究表明,染料处理和紫外线照射能引起许多不同特性的丢失,如抗生素的产生、对自身产物的抗性以及气生菌丝和孢子的形成等。链霉素(SM)产生菌灰色链霉菌能产生刺激自身抗生素产生的A因子。紫外照射获得A因子缺失灰色链霉菌... 详细信息

链霉菌的遗传研究表明,染料处理和紫外线照射能引起许多不同特性的丢失,如抗生素的产生、对自身产物的抗性以及气生菌丝和孢子的形成等。链霉素(SM)产生菌灰色链霉菌能产生刺激自身抗生素产生的A因子。紫外照射获得A因子缺失灰色链霉菌突变株IFO 13189。

关键词：链霉菌链霉素磷酸转移酶基因

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Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1219-1229页

作者： Kohei Nishio Kenjiro Kimura Akihiro Murata Go Ohira hiroj. shinkawa Shintaro Kodai Ryosuke Amano Shogo Tanaka Sadatoshi Shimizu Shigekazu Takemura Akishige Kanazawa Shoji Kubo Takeaki Ishizawa Department of Hepato-Biliary-Pancreatic Surgery Osaka Metropolitan UniversityOsaka 5458585Japan Department of HepatoBiliary-Pancreatic Surgery Osaka City General HospitalOsaka 5340021Japan

BACKGROUND Few studies compared the oncological and biological characteristics between ampullary carcinoma(AC) and cancer of the second portion of the duodenum(DC-Ⅱ), although both tumors arise from anatomically close *** To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis(LNM), between AC and DC-Ⅱ.METHODS This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-Ⅱ who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two *** The patients with AC and DC-Ⅱ did not exhibit significant differences in 5-year overall survival(66.0% and 67.1%, respectively) and 5-year relapse-free survival(63.5% and 62.2%, respectively). Compared to the patients with DC-Ⅱ, the rate of preoperative biliary drainage was higher(P = 0.042) and the rates of digestive symptoms(P = 0.0158), ulcerative-type cancer(P < 0.0001), large tumor diameter(P < 0.0001), and advanced tumor stage(P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-Ⅱ,respectively, without significant difference(P = 0.23). The rates of LNM to hepatic nodes(N-He)and pyloric nodes(N-Py) were significantly higher in patients with DC-Ⅱ than in those with AC(metastasis to N-HE: 18.5% and 5% in patients with DC-Ⅱ and AC, respectively;P = 0.0432;metastasis to N-Py: 11.1% and 0% in patients with DC-Ⅱ and AC, respectively;P = 0.0186)CONCLUSION Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-Ⅱ than in those with AC.

关键词： Ampulla of Vater Duodenum Lymphatic metastasis pattern Lymphatic metastasis station Lymph node excision Neoplasm Pancreaticoduodenectomy

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Removal of Radioactivity from Sediment Mud and Soil and Use for Cultivation of Safe Vegetables in Fukushima, and Removal of Toxic Metals Using Photosynthetic Bacteria

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Journal of Agricultural Chemistry and Environment 2015年第3期4卷 63-75页

作者： Kei Sasaki Kaoru Nakamura Kenji Takeno Hidenori shinkawa Nachiketa Das Ken Sasaki Faculty of Engineering Department of Food and Agriculture Bio-Recycle Hiroshima Kokusai Gakuin University Hiroshima Japan Department of Geology School of Earth Sciences Ravenshaw University Odisha India

The immobilized photosynthetic bacterium, Rhodobacter shpaeroides SSI (SSI), cultured on porous 2 cm ceramic beads, effectively removed and recovered 20 mg/L of non-radioactive Cs (almost 100%) and Sr (≌50%), after 3 - 5 days of aerobic treatment. Toxic and heavy metals such as Hg, Cr, Pb and As were also removed, almost 100%, after 6days of aerobic treatment. A practical method of removal of radioactivity of 10 - 30 μSv/h, caused mainly by radioactive Cs released from the accident at the Daiichi Nuclear Power Plant on 11th March 2011, from sediment mud and soil in Fukushima, Japan, was also carried out. Using immobilized SSI beads, more than 90% and 42% - 73% of radioactive Cs was removed and recovered from sediment mud and soil, respectively, after 3 - 14 days of aerobic treatment in an outdoor 60 L vessel. The weight and mass of the harvested beads could be reduced by more than 97% after desiccation. This technology of removal and recovery had therefore, considerable advantages over other technologies that demanded very large storage facilities in Fukushima. After removal of radioactivity from polluted soil, vegetables like Komatsuna (Turrip leaves) and Chingensai (Green pakchoi) were cultivated on remediated soil. Safe vegetables grown on these treated soils showed a radioactivity content lower than the recommended limit for edible foods in Japan, i.e. less than <100 Bq/kg. Treatment by SSI beads, therefore, appeared to be a compact and suitable technology that could make significant contributions towards agricultural recovery in radioactively polluted areas of Fukushima.

关键词： Immobilized Photosynthetic Bacteria Cs and Sr Heavy Metals Removal of Radioactivity Radioactive Cs Safe Vegetables

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DVD-R光盘的预写技术

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记录媒体技术 2005年第3期 37-39页

作者： RYUJI shinkawa 白祥国 PULSTEC工业株式会社 PULSTEC(北京)科技有限公司

概述所谓“预写(Pre-write)”,就是在DVD-R for General (以下简称为DVD-R)光盘的控制数据区(Control data zone)用预写机刻录特殊信息的操作。控制数据区在光盘的导入区(Lead-in Area)内,起止扇区为02F200h- 02FE00h,共192个ECC Bloc... 详细信息

概述所谓“预写(Pre-write)”,就是在DVD-R for General (以下简称为DVD-R)光盘的控制数据区(Control data zone)用预写机刻录特殊信息的操作。控制数据区在光盘的导入区(Lead-in Area)内,起止扇区为02F200h- 02FE00h,共192个ECC Blocks(见图1中阴影部分)。预 DVD-RW,DVD-R(G)

关键词： DVD-R 数据区阴影部分刻录机 Blocks write 盘片倍速视频节目 formal

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Recent evidence for subcutaneous drains to prevent surgical site infections after abdominal surgery:A systematic review and metaanalysis

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2879-2889页

作者： Tomohiro Ishinuki hiroj. shinkawa Keita Kouzu Seiichi Shinji Erika Goda Toshio Ohyanagi Masahiro Kobayashi Motomu Kobayashi Katsunori Suzuki Yuichi Kitagawa Chizuru Yamashita Yasuhiko Mohri Junzo Shimizu Motoi Uchino Seiji Haji Masahiro Yoshida Hiroki Ohge Toshihiko Mayumi Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 060-8556HokkaidoJapan Department of Hepatobiliary-Pancreatic Surgery Osaka Metropolitan University Graduate School of MedicineAbeno-Ku 545-0051Japan Department of Surgery National Defense Medical CollegeTokorozawa 359-8513Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8602Japan Department of Nursing Japan Health Care UniversitySapporo 062-0053Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 060-8556Japan Department of Clinical Pharmacokinetics Research and Education Center for Clinical PharmacyKitasato UniversityTokyo 108-8641Japan Department of Anesthesiology Hokushinkai Megumino HospitalEniwa 061-1395Japan Department of Infectious Disease Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Gastrointestinal Surgery National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Anesthesiology and Critical Care Medicine Fujita Health UniversityToyoake 470-1192Japan Department of Gastrointestinal Surgery Mie Prefectural General Medical CenterYokkaich 510-8561Japan Department of Surgery Toyonaka Municipal HospitalToyonaka 560-8565Japan Department of Gastroenterological Surgery Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Surgery Soseikai General HospitalKyoto 612-8473Japan Department of Hepato-Biliary-Pancreatic&Gastrointestinal Surgery International University of Health and WelfareIchikawa 272-0827Japan Department of Infectious Disease Hiroshima University HospitalHiroshima 734-8551Japan Department of Intensive Care Unit Chukyo HospitalJapan Community Health Care OrganizationNagoya 457-8510Japan

BACKGROUND Surgical site infections(SSIs)increase mortality,hospital stays,additional medical treatment,and medical *** drains prevent SSIs in gynecological and breast surgeries;however,their clinical impact in abdominal surgery remains *** To investigate whether subcutaneous drains were beneficial in abdominal surgery using a systematic review and *** The database search used PubMed,MEDLINE,and the Cochrane *** following inclusion criteria were set for the systematic review:(1)Randomized controlled trial studies comparing SSIs after abdominal surgery with or without subcutaneous drains;and(2)Studies that described clinical outcomes,such as SSIs,seroma formation,the length of hospital stays,and *** Eight studies were included in this *** rate of total SSIs was significantly lower in the drained group(54/771,7.0%)than in the control group(89/759,11.7%),particularly in gastrointestinal ***,the rate of superficial SSIs was slightly lower in the drained group(31/517,6.0%)than in the control group(49/521,9.4%).No significant differences were observed in seroma formation between the *** stays were shorter in the drained group than in the control *** Subcutaneous drains after abdominal surgery prevented SSIs and reduced hospital stays but did not significantly affect seroma *** timing of drain removal needs to be reconsidered in future studies.

关键词： Abdominal surgery Mortality Seroma formation Subcutaneous drain Surgical site infections

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7岁日本男孩原发性硬化性纵隔炎病例报道1例

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 49-50页

作者： shinkawa T. Nakajima M. Kishimoto T. 虎小毅 Department of Paedia trics Nara Medical University 840 Shijo-cho 634-8522 Kashihara City Nara Japan

Sclerosing mediastinitis is a very rare benign disorder characterised by the d evelopment of dense fibrous tissue within the mediastinum. Affected patients are typically young adults with infant cases being uncommon especially in areas wit hout endemic histoplasmosis. We report a Japanese boy with markedly elevated ser um inflammatory markers for more than 1 year in the absence of any clinical mani festations. 67Gascintigraphy demonstrated an accumulation in the mediastinal reg ion and an open biopsy revealed a hard fibrous mass in the anteriosuperior media stinum. Thus, a diagnosis of idiopathic sclerosing mediastinitis was made. Concl usion:To the best of our knowledge, this case is the youngest patient reported w ith this disorder. In patients with mediastinal mass lesions the diagnosis of sc lerosing mediastinitis should be considered as well as infectious, autoimmune or neoplastic disease even in children.

关键词：硬化性纵隔炎闪烁照相术组织胞浆菌病肿瘤性疾病纤维性前上方组织增生组织损伤感染性

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