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中国药科大学学报 2011年第5期42卷 423-427页

作者：黄爱文竹内洋文肖衍宇孙敏捷平其能牛江秀苏志桂中国药科大学药剂学教研室南京210009 岐阜药科大学制剂学实验室

制备海藻酸钠包覆的脂质体,并对其黏膜黏附性质进行研究。采用薄膜水化法制备了包封率为(86.2±2.3)%的带正电荷的降钙素脂质体,并用不同黏度的海藻酸钠对脂质体进行包覆,包覆后的脂质体实现了电荷反转。通过黏蛋白-颗粒结合法、组织匀... 详细信息

制备海藻酸钠包覆的脂质体,并对其黏膜黏附性质进行研究。采用薄膜水化法制备了包封率为(86.2±2.3)%的带正电荷的降钙素脂质体,并用不同黏度的海藻酸钠对脂质体进行包覆,包覆后的脂质体实现了电荷反转。通过黏蛋白-颗粒结合法、组织匀浆法和激光共聚焦显微镜法分别对海藻酸钠包覆脂质体的体内外黏附性质进行研究,黏蛋白-颗粒结合法研究结果表明:海藻酸钠可以与黏蛋白颗粒结合使其电位发生变化,组织匀浆法研究结果表明:海藻酸钠包覆脂质体能够增加肠道中荧光标记物的含量,并且随着海藻酸钠黏度的增加,肠道中荧光标记物的含量增大。激光共聚焦显微镜法研究表明:高黏度的海藻酸钠包覆脂质体与未包覆脂质体相比表现出了更强的荧光强度,海藻酸钠包覆脂质体与未包覆脂质体相比具有良好的黏膜黏附特性,且这一特性随着海藻酸钠黏度的增加而增大。

关键词：海藻酸钠降钙素脂质体黏膜黏附激光共聚焦

Current status and challenges in sentinel node navigation surgery for early gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 150-158页

作者： Satoru Matsuda Tomoyuki Irino hirofumi Kawakubo Hiroya takeuchi Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Surgery Hamamatsu University School of MedicineShizuoka 431-3192Japan

As an optimal surgical procedure to accurately evaluate lymph node(LN)metastasis during surgery with minimal surgical resection,we have been developing sentinel node(SN)biopsy for early gastric cancer since the *** institutions from the Japanese Society of Sentinel Node Navigation Surgery(SNNS),including Keio University Hospital,conducted a multicenter prospective trial to validate the SN concept using the dual-tracer method with blue dye and a *** to the results,397 patients were included in the final analysis,and the overall accuracy in detecting LN metastasis using SN biopsy was 99%(383 of 387).Based on the validation study,we are targeting cT1N0 with a primary tumor of≤4 cm in diameter as an indication for SN biopsy for gastric *** are currently running a multicenter nonrandomized phaseⅢtrial to assess the safety and efficacy of SN navigation *** Korean group has reported the result of a multicenter randomized phaseⅢ*** meticulous gastric cancer in the remnant stomach was rescued by subsequent gastrectomy,the disease-specific survival was comparable between the two techniques,implying that SN navigation surgery can be an alternative to standard *** the development of SN biopsy procedure and treatment modalities,the application of SN biopsy will be expanded to achieve an individualized minimally invasive surgery.

关键词： Sentinel node gastric cancer minimally invasive surgery

Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 46-55页

作者： Masashi takeuchi hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya takeuchi Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Preventive Medicine and Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Surgery Hamamatsu University School of MedicineShizuoka 431-3192Japan

BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical *** studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal ***,no study has shown the association between postoperative complications and long-term survival of patients with EGJ *** To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ *** A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this *** examined the association between complications and long-term oncologic *** In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic ***,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic *** anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage.

关键词： Esophagogastric junction cancer Complication Long-term outcome

The Prognostic Significance of the Preoperative Platelet-Lymphocyte Ratio in Japanese Patients with Localized Breast Cancer

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Advances in Breast Cancer Research 2016年第2期5卷 49-57页

作者： Hideya takeuchi Seiichi Fukuyama Nobuhide Kubo Shoji Hiroshige hirofumi Kawanaka Yasuji Yoshikawa Tokujiro Yano Department of Surgery National Hospital Organization Beppu Medical Center Beppu Japan Clinical Research Institute National Hospital Organization Beppu Medical Center Beppu Japan Department of Pathology National Hospital Organization Beppu Medical Center Beppu Japan

Inflammation has been shown to be a factor in tumorigenesis. The circulating platelet to lymphocyte ratio (PLR) is a representative index of systemic inflammation. In this study, we analyzed the association between preoperative PLR levels and clinicopathological variables in two hundred sixty-four Japanese patients with localized breast carcinoma. We also evaluated the prognostic significance of preoperative PLR levels using the Cox proportional hazard model. Seventy-five patients (28.4%) had elevated PLR values, whereas 189 (71.6%) had depressed PLR values. The PLR correlated significantly with venous invasion (P < 0.05). Disease-free survival rates were significantly worse among patients with elevated PLR values than among those with lower PLR value (5-year survival, 81.6% vs. 90.7%, respectively;P < 0.05). In multivariate analysis, elevated PLR, nuclear grade, and lymph node involvement were significant prognostic factors for disease-free survival in patients with breast carcinoma (P < 0.05). Preoperative PLR levels may be an independent prognostic factor in patients with breast carcinoma.

关键词： Platelet-Lymphocyte Ratio Breast Cancer Inflammation

Laparoscopic Submucosal Dissection for Gastrointestinal Stromal Tumor of the Stomach: A Novel Technique for Local Excision with a Minimal Curative Margin

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Surgical Science 2012年第10期3卷 494-498页

作者： Norihito Wada Yoshiro Saikawa Hiroya takeuchi Tsunehiro Takahashi Rieko Nakamura hirofumi Kawakubo Kaori Kameyama Makio Mukai Yuko Kitagawa Department of Surgery School of Medicine Keio University Tokyo Japan Departments of Pathology School of Medicine Keio University Tokyo Japan

Background: Laparoscopic wedge resection is accepted as a curative treatment for small- and mediumsized gastroin-testinal stromal tumors (GISTs) of the stomach. Conventional methods involving surgical staplers require relatively large lateral margins, which may cause deformity and postoperative dysfunction of the gastric remnant. In this study, we introduce a novel technique called laparoscopic submucosal dissection (LSD) in which the defects of the stomach are minimized and a microscopic negative margin is secured. Methods: The normal seromuscular layer of the gastric wall was dissected with a 5 mm lateral margin. Then, the submucosal tissue was divided carefully using a monopolar electrosurgical device with a curved spatula tip. Results: The operation time was 170 min, and the amount of bleeding was very small. We confirmed an intact pseudo-capsule and marginal subserosal or submucosal tissue of the tumor by histological analysis. The postoperative course was uneventful with no complications. Endoscopy showed minimal deformity of the gastric remnant. Conclusions: We think that LSD is a curative and less invasive treatment for GIST of the stomach. Further investigations are necessary to evaluate the oncological and functional outcomes of this procedure.

关键词： Gastrointestinal Stromal Tumor Submucosal Tumor Endoscopic Submucosal Dissection Wedge Resection Laparoscopic Surgery Minimally Invasive Surgery

Relationship between Senior Drivers’ Cognitive and Physical Functions and Urban Driving Behaviors during Behind-the-Wheel Driving Education Sessions with Driving Instructors

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Journal of Transportation Technologies 2017年第2期7卷 148-166页

作者： Takashi Yonekawa Takahiro Tanaka hirofumi Aoki Misako Yamagishi Yuki Yoshihara Eijiro takeuchi Issey Takahashi Yoshiki Ninomiya Hitoshi Kanamori Tatsuya Suzuki Makoto Inagami Institute of Innovation for Future Society Nagoya University Nagoya Japan

Recently, traffic accidents caused by elderly drivers have been increasing. It is thought that the reasons of accidents are functions such as decline of eyesight, cognition and physical strength caused by aging. In order to assist safe driving for elderly drivers, it is necessary to sufficiently understand any possible relationship of various senior drivers’ cognition, physical strength and driving behavior. In this paper relationship of elderly driver’s cognition, physical strength and driving behaviors were analyzed using the result of driving instructions on urban road by driving school instructors.

关键词： Human Engineering Elderly Person Driver Characteristics Driving Instruction

真鲷仔鱼用微粒子饲料中肽酶与大豆卵磷脂添加效果的研究(英文)

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水生生物学报 2006年第6期30卷 734-741页

作者：王秋荣竹内俊郎古板博文集美大学水产学院福建厦门361021 东京海洋大学日本独立行政法人水产综合研究中心养殖研究所

本研究以酪蛋白分解物为蛋白源配制三种微粒子饲料MD-S、MD-T和MD-U对真鲷开口仔鱼进行饲养试验。以MD-S的配方为基准,MD-T采用粉状大豆卵磷脂和麸质代替液状大豆卵磷脂;MD-U则另外添加0.1%的肽酶。结果表明,微粒子饲料在水中浸泡15min... 详细信息

本研究以酪蛋白分解物为蛋白源配制三种微粒子饲料MD-S、MD-T和MD-U对真鲷开口仔鱼进行饲养试验。以MD-S的配方为基准,MD-T采用粉状大豆卵磷脂和麸质代替液状大豆卵磷脂;MD-U则另外添加0.1%的肽酶。结果表明,微粒子饲料在水中浸泡15min后,MD-T的溶出率(35.5%)低于MD-S(46.8%)和MD-U(45.8%);实验结束时(20日龄),仔鱼的成活率以生物饵料(轮虫)组为最高(86.3%),其次是MD-T组为20.7%,显著高于(P0.05)。在孵化后第12d,微粒子饲料组的仔鱼肠上皮细胞发育良好,但至孵化后第18d,仔鱼肠上皮细胞大部分萎缩、并发生脱落。鱼体的蛋白质、DNA与RNA日间增长率微粒子饲料MD-T组高于MD-S和MD-U组,但都低于生物饵料组。由此可见,微粒子饲料中添加肽酶并无助真鲷仔鱼对其消化吸收;可是,使用粉状大豆卵磷脂与麸质代替液状卵磷脂能增强微粒子饲料的黏合性,可减少其营养成分的溶出率,从而提高微粒子饲料的饲育效果。

关键词：真鲷仔鱼微粒子饲料肽酶大豆卵磷脂

Laparoscopic Submucosal Dissection for Gastrointestinal Stromal Tumor of the Stomach: A Novel Technique for Local Excision with a Minimal Curative Margin

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