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Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

World Journal of Gastroenterology 2008年第31期14卷 4915-4922页

作者： Atsushi Nanashima Toshiyuki Nakayama Yorihisa Sumida Takafumi Abo hiroaki takeshita Kenichirou Shibata Shigekazu Hidaka Terumitsu Sawai Toru Yasutake Takeshi Nagayasu Division of Surgical Oncology Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 8528501 Japan Department of Molecular Pathology Atomic Disease Institute Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan

AIM: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modifi ed Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm^2, which was used as a cut-off value. MVC was not signif icantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox’s multivariateanalysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic fi nding and hepatic dysfunction. Signifi cant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2.

关键词： Hepatocellular carcinoma Hepatic resection Microvessel count CD34 Modified Japan integrated staging score

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Cardiac Computed Tomography for the Diagnosis of Coronary Artery Atherosclerosis

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International Journal of Clinical Medicine 2013年第3期4卷 183-189页

作者： Ryotaro Wake Hidetaka Iida Hirohito Ogata hiroaki takeshita Takanori Kusuyama hiroaki Kohno Shinichi Shimodozono Kenei Shimada Minoru Yoshiyama Department of Cardiology Tsukazaki Hospital Himeji Japan. Department of Cardiology Tsukazaki Memorial Hospital Himeji Japan. Department of Internal Medicine and Cardiology Osaka City University Graduate School of Medicine Osaka Japan.

Coronary artery disease (CAD) is a leading cause of mortality and morbidity in developed countries, although percutaneous coronary intervention and coronary artery bypass grafting have developed recently. Appropriate diagnosis will improve the prevention, treatment, and care of all patients. We could diagnose only calcification in the coronary arteries with the past computed tomography. Recently, multislice computed tomography has been already accepted as an efficient non-invasive tool for the detection of coronary artery stenosis. We get to estimate the coronary artery stenosis with cardiac computed tomography. We discuss the usefulness of cardiac computed tomography for the risk stratification of coronary artery atherosclerosis.

关键词： Cardiac CT Coronary Atherosclerosis

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Relationship between Serum Hyaluronic Acid Level and Patient Prognosis in Hepatocellular Carcinoma Patients Who Underwent Hepatectomy

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Journal of Cancer Therapy 2013年第2期4卷 359-366页

作者： Atsushi Nanashima Takafumi Abo Goushi Murakami Masaki Kunizaki hiroaki takeshita Shigekazu Hidaka Kazuo To Tomoshi Tsuchiya Takeshi Nagayasu Division of Surgical Oncology Department of Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan

We examined the relationship between hyaluronic acid (HA) and tumor-related factors after hepatectomy in 158 patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. We examined serum HA levels before hepatectomy by evaluating data for clinicopathological parameters, surgical records, postoperative complications and survival. The mean HA level was 190 ± 202 ng/ml. Patients were divided into 3 groups: group A had serum HA levels less than 50 ng/ml (normal range), group B had levels between 50 and 190 ng/ml, and group C had levels over 190 ng/ml. Group C had a higher rate of poor liver function compared to others. Multiple tumors were significantly more frequent in groups B and C compared to A. The grade of fibrosis and the inflammatory responses were positively correlated with the serum HA level. Postoperative long-term ascites was significantly more frequent in group C compared to others. Although the recurrence rate and the relapse-free period were not significantly related to the serum HA level, the serum HA level was significantly associated with overall survival after hepatectomy (p 0.05). Cox’s multivariate analysis did not show a significant relationship between HA level and survival. Serum HA reflects progression and survival in HCC patients.

关键词： Hepatocellular Carcinoma Hepatectomy Serum Hyaluronic Acid Level Prognosis

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Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism

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World Journal of Hepatology 2014年第12期6卷 870-879页

作者： Yo-ichi Ishida Masahiko takeshita hiroaki Kataoka Department of Molecular and Cellular Biochemistry Meiji Pharmaceutical University Kiyose Tokyo 204-8588 Japan Research Division Minami Nippon Dairy Co-op. Ltd. Miyakonojo Miyazaki 885-0003 Japan Section of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Kiyotake Miyazaki 889-1692 Japan

Hepatitis C virus(HCV)is a major cause of viral hepatitis and currently infects approximately 170 million people *** infection by HCV causes high rates of chronic hepatitis(>75%)and progresses to liver cirrhosis and hepatocellular carcinoma *** can be eliminated by a combination of pegylatedα-interferon and the broad-spectrum antiviral drug ribavirin;however,this treatment is still associated with poor efficacy and tolerability and is often accompanied by serious *** some novel direct-actingantivirals against HCV have been developed recently,high medical costs limit the access to the therapy in cost-sensitive *** search for new natural anti-HCV agents,we screened local agricultural products for their suppressive activities against HCV replication using the HCV replicon cell system in *** found a potent inhibitor of HCV RNA expression in the extracts of blueberry leaves and then identified oligomeric proanthocyanidin as the active *** investigations into the action mechanism of oligomeric proanthocyanidin suggested that it is an inhibitor of heterogeneous nuclear ribonucleoproteins(hn RNPs)such as hn RNP A2/*** this review,we presented an overview of functional foods and ingredients efficient for HCV infection,the chemical structural characteristics of oligomeric proanthocyanidin,and its action mechanism.

关键词： Hepatitis C virus Blueberry leaves Functional foods Oligomeric proanthocyanidin Heterogeneous nuclear ribonucleoproteins

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Investigation of a Network Failure Problem with a Significant Path, from the Perspective of Crisis Management

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Journal of Mathematics and System Science 2014年第7期4卷 479-485页

作者： Jun-ichi takeshita hiroaki Mohri Research Institute of Science for Safety and Sustainability (RISS) National Institute of Advanced Industrial Sciene and Technology (AIST) 16-1 Onogawa Tsukuba Ibaraki 305-8569 JAPAN Faculty of Commerece Waseda University 1-6-1 Nishi-Waseda Shunjuku-ku Tokyo 169-8050 JAPAN

The objective of this study is to investigate a network failure problem with a significant path, emerging from the context of crisis management, such as in the case of natural disasters. For a given tree with m failed edges, we assume that we have sufficient resources to recover k edges of the m edges. Each node has a positive weight. In this situation, we consider which k edges should be fixed in order to maximize the sum of the weights of the nodes reachable from the significant path. In this paper, we formulate such a problem as a combinatorial problem. Further, we show that a part of our problem may be solved by translating it into the terms of the so-called tree knapsack problem.

关键词： Network failure graph tree structure combinatorial optimization risk management

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A Water Line Network Failure Application of Network Design Problems

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Journal of Mathematics and System Science 2015年第12期5卷 493-500页

作者： hiroaki Mohri Jun-ichi takeshita Faculty of Commerce Waseda University 1-6-1 Nishi-Waseda Shinjuku-ku Tokyo 169-8050 Japan. Research Institute of Science for Safety and Sustainability National Institute of Advanced Industrial Science and Technology(AIST) 16-1 Onogawa Tsukuba Ibaraki 305-8569 Japan.

This study investigated a water supply recovery problem involving municipal water service piping. The problem consisted in recovering full service after network failure, in order to rapidly satisfy all urgent citywide demands. The optimal recovery solution was achieved through the application of so-called network design problems （NDPs）, which are a form of combinatorial optimization problem. However, a conventional NDP is not suitable for addressing urgent situations because （1） it does not utilize the non-failure arcs in the network, and （2） it is solely concerned with stable costs such as flow costs. Therefore, to adapt the technique to such urgent situations, the conventional NDP is here modified to deal with the specified water supply problem. In addition, a numerical illustration using the Sendai water network is presented.

关键词： Water supply recovery problem Network design problem Network failure Recovery and reconstruction plan Combinatorial optimization Risk assessment/management

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CO₂ Capture at Room Temperature and Ambient Pressure: Isomer Effect in Room Temperature Ionic Liquid/Propanol Solutions

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Green and Sustainable Chemistry 2016年第2期6卷 116-124页

作者： Hiroshi Abe Azusa takeshita Hirokazu Sudo Koichi Akiyama hiroaki Kishimura Department of Materials Science and Engineering National Defense Academy Yokosuka Japan

A CO2 capture system without supercritical CO2 was optimized for mixtures of hydrophobic room temperature ionic liquids (RTILs) and propanol. We tested RTILs using bis(trifluoromethanesulfonyl)imide, TFSI-, anion and four quaternary ammonium cations, two quaternary phosphonium cations, and one imidazolium cation. The addition of 2-propanol into the RTILs clearly promoted the capture of normal CO2(nCO2) at ambient temperature and pressure. When combined with 2-propanol, the most efficient RTILs for nCO2 capture were N-butyl-N,N,N-trimethylammonium TFSI-. This enhancement of nCO2 capture was not observed in RTIL mixtures with 1-propanol or in propanol mixtures containing other phosphonium- and imidazolium-based RTILs. The torsion angle of TFSI-, which was calculated using density functional theory, is thought to be related to high nCO2 capture efficiently.

关键词： CO2 Capture Room Temperature Ionic Liquids Propanol Isomer Effect Torsion Angle of TFSI- Anion

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