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Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury

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World Journal of Gastroenterology 2009年第36期15卷 4571-4575页

作者： hiroaki sato Kiyohiro Oshima Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine3-39-15 Showa-machiMaebashiGunma 371-8511 Japan Intensive Care Unit Gunma University Hospital3-39-15 Showa-machiMaebashiGunma 371-8511 Japan

AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion （THVE） using a porcine model. METHODS： Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly： the DHP-PMX group （n = 5） underwent DHP-PMX at a flow rate of 80 mL/min for 220 min （beginning 10 rain before reperfusion）, while the control group did not （n = 6）. The rate pressure product （RPP）： heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow （HTBF）, portal vein blood flow （PVBF）, and serum aspartate aminotransferase （AST） levels were compared between the two groups. RESULTS： RPP and HTBF were significantly （P 〈 0.05） higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly （P 〈 0.05） compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly （P 〈 0.05） lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION： DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.

关键词： Ischemia-reperfusion injury Total hepaticvascular exclusion Polymyxin B-immobilized fiber column

Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion

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World Journal of Gastroenterology 2008年第35期14卷 5436-5441页

作者： hiroaki sato Kazuhisa Arakawa Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Kiyohiro Oshima Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Intensive Care Unit Gunma University HospitalMaebashiGunma 371-8511Japan

AIM： To investigate the effectiveness of direct hemoperfusion with polymyxin B-immobilized fibers （DHPPMX therapy） on warm ischemia-reperfusion （I/R） injury of the small intestine.METHODS： The proximal jejunum and distal ileum of mongrel dogs were resected. Warm ischemia was performed by clamping the superior mesenteric artery （SMA） and vein （SMV） for 2 h. Blood flow to the proximal small intestine was restored 1 h after reperfusion, and the distal small intestine was used as a stoma. The experiment was discontinued 6 h after reperfusion. The dogs were divided into two groups： the DHP-PMX group （n = 6, DHP-PMX was performed for 180 min; from 10 min prior to reperfusion to 170 rain after reperfusion） and the control group （n = 5）. The rate pressure product （RPP）, SMA blood flow, mucosal tissue blood flow, and intramucosal pH （pHi） were compared between the two groups. The serum interleukin （IL）-10 levels measured 170 min after reperfusion were also compared.RESULTS： The RPP at 6 h after reperfusion was significantly higher in the PMX group than in the control group （12174 ± 1832 mmHg/min vs 8929 ± 1797 mmHg/min, P 〈 0.05）. The recovery rates of the SMA blood flow at I and 6 h after reperfusion were significantly better in the PMX group than in the control group （61%±7% vs 44% ±4%, P 〈 0.05, and 59%±5% vs 35%±5%, P 〈 0.05, respectively）. The recovery rate of the mucosal tissue blood flow and the pHi levels at 6 h after reperfusion were significantly higher in the PMX group （61%±8% vs 31%±3%, P 〈 0.05 and 7.91±0.06 vs 7.69±0.08, P 〈 0.05, respectively）. In addition, the serum IL-IO levels just before DHP-PMX removal were significantly higher in the PMX group than in the control group （1 569 ± 253 pg/mL vs 211± 40 pg/mL, P 〈 0.05）.CONCLUSION： DHP-PMX therapy reduced warm I/R injury of the small intestine. IL-10 may play a role in inhibiting I/R injury during DHP-PMX therapy.

关键词： Ischemia-reperfusion injury Interleukin-10 Polymyxin B-immobilized hemoperfusion cartridge PMX

新疆北部富蕴县沙尔布拉克玻安岩的地球化学特征及构造意义

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地球化学 2003年第2期32卷 155-160页

作者：张海祥牛贺才于学元 hiroaki sato Junichi Ito 单强中国科学院广州地球化学研究所广东广州510640 日本神户大学理学部地球惑星科学教室

详细的地球化学研究表明,新疆北部富蕴县沙尔布拉克中泥盆统北塔山组的辉石安山岩具有中等的SiO2含量(52.13%～60.45%);高MgO(3.91%～9.31%)和相容元素(包括Ni、Cr、Co等)含量,以及高Mg#和Al2O3/TiO2比值;低TiO2含量(0.21%～0.35%);同... 详细信息

详细的地球化学研究表明,新疆北部富蕴县沙尔布拉克中泥盆统北塔山组的辉石安山岩具有中等的SiO2含量(52.13%～60.45%);高MgO(3.91%～9.31%)和相容元素(包括Ni、Cr、Co等)含量,以及高Mg#和Al2O3/TiO2比值;低TiO2含量(0.21%～0.35%);同时具有U型稀土元素分布模式;并强烈亏损高场强元素。这些特征均与玻安岩的地球化学特征一致,应属于玻安岩,形成于前弧环境。沙尔布拉克玻安岩的存在表明,古亚洲洋在早—中泥盆世向南发生了洋壳俯冲作用。

关键词：玻安岩地球化学新疆火山岩洋壳俯冲作用岩石学

Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model

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World Journal of Gastroenterology 2007年第25期13卷 3487-3492页

作者： Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu hiroaki sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine 3-39-15 Showa-Machi Maebashi Gunma 371-8511 Japan Intensive Care Unit Gunma University Hospital 3-39-15 Showa-Machi Maebashi Gunma 371-8511 Japan Animal Resource Project Center for Molecular Medicine Jichi Medical University Institute 3311-1 Yakushiji Shimotsuke Tochigi 329-0498 Japan Department of Pathology Nippon Medical School Musashi-Kosugi Hospital 1-396 Kosugi-chou Nakaharaku Kawasaki Kanagawa 211-8533 Japan

AIM： To evaluate the effect of ANP on warm I/R injury in a porcine THVE model.METHODS： Miniature pigs （mini-pigs） weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP （0.1 μg/kg per min） was administered to the ANP group （n = 7）, and vehicle was administered to the control group （n = 7）. Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood flow （HTBF） was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups.RESULTS： The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were significantly different between the two groups （60 min： 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 〈 0.05, 120 rain： 673.6± 148.2 vs 281.1±44.8, P = 0.004 〈 0.01）. No significant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not significant. A significantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the control group （0min： 2.92± 1.1 vs 6.38 ±1.1,,P= 0.011 〈 0.05）.Histological tissue damage was milder in the ANP group than in the control group.CONCLUSION： Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model.

关键词： Atrial natriuretic peptide p38 MAPK Ischemia-reperfusion injury Porcine liver Total hepaticvascular exclusion

玄武质岩石中橄榄石斑晶的NiO-Fo关系—原始岩浆组分的指示剂

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世界地质 1993年第1期 38-39页

作者： hiroaki sato 贺云龙

橄榄石是幔源原始岩浆中最早结晶的一种矿物,而且其化学成分可以提供源区橄榄岩性质的信息。地幔橄榄岩中橄榄石的100Mg/(Mg+Fe)值(Fo)范围较宽,从94到85,而NiO的含量约为0.4％(wt,以下同)。橄榄石Fo值的微小差异导致对原始岩浆MgO含量... 详细信息

橄榄石是幔源原始岩浆中最早结晶的一种矿物,而且其化学成分可以提供源区橄榄岩性质的信息。地幔橄榄岩中橄榄石的100Mg/(Mg+Fe)值(Fo)范围较宽,从94到85,而NiO的含量约为0.4％(wt,以下同)。橄榄石Fo值的微小差异导致对原始岩浆MgO含量估计的较大不同。例如,原始的洋中脊玄武岩中橄榄石的Fo值相当于92、90和88,而MgO的含量分别约为16、12.5和10％。因此,在估计原始岩浆组分时,关键在于得到源区中橄榄石Fo的精确值。

关键词：橄榄石斑晶玄武质岩石岛状硅酸盐矿物原始岩浆 NiO-Fo

新疆北部晚古生代埃达克岩、富铌玄武岩组合:古亚洲洋板块南向俯冲的证据

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高校地质学报 2004年第1期10卷 106-113页

作者：张海祥牛贺才 hiroaki sato 单强于学元 Jun’ichi Ito 张旗中国科学院广州地球化学研究所广州510640 日本神户大学理学部地球和行星科学教室日本神户6578501 中国科学院地质及地球物理研究所北京100029

地球化学研究结果表明 ,新疆北部富蕴县境内的晚古生代下泥盆统托让格库都克组的安山质岩石具有与埃达克岩非常相似的地球化学特征 ,它们具有较高的Al2 O3 ,Na2 O和Sr含量以及Sr/Y比值 ;明显亏损重稀土和Y ,它们的MORB标准化微量元素蛛... 详细信息

地球化学研究结果表明 ,新疆北部富蕴县境内的晚古生代下泥盆统托让格库都克组的安山质岩石具有与埃达克岩非常相似的地球化学特征 ,它们具有较高的Al2 O3 ,Na2 O和Sr含量以及Sr/Y比值 ;明显亏损重稀土和Y ,它们的MORB标准化微量元素蛛网图表现为明显的Nb ,Ta负异常和Sr正异常 ,同时强烈亏损高场强元素。与埃达克岩共生的玄武岩的地球化学特征则与富铌玄武岩一致 ,表现为Si过饱和及富Na的特征 ,同时具有较高的Nb ,TiO2 和P2 O5含量 ,并富集高场强元素。由于埃达克岩和富铌玄武岩的形成均与板块俯冲有关 ,因此 ,它们的存在表明 ,古亚洲洋在早 -中泥盆世向南 (哈萨克斯坦 -准噶尔板块 )

关键词：哈萨克斯坦-准噶尔板块埃达克岩和富铌玄武岩古亚洲洋板块俯冲

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卢旺达难民对刚果东部环境影响的跟踪调查

AMBIO－人类环境杂志 2000年第2期29卷 122-123页

作者： Dr hiroaki sato Dr Kinya Yasui Mrs Kizungu Byamana 闻怡 Department of Biological Science Faculty of Science Nara Women's University Nara630-8506 Japan Department of Oral Anatomy 1 Kagoshima University Dental School 8-35-1Sakuragaoka Kagoshima 890-8544 Japan. Bashonga

引言基伍(Kivu)位于刚果人民共和国(以前的扎伊尔)的东部,其境内包括拥有大量物种丰富多样的动物区系和植物区系的低地和季雨林。境内有8个国家公园和保留林,其中两个由于具有突出的自然环境价值而被列入联合国教科文组织编写的世界遗... 详细信息

引言基伍(Kivu)位于刚果人民共和国(以前的扎伊尔)的东部,其境内包括拥有大量物种丰富多样的动物区系和植物区系的低地和季雨林。境内有8个国家公园和保留林,其中两个由于具有突出的自然环境价值而被列入联合国教科文组织编写的世界遗产之中。它们分别为Virungs国家公园和Kahuzi-Biaga国家公园(见图1)。同时,这个地区的人口密度为每平方公里49人,是该国平均人口密度的4倍,是一个以高人口密度著称的地区。这种高度密集的人口和不断增长的人口压力导致了狩猎、砍伐以及种植等活动的大量增加。

关键词：卢旺达难民刚果东部地区环境影响调查

准噶尔板块东北缘富铌玄武岩的发现及其地质意义

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地质找矿论丛 2003年第1期18卷 71-72页

作者：张海祥牛贺才于学元单强 hiroaki sato Junichi Ito 中国科学院广州地球化学研究所广东广州510640 日本神户大学理学部地球惑星科学教室

富铌玄武岩是硅过饱和,富Na2O,TiO2,P2O5,同时富集高场强元素的一类岛弧玄武岩,这类玄武岩的w(Nb)＞7×10-6,(w(La)/w(Nb))MN＜2.它是由来源于70～100 km深处、受adakite熔体交代过的地幔楔橄榄岩部分熔融形成的,是大洋板块俯冲作用的产... 详细信息

富铌玄武岩是硅过饱和,富Na2O,TiO2,P2O5,同时富集高场强元素的一类岛弧玄武岩,这类玄武岩的w(Nb)＞7×10-6,(w(La)/w(Nb))MN＜2.它是由来源于70～100 km深处、受adakite熔体交代过的地幔楔橄榄岩部分熔融形成的,是大洋板块俯冲作用的产物.目前发现的富铌玄武岩大多分布在环太平洋新生代岛弧环境,与洋壳俯冲作用密切相关[1-5].

关键词：地球化学洋壳俯冲作用新生代准噶尔板块富铌玄武岩

新疆北部富蕴县沙尔布拉克玻安岩的地球化学特征及岩石成因:玻安岩一种可能的新成因模式

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新疆北部富蕴县沙尔布拉克玻安岩的地球化学特征及岩石成因:玻安...