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Sofosbuvir/Ribavirin therapy for patients experiencing failure of ombitasvir/paritaprevir/ritonavir + ribavirin therapy: Two cases report and review of literature

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World Journal of Clinical Cases 2019年第9期7卷 1043-1052页

作者： Ken Sato Yuichi Yamazaki Takeshi Kobayashi Satoshi Takakusagi Norio Horiguchi Satoru Kakizaki Masayasu Andou Yoshihiro Matsuda Toshio Uraoka Hiroshi Ohnishi hiroaki okamoto Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Department of Nephrology and Rheumatology Gunma University Graduate School of Medicine Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine

BACKGROUND The effectiveness of sofosbuvir/ribavirin(SOF/RBV) combination therapy,which is one of the 1 st-choice therapeutic options for patients with hepatitis C virus(HCV) genotype 2(HCV-G2) in Japan according to the most recent version of the Japan Society of Hepatology guideline, for patients who experienced failure of the ombitasvir/paritaprevir/ritonavir plus ribavirin(OBV/PTV/r+RBV) combination therapy, which was another option for patients with HCV-G2, is unknown.CASE SUMMARY We evaluated the effects of SOF/RBV combination therapy in two patients with genotype 2 a who could not achieve a sustained virological response(SVR) by OBV/PTV/r+RBV combination therapy. One patient was complicated with VogtKoyanagi-Harada(VKH) disease. Resistance-associated variations before SOF/RBV combination therapy were not detected in two patients. Both patients had an SVR at 12 wk after the treatment(SVR12). Regarding adverse events(AEs), itching, chill, a dull feeling in the throat and cough as well as increase of alanine transaminase level were shown in one patient, while a headache and deterioration of light aversion probably due to the recurrence of VKH disease were shown in the other patients. In addition, the latter patient developed arthralgia and morning stiffness approximately 7 wk after the therapy and turned out to be diagnosed with rheumatoid arthralgia.CONCLUSION SOF/RBV therapy might be effective for patients experiencing failure of OBV/PTV/r+RBV therapy, but caution should be taken regarding the AEs.

关键词： Direct-acting antiviral agent failure Hepatitis C Genotype 2 Ribavirin Sofosbuvir Case report

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Resonant Third-Order Optical Nonlinearities of Poly（methyl methacrylate） Films Containing J-Like Aggregates of a Thiadicarbocyanine Dye

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Chinese Physics Letters 2005年第10期22卷 2571-2574页

作者：李忠玉金朝辉 KASATANI Kazuo okamoto hiroaki Department of Advanced Materials Science and Engineering Faculty of Engineering Yamaguchi University Tokiwadai Ube Yamaguchi 755-8611 Japan

The third-order optical nonlinearities and responses of poly（methyl methacrylate）（PMMA） coating films containing J-like aggregates of a thiadicarbocyanine dye, 3,3＇-diethyl-2,2＇-thiadicarbocyanine iodide （DTDC1）, are measured by degenerate four-wave mixing （DFWM） technique under resonant conditions. The temporal profiles of the DFWM signal of PMMA coating films containing J-like aggregates of DTDC1 are found to consist of three components： i.e., the coherent instantaneous nonlinear response （electronic response） and the two slow responses uqth decay time constants of about 0.8ps and about 7.0ps. The electronic component of the effective third-order nonlinear susceptibility, χc^（3）, of one of the present films is as high as about 2.1×10^-8 esu, and the figure of merit of third-order nonlinearity F （F=χ^（3）/α） is evaluated to be about 1.9 ×10^-13 esu cm at 850nm.

关键词： ABSORPTION FLUORESCENCE DYNAMICS EXCITONS SYSTEM STATE

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Fast Optical Switching Using Oriented Cyanine Dye-Doped Nematic Liquid Crystal

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Chinese Physics Letters 2006年第10期23卷 2786-2789页

作者：金朝辉李忠玉 KASATANI Kazuo okamoto hiroaki Department of Advanced Materials Science and Engineering Faculty of Engineering Yamaguchi University Tokiwadai Ube 755-8611 Japan

A cyanine dye, 2-[7-（1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene）-1,3,5-heptatrienyl]-1,3,3-trimethyl-3H-indolium iodide （NK-125）, is doped in 4-cyano-4＇-pentylbiphenyl （5 CB）, and the mixture is sandwiched between two pieces of rubbed glass plates. The third-order nonlinear optical properties of the oriented NK-125-SCB layers are measured by the resonant femtosecond degenerate four-wave mixing （DFWM） technique at 760 nm. The third-order nonlinear optical susceptibility of one of the present samples is 5.5×10^-8 esu. The slow DFWM response of the NK-125-SCB layers due to a population grating is accelerated by the increasing laser power because of amplified spontaneous emission （ASE）. On the other hand, we do not observe a similar phenomenon for NK-125- polyethylene glycol （PEG-400）. Oriented NK-125 molecules in nematic liquid crystals must have very high ASE efficiency. Hence the population grating in a DFWM signal disappears within about 4 ps. It is expected that NK-125-SCB can be used as a material for very fast all-optical switching.

关键词： RELAXATION DYNAMICS ENERGY-TRANSFER SQUARYLIUM DYE COATING FILMS POLYMER-FILMS FAST-RESPONSE NONLINEARITIES STATE SUSCEPTIBILITY SPECTROSCOPY

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Anisotropy in Third-Order Nonlinear Optical Susceptibility of a Squarylium Dye in a Nematic Liquid Crystal

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Chinese Physics Letters 2006年第3期23卷 635-638页

作者：金朝辉李忠正 KASATANI Kazuo okamoto hiroaki Department of Advanced Materials Science and Engineering Faculty of Engineering Yamaguchi University Tokiwadai Ube 755-8611 Japan

A squarylium dye is dissolved in 4-cyano-4＇-pentylbiphenyl （SCB） and oriented by sandwiching mixtures between two pieces of rubbed glass plates. The optical absorption spectra of the oriented squarylium dye-5CB layers exhibit high anisotropy. The third-order nonlinear optical responses and susceptibilities X^（3）e of squarylium dye in 5CB are measured with light polarizations parallel and perpendicular to the orientational direction by the resonant femtosecond degenerate four-wave mixing （DFWM） technique. Temporal profiles of the DFWM signal of the oriented squarylium dye-5CB layers with light polarizations parallel and perpendicular to the orientational direction are measured with a time resolution of 0.3ps （FWHM）, and are found to consist of two components, i.e., the coherent instantaneous nonlinear response and slow response due to the formation of excited molecules. A high anisotropic ratio of x^（3）e, 10.8 ：k 1.2, is observed for the oriented layers.

关键词： MULTIPLE FLUORESCENCE EMISSION DOPED POLYMER SYSTEMS SQUARAINE DYE UNSYMMETRICAL SQUARAINES EXCITED-STATES CYANINE DYE FILMS ABSORPTION CHEMISTRY ORIGIN

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Large Third-Order Optical Nonlinearity and Fast Response of a Squarylium Dye

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Chinese Physics Letters 2005年第9期22卷 2282-2285页

作者：李忠玉金朝辉 KASATANI Kazuo okamoto hiroaki Department of Advanced Materials Science and Engineering Faculty of Engineering Yamaguchi University Tokiwadai Ube Yamaguchi 755-8611 Japan

The third-order optical nonlinearities and responses of a squarylium dye, 2,4-di-3-guaiazulenyl-1,3-dihydroxycyclobutenediylium dihydroxide, in tetrahydrofuran （THF） solution and in polystyrene （PS） coating films are measured by the femtosecond degenerate four-wave mixing technique under resonant conditions. The molecular hyperpolarizability γ of the squarylium dye in the THF solution is determined to be 3.0 × 10^-29 esu at 764 nm, and its electronic component γe is determined to be 1.1 × 10^-29 esu. The third-order nonlinear susceptibility X^（3） of one of the present PS coating films containing the squarylium dye is as high as 3.1 × 10^-8 esu at 80Ohm, and its electronic component Xe^（3） is 1.3 × 10^-8 esu.

关键词： Thf DFWM PS

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A novel approach to Parkinson's disease treatment with a potentially dual-acting therapeutic agent that targetsα-synuclein aggregation and neuron death

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Neural Regeneration Research 2024年第12期19卷 2577-2578页

作者： Allison RBalaj hiroaki Kaku Department of Investigative Medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parkinson's disease(PD),a prevalent neurodegenerative disorder,is chara cterized by the loss of dopaminergic neurons and the aggregation ofα-synuclein protein into Lewy bodies.While the current standards of therapy have been successful in providing some symptom relief,they fail to address the underlying pathophysiology of PD and as a result,they have no effect on disease progression.

关键词： aggregation death therapeutic

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Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice

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Animal Models and Experimental Medicine 2024年第1期7卷 77-81页

作者： Tatsushi Mutoh Ryota Tochinai hiroaki Aono Masayoshi Kuwahara Yasuyuki Taki Tatsuya Ishikawa Department of Surgical Neurology Research Institute for Brain and Blood VesselsAkita Cerebrospinal and Cardiovascular CenterAkitaJapan Department of Aging Research and Geriatric Medicine Institute of DevelopmentAging and CancerTohoku UniversitySendaiJapan Department of Veterinary Pathophysiology and Animal Health Graduate School of Agriculture and Life SciencesThe University of TokyoTokyoJapan

The murine model of subarachnoid hemorrhage(SAH)is a valuable experimental tool for investigating molecular and cellular mechanisms,and the endovascular filament perforation technique can be used to simulate prominent pathophysiological features observed after human SAH;however,current validation methods for assessing an appropriate SAH model are limited.Here,we introduce a simple procedure for se-lecting a mouse model of diffuse SAH.SAH was induced in 24 mice using a standard filament perforation method.After confirming survival at 24 h,SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging(MRI)and visual surveillance of the cisterna magna(CM)through the dura mater.The CM-based SAH grading correlated well with a reference parameter defined by extracted brain(r^(2)=0.53,p<0.0001).The receiver operating characteristic curve revealed a sensi-tivity of 85%and a specificity of 91%for detecting diffuse SAH,with a similar area under the curve(0.89±0.06[standard error of the mean])as the MRI-based grading(0.72±0.10,p=0.12).Our data suggest that confirming an SAH clot in the CM is a valuable way to select a clinically relevant diffuse SAH model that can be used in future experimental studies.

关键词： cisterna magna clot distribution filament perforation mouse model subarachnoid hemorrhage

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A unified multi-view multi-person tracking framework

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Computational Visual Media 2024年第1期10卷 137-160页

作者： Fan Yang Shigeyuki Odashima Sosuke Yamao hiroaki Fujimoto Shoichi Masui Shan Jiang Nanjing University China 不详 Fujitsu Research

Despite significant developments in 3D multi-view multi-person (3D MM) tracking, current frameworks separately target footprint tracking, or pose tracking. Frameworks designed for the former cannot be used for the latter, because they directly obtain 3D positions on the ground plane via a homography projection, which is inapplicable to 3D poses above the ground. In contrast, frameworks designed for pose tracking generally isolate multi-view and multi-frame associations and may not be sufficiently robust for footprint tracking, which utilizes fewer key points than pose tracking, weakening multi-view association cues in a single frame. This study presents a unified multi-view multi-person tracking framework to bridge the gap between footprint tracking and pose tracking. Without additional modifications, the framework can adopt monocular 2D bounding boxes and 2D poses as its input to produce robust 3D trajectories for multiple persons. Importantly, multi-frame and multi-view information are jointly employed to improve association and triangulation. Our framework is shown to provide state-of-the-art performance on the Campus and Shelf datasets for 3D pose tracking, with comparable results on the WILDTRACK and MMPTRACK datasets for 3D footprint tracking.

关键词： multi-camera multi-person tracking pose tracking footprint tracking triangulation spatiotemporal clustering

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Thermal stability of the Cr-coated zirconium alloy microstructure prepared by pulsed laser deposition

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Tungsten 2024年第2期6卷 333-341页

作者： Bo Li Hui-Long Yang Reuben Holmes Li-Juan Cui Sho Kano hiroaki Abe Department of Nuclear Engineering and Management The University of TokyoTokyo 113-8656Japan School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nuclear Professional School The University of TokyoIbaraki 319-1188Japan

Cr-coated zirconium alloy was prepared by pulsed laser deposition(PLD)for the application of accident-tolerant fuel cladding in light water reactors.The microstructural characteristics of the Cr coating and its evolution with temperature were investigated using grazing incidence X-ray diff raction and in situ heating transmission electron microscopy(TEM).Results show that the microstructure of the laser-deposited Cr coatings consists mainly of fine and non-specific shaped nano-crystals in the inner layer and columnar crystals in the outer layer.The recrystallization of the Cr-coating layer starts at 300–400℃ to release the high strain introduced by PLD,and the grain coalescence starts at temperatures>400°C.Upon annealing,the(110)-texture gradually intensifi es because of its high reticular density and low close-packed energy.Additionally,in situ heating TEM observation shows the presence of cavities on the Cr–Zr interface,which may result from the interdiff usion and/or the transformation from amorphous to crystalline.

关键词： Accident tolerant fuel Crcoating Interface Microstructure Pulsed laser deposition

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Combinations of Transportation Policies to Promote BRT Usage Using Artificial Society Model

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Journal of Traffic and Transportation Engineering 2024年第1期12卷 1-10页

作者： hiroaki Inokuchi Faculty of Environmental and Urban Engineering Kansai University3-3-35 Yamate-choSuitaOsaka 564-8680Japan

Various transportation systems have been developed in recent years.In this study,an artificial society model is developed to examine the combination of transportation policies in urban areas.In this model,each trip maker selects the primary and terminal transportation modes.An artificial society model is applied to the southeastern region of Osaka City,Japan.The effects of introducing BRT(bus rapid transit,primary transportation)and on-demand buses(terminal transportation)are investigated.The results confirm that BRT is used by a certain number of users.An increase in the use of BRT will increase the amount of walking,thus resulting in a healthy city.However,on-demand buses are rarely used as terminal transportation.Additionally,the development of bicycle parking stations near BRT stops is shown to be effective in the northern section of the BRT route.

关键词： Artificial society model bus rapid transit on-demand bus transportation policy.

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