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Gallbladder Burkitt's lymphoma mimicking gallbladder cancer:A case report

World Journal of Gastroenterology 2022年第6期28卷 675-682页

作者： Kiyotaka Hosoda Akira Shimizu Koji Kubota Tsuyoshi Notake Hikaru Hayashi Koya Yasukawa Kentaro Umemura Atsushi Kamachi Takamune goto Hidenori Tomida Shiori Yamazaki Yuri Narusawa Naoko Asano Takeshi Uehara Yuji Soejima Division of Gastroenterological Hepato-Biliary-PancreaticTransplantation and Pediatric SurgeryDepartment of SurgeryShinshu University School of MedicineMatsumoto 390-8621Japan Department of Laboratory Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

BACKGROUND Malignant lymphoma is a rare form of gallbladder *** of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas;however,Burkitt’s lymphoma of the gallbladder is extremely rare,and only two previous reports are available in the ***,we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder *** SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography(CT)performed for hypertension *** laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 *** examinations revealed two irregular and contrastenhanced masses extending into the gallbladder lumen,but these did not infiltrate the ***,a periportal lymph node had enlarged to 30 *** on these findings,we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis,which was treated using bile duct resection with gallbladder bed resection and periportal lymph node ***,the patient was finally diagnosed as having Burkitt’s *** the surgical margin was pathologically negative,recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after ***,he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide,doxorubicin,vincristine,and *** Burkitt’s lymphoma can occur in the *** can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

关键词： Gallbladder Malignant lymphoma Burkitt’s lymphoma Gallbladder cancer Lymphadenopathy Case report

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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation Dronedarone

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Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus

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World Journal of Hepatology 2022年第6期14卷 1226-1234页

作者： Ryosuke Yamane Kentaro Yoshioka Kazuhiko Hayashi Yuko Shimizu Yuki Ito Komei Matsushita Michiyo Yoshizaki Go Kajikawa Taro Mizutani Atsuko Watarai Kosuke Tachi Hidemi goto Department of Gastroenterology and Hepatology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Center for Liver Diseases Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Department of Diabetes and Endocrinology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan

BACKGROUND Type 2 diabetes mellitus(T2DM)is a risk factor for nonalcoholic fatty liver disease(NAFLD).AIM To determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with *** Four hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography(CT)were *** mean age was 74±13 years,and 269 were *** attenuation minus splenic attenuation(CTL−S)less than 1 Hounsfield unit was considered fatty *** was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection.A multiple logistic regression was used to assess the independent factors associated with *** NAFLD was identified in 25.2%of the *** age(odds ratio[OR]=−0.945;95%confidence interval[CI]:0.922–0.969),higher hemoglobin levels(OR=1.501,95%CI:1.278–1.764),lower high-density lipoprotein(HDL)cholesterol levels(OR=0.971,95%CI:0.953–0.989),and the absence of dialysis(OR=0.109,95%CI:0.014–0.856)were independent predictors of *** NAFLD was detected with CT in 25.2%of the *** was associated with younger age,higher hemoglobin levels,lower HDL cholesterol levels,and an absence of dialysis.

关键词： Age Computed tomography Dialysis Hemoglobin Nonalcoholic fatty liver disease Type 2 diabetes mellitus

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Deep learning-based magnetic resonance imaging reconstruction for improving the image quality of reduced-field-of-view diffusionweighted imaging of the pancreas

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World Journal of Radiology 2023年第12期15卷 338-349页

作者： Yukihisa Takayama Keisuke Sato Shinji Tanaka Ryo Murayama Nahoko goto Kengo Yoshimitsu Department of Radiology Faculty of MedicineFukuoka UniversityFukuoka 8140180Japan

BACKGROUND It has been reported that deep learning-based reconstruction(DLR)can reduce image noise and artifacts,thereby improving the signal-to-noise ratio and image ***,no previous studies have evaluated the efficacy of DLR in improving image quality in reduced-field-of-view(reduced-FOV)diffusionweighted imaging(DWI)[field-of-view optimized and constrained undistorted single-shot(FOCUS)]of the *** hypothesized that a combination of these techniques would improve DWI image quality without prolonging the scan time but would influence the apparent diffusion coefficient *** To evaluate the efficacy of DLR for image quality improvement of FOCUS of the *** This was a retrospective study evaluated 37 patients with pancreatic cystic lesions who underwent magnetic resonance imaging between August 2021 and October *** evaluated three types of FOCUS examinations:FOCUS with DLR(FOCUS-DLR+),FOCUS without DLR(FOCUS-DLR−),and conventional FOCUS(FOCUS-conv).The three types of FOCUS and their apparent diffusion coefficient(ADC)maps were compared qualitatively and *** FOCUS-DLR+(3.62,average score of two radiologists)showed significantly better qualitative scores for image noise than FOCUS-DLR−(2.62)and FOCUS-conv(2.88)(P<0.05).Furthermore,FOCUS-DLR+showed the highest contrast ratio and 600 s/mm^(2)(0.72±0.08 and 0.68±0.08)and FOCUS-DLR−showed the highest CR between cystic lesions and the pancreatic parenchyma for the b-values of 0 and 600 s/mm2(0.62±0.21 and 0.62±0.21)(P<0.05),***-DLR+provided significantly higher ADCs of the pancreas and lesion(1.44±0.24 and 3.00±0.66)compared to FOCUS-DLR−(1.39±0.22 and 2.86±0.61)and significantly lower ADCs compared to FOCUS-conv(1.84±0.45 and 3.32±0.70)(P<0.05),*** This study evaluated the efficacy of DLR for image quality improvement in reduced-FOV DWI of the *** can significantly denoise images without prolonging the scan time or

关键词： Deep learning-based reconstruction Magnetic resonance imaging Reduced field-of-view Diffusion-weighted imaging Pancreas

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Autoimmune pancreatitis complicated by gastric varices:A report of 3 cases

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World Journal of Gastroenterology 2012年第31期18卷 4228-4232页

作者： Norihiro goto Jun Mimura Toshinao Itani Motohito Hayashi Yukari Shimada Tomoaki Matsumori Department of Gastroenterology Nishi-Kobe Medical CenterHyogo 651-2273Japan

We present three cases of autoimmune pancreatitis(AIP) complicated by gastric *** 1:A 57-yearold man was diagnosed with AIP complicated by gastric varices and splenic vein *** was not detected at the time of the *** AIP improved using steroid therapy,the splenic vein was reperfused,and the gastric varices disappeared;case 2:A 55-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and *** the AIP improved using steroid therapy,the gastric varices and splenic vein obstruction did not resolve;case 3:A 68-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and *** gastric varices,splenic vein obstruction,and AIP did not improve using steroid *** three cases suggest that gastric varices or splenic vein obstruction without splenomegaly may be an indication for steroid therapy in patients with AIP because the complications will likely become irreversible over time.

关键词：静脉曲张自身免疫性胰腺炎合并胃脾肿大 AIP 类固醇

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Tetra-EDOT substituted 3D electrochromic polymers with lower band gaps

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Science China Chemistry 2017年第1期60卷 90-98页

作者： Jingjing Shi Imran Murtaza Shan Shao Xiaosi Zhu Yang Zhao Mengmeng Zhu Osamu goto Hong Meng School of Advanced Materials Peking University Shenzhen Graduate School Key Laboratory of Flexible Electronics & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University Department of Physics International Islamic University

A couple of novel electrochromic materials poly(2,3,4,5-tetrakis(2,3-hydrothieno[3,4-b]dixin-5-yl)-1-methyl-1H-pyrrole)(P(t-EDOT-mPy))and poly(5,5',5",5'"-(thiophene-2,3,4,5-tetrayl)tetrakis(2,3-dihydrothieno[3,4-b][1,4]dioxine))(P(t-EDOTTh))are electrodeposited via multi-position polymerization of their tetra-EDOT substituted monomers t-EDOT-mPy and t-EDOT-Th,*** with the linear 2D structured poly(thiophene)(E_g=2.2 eV)and poly(2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)thiophene)(E_g=1.7eV),P(t-EDOT-Th)(E_g=1.62eV)has the lowest band ***,we speculate that the band gaps of the two polymers,having 3D structures,are decreased in contrast to non-substituted polymers or bi-EDOT substituted polymers,thiophene and *** results indicated that P(t-EDOT-Th)thin films are more stable and show higher transmittance amid two polymers,which may find their utilization in organic optoelectronics.

关键词：变色聚合物带隙 3d 电致变色材料 TETRA 二维结构三维结构光电子学

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Preparation of TiO_(2)-rich Ba-Ti-O thick films by laser chemical vapor deposition method

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Journal of Advanced Ceramics 2013年第2期2卷 167-172页

作者： Dongyun GUO Akihiko ITO Takashi goto Rong TU Chuanbin WANG Qiang SHEN Lianmeng ZHANG State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan

TiO_(2)-rich Ba-Ti-O films were prepared on Pt/Ti/SiO_(2)/Si substrate by laser chemical vapor deposition(LCVD).Their phase relationship and microstructure were *** single-phase BaTi_(2)O_(5),Ba_(4)Ti_(13)O_(3)0 and BaTi_(5)O_(11) films were prepared at Ti/Ba molar ratios m_(Ti/Ba)=1.84-1.90,2.83 and 4.49-4.55,*** high deposition rate of TiO_(2)-rich Ba-Ti-O films ranged from 54.0μm/h to 177.6μm/*** permittivity of BaTi_(2)O_(5)film(prepared at m_(Ti/Ba)=1.84 and deposition temperature T_(dep)=877 K),Ba_(4)Ti_(13)O_(3)0 film(prepared at m_(Ti/Ba)=2.83 and T_(dep)=914 K)and BaTi5O11 film(prepared at m_(Ti/Ba)=4.49 and T_(dep)=955 K)were 50,40 and 21,respectively.

关键词： laser chemical vapor deposition(LCVD) TiO_(2)-rich Ba-Ti-O film microstructure deposition temperature dielectric properties

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Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography

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World Journal of Gastroenterology 2012年第12期18卷 1385-1390页

作者： Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of Tokyo Department of Clinical Laboratory The University of Tokyo Hospital Yamanashi Prefectural Hospital Organization

AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were *** stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by *** of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each *** linear regression analysis was used to determine the factors associated with liver ***:A total of 524 patients underwent *** patients were excluded because of unsuccessful *** 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 *** median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old *** stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol

关键词：丙型肝炎评估患者病情慢性血相弹性瞬时

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A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 156-164页

作者： Reiko Hayashi Takako Arauchi Moe Tategu Yuya goto Kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture Kawasaki Kanagawa 214-8571 Japan.

GINS, a heterotetramer of SLD5, PSF1, PSF2, and PSF3 proteins, is an emerging chromatin factor recognized to be involved in the initiation and elongation step of DNA replication. Although the yeast and Xenopus GINS genes are well documented, their orthologous genes in higher eukaryotes are not fully characterized. In this study, we report the genomic structure and transcriptional regulation of mammalian GINS genes. Serum stimulation increased the GINS mRNA levels in human cells. Reporter gene assay using putative GINS promoter sequences revealed that the expression of mammalian GINS is regulated by 17β-Estradiolstimulated estrogen receptor a, and human PSF3 acts as a gene responsive to transcription factor E2F1. The goal of this study is to present the current data so as to encourage further work in the field of GINS gene regulation and functions in mammalian cells.

关键词： DNA replication initiation bioinformatics gene structure gene regulation 17β-Estradiol transcription factor E2F1

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Quantitative evaluation of deep convolutional neural network-based image denoising for low-dose computed tomography

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Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 199-207页

作者： Keisuke Usui Koichi Ogawa Masami goto Yasuaki Sakano Shinsuke Kyougoku Hiroyuki Daida Department of Radiological Technology Faculty of Health ScienceJuntendo UniversityTokyo 113-8421Japan Department of Radiation Oncology Faculty of MedicineJuntendo UniversityTokyo 113-8421Japan Faculty of Science and Engineering Hosei UniversityTokyo 184-8584Japan

To minimize radiation risk,dose reduction is important in the diagnostic and therapeutic applications of computed tomography(CT).However,image noise degrades image quality owing to the reduced X-ray dose and a possible unacceptably reduced diagnostic *** learning approaches with convolutional neural networks(CNNs)have been proposed for natural image denoising;however,these approaches might introduce image blurring or loss of original *** aim of this study was to compare the dose-dependent properties of a CNN-based denoising method for low-dose CT with those of other noise-reduction methods on unique CT noise-simulation *** simulate a low-dose CT image,a Poisson noise distribution was introduced to normal-dose images while convoluting the CT unit-specific modulation transfer *** abdominal CT of 100 images obtained from a public database was adopted,and simulated dose-reduction images were created from the original dose at equal 10-step dose-reduction intervals with a final dose of 1/*** images were denoised using the denoising network structure of CNN(DnCNN)as the general CNN model and for transfer *** evaluate the image quality,image similarities determined by the structural similarity index(SSIM)and peak signal-to-noise ratio(PSNR)were calculated for the denoised *** better denoising,in terms of SSIM and PSNR,was achieved by the DnCNN than by other image denoising methods,especially at the ultra-low-dose levels used to generate the 10%and 5%dose-equivalent ***,the developed CNN model can eliminate noise and maintain image sharpness at these dose levels and improve SSIM by approximately 10%from that of the original *** contrast,under small dose-reduction conditions,this model also led to excessive smoothing of the *** quantitative evaluations,the CNN denoising method improved the low-dose CT and prevented over-smoothing by tailoring the CNN model.

关键词： Deep learning Convolutional neural network Low-dose computed tomography Denoising Image quality

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