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Treatment outcomes and adverse drug reactions among patients with drug-resistant tuberculosis receiving all-oral,long-term regimens:First record viewing report from Pakistan

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 58-64,I0003页

作者： hira aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah Aamir Khan Yusra Habib Khan Tauqeer Hussain Mallhi Provincial Tuberculosis Control Program Punjab Pakistan Cardio-metabolic Division CCL Research Laboratories Lahore PunjabPakistan Common Management Unit National Tuberculosis Control Program of PakistanIslamabadPakistan Department of Pharmacy Practice Shifa College of Pharmaceutical SciencesShifa Tameer-e-Millat UniversityIslamabadPakistan Association for Social Development IslamabadPakistan Department of Clinical Pharmacy College of PharmacyJouf UniversitySakakaAl-Jouf ProvinceSaudi Arabia

Objective:To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant ***:This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of *** receiving treatment for drug resistant tuberculosis from July 2019 to December 2020 with at least interim result i.e.6th month culture conversion or final outcomes(cured,complete,lost to follow-up,failure,death)available,were included in the *** was extracted from electronic data management *** the reporting and management of adverse drug events,active tuberculosis drug safety monitoring and management was implemented across all *** the data was analyzed using SPSS version ***:Out of 947 drug resistant tuberculosis patients included in this study,579(68%)of the patients had final outcomes *** these,384(67.9%)successfully completed their *** of 368(32%)patients who had their interim results available,all had their 6th month culture *** new medications was thought to result in serious adverse outcomes such as QT ***,this study did not record any severe adverse events among ***:All-oral regimens formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with traditional injectable treatment.

关键词： All-oral long-term regimens Long-term regimens Bedaquiline Linezolid Clofazimine Drug resistant tuberculosis Treatment outcomes aDSM

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Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani Sarah aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

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Phytochemical Study of <i>Glycosmis Mauritiana</i>

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American Journal of Plant Sciences 2011年第5期2卷 657-659页

作者： Javed Intekhab Mohammad aslam hira Khalid 不详

Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1- Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteolin-4'-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyra- nosyl-(1→6)}-β-D-glycopyranoside]. The isolated compounds were characterized by UV, IR and N. M. R (1H, 13C) studies.

关键词： Glycosmis Mauritiana Rutaceae Flavanone Glycoside

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Current Status of <i>Withania somnifera</i>(L.) Dunal: An Endangered Medicinal Plant from Himalaya

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American Journal of Plant Sciences 2017年第5期8卷 1159-1169页

作者： Sumaira aslam Naveed Iqbal Raja Mubashir Hussain Muhammad Iqbal Muhammad Ejaz Danish Ashfaq hira Fatima Muhammad Ali Shah Abd-Ur-Rehman Maria Ehsan Department of Botany PMAS Arid Agriculture University Rawalpindi Pakistan Department of Botany University of Sargodha Sargodha Pakistan Department of Biological Sciences University of Lahore Sargodha Pakistan Department of Biotechnology University of Azad Jammu & Kashmir Muzaffarabad Pakistan

Withania somnifera is highly medicinal plant species of Pakistan floristically placed in the Western Himalayan Province, Himalaya Range of Azad Jammu and Kashmir and in the Soon valley (Salt Range) of Punjab Pakistan. It grows in high altitude of 5500 feet in the Himalayas. Its English name is Winter Cherry and its Urdu name is Asghand/Kutilal. It is the low lying shrub of about 1.50 m in height with erect branching. It grows in dry arid regions of Pakistan, India, China and Bangladesh. Its flowers are bisexual, small, axillary, greenish, solitary and few-flowered cymes. Chemical analysis of Ashwagandha showed that it has alkaloids and steroidal lactones (withanolides) as the main chemical constituent. W. somnifera has not yet been assessed for the IUCN Red List. However, in Pakistan, W. somnifera is falling under criteria A of endangered category. Asghand (W. somnifera) acquires much therapeutic potential which include sedative, narcotic, thyroid stimulation, anti-inflammatory, hypnotic, anti-stress, general tonic, diuretic, antimicrobial, and antitumor activities. There are number of threats responsible for the decrease of W. somnifera number in western Himalayan range and salt range of Punjab Pakistan which may include deforestation over exploitation and climatic changes. Conservation strategies need to be adopted for improving the population pool of W. somnifera. There is also the dire need to conserve this important medicinal plant species with some standard biotechnological approaches and conservation strategies in future.

关键词： Withania somnifera Endangered Antimicrobial Antitumor Conservation

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