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Anti-tumor immunity of BAM-SiPc-mediated vascular photodynamic therapy in a BALB/c mouse model

Cellular & Molecular Immunology 2017年第2期14卷 223-234页

作者： hing-yuen yeung Pui-Chi Lo Dennis K.P. Ng Wing-Ping Fong School of Life Sciences The Chinese University of Hong Kong Shatin N.T. Hong Kong China Department of Biomedical Sciences City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China Department of Chemistry The Chinese University of Hong Kong Shatin N.T. Hong Kong China

In recent decades, accumulating evidence from both animal and clinical studies has suggested that a sufficiently activated immune system may strongly augment various types of cancer treatment, including photodynamic therapy （PDT）. Through the generation of reactive oxygen species, PDT eradicates tumors by triggering localized tumor damage and inducing anti-tumor immunity. As the major component of anti-tumor immunity, the involvement of a cell-mediated immune response in PDT has been well investigated in the past decade, whereas the role of humoral immunity has remained relatively unexplored. In the present investigation, using the photosensitizer BAM-SiPc and the CT26 tumor-bearing BALB/c mouse model, it was demonstrated that both cell-mediated and humoral adaptive immune components could be involved in PDT. With a vascular PDT （VPDT） regimen, BAM-SiPc could eradicate the tumors of -70% of tumor-bearing mice and trigger an anti-tumor immune response that could last for more than 1 year. An elevation of Th2 cytokines was detected ex vivoafter VPDT, indicating the potential involvement of a humoral response. An analysis of serum from the VPDT-cured mice also revealed elevated levels of tumor-specific antibodies. Moreover, this serum could effectively hinder tumor growth and protect the mice against further re-challenge in a T-cell-dependent manner. Taken together, these results show that the humoral components induced after BAM-SiPc-VPDT could assist the development of anti-tumor immunity.

关键词： anti-tumor immunity damage-associated molecular patterns humoral immunity photodynamic therapy tumor-bearing mice

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Male Advertisement Call of the Endangered Leptobrachella tengchongensis(Anura: Megophryidae) from Mount Gaoligongshan, Yunnan Province, China

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Asian Herpetological Research 2021年第2期12卷 221-227页

作者： Ho yuen yeung Xiangyuan HUANG Shenpin YANG Jianhuan YANG Kadcxfrie Conservation China Department Kcuioorie Farm and Botanic GardenLam Kam RoadTai PoN.T.Hong KongChina Gaoligongshan National Nature Reserve(Tengchong Bureau) Tengchong 679100YunnanChina

We present the first description of the acoustic characters of the endangered Tengchong leaf litter toad(Leptobrachella tengchongensis), aiming to inform future ecological studies of the species and taxonomic studies in the genus Leptobrachella. A total of 1179 calls, belonging to 6 adults male individuals, were recorded using TASCAM DR-40 digital sound recorder from its type locality in May 2015 and then analyzed using Raven Pro v.1.6.1 software. The advertisement call of male L. tengchongensis consists of primary advertisement call and secondary advertisement call. The primary advertisement call is invariably composed of two notes and has a call duration of 61 ± 5 ms(23–87 ms, n = 1142). The secondary advertisement call is composed of 3–10 notes(mean 5.25 ± 1.41 notes/call, n = 37) with a call duration of 90 ± 6 ms(37–127 ms, n = 37). The mean inter-call interval is 212 ± 121 ms(88–1121 ms, n = 1092). An introductory note is absent in advertisement calls and the dominant of calls is 4.1–4.8 kHz(at 20 ℃). We discuss the interspecific and intraspecific variations on advertisement calls in L. tengchongensis and among Leptobrachella species, and provide a summary on the major acoustic characters of all Leptobrachella species occurring north of the Isthmus of Kra.

关键词： acoustic analysis amphibians bioacoustics breeding ecology Leptolalax taxonomy Tengchong

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Viscosity behavior of magnetic suspensions in fluid-assisted finishing

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Progress in Natural Science:Materials International 2008年第1期18卷 91-96页

作者： Yam yeung China Department of Mechanical and Automation Engineering The Chinese University of Hong Kong New Territories Shatin

Magnetic fluid-assisted finishing has been verified both theoretically and experimentally as an effective fabrication technology for opti- cal mirrors and *** purpose of this paper is to introduce a novel design of polishing tool and demonstrate the possible applica- tions of this *** work includes studying the viscosity of the magnetic suspensions of micrometer-sized Carbonyl iron particles under the influence of a magnetic *** the cases of magnetizable suspension with and without abrasive cerium oxide par- ticles are studied for their ensuing polishing *** of material removal function is conducted using a Wyko Nat1100 *** to reduce surface roughness with the proposed tool are also performed using a K9 mirror as the *** show that the surface accuracy is improved over three times to less than 0.5 nm after two cycles of polishing.

关键词： Surface roughness Micro-structure Super-smooth Fluid-assisted finishing Material removal rate

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Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam Xinjie Meng Zheng Peng Man Lung yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta

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Aquaporins in spermatozoa and testicular germ cells： identification and potential role

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Asian Journal of Andrology 2010年第4期12卷 490-499页

作者： Ching-Hei yeung Centre of Reproductive Medicine and Andrology University Clinic Muenster D48149 Germany

Mammalian spermatozoa have relatively high water permeability and swell readily, as in the hypo-osmotic swelling test used in the andrology clinic. Physiologically, spermatozoa experience changes in the osmolality of the surrounding fluids in both the male and the female tracts on their journey from the testis to the ovum. Sperm volume regulation in response to such osmotic challenges is important to maintain a stable cell size for the normal shape and function of the sperm tail. Alongside ion channels for the fluxes of osmolytes, water channels would be crucial for sperm volume regulation. In contrast to the deep knowledge and numerous studies on somatic cell aquaporins （AQPs）, the understanding of sperm AQPs is limited. Among the 13 AQPs, convincing evidence for their presence in spermatozoa has been confined to AQP7, AQP8 and AQP 11. Overall, current findings indicate a major role of AQP8 in water influx and efltux for sperm volume regulation, which is required for natural fertilization. The preliminary data suggestive of a role for AQP7 in sperm glycerol metabolism needs further substantiation. The association of AQP 11 with the residual cytoplasm of elongated spermatids and the distal tail of spermatozoa supports the hypothesis of more than just a role in conferring water permeability and also in the turnover and recycling of surplus cellular components made redundant during spermiogenesis and spermiation. This would be crucial for the maintenance of a germinal epithelium functioning efficiently in the production of spermatozoa.

关键词： fertility sperm volume regulation spermatid residual cytoplasm spermiogenesis water channels

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Foliations associated to harmonic maps on some complex two ball quotients

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Science China Mathematics 2017年第6期60卷 1137-1148页

作者： yeung Sai-Kee Department of Mathematics Purdue University West Lafayette IN 47907 USA

This article is an attempt to understand harmonic and holomorphic maps between two bounded symmetric domains in special situations. We study foliations associated to a lattice-equivariant harmonic map of small rank from a complex ball to another. The result is related to rigidity of some complex two ball *** open questions are raised as well.

关键词： harmonic maps foliations rigidity

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Radiometric normalization of overlapping LiDAR intensity data for reduction of striping noise

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International Journal of Digital Earth 2016年第7期9卷 649-661页

作者： Wai yeung Ahmed Shaker Department of Civil Engineering Ryerson UniversityTorontoOntarioCanada

Airborne LiDAR data are usually collected with partially overlapping strips in order to serve a seamless and fine resolution mapping *** of the factors limiting the use of intensity data is the presence of striping noise found in the overlapping *** recent researches have proposed physical and empirical approaches for intensity data correction,the effect of striping noise has not yet been *** paper presents a radiometric normalization technique to normalize the intensity data from one data strip to another one with partial *** normalization technique is built based on a second-order polynomial function fitted on the joint histogram plot,which is generated with a set of pairwise closest data points identified within the overlapping *** proposed method was tested with two individual LiDAR datasets collected by Teledyne Optech’s Gemini(1064 nm)and Orion(1550 nm)*** experimental results showed that radiometric correction and normalization can significantly reduce the striping noise found in the overlapping LiDAR intensity data and improve its capability in land cover *** coefficient of variation of five selected land cover features was reduced by 19–65%,where a 9–18%accuracy improvement was achieved in different classification *** the proven capability of the proposed method,both radiometric correction and normalization should be applied as a pre-processing step before performing any surface classification and object recognition.

关键词： LiDAR intensity striping noise radiometric correction radiometric normalization joint histogram land cover classification

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Segment routing for traffic engineering and effective recovery in low-earth orbit satellite constellations

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Digital Communications and Networks 2024年第3期10卷 706-715页

作者： Shengyu Zhang Xiaoqian Li Kwan Lawrence yeung Department of Electrical and Electronic Engineering The University of Hong KongHKSARChina National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengduSichuan611731China

Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote *** inter-satellite links are not supported in initial deployment(*** Starlink),the communication between satellites is based on ground stations with radio frequency *** to the rapid movement of satellites,this hybrid topology of LEO-SCs and ground stations is time-varying,which imposes a major challenge to uninterrupted service provisioning and network *** this paper,we focus on solving two notable problems in such a ground station-assisted LEO-SC topology,i.e.,traffic engineering and fast reroute,to guarantee that the packets are forwarded in a balanced and uninterrupted ***,we employ segment routing to support the arbitrary path routing in *** solve the traffic engineering problem,we proposed two source routings with traffic splitting algorithms,Delay-Bounded Traffic Splitting(DBTS)and DBTS+,where DBTS equally splits a flow and DBTS+favors shorter ***-lation results show that DBTS+can achieve about 30%lower maximum satellite load at the cost of about 10%more *** guarantee the fast recovery of failures,two fast reroute mechanisms,Loop-Free Alternate(LFA)and LFA+,are studied,where LFA pre-computes an alternate next-hop as a backup while LFA+finds a 2-segment backup *** show that LFA+can increase the percentage of protection coverage by about 15%.

关键词： Fast reroute Low-earth orbit satellite constellation Segment routing Traffic engineering Traffic splitting

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SHAPE MEMORY EFFECT OF PU IONOMERS WITH IONIC GROUPS ON HARD-SEGMENTS

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Chinese Journal of Polymer Science 2006年第2期24卷 173-186页

作者：胡金莲 Kwok-wing yeung Institute of Textiles and Clothing Hong Kong Polytechnic University Hung HomHong KongChina

SMPU （shape memory polyurethane） non-ionomers and ionomers, synthesized with poly（c-caprolactone）（PCL）, 4, 4＇-diphenylmethane diisocyanate （MDI）, 1,4-butanediol （BDO）, dimethylolpropionic acid （DMPA） were measured with cyclic tensile test and strain recovery test. The relations between the structure and shape memory effect of these two series were studied with respect to the ionic group content and the effect of neutralization. The resulting data indicate that, with the introduction of asymmetrical extender, the stress at 100% elongation is decreased for PU non-ionomer and ionomer series, especially lowered sharply for non-ionomer series; the fixation ratio of ionomer series is not affected obviously by the ionic group content; the total recovery ratio of ionomer series is decreased greatly. After sufficient relaxation time for samples stretched beforehand, the switching temperature is raised slightly, whereas the recovery ratio measured with strain recovery test method is lowered with increased DMPA content. The characterization with FT-IR, DSC, DMA elucidated that, the ordered hard domain of the two series is disrupted with the introduction of DMPA which causes more hard segments to dissolve in soft phase; ionic groups on hard segment enhance the cohesion between hard segments especially at high ionic group content and significantly facilitate the phase separation compared with the corresponding non-ionomer at moderate ionic group content.

关键词： Polyurethane Ionomers Cyclic thermo-mechanical investigations Shape memory effect Cyclic tensile test Strain recovery test.

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Exotic structures arising from fake projective planes

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Science China Mathematics 2013年第1期56卷 43-54页

作者： yeung Sai-Kee Department of Mathematics Purdue University

We present examples of exotic structures on pPC2#qPC2 for some small p and q obtained naturally from quotients of fake projective planes in complex geometry,which are classified by the work of Prasad-yeung and Cartwri... 详细信息

关键词： exotic four-folds fake projective planes

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