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Rare tumor of the ovary: Primitive choriocarcinoma

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 448-450页

作者： Sanaa Errarhay Najia Hmidani Samia Mahmoud hind el fatemi Hanane Saadi Omar el Mesbahi Nadia Squalli Chahrazed Bouchikhi Amarti Afaf Abdelaziz Banani Department of Gynecology and Obstetrics University Hospital of Fez Fez Morocco Department of Oncology University Hospital of Fez Fez Morocco Department of Pathology University Hospital of Fez Fez Morocco Department of Radiology University Hospital of Fez Fez Morocco

We report the case of a patient of 30 years with primary choriocarcinoma of the ovary. This patient referred for abdomino-pelvic mass suspected clinically and sonographically. Exploratory laparotomy was performed with the presence of two latero-uterine mass adherents to the highly vascularised uterus and difficult to resects deep plane with a mass left hepatic bleeding. A biopsy of both masses was performed and histological examination with immunehistochemical study returned for a primary ovarian non-gestational choriocarcinoma and the patient received 4 cycles of chemotherapy after hepatic artery embolization with good clinical, biological and radiological evaluation.

关键词： Germinal Ovarian Tumour Ovarian Choriocarcinoma Chemotherapy

Juvenile Xanthogranuloma: A Case Report with Literature Review

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Open Journal of Pediatrics 2024年第3期14卷 531-535页

作者： Ayad Ghanam Manal Azizi hind Zahiri Aziza el Ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Juvenile xanthogranuloma (XGJ) is the most common form of non-Langerhansian histiocytosis. We report a pediatric case of multiple XGJ without visceral involvement in a 6-month-old female infant who was hospitalized with disseminated congenital skin nodules, of firm consistency, of variable diameter ranging from a few millimetres to 1 cm, involving the face, scalp, trunk and limbs. There was no mucosal localization. The remainder of the somatic examination was unremarkable. The diagnosis of disseminated XGJ was confirmed by skin biopsy without visceral or systemic involvement. Therapeutic abstention was recommended. This observation underlines the fact that XGJ is a rare clinical entity that should not be overlooked when faced with congenital skin nodules.

关键词： Cutaneous Nodules Juvenile Xanthogranuloma Child

Sacrococcygeal Teratoma a Rare Tumor in Children: Case Report

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Open Journal of Pediatrics 2024年第1期14卷 78-83页

作者： Hanae Bahari Hanane Hajaj hind Zahiri Ayyad Ghanam Aziza el Ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Medical School University Mohammed First Oujda Morocco

Sacrococcygeal teratomas (SCTs) are uncommon congenital tumors that typically develop in newborns, they are rarely associated with chromosomal abnormalities or other congenital anomalies. The majority of pediatric teratomas are benign in the neonatal age group, but the risk of malignancy increases with age. Diagnosis is based on a combination of clinical, radiological, and hormonal findings, but confirmed by anatomopathological study. Treatment is primarily surgical, with the aim of achieving complete resection to prevent recurrence. We present the case of a 22-month-old child who was admitted for management of a sacrococcygeal mass and was diagnosed with an immature teratoma.

关键词： Sacrococcygeal Mass Alpha-Fetoprotein Surgery

Ecthyma Gangrenosum in Patient with Bone Marrow Aplasia: A Case Report and Review of the Literature

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Open Journal of Pediatrics 2024年第2期14卷 272-278页

作者： Hanane Hajaj Hanae Bahari hind Zahiri Ayyad Ghanam Aziza el Ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Mohammed VI University Hospital Medical School Mohammed First University Oujda Morocco

Background: Ecthyma gangrenosum (EG) is an infrequent and discernible cutaneous disease caused by Pseudomonas aeruginosa. In situations where it is associated with septicemia in debilitated patients, the prognosis is usually unfavorable. Objective: In this case, we aim to verify risk factors, clinical, bacteriological and therapeutic characteristics of ecthyma gangrenosum and we review the literature to highlight the features of this rare condition and discuss the role of early diagnosis and treatment. Case Report: We describe the clinical case of a 4-year-old male with bone marrow aplasia who was presented with characteristic skin lesions of EG and developed sepsis later. Conclusion: EG is a cutaneous disease characterized by its aggressive nature. The presence of delayed diagnosis and therapy, along with sepsis, is closely linked to a high mortality rate. Treatment is empirically founded on an aggressive initial approach.

关键词： Ecthyma Gangrenosum Child Bone Marrow Aplasia

Rhabdomyosarcoma in Children: About 10 Cases

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Open Journal of Pediatrics 2024年第3期14卷 522-530页

作者： Ayad Ghanam Manal Azizi hind Zahiri Houssain Benhaddou Imane Kamaoui Amal Bennani Aziza el Ouali Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Pediatric Surgery Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Radiology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Anatomopathology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Introduction: Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumor arising from striated muscle cells. It accounts for 60% - 70% of malignant mesenchymal tumors and 5% of pediatric cancers. Two-thirds of these cancers are diagnosed in children under 6 years of age, with a slight male predominance. Materials and Methods: This is a retrospective descriptive study of 10 cases of RMS collected in the pediatric hematology and oncology department of the Oujda university hospital, over a 5-year period, running from January 2018 to December 2022. Results: The median age at diagnosis was 3 years, with a sex ratio of 1. The mean time to diagnosis was 2 months. The most common site was the head and neck (50%), followed by the genitourinary tract (20%), the extremities (20%) and finally the abdomen (10%). The most frequent mode of discovery was a mass or swelling found in 90% of patients (all sites included), followed by exophthalmos in 30% of cases. At the diagnostic stage, CT scans were performed in 70% of cases and MRI in 5 patients (50%). Histological diagnosis was determined by immunohistochemical pathology in all our patients, with a predominance of embryonal (70%) versus alveolar (20%) and spindle cell types (10%). All patients underwent an extension workup, and a cervico-thoraco-abdominopelvic CT was performed in all patients (100%);MRI was performed in 2 patients (20%);lymph node involvement was present in 5 patients (50%). Metastases at the time of diagnosis were noted in only 1 patient (10%), who simultaneously presented with two metastatic sites;testicular and abdominal wall. Sixty percent of patients presented with advanced disease (high risk) and 40% with standard risk. Chemotherapy was used in all patients (100%), with upfront tumor resection performed in 40%. Fifty percent of patients received radiotherapy at a mean dose of 43 Gy, with the orbit the most frequently irradiated area (30%). All patients underwent CTscan and/or MRI and/or ultrasound surveillance.

关键词： Rhabdomyosarcoma Child Chemotherapy Surgery Radiotherapy

Technical crystallization for application in pharmaceutical material engineering:Review article

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Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 283-291页

作者： Abdul Khaliq el-Zhry el-Yafi hind el-Zein Department of Pharmaceutical Technology Faculty of PharmacyDamascus UniversityDamascusSyria

In recent years,engineering the total morphology of pharmaceutical materials particles to desirable shape,size and surface area has long been actively increased because it has many advantages especially for improving physicochemical properties of Active Pharmaceutical Ingredients(APIs).This article therefore considers the potential utility of crystal engineering as a tool for controlling and designing properties of pharmaceutical solid particles in purpose to developing efficacious performance of solid dosage form,fundamentals of crystallization process,*** addition,understanding the relationship between molecular recognition,thermodynamic,and kinetics which controls the crystallization process so that it benefits in designing successful experiments to have desirable crystal habit for materials.

关键词： Crystallization Nucleation Crystal growth dispersion Thermodynamic

Management of Cerebral Metastases—About 25 Cases

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Open Journal of Modern Neurosurgery 2022年第3期12卷 160-166页

作者： Mustapha Hemama Salma Mrichi Nizare el fatemi Moulay Rachid el Maaqili Department of Neurosurgery Ibn Sina University Hospital Rabat Morocco

Approximately, 20% of all cancer patients will end up having brain metastases. This is especially the case of patients in which the primary tumor is lung cancer, breast and colorectal cancers, melanoma, or renal cell carcinoma. Development of brain metastases contributes substantially to overall cancer mortality in patients with advanced-stage cancer given the associated poor prognosis despite multimodal treatments and advances in systemic therapies. The objective of this retrospective single center study is to describe the experience of the Department of Neurosurgery of the Ibn Sina University Hospital in Rabat in the management of patients with brain metastases, highlighting the therapeutic choices as well as the various challenges encountered during treatment.

关键词： Brain Metastases Therapeutic Management

Laminated Epoxy Biocomposites Based on Clay and Jute Fibers

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Journal of Bionic Engineering 2017年第2期14卷 379-389页

作者： hind Abdellaoui Hala Bensalah Marya Raji Denis Rodrigue Rachid Bouhfid Abou el kacem Qaiss Moroccan Foundation for Advanced Science Innovation and Research (MASclR) Institute of Nanomaterials and Nanotechnology (NANOTECIt) Laboratory of Polymer Processing Rabat Morocco Faculty of Science Laboratory of Simulation in Mechanics and Energy Mohammed V University Rabat Morocco Faculty of Science Laboratory Laboratoire de Chimieorganique et Heterocyclique Mohammed V University Rabat Morocco Department of chemical engineering and CERMA Universite Laval Quebec G1V0A6 Canada

Jute/epoxy hybrid laminated biocomposites were manufactured by using Illite clay particles at various content （5 wt.% - 20 wt.%）. The effects of hybridization on the morphology, structure, and mechanical properties were investigated. The properties of the biocomposites reinforced with jute fibers were mainly influenced by the interfacial adhesion between the jute fibers and the epoxy matrix. An alkali treatment was applied to improve the interfacial fiber-matrix adhesion and thus obtaining better mechanical properties. Besides the chemical treatment, epoxy hybridization using clay particles also had a strong effect on the overall properties of laminated biocomposites. The mechanical properties of the jute/epoxy biocomposites reinforced with Illite clay increased with clay content, up to an optimum value at 15 wt.%. The average technique and the laminates theory were performed to validate the coherence of the elastic moduli between the calculated and experimental values. A difference between the experimental and predicted data was observed, which was attributed to the simplifying assumptions made in both models. The laminates theory gave better overall predictions.

关键词： laminated biocomposites hybridization mechanical properties interracial adhesion surface treatment

Metastases Extracranial Mimicking Meningioma: A Case Report

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Open Journal of Modern Neurosurgery 2023年第4期13卷 175-182页

作者： Dimbi José Makoso Touati Lina Mouné Michel Yolande Djimrabeye Alngar Moussa elmi Saad Nizaire el fatemi Rachid el Maaqili Department of Neurosurgery Center Hospital University of IBN SINA Rabat Morocco Faculty of Medicine University of Mohamed V Rabat Morocco

Background: Skull vault lesions are rare and represent 1% - 2% of all bone masses. Most cerebral metastases are the intra axial tumors, whereas extra-axial masses mimicking meningioma are extremely rare. Case presentation: A 35-year-old woman with a history of mastectomy left breast cancer 5 years below radiotherapy was referred to the neurosurgery department with a parietal extra-axial mass parietal evolving for one year. CT scan with Magnetic resonance imaging revealed an extra-axial tumor with lysis bone. A craniotomy was performed to remove the mass that was located extra-axial. Histopathological examination revealed metastasis. Conclusions: Lesion skull vaults are rare but they should be considered in the differential diagnosis of intraosseous meningioma lesions. In this report, we discuss the clinical aspects of cases we observed, in which the metastasis bone was found thanks to the histological examination of a calvarial mass after surgery.

关键词： Metastases Calvarial Meningioma Exerese