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Constructing Genetic Linkage Maps Using the Whole Genome Sequence of Pacific Bluefin Tuna (Thunnus orientalis) and a Comparison of Chromosome Structure among Teleost Species

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Advances in Bioscience and Biotechnology 2016年第2期7卷 85-122页

作者： Tsubasa Uchino Yoji Nakamura Masashi Sekino Wataru Kai Atushi Fujiwara Motoshige Yasuike Takuma Sugaya himeko fukuda Motohiko Sano Takashi Sakamoto Faculty of Marine Science Tokyo University of Marine Science and Technology Tokyo Japan Research Center for Aquatic Genomics National Research Institute of Fisheries Science Fisheries Research Agency Yokohama Japan Research Center for Marine Invertebrate Animals National Research Institute of Fisheries and Environment of Inland Sea Fisheries Research Agency Hiroshima Japan

Pacific bluefin tuna (Thunnus orientalis) is one of the most economically important species in the Percomorpha group of teleost fishes. Their migrations are extensive and depend upon continuous swimming at a high rate of speed throughout their life. The draft genome sequence of this species has been reported but remains highly fragmented. We constructed a Pacific bluefin tuna genetic linkage map using microsatellite markers developed on each of the scaffolds from the draft genome sequence to link these genome fragments and understand the genomic structure of species in Percomorpha. Of the 606 polymerase chain reaction microsatellite primer pairs tested, 473 were polymorphic in the mapping populations for the linkage analysis. We constructed sex-specific maps for 24 linkage groups consisting of 470 markers, which allowed us to place scaffolds that cumulatively represented 20.8% (153.8 Mb) of the sequenced genome onto the linkage groups. The distribution of orthologous genes on the chromosomes of tuna and four other teleost fish species suggested that the constitution of tuna chromosomes is closest to that of medaka. Both species have the 24 chromosomes of the ancestral teleost, including several chromosomal inversions. The integrated map developed in this study will be useful to construct a complete physical map to conduct comparative teleost genomics and genetic studies on economically useful traits in Pacific bluefin tuna.

关键词： Pacific Bluefin Tuna Microsatellite Marker Genetic Linkage Map

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Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： Kenji Matsuda Kazuhiro Shimazu Hanae Shinozaki Koji fukuda Taichi Yoshida Daiki Taguchi Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced *** is necessary not only to simply extend survival time,but also to maintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival

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Vertical impedance functions of pile groups under low-to-high loading amplitudes:numerical simulations and experimental validation

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 647-666页

作者： Usama Zafar Chandra Shekhar Goit Masato Saitoh Riku fukuda School of Science and Engineering Saitama University255 Shimo-OkuboSaitamaJapan

Piles in a group experience additional displacements in soil due to pile-to-pile interactions apart from those resulting from the external *** effect of these interactions determined assuming soil as an elastic and/or viscoelastic material on pile head impedance functions of the pile group is studied by relating the group stiffness to the static stiffness of a single ***,the prevailing elastic solutions may misestimate the resulting pile group response due to the lack of consideration for either soil(material)and/or soil-pile interface *** is well established that soil behaves nonlinearly under moderate-to-high loading amplitudes,and besides,the soil-pile interface nonlinearity can exist even at small loading *** study addresses the effects of these nonlinearities on the vertical impedance functions of a 3×3-pile group using numerical methods by direct analyses and superposition using pile-to-pile interaction *** numerical results are validated using scaled model tests under 1 g *** results highlight the overestimation of pile-to-pile interactions in the pile group when assuming elastic soil *** cases either by direct analyses or superposition approach involving soil and soil-pile interface nonlinearities agree well with the experimental pile group responses under close-to-elastic and nonlinear conditions.

关键词： impedance functions numerical simulations model-scale experiment superposition approach soil-pile interface nonlinearity

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Recent progress in solution-processed flexible organic photovoltaics

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npj Flexible Electronics 2022年第1期6卷 871-884页

作者： Lulu Sun Kenjiro fukuda Takao Someya Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Center for Emergent Matter Science(CEMS) RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Electrical Engineering and Information Systems School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The certified power conversion efficiency(PCE)of organic photovoltaics(OPV)fabricated in laboratories has improved dramatically to over 19%owing to the rapid development of narrow-bandgap small-molecule acceptors and wide bandgap polymer donor *** next pivotal question is how to translate small-area laboratory devices into large-scale commercial *** requires the OPV to be solution-processed and flexible to satisfy the requirements of high-throughput and large-scale production such as roll-to-roll *** review summarizes and analyzes recent progress in solution-processed flexible *** a detailed discussion from the perspective of the behavior of the narrow bandgap small-molecule acceptor and wide bandgap polymer donor active layer in solution-processed flexible devices,the existing challenges and future directions are discussed.

关键词： donor narrow translate

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Editorial for the Special Issue on Unmanned Intelligent Cluster

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Engineering 2022年第5期8卷 1-2页

作者： Jun Zhang Toshio fukuda Defu Lin Florian Holzapfel School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Flight System Dynamics Technical University of MunichGarching 85748Germany

Recent advances in networked cooperative autonomous sys-tems offer the potential to significantly improve system quality for a wide range of *** in embedded processor,sensor,communication,and networking technology in the last few decades has accelerated interest in networked cooperative autonomous systems,multirobot systems,and distributed sensor networks for applications such as manufacturing,logistics,pro-cess monitoring,enhanced situational awareness,plant safety,inspection,security,and rescue operations.

关键词： robot networks autonomous

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Acute and delayed psychiatric sequelae among patients hospitalised with COVID-19:a cohort study using LIFE study data

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General Psychiatry 2022年第3期35卷 173-182页

作者： Fumiko Murata Megumi Maeda Chieko Ishiguro Haruhisa fukuda Department of Health Care Administration and Management Kyushu University Graduate School of Medical SciencesFukuokaJapan National Center for Global Health and Medicine ShinjukukuTokyoJapan

Background Characterising the psychiatric sequelae of coronavirus disease 2019(COVID-19)can inform the development of long-term treatment ***,few studies have examined these sequelae at different time points after COVID-19 *** The study aimed to investigate the incidences and risks of acute and delayed psychiatric sequelae in patients hospitalised with COVID-19 in *** This retrospective cohort study was conducted using a database comprising healthcare claims data from public health insurance enrollees residing in a Japanese *** analysed a primary cohort comprising patients hospitalised with COVID-19 between March 2020 and July 2021 and two control cohorts comprising patients hospitalised with influenza or other respiratory tract infections(RTI)during the same *** calculated the incidences of acute(1–3 months after infection)and delayed(4–6 months after infection)psychiatric *** sequelae were identified using diagnosis codes and categorised as mood/anxiety/psychotic disorder,mood disorder,anxiety disorder,psychotic disorder or *** logistic regression models were used to estimate the odds ratios(ORs)of psychiatric sequelae occurrence after COVID-19 infection compared with influenza and other *** The study population with acute psychiatric sequela consisted of 662 patients with COVID-19,644 patients with influenza,and 7369 patients with RTI who could be followed for 3 months;the study population with delayed psychiatric sequelae consisted of 371 patients with COVID-19,546 patients with influenza,and 5397 patients with RTI who could be followed for 6 *** the analysis of acute psychiatric sequelae,COVID-19 had significantly higher odds of mood/anxiety/psychotic disorder(OR:1.39,p=0.026),psychotic disorder(OR:2.13,p<0.001),and insomnia(OR:2.59,p<0.001)than influenza,and significantly higher odds of insomnia(OR:1.44,p=0.002)and significantly lower odds of anxiety disorder(OR:0.56,p<0.

关键词： patients psychiatric sequelae

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Learning Rat-Like Behavior for a Small-Scale Biomimetic Robot

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Engineering 2022年第10期17卷 232-243页

作者： Zihang Gao Guanglu Jia Hongzhao Xie Qiang Huang Toshio fukuda Qing Shi Key Laboratory of Biomimetic Robots and Systems(Beijing Institute of Technology) Ministry of EducationBeijing 100081China Intelligent Robotics Institute School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of TechnologyBeijing 100081China

Existing biomimetic robots can perform some basic rat-like movement primitives(MPs)and simple behavior with stiff combinations of these *** mimic typical rat behavior with high similarity,we propose parameterizing the behavior using a probabilistic model and movement ***,an analysis of fifteen 10 min video sequences revealed that an actual rat has six typical behaviors in the open field,and each kind of behavior contains different bio-inspired combinations of eight *** used the softmax classifier to obtain the behavior-movement hierarchical probability ***,we specified the MPs using movement parameters that are static and *** obtained the predominant values of the static and dynamic movement parameters using hierarchical clustering and fuzzy C-means clustering,*** predominant parameters were used for fitting the rat spinal joint trajectory using a second-order Fourier series,and the joint trajectory was generalized using a back propagation neural network with two hidden ***,the hierarchical probability model and the generalized joint trajectory were mapped to the robot as control policy and commands,*** implemented the six typical behaviors on the robot,and the results show high similarity when compared with the behaviors of actual rats.

关键词： Biomimetic Bio-inspired robot Neural network learning system Behavior generation

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Law Education in Japan and China:Comparative Analysis Focusing on Law-Related Materials

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ECNU Review of Education 2023年第2期6卷 261-279页

作者： Masanobu Umeno Yoshihiko fukuda Naho Inoue Gakushuin University Hyogo University of Teacher Education Naruto University of Education

Purpose:This study examines law-related education in Japan and China to reveal the current state of research and identify the roles,possibilities,and challenges facing such teaching at the elementary,junior high,and senior high school *** study conducts a comparative review of research on perspectives toward law education in both countries,as well as the characteristics of and issues facing law education in ***/Approach/Methods:This study examines trends in research and educational reform related to law education in *** doing so,it evaluates how the characteristics of and issues facing law education in Japan are related to law education in ***:Results show no evidence of a systematic study of law in *** subjects to engage in collaborative learning is a more realistic strategy than attempting to design wholly new ***,exploring what kind of learning activities are linked to law-abiding education in China offers insights and references for *** these strategies to the Japanese context and law material can help create a more systematic form of ***/Value:Through joint research by researchers and educators from East Asian countries,we intend to conduct further research on the development of curricula,textbooks,and class models suited to specific *** the joint research learning approach discussed in this study in Japan and China may result in further learning possibilities.

关键词： Curriculum East Asia law-related education normative awareness social studies

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Nano-bubble hydrogen water:An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

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Virologica Sinica 2022年第2期37卷 277-283页

作者： Chen Li Yiran Cao fukuda Kohei Haihong Hao Guiqing Peng Can Cheng Jing Ye State Key Laboratory of Agricultural Microbiology College of FisheriesHuazhong Agricultural UniversityWuhan430070China Wuhan Britain-China School Wuhan430070China Shenzhen Nano Buddy Technology Co. Ltd.Shenzhen518000China MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan430070China State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China

Since the anti-inflammatory effect of hydrogen has been widely known,it was supposed that hydrogen could suppress tissue damage by inhibiting virus-related inflammatory ***,hydrogen is slightly soluble in water,which leads to poor effect of oral hydrogen-rich water *** this study,the nano-bubble hydrogen water(nano-HW)(about 0.7 ppm)was prepared and its therapeutic effect against viral infection was investigated by utilizing spring viraemia of carp virus(SVCV)-infected zebrafish as ***-month-old zebrafish were divided into nano-HW treatment-treated group and aquaculture water treated group(control group).The results revealed that the cumulative mortality rate of SVCV-infected zebrafish was reduced by 40%after treatment with nano-bubble hydrogen water,and q RT-PCR results showed that SVCV replication was significantly *** examination staining showed that SVCV infection caused tissue damage was greatly alleviated after treatment with nano-bubble hydrogen ***,SVCV infection caused reactive oxygen species(ROS)accumulation was significantly reduced upon nano-HW *** level of proinflammatory cytokines IL-1β,IL-8,and TNF-αwas remarkably reduced in the nano-HW-treated group in vivo and in *** together,our data demonstrated for the first time that nano-HW could inhibit the inflammatory response caused by viral infection in zebrafish,which suggests that nano-HW can be applied to antiviral research,and provides a novel therapeutic strategy for virus-caused inflammation related disease.

关键词： Nano-bubble hydrogen water(nano-HW) Spring viraemia of carp virus(SVCV) Zebrafish Inflammation

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Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

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World Journal of Gastroenterology 2022年第25期28卷 2843-2853页

作者： Shintaro Akiyama Soma fukuda Joshua M Steinberg Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Patients with inflammatory bowel disease(IBD)are more likely to have concurrent immune-mediated inflammatory diseases(IMIDs)than those without *** have been observed to alter the phenotype and outcomes of IBD in recent *** studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes,and are considered to be at increased risk of requiring biologics and IBD-related surgeries,suggesting that having multiple IMIDs is a poor prognostic factor for ***,IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes,suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory *** this review,we discuss the pathogenesis,disease phenotypes,and clinical outcomes in IBD patients with concomitant IMIDs.

关键词： Inflammatory bowel disease Phenotypes Outcomes Concurrent immunemediated inflammatory diseases

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