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Biotransformation,multifunctional recycling mechanism of nanostructures,and evaluation of the safety of nanoscale materials

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Particuology 2023年第11期82卷 76-86页

作者： Debjyoti Talukdar Parveen Kumar Benu Chaudhary Deepak Sharma Nishant Yadav Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Sami IAlzarea Imran Kazmi Ashutosh Pareek Gaurav gupta Madan Mohan gupta Department of Medical Research Armenian Russian International University“Mkhitar Gosh”YerevanArmenia Shri Ram College of Pharmacy KarnalHaryanaIndia Guru Gobind Singh College of Pharmacy YamunanagarHaryanaIndia Department of Pharmaceutical Technology SOMSAdamas UniversityBarasat-Barracpore RoadKolkataWest BengalIndia B.S.Anangpuria Institute of Pharmacy FaridabadHaryanaIndia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia Department of Pharmacology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakaAl-JoufSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Banasthali VidyapithBanasthali-RajasthanIndia School of Pharmacy Suresh Gyan Vihar UniversityJagatpura302017Mahal RoadJaipurIndia Department of Pharmacology Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal UniversityDehradunIndia School of Pharmacy Faculty of Medical SciencesThe University of the West IndiesSt.AugustineTrinidad and Tobago

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

关键词： Nanostructure Nanoparticle Biotransformation Toxiceffect Environmental risk

Physical Characterization of Ionic Liquid-Modified Polyvinyl Alcohol and Sodium Thiocyanate Polymer Electrolytes for Electrochemical Double-Layer Capacitor Application

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Journal of Shanghai Jiaotong university(Science) 2023年第2期28卷 161-171页

作者： AZEMTSOP Manfo Theodore MEHRA Ram Mohan KUMAR Yogesh gupta Meenal Material Research Laboratory Department of PhysicsSBSRSharda UniversityGreater Noida 201310India Department of Electronics and Communication Engineering Sharda UniversityGreater Noida 201310India Department of Physics Atma Ram Sanatan Dharma CollegeUniversity of DelhiNew Delhi 110021India

Novel gel polymer electrolytes(GPEs)composed of polyvinyl alcohol(PVA)and sodium thiocyanate were developed via a solution casting *** ionic liquid(IL),1-ethyl-3-methyl-imidazolium tricyanomethanide([EMIM][TCM]),was doped into a polymer–salt complex system(PVA+NaSCN)to further enhance the ***-doped polymer electrolyte(ILDPE)films were characterized using X-ray diffraction(XRD),polarized optical microscopy(POM),Fourier-transform infrared(FTIR)spectroscopy,and conductivity *** was performed to check the degree of crystallinity and amorphicity of the ILDPE films,and the amorphicity of GPEs increased with the increase of the IL *** was employed to evaluate the changes in the surface morphology due to the inclusion of salt and IL in the *** compositional nature of the GPE films was examined via FTIR *** electrical and electrochemical properties were characterized by cyclic voltammetry and electrochemical impedance *** maximum conductivity for the GPE film was estimated to be 1.10×10^(-5) S/cm for 6%(mass fraction)of IL in the polymer–salt *** ionic transference number was approximately *** electrochemical double-layer capacitor(EDLC)was built from optimized GPE films and reduced graphene oxide-based *** specific capacitance calculated from the cyclic voltammograms of the EDLC cells was 3 F/g.

关键词： ionic conductivity ionic liquid(IL) mobility transference number cyclic voltammetry polymer electrolyte

Meta-QTL analysis for mining of candidate genes and constitutive gene network development for fungal disease resistance in maize(Zea mays L.)

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The Crop Journal 2023年第2期11卷 511-522页

作者： Mamta gupta Mukesh Choudhary Alla Singh Seema Sheoran Deepak Singla Sujay Rakshit ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6009Australia School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India

The development of resistant maize cultivars is the most effective and sustainable approach to combat fungal *** the last three decades,many quantitative trait loci(QTL)mapping studies reported numerous QTL for fungal disease resistance(FDR)in ***,different genetic backgrounds of germplasm and differing QTL analysis algorithms limit the use of identified QTL for comparative *** meta-QTL(MQTL)analysis is the meta-analysis of multiple QTL experiments,which entails broader allelic coverage and helps in the combined analysis of diverse QTL mapping studies revealing common genomic regions for target *** the present study,128(33.59%)out of 381 reported QTL(from 82 studies)for FDR could be projected on the maize genome through MQTL *** revealed 38 MQTL for FDR(12 diseases)on all chromosomes except chromosome *** MQTL namely 1_4,2_4,3_2,3_4,and 5_4 were linked with multiple *** of 1910 candidate genes were identified for all the MQTL regions,with protein kinase gene families,TFs,pathogenesis-related,and disease-responsive proteins directly or indirectly associated with *** comparison of physical positions of marker-traits association(MTAs)from genome-wide association studies with genes underlying MQTL interval verified the presence of QTL/candidate genes for particular *** linked markers to MQTL and putative candidate genes underlying identified MQTL can be further validated in the germplasm through marker screening and expression *** study also attempted to unravel the underlying mechanism for FDR resistance by analyzing the constitutive gene network,which will be a useful resource to understand the molecular mechanism of defense-response of a particular disease and multiple FDR in maize.

关键词： Meta-QTL Maize genome Fungal disease resistance Candidate gene Constitutive genes Gene network

Does friction contribute to formability improvement using servo press?

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Friction 2023年第5期11卷 820-835页

作者： Kali PRASAD Aishwary gupta Hariharan KRISHNASWAMY Uday CHAKKINGAL Dilip K.BANERJEE Myoung-Gyu LEE Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India Material Measurement Laboratory National Institute of Standards and Technology(NIST)Gaithersburg 20899USA

Servo press forming machines are advanced forming systems that are capable of imparting interrupted punch motion,resulting in enhanced room temperature *** exact mechanism of the formability improvement is not yet *** contribution of interrupted motion in the ductility improvement has been studied through stress relaxation phenomena in uniaxial tensile(UT)***,the reason for improved formability observed when employing servo press is complicated due to the additional contribution from frictional *** the present work,an attempt is made to decouple the friction effect on formability improvement *** improved formability is studied using a hole expansion test(HET).The limit of forming during hole expansion is modeled using the Hosford–Coulomb(HC)damage criteria,which is implemented as a user subroutine in a commercial explicit finite element(FE)*** the contribution of stress relaxation is accounted for in the evolution of the damage variable during interrupted ***,the difference between simulation and experimental hole expansion ratio(HER)can be used to decouple the friction effect from the overall formability improvement during hole *** improvement in HER due to stress relaxation and friction effect is *** study showed that the model effectively captures the hole expansion deformation process in both monotonic and interrupted loading *** to stress relaxation,friction effect played a major role during interrupted HET.

关键词： servo press hole expansion test(HET) dual phase steel finite element(FE)analysis Hosford-Coulomb(HC)ductile fracture model

Optimal Secondary Control of Islanded AC Microgrids with Communication Time-delay Based on Multi-agent Deep Reinforcement Learning

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1301-1311页

作者： Yang Xia Yan Xu Yu Wang Suman Mondal Souvik Dasgupta Amit.K.gupta the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore Rolls-Royce@NTU Corporate Lab Nanyang Technological UniversitySingaporeand now is with the School of Electrical EngineeringChongqing University Rolls-Royce Singapore Pte.Ltd.Singapore Rolls-Royce Solutions GmbH Germany

In this paper,an optimal secondary control strategy is proposed for islanded AC microgrids considering communi-cation *** proposed method is designed based on the data-driven principle,which consists of an offine training phase and online application *** offline training,each control agent is formulated by a deep neural network(DNN)and trained based on a multi-agent deep reinforcement learning(MA-DRL)framework.A deep deterministic policy gradient(DDPG)algorithm is improved and applied to search for an optimal policy of the secondary control,where a global cost function is developed to evaluate the overall control *** addition,the communication time-delay is introduced in the system to enrich training scenarios,which aims to solve the time-delay problem in the secondary *** the online stage,each controller is deployed in a distributed way which only requires local and neighboring information for each *** on this,the well-trained controllers can provide optimal solutions under load variations,and communication time-delays for online *** case studies are conducted to validate the feasibility and stability of the proposed secondary *** Terms-Communication time-delay,global cost function,islanded AC microgrid,multi-agent deep reinforcement learning(MA-DRL),secondary control.

关键词： Communication time-delay global cost function islanded AC microgrid multi-agent deep reinforcement learning(MA-DRL) secondary control.

GRADE: Deep learning and garlic routing-based secure data sharing framework for IIoT beyond 5G

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Digital Communications and Networks 2023年第2期9卷 422-435页

作者： Nilesh Kumar Jadav Riya Kakkar Harsh Mankodiya Rajesh gupta Sudeep Tanwar Smita Agrawal Ravi Sharma Department of Computer Science and Engineering Institute of TechnologyNirma UniversityAhmedabadGujaratIndia Centre for Inter-Disciplinary Research and Innovation University of Petroleum and Energy StudiesP.O.Bidholi Via-Prem NagarDehradunIndia

The rise of automation with Machine-Type Communication(MTC)holds great potential in developing Industrial Internet of Things(IIoT)-based applications such as smart cities,Intelligent Transportation Systems(ITS),supply chains,and smart industries without any human ***,MTC has to cope with significant security challenges due to heterogeneous data,public network connectivity,and inadequate security *** overcome the aforementioned issues,we have proposed a blockchain and garlic-routing-based secure data exchange framework,i.e.,GRADE,which alleviates the security constraints and maintains the stable connection in ***,the Long-Short-Term Memory(LSTM)-based Nadam optimizer efficiently predicts the class label,i.e.,malicious and non-malicious,and forwards the non-malicious data requests of MTC to the Garlic Routing(GR)*** GR network assigns a unique ElGamal encrypted session tag to each machine partaking in ***,an Advanced Encryption Standard(AES)is applied to encrypt the MTC data ***,the InterPlanetary File System(IPFS)-based blockchain is employed to store the machine's session tags,which increases the scalability of the proposed GRADE ***,the proposed framework has utilized the indispensable benefits of the 6G network to enhance the network performance of ***,the proposed GRADE framework is evaluated against different performance metrics such as scalability,packet loss,accuracy,and compromised rate of the MTC data *** results show that the GRADE framework outperforms the baseline methods in terms of accuracy,i.e.,98.9%,compromised rate,i.e.,18.5%,scalability,i.e.,47.2%,and packet loss ratio,i.e.,24.3%.

关键词： Garlic routing Blockchain I2P LSTM Artificial intelligence Onion routing

A Complete Analysis of Clarity(C50)Using I-SIMPA to Maintain Ideal Conditions in an Acoustic Chamber

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Sound & Vibration 2022年第1期56卷 51-64页

作者： R.Adithya Pillai S.Sakthivel Murugan Guruprasad gupta Department of Electrical and Electronics Engineering Sri Sivasubramaniya Nadar College of EngineeringChennai603110India Department of Electronics and Communication Engineering Sri Sivasubramaniya Nadar College of EngineeringChennai603110India

In any closed environment considered,it can be seen that the acoustic parameters are inherently not constant over the entire area *** a closed environment,it is ideally preferred to maintain the acoustic parameters as constant so that there exists better quality of sound leading to better auditory perception with respect to the ***,some of the acoustic parameters like reverberation time and clarity do not strictly pertain to the pattern obtained *** this paper,simulations are carried out using I-SIMPA under different values of Sound Transmission Class(STC),source position,distribution and the chamber dimensions and provides an insight into the behaviour of these acoustic parameters and the appropriate values that have to be infused into the system to build the *** acoustic environment is modelled keeping an actual closed room in mind and testing is done with respect to different values of surface absorption coefficients(practically indicated using Sound Transmission Class)and dimensions to determine ideal conditions.

关键词： Clarity C50 sound source surface receiver sound transmission class STC surface absorption percentages

Detection of Diabetic Retinopathy from Retinal Images Using DenseNet Models

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Computer Systems Science & Engineering 2023年第4期45卷 279-292页

作者： R.Nandakumar P.Saranya Vijayakumar Ponnusamy Subhashree Hazra Antara gupta Department of ECE K S R Institute for Engineering and TechnologyTiruchengode637215India Department of Computer Science and Engineering SRM Institute of Science and TechnologyChennai603203India Department of Electronics and Communication and Engineering SRM Institute of Science and TechnologyChennai603203India

A prevalent diabetic complication is Diabetic Retinopathy(DR),which can damage the retina’s veins,leading to a severe loss of *** treated in the early stage,it can help to prevent vision *** since its diagnosis takes time and there is a shortage of ophthalmologists,patients suffer vision loss even before ***,early detection of DR is the necessity of the *** primary purpose of the work is to apply the data fusion/feature fusion technique,which combines more than one relevant feature to predict diabetic retinopathy at an early stage with greater *** procedures for diabetic retinopathy analysis are fundamental in taking care of these *** profound learning for parallel characterization has accomplished high approval exactness’s,multi-stage order results are less noteworthy,especially during beginning phase *** Connected Convolutional Networks are suggested to detect of Diabetic Retinopathy on retinal *** presented model is trained on a Diabetic Retinopathy Dataset having 3,662 images given by *** results suggest that the training accuracy of 93.51%0.98 precision,0.98 recall and 0.98 F1-score has been achieved through the best one out of the three models in the proposed *** same model is tested on 550 images of the Kaggle 2015 dataset where the proposed model was able to detect No DR images with 96%accuracy,Mild DR images with 90%accuracy,Moderate DR images with 89%accuracy,Severe DR images with 87%accuracy and Proliferative DR images with 93%accuracy.

关键词： Convolutional Neural Networks vision loss pathogenic blood vessels DenseNet AlexNet ResNet

Design and development of self-cleaning PV sliding system

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Clean Energy 2022年第3期6卷 392-403页

作者： Vinay gupta Madhu Sharma Rupendra Pachauri K N Dinesh Babu Department of Electrical Engineering Manipal University Jaipur-303007India School of Engineering University of Petroleum and Energy StudiesDehradun-248007India Megger Group Ltd MylaporeChennai-600004India

This study describes the designing steps of the proposed self-cleaning system for the photovoltaic(PV)system and experimentally investigates the effectiveness of the proposed self-cleaning PV sliding system for solar power plants under all Indian climate *** investigate the performance of the proposed self-cleaning PV sliding system,we used three PV panels of 20 W with a sliding structure and another set of three PV panels of 20 W with a traditional(fixed)technique,and recorded the output power for the period of December 2019 to April *** experimental results show that the proposed self-cleaning PV sliding system improved efficiency by 18.3%,13.3%and 6.4%,respectively,in the summer,winter and post-monsoon seasons when compared to the fixed PV *** results also revealed that energy consumption was very low when compared to the amount of energy *** proposed system not only cleans the PV system,but also protects it from *** results of this study show that there is a significant improvement in PV efficiency and thus an increase in electricity production under all climate conditions.

关键词： solar energy photovoltaics cleaning soiling hailstorm protection sliding PV system