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Renal resistive index measurements by ultrasound in patients with liver cirrhosis:Magnitude and associations with renal dysfunction

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World Journal of Radiology 2024年第6期16卷 221-231页

作者： himanshu surya Ramesh Kumar Rajeev Nayan Priyadarshi Sabbu surya Prakash Sudhir Kumar Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India

BACKGROUND The hemodynamic alterations seen in liver cirrhosis lead to renal vasoconstriction,ultimately causing acute kidney injury(AKI).The renal resistive index(RRI)is the most common Doppler ultrasound variable for measuring intrarenal vascular *** To evaluate the association of the RRI with AKI in patients with liver cirrhosis and to identify risk factors for high *** This was a prospective observational study,where RRI was measured using Doppler ultrasound in 200 consecutive hospitalized patients with *** association of RRI with AKI was *** receiver operating characteristic(ROC)curve analysis was utilized to determine discriminatory cut-offs of RRI for various AKI *** analysis was conducted to determine the predictors of high *** The mean patient age was 49.08±11.68 years,with the majority(79.5%)being male;the predominant etiology of cirrhosis was alcohol(39%).The mean RRI for the study cohort was 0.68±0.09,showing a progressive increase with higher Child-Pugh class of ***,AKI was present in 129(64.5%)*** mean RRI was significantly higher in patients with AKI compared to those without it(0.72±0.06 vs 0.60±0.08;P<0.001).A total of 82 patients(41%)had hepatorenal syndrome(HRS)-AKI,29(22.4%)had prerenal AKI(PRA),and 18(13.9%)had acute tubular necrosis(ATN)-*** mean RRI was significantly higher in the ATN-AKI(0.80±0.02)and HRS-AKI(0.73±0.03)groups than in the PRA(0.63±0.07)and non-AKI(0.60±0.07)*** demonstrated excellent discriminatory ability in distinguishing ATN-AKI from non-ATN-AKI(area under ROC curve:93.9%).AKI emerged as an independent predictor of high RRI(adjusted odds ratio[OR]:11.52),and high RRI independently predicted mortality among AKI patients(adjusted OR:3.18).CONCLUSION In cirrhosis patients,RRI exhibited a significant association with AKI,effectively differentiated between AKI phenotypes,and predicted AKI mortality.

关键词： Renal resistive index Cirrhosis Acute kidney injury Hepatorenal syndrome Renal Doppler

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Improved survival at the cost of more chronic lung disease?Current management and outcomes in extremely preterm infants born in New South Wales and the Australian Capital Territory:2010-2020

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World Journal of Pediatrics 2024年第3期20卷 230-238页

作者： Nele Legge himanshu Popat Dominic Fitzgerald Liverpool Hospital Corner Elizabeth and Goulburn StreetsLiverpoolNSWAustralia University of Sydney CamperdownAustralia Children's Hospital Westmead WestmeadAustralia

Background Since 2010,most tertiary care hospitals in Australia have changed how they care for extremely premature ***,in-hospital and longer-term outcome data have suggested unchanged or even worse health outcomes in later epochs,especially respiratory *** study examined the trend in outcomes since these changes were introduced,particularly the prevalence of chronic neonatal lung disease(CLD).Methods This is a retrospective cross-sectional analysis of data from the Neonatal Intensive Care Units'(NICUS)database of all perinatal intensive care units in New South Wales and the Australian Capital Territory,including infants born at≥24 and≤28 weeks of gestational age in tertiary perinatal units between January 1,2010,and December 31,*** trends and changes in primary outcome were examined by linear and adjusted multivariable logistic regression *** This study included 3258 *** saw significant changes in antenatal magnesium sulfate(75% increase),delayed cord clamping(66% increase),delivery room intubations(30% decrease),any time(20% decrease),duration on mechanical ventilation(100-hour decrease),and hours on noninvasive ventilation(200-hour increase).Mortality decreased from 17% to 6%.The incidence of CLD increased significantly even when adjusted for confounders(15% increase).Any time and mean hours spent on mechanical ventilation significantly increased the odds of *** study could not find a significant association of any of the protective antenatal treatments on *** The last decade saw a significant improvement in survival and survival to discharge without major *** was increased use of magnesium sulfate,delayed cord clamping,and less invasive respiratory management of extremely preterm *** avoidance of mechanical ventilation may impact the incidence of CLD.

关键词： Chronic lung disease Extreme prematurity Health outcomes Survival

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Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab

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Genes & Diseases 2024年第1期11卷 38-41页

作者： Pandikannan Krishnamoorthy Athira S.Raj himanshu Kumar Department of Biological Sciences Laboratory of Immunology and Infectious Disease BiologyIndian Institute of Science Education and Research(llSER)BhopalBhopalMP 462066India Laboratory of Host Defense WPl ImmunologyFrontier ResearchCentreOsakaUniversityOsaka 5650871Japan

During a sudden viral pandemic,where the pathogenesis and nature of the infection are unclear,early and accurate identification of the patients infected with the pandemiccausing pathogen is crucial to prevent excess *** the coronavirus disease 2019(COvID-19)pandemic,early diagnosis of severe acute respiratory syndrome virus-2(SARS-CoV-2)is limited by the incidence of the symptoms that are shared with acute respiratory illnesses(ARl)caused by other pathogens.

关键词： acute diagnosis respiratory

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Dengue causing relapse of minimal change disease: A double-edged sword

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 237-238页

作者： Sourabh Sharma himanshu Verma Sanjay Kalra Department of Nephrology VMMC&Safdarjung HospitalNew DelhiIndia Department of Endocrinology Bharti HospitalKarnalIndia

Dengue virus infection is endemic in India with seasonal *** can lead to lethal consequences with plasma leakage and/or bleeding[1,2].Dengue shock syndrome has high mortality in developing countries like *** can cause functional proteinuria and even heavy proteinuria[3-6].Though dengue has been implicated to cause glomerulonephritis[7],to the best of our knowledge,dengue as a cause of relapse of minimal change disease(MCD)has not been reported.

关键词： relapse mortality bleeding

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Charting the course:India's health expenditure projections for 2035

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Global Health Journal 2024年第2期8卷 58-66页

作者： Pragyan Monalisa Sahoo himanshu Sekhar Rout Department of Analytical&Applied Economics Utkal UniversityBhubaneswarOdishaIndia Department of Analytical and Applied Economics&RUSA Centre of Excellence in Public Policy and Governance Utkal UniversityVani ViharBhubaneswarOdishaIndia

Objectives Understanding past trends and forecasting future changes in health spending is vital for planning and reducing reliance on out-of-pocket(OOP)*** current study analyzed health expenditure patterns in India and forecasted future trends and patterns until *** Data on health expenditure in India from 2000 to 2019 was collected from the Organisation for Economic Co-operation and Development(OECD)iLibrary and National Health Accounts 2019 *** domestic product(GDP)data from the World Bank was also *** statistics analyzed the composition and pattern,while the exponential smoothing model forecasted future health *** The findings revealed that expenditure made by OOP is the primary health financing source,followed by government and pre-paid private *** percentage of GDP allocated to total health expenditure remains stable,while the per capita health expenditure *** in expenditure among states are observed,with Karnataka relying heavily on pre-paid private *** projections suggest a decline in per capita and total health expenditure as a share of GDP,with a slight increase in the government’s ***-paid private expenditure per capita and OOP health expenditure as a share of the total is projected to remain relatively constant but still high in absolute *** The study highlights variations in health spending in India,characterized by high OOP spending,limited public coverage,and a need for investments,and reforms to improve healthcare access and equity.

关键词： Health expenditure Health spending Health financing Forecasting Exponential smoothing India

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Identification of optimal composition with superior electrochemical properties along the zero Mn^(3+)line in Na_(0.75)(Mn-Al-Ni)O_(2)pseudo ternary system

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Journal of Energy Chemistry 2024年第9期96卷 206-216页

作者： Hari Narayanan Vasavan Manish Badole Samriddhi Saxena Velaga Srihari Asish Kumar Das Pratiksha Gami Neha Dagar Sonia Deswal Pradeep Kumar himanshu Kumar Poswal Sunil Kumar Department of Metallurgical Engineering and Materials Science Indian Institute of Technology IndoreSimrol 453552India High Pressure&Synchrotron Radiation Physics Division Bhabha Atomic Research Centre400085 MumbaiIndia School of Physical Sciences Indian Institute of Technology MandiHimachal Pradesh 175005India Center for Electric Vehicle and Intelligent Transport Systems Indian Institute of Technology IndoreSimrol 453552India

Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion ***,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary *** structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate *** each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance *** synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during *** high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 *** results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.

关键词： Layered oxides Biphasic cathode Operando Synchrotron XRD Electrochemical behavior Cyclic performance

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Tuberculosis in kidney transplant candidates and recipients

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World Journal of Transplantation 2024年第3期14卷 59-69页

作者： Pallavi Prasad Sourabh Sharma Subashri Mohanasundaram Anupam Agarwal himanshu Verma Department of Nephrology Vardhman Mahavir Medical College and Safdarjung HospitalNew Delhi 110029DelhiIndia Department of Nephrology Prashanth HospitalChennai 600042Tamil NāduIndia

Tuberculosis(TB)is the leading cause of infectious mortality and morbidity in the world,second only to coronavirus disease *** with chronic kidney disease and kidney transplant recipients are at a higher risk of developing TB than the general *** TB is difficult to diagnose in this population due to close *** transplant candidates should be screened for latent TB infection and given TB *** who develop active TB pre-or post-trans-plantation should receive multidrug combination therapy of antitubercular therapy for the recommended duration with optimal dose modification as per glomerular filtration rate.

关键词： Tuberculosis Latent Antitubercular therapy Kidney transplantation Donor Interferon-gamma release assays Tuberculin Rifampicin Isoniazid

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Evaluation of Rainfall Tendency for the Twentieth Century over Indira Sagar Region in Central India

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American Journal of Climate Change 2024年第1期13卷 47-68页

作者： Rituraj Shukla Deepak Khare Ramesh P. Rudra Priti Tiwari himanshu Sharma Prasad Daggupati Pradeep Goel School of Engineering University of Guelph Guelph Canada Department of Water Resources Development and Management Indian Institute of Technology Roorkee India Indira Gandhi Agricultural University Raipur India Department of Civil Engineering Institute of Infrastructure Technology Research and Management (IITRAM) Ahmedabad India

The study investigates long-term changes in annual and seasonal rainfall patterns in the Indira Sagar Region of Madhya Pradesh, India, from 1901 to 2010. Agriculture sustainability, food supply, natural resource development, and hydropower system reliability in the region rely heavily on monsoon rainfall. Monthly rainfall data from three stations (East Nimar, Barwani, and West Nimar) were analyzed. Initially, the pre-whitening method was applied to eliminate serial correlation effects from the rainfall data series. Subsequently, statistical trends in annual and seasonal rainfall were assessed using both parametric (student-t test) and non-parametric tests [Mann-Kendall, Sen’s slope estimator, and Cumulative Sum (CUSUM)]. The magnitude of the rainfall trend was determined using Theil-Sen’s slope estimator. Spatial analysis of the Mann-Kendall test on an annual basis revealed a statistically insignificant decreasing trend for Barwani and East Nimar and an increasing trend for West Nimar. On a seasonal basis, the monsoon season contributes a significant percentage (88.33%) to the total annual rainfall. The CUSUM test results indicated a shift change detection in annual rainfall data for Barwani in 1997, while shifts were observed in West and East Nimar stations in 1929. These findings offer valuable insights into regional rainfall behavior, aiding in the planning and management of water resources and ecological systems.

关键词： Precipitation Parametric Non-Parametric Tests Trend Analysis Serial Correlations

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Current evidence on artificial intelligence in regional anesthesia

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World Journal of Clinical Cases 2024年第33期12卷 6613-6619页

作者： Bhanu Pratap Swain Deb Sanjay Nag Rishi Anand himanshu Kumar Pradip Kumar Ganguly Niharika Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

The recent advancement in regional anesthesia(RA)has been largely attributed to ultrasound ***,the safety and efficiency of ultrasound-guided nerve blocks depend upon the skill and experience of the *** with adequate training,experience,and knowledge,human-related limitations such as fatigue,failure to recognize the correct anatomical structure,and unintentional needle or probe movement can hinder the overall effectiveness of *** amalgamation of artificial intelligence(AI)to RA practice has promised to override these human *** learning,an integral part of AI can improve its performance through continuous learning and experience,like the human *** enables computers to recognize images and patterns specifically useful in anatomic structure identification during the performance of *** can provide real-time guidance to clinicians by highlighting important anatomical structures on ultrasound images,and it can also assist in needle tracking and accurate deposition of local *** future of RA with AI integration appears promising,yet obstacles such as device malfunction,data privacy,regulatory barriers,and cost concerns can deter its clinical *** current mini review deliberates the current application,future direction,and barrier to the application of AI in RA practice.

关键词： Artificial intelligence Regional anesthesia Machine learning Ultrasonography Nerve block

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A novel formulation of material nonlinear analysis in structural mechanics

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Defence Technology（防务技术） 2021年第1期17卷 36-49页

作者： himanshu Gaur Anupam Srivastav Institute of Structural Mechanics Bauhause Universitat WeimarMarienstrasse 15D-99423WeimarGermany Department of Civil Engineering Middle East CollegeMuscatOman

This article demonstrates a novel approach for material nonlinear *** analysis procedure eliminates tedious and lengthy step by step incremental and then iterative procedure adopted classically and gives direct results in the linear as well as in nonlinear range of the material *** of elastic moduli is ***,stress and strain functions are used as the material input in the analysis *** stress and strain functions are directly derived from the stress-strain behavior of the material by the method of curve *** way,the whole stress-strain diagram is utilized in the analysis which naturally exposes the response of structure when loading is in nonlinear range of the material *** is found that it is an excellent computational procedure adopted so far for material nonlinear analysis which gives very accurate results,easy to adopt and simple in *** method eliminates all types of linearity assumptions in basic derivations of equations and hence,eliminates all types of possibility of errors in the analysis procedure as *** it is required to know stress distribution in the structural body by proper modelling and structural idealization,the proposed analysis approach can be regarded as stress-based analysis *** problems such as uniaxial problem,beam bending,and torsion problems are *** is found that approach is very suitable for solving the problems of fracture *** release rate for plate with center crack and double cantilever beam specimen is also *** approach solves the fracture problem with relative ease in strength of material style *** all problems,results are compared with the classical displacement-based liner theory.

关键词： Computational methods Material nonlinear analysis Fracture mechanics Energy release rate etc

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