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New insights into the therapeutic approaches for the treatment of tauopathies

Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： himanshi singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

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Acute Massive Gastric Dialation—A Case Report

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International Journal of Clinical Medicine 2015年第6期6卷 407-410页

作者： Kiran Kumar Rifah Anwar Assadi Mohammed Khalid Mohammed Hamdy Ibrahim himanshi singh Sonia Lamichhane Shaikh Altaf Basha Department of Internal Medicine GMC Hospital and Research Centre Ajman UAE

Acute gastric dilation leading to ischemia of the stomach is an underdiagnosed condition and can be potentially fatal. It can occur in various medical and surgical conditions such as post operative state, trauma, anorexia, spinal abnormalities, diabetes mellitus and electrolyte imbalance. Without proper and timely diagnosis and treatment, gastric perforation and hemorrhage can occur. In this report, we present a case of acute massive gastric dilation in a settling of type II diabetes mellitus and urosepsis. We will also present a review of literature and management options for such condition. Our report highlights the need for high index of suspicion and early intervention to avoid life threatening complications.

关键词： Acute Gastric Dilatation Infection Urinary Tract Infection Gastric Distension

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Spontaneous Intracranial Hypotension: An Interesting Cause of Intractable Headache

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Neuroscience & Medicine 2015年第3期6卷 130-133页

作者： Kiran Kumar himanshi singh Sameh Saied Mohammed Hamdy Ibrahim Mohammed Khalid Rifah Anwar Assadi Sonia Lamichhane Shaikh Altaf Basha Rajashree Ganesh Neha Arora GMC Hospital and Research Centre Ajman UAE

Intracranial hypotension (ICH) is a benign syndrome which is often under-diagnosed. It is characterized by orthostatic headache which is predominantly occipital. ICH is diagnosed in the presence of a typical history and characteristic imaging findings. Further confirmation by lumbar puncture to document low CSF pressure might be necessary in some cases. Treatment is mainly conservative in the form of bed rest and intravenous saline infusion. However, surgical intervention may be required if conservative measures fail. In this report we presented a case of 42-year-old male patient who presented with symptoms of orthostatic occipital headache of three-month duration and was subsequently diagnosed with intracranial hypotension based on characteristic MRI findings of pachymeningeal enhancement on gadolinium enhanced MRI of the brain with sagging of the mid-brain.

关键词： Intracranial Hypotension Headache CSF Leak Orthostatic Headache

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Current status and prospects of primary immunodeficiency diseases in Asia

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Genes & Diseases 2020年第1期7卷 3-11页

作者： Rakesh Kumar Pilania himanshi Chaudhary Ankur Kumar Jindal Amit Rawat Surjit singh Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarh160012India

Primary Immunodeficiency Diseases(PIDs)are increasingly being reported across the *** advances have been made in the diagnostic and therapeutic research related to *** increasing awareness,the field of PIDs has rapidly evolved in Asia as *** this review,we summarize the progress that has been made in the field of PIDs in Asian countries;major limitations and challenges faced by the clinicians working in this field in Asia;difference in spectrum of PIDs in Asia from rest of the World;current state of diagnostic and treatment facilities available in various countries in Asia and the future prospects of these diseases in the continent.

关键词： Asia Genetic diagnosis Hematopoietic stem cell transplant Intravenous immunoglobulin Primary immunodeficiency diseases

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A multidisciplinary approach for rehabilitation following ocular trauma

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Burns & Trauma 2014年第1期2卷 41-44页

作者： Pradeep Kumar himanshi Aggarwal Varun Baslas Raghuwar Dayal singh Department of Prosthodontics Faculty of Dental SciencesKing George’s Medical UniversityLucknowUttar PradeshIndia

Ocular trauma is a very common incidence that occurs in up to 67%of patients with maxillofacial *** results in life-long agony of not being like others with two eyes,which can see and admire the nature’s *** article reports on a case of a 23-year-old male patient with phthisis bulbi,resulting from ocular *** patient was rehabilitated aesthetically by fabrication of custom-made ocular prosthesis for his traumatically injured right *** patient was pleased with the aesthetic outcome,comfort,and mobility offered by the custom ocular *** were no complications with regard to health of underlying residual ocular tissues and there was no need of relining of the prosthesis at 6 month recall *** of patients with ocular trauma requires a multidisciplinary approach involving ophthalmologist,psychologist,and skilled maxillofacial ***-made ocular prosthesis fitted over the phthisical globe seems to be a highly positive,logical,noninvasive,and beneficial approach to increase mobility to the prosthesis,improve the cosmetic appearance and psychological well-being of the patient.

关键词： Custom ocular prosthesis ocular trauma prosthesis replacement

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