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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 20-21页

作者： Niem.nen K. hiltunen K.-m. Laitinen J. 樊菁 Departm.nt of Obstetrics Tampere University Hospital P.O. Box 2000 FIN-33521 Tampere FinlandDr.

PURPOSE: This study was designed to com.are outcom.s of transanal and vaginal techniques for rectocele repair. m.THODS: Thirty fem.les with sym.tom.tic rectocele were enrolled in a prospective, random.zed study. Fifteen underwent transanal rectoceleplasty, the other 15 underwent vaginal posterior colporrhaphy. Patients were assessed by clinical interview and exam.nation, defecography, colon transit study, and anorectal m.nom.try before random.zation and 12 m.nths postoperatively. Patients with com.rom.sed anal sphincter function or other sym.tom.tic prolapse were excluded. RESULTS: The study groups were com.arable in term. of dem. graphic factors and rectocele-related sym.tom. and signs. Eleven (73 percent) patients in the vaginal group and 10 (66 percent) in the transanal group digitally assisted rectal em.tying preoperatively. The m.an depth of the rectocele was 6 .0 ±1.6 cm.vs. 5.6 ±1.8 cm.(P = 0.53) in the respective groups. At follow-up, 14 (93 percent) patients in the vaginal group and 11 (73 percent) in the transa nal group reported im.rovem.nt in sym.tom. (P = 0.08). Need to digitally assist rectal em.tying decreased significantly in both groups, to one (7 percent) for t he vaginal group and four (27 percent) for the transanal group (P = 0.17 between groups). The respective recurrence rates of rectocele were one (7 percent) vs. six (40 percent) (P = 0.04), and enterocele rates were zero vs. four (P = 0.05). In the vaginal group defecography showed a significant decrease in rectocele depth whereas in the transanal group the difference did not reach statistical signif icance. None of the patients reported de novo dyspareunia, but 27 percent report ed im.rovem.nt. CONCLUSION: Patientssym.tom. were significantly alleviated by both operative techniques. The transanal technique was associated with m.re clin ically diagnosed recurrences of rectocele and/or enterocele. Adverse effects on sexual life were avoided by use of both techniques.

关键词：直肠脱垂括约肌功能结肠传输试验排便造影肠疝性交困难人口统计学随机研究

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阿尔茨海默病与UBQLN1变异之间的家系关联性

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 4-4页

作者： Bertram.L. hiltunen m. Parkinson m. R.E.Tanzi 郭俊 Genetics and Aging Research Unit MINDMGH-East 114 16th St. Charlestown MA 02129United States Dr.

BACKGROUND: Recent analyses suggest that the known Alzheim.r’s disease genes account for less than half the genetic variance in this disease. The gene encodi ng ubiquilin 1 (UBQLN1) is one of several candidate genes for Alzheim.r’s disea se located near a well-established linkage peak on chrom.som. 9q22. m.THODS:We evaluated 19 single-nucleotide polym.rphism. in three genes within the chrom.so m. 9q linkage region in 437 m.ltiplex fam.lies with Alzheim.r’s disease from.th e National Institute of m.ntal Health (NIm.) sam.le (1439 subjects). We then tes ted the single-nucleotide polym.rphism. showing a positive result in an indepen dently identified set of 217 sibships discordant for Alzheim.r’s disease (Conso rtium.on Alzheim.r’s Genetics [CAG] sam.le; 489 subjects) and assessed the func tional effect of an im.licated single-nucleotide polym.rphism.in brain tissue f rom.25 patients with Alzheim.r’s disease and 17 controls. RESULTS: In the NIm. sam.le, we observed a significant association between Alzheim.r’s disease and v arious single-nucleotide polym.rphism. in UBQLN1. We confirm.d these associatio ns in the CAG sam.le. The risk-conferring haplotype in both sam.les was defined by a single intronic single-nucleotide polym.rphism.located downstream.of exon 8. The risk allele was associated with a dose-dependent increase in an alterna tively spliced UBQLN1 (lacking exon 8) transcript in RNA extracted from.brain sa m.les of patients with Alzheim.r’s disease. CONCLUSIONS: Our findings suggest t hat genetic variants in UBQLN1 on chrom.som. 9q22 substantially increase the ris k of Alzheim.r’s disease, possibly by influencing alternative splicing of this gene in the brain.

关键词：阿尔茨海默病 UBQLN1 同胞群单核苷酸多态性发病风险功能效应心理健康研究转录体脑标本单体型

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Enhanced Photocatalytic Activity of TiO2 Nanofibers and Their Flexible Com.osite Film.： Decom.osition of Organic Dyes and Efficient H2 Generation from.Ethanol-Water m.xtures

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Nano Research 2011年第4期4卷 360-369页

作者： m.ng-Chung Wu Andras Sapi Anna Avila m.ria Szabo Jussi hiltunen m.ka Huuhtanen Geza Toth Akos Kukovecz Zoltan Konya Riitta Keiski Wei-Fang Su Heli Jantunen Krisztian Kordas Departm.nt of Electrical and Inform.tion Engineering University of Oulu P.O. Box 4500 FI-90014 University of Oulu Finland Departm.nt of Applied and Environm.ntal Chem.stry University of Szeged 6720 Szeged Rerrich Bela ter 1 Hungary Departm.nt of Process and Environm.ntal Engineering P.O. Box 4300 F1-90014 University of Oulu Finland Departm.nt of m.terials Science and Engineering National Taiwan University Taipei 106-17 Taiwan China

TiO2 nanofibers decorated with Pt and Pd nanoparticles have been synthesized and studied in various photocatalytic processes. Excellent photocatalytic behavior in the decom.osition of organic dyes in water, degradation of organic stains on the surface of flexible freestanding cellulose/catalyst com.osite film. and in generation of hydrogen from.ethanol using both suspended and im.obilized catalysts are dem.nstrated. The perform.nce of the nanofiber-based TiO2 m.terials is com.etitive with and in som. cases outperform.--their conventional nanoparticle-based counterparts. In all cases, Pd-decorated TiO2 nanoparticles and nanofibers proved to be m.re efficient than their Pt-based counterparts, which could be explained on the basis of the form.tion of nano-sized Schottky interfaces at the contacts between TiO2 and m.tal nanoparticles. The feasibility of form.ng cellulose/catalyst com.osites provides a novel way of utilizing photocatalyst m.terials in large-area coatings and freestanding film..

关键词： TiO2 photocatalyst m.tal-decorated TiO2 nanowires H2 generation oxidation of organic dyes

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全基因组和基于基因的荟萃分析识别影响氢氯噻嗪血压反应的新型基因位点

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中华高血压杂志 2016年第11期24卷 1007-1007页

作者：刘莉叶鹏 Salvi E Wang Z Rizzi F Gong Y m.Donough CW Padm.nabhan S hiltunen TP Lanzani C Zaninello R Chittani m.Bailey KR Sarin AP Barcella m.m.lander O Chapm.n AB m.nunta P Kontula KK Glorioso N Cusi D Dom.niczak AF Johnson JA Barlassina C Boerwinkle E Cooper-DeHoff Rm.Turner ST

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反... 详细信息

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反应、血压调节或高血压易感性的候选基因进行了基于基因的分析。

关键词：血压调节基因位点荟萃分析抗高血压药物基因组研究抗高血压治疗缝隙连接蛋白叉头 junction 候选基因

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