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Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population

World Journal of Gastroenterology 2003年第7期9卷 1580-1583页

作者： Kantarceken Bulent Aladag Murat Atik Esin Koksal fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent hilmioglu fatih Division of Gastroenterology Medical FacultyInonu UniversityMalatyaTurkey Mustafa Kemal University Department of PathologyMedical FacultyHatayTurkey Department of Microbiology Medical Faculty Cukurova UniversityAdanaTurkey Department of Internal Medicine Medical FacultyInonu UniversityMalatyaTurkey

AIM:The mostly known genotypic virulence features,of *** are cytotoxin associated gene A (cagA) and Vacuolating cytotoxin gene A (VacA).We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region. METHODS:One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years,range 15-87 years,64 males and 78 females).Antral and corpus biopsies were taken for detecting and genotyping of ***.107 patients who were *** positive by histological assessment were divided into three groups according to endoscopic findings:Duodenal ulcer (DU),gastric ulcer (GU) and non-ulcer dyspepsia (NUD).The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of *** using specific primers. RESULTS:*** isolated from 75.4% (107/142) of the *** the 107 patients,66 (61.7%) were cagA- positive and 82 (76.6%) were *** gene was positively associated with DU and GU (P0.05).Although VacA positivity in ulcer patients was higher than that in NUD group,the difference was not statistically significant (P>0.05). CONCLUSION:There is a significantly positive association between CagA genes and DU and *** presence of VacA is not a predictive marker for DU,GU,and NUD in our patients.

关键词： Adolescent Adult Aged Aged, 80 and over Antigens, Bacterial Bacterial Proteins Biopsy Dyspepsia Female Genotype Helicobacter Infections Helicobacter pylori Humans Male Middle Aged Predictive Value of Tests Prevalence Stomach Ulcer Turkey Virulence

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