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Prolonged QT dispersion in inflammatory bowel disease

World Journal of Gastroenterology 2013年第1期19卷 65-71页

作者： Elif Yorulmaz Aslihan Sezgin Gupse Adali Hatice Yorulmaz hilmi ciftci Department of Gastroenterology Goztepe Training and Research Hospital34470 IstanbulTurkey Department of Ⅲ Internal Medicine Goztepe Training and Research Hospital34470 IstanbulTurkey School of Nursing Halic University34394 IstanbulTurkey

AIM:To investigate the frequency and factors of prolonged QT dispersion that may lead to severe ventricular arrhythmias in patients with inflammatory bowel disease(IBD).METHODS:This study included 63 ulcerative colitis(UC) and 41 Crohn's disease(CD) ***-seven healthy patients were included as the control *** rate was calculated using electrocardiography,corrected QT dispersion(QTcd) and the Bazett's *** model assessment(HOMA) was used to determine insulin resistance(IR).HOMA values 2.5 indicated a high probability of ***:Prolonged QTcd was found in 12.2% of UC patients,and in 14.5% of CD patients compared with the control group(P < 0.05).A significant difference was found between the insulin values(CD:10.95 ± 6.10 vs 6.44 ± 3.28,P < 0.05;UC:10.88 ± 7.19 vs 7.20 ± 4.54,P < 0.05) and HOMA(CD:2.56 ± 1.43 vs 1.42 ± 0.75,P < 0.05;UC:2.94 ± 1.88 vs 1.90 ± 1.09,P < 0.05) in UC and CD patients with and without prolonged *** behavior types were determined in CD patients with prolonged *** systolic arterial pressure(125 ± 13.81 vs 114.09 ± 8.73,P < 0.01) and age(48.67 ± 13.93 vs 39.57 ± 11.58,P < 0.05) in UC patients were significantly associated with prolonged ***:Our data show that IBD patients have prolonged QTcd in relation to *** routine followup of IBD patients should include determination of HOMA,insulin values and electrocardiogram examination.

关键词： Crohn’s disease Homeostasis model assessment Insulin QT dispersion Ulcerative colitis

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