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Cretaceous source to sink system reconstruction of northeastern Asian continental margin:Insight from integrated detrital geochronology in NE China

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Geoscience Frontiers 2023年第5期14卷 213-232页

作者： Jianping Zhou István Dunkl Yongjiang Liu Sanzhong Li Weimin Li hilmar von eynatten University of Göttingen Geoscience CenterDepartment of Sedimentology and Environmental GeologyGoldschmidtstrasse 3Göttingen D-37077Germany Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Lab of Submarine Geosciences and Prospecting Techniquesand College of Marine GeosciencesOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Laoshan LaboratoryQingdao 266100China College of Earth Sciences Jilin UniversityJianshe Str.2199Changchun 130061China

The Cretaceous sedimentary successions in NE China are largely incomplete as the basins are inverted and younger strata are *** for the Songliao Basin,whose depositional record has remained relatively intact,the burial record to the east was interrupted in the late Early or Late *** is still controversy on the possible connection between the Songliao Basin and the eastern basin group,as well as the extent of the previously suggested“pan-Sanjiang”proto-basin that covered most current eastern satellite *** address these questions,we studied modern river catchments of variable sizes from sediment-supplying basement highs that cover most of eastern NE China to track the intense denudation events and provenance changes through the *** found a great inconsistency between detrital age patterns of the modern river sands and the spatial proportions of the source *** detrital age distributions allow to re-evaluate the basement units that are mostly composed of the Triassic–Jurassic igneous suite and some metasedimentary units with Paleozoic ages,but the contribution from Proterozoic formations is *** the newly dated modern catchment detrital U-Pb ages,the region-wide compilation of the basement emplacement ages,and the U-Pb ages in the Cretaceous formations in NE China,we systematically refine the Cretaceous provenance *** the Early Cretaceous,the eastern satellite basins accumulated sediments from the Lesser Xing’an range(LXR)in the west,Zhangguangcai range(ZGCR)in the south,and the Nadanhada terrane(NT)in the *** sediment of the southern Songliao Basin derived from the North China Craton(NCC)and from ZGCR but barely from the Great Xing’an Range(GXR).The Jiamusi uplift(JU)did not provide sediments to the eastern satellite basins and the Songliao *** the Late Cretaceous,the eastern satellite basins received sediments from the exhumed JU but barely from ZGCR and *** Songliao Basin still accumula

关键词： Detrital zircon U-Pb Modern sediment Source to sink Provenance change NE China

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Silver-integrated EDM processing of TiAl6V4 implant material has antibacterial capacity while optimizing osseointegration

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Bioactive Materials 2024年第1期31卷 497-508页

作者： hilmar Büssemaker Ann-Kathrin Meinshausen Viet Duc Bui Joachim Döring Vadym Voropai Adrian Buchholz Andreas J.Mueller Karsten Harnisch André Martin Thomas Berger Andreas Schubert Jessica Bertrand Department of Orthopaedic Surgery Otto-von-Guericke University MagdeburgGermany Professorship Micromanufacturing Technology Chemnitz University of TechnologyChemnitzGermany Institute of Molecular and Clinical Immunology Otto-von-Guericke University MagdeburgGermany Health Campus Immunology Infectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Materials and Joining Technology Otto-von-Guericke UniversityMagdeburgGermany Fraunhofer Institute for Machine Tools and Forming Technology ChemnitzGermany

Periprosthetic joint infections(PJI)are a common reason for orthopedic revision *** has been shown that the silver surface modification of a titanium alloy(Ti-6Al-4V)by PMEDM(powder mixed electrical discharge machining)exhibits an antibacterial effect on Staphylococcus *** the thickness of the silver-modified surface influences the adhesion and proliferation of bacteria as well as the ossification processes and in-vivo antibacterial capacity has not been investigated ***,the aim of this work is to investigate the antibacterial effect as well as the in vitro ossification process depending on the thickness of PMEDM silver modified *** attachment of *** on the PMEDM modified surfaces was significantly lower than on comparative control samples,independently of the tested surface *** proliferation,however,was not affected by the silver content in the surface *** observed a long-term effect of antibacterial capacity in vitro,as well as in *** induction of ROS,as indicator for oxidative stress,was observed in the bacteria,but not in osteoblast-like *** influence on the in vitro osteoblast function was observed,whereas osteoclast formation was drastically reduced on the silver *** changes in cell death,the metabolic activity and oxidative stress was measured in *** show that already small amounts of silver exhibit a significant antibacterial capacity while not influencing the osteoblast ***,PMEDM using silver nano-powder admixed to the dielectric represents a promising technology to shape and concurrently modify implant surfaces to reduce infections while at the same time optimizing bone ingrowth of endoprosthesis.

关键词： alloy silver powder

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利格列汀应用于已经接受标准治疗的糖尿病肾病患者中时可减少患者的白蛋白尿

利格列汀应用于已经接受标准治疗的糖尿病肾病患者中时可减少患者...

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中华医学会糖尿病学分会第十六次全国学术会议

作者： PER-HENRIK GROOP MARK COOPER VLADO PERKOVIC ANGELA EMSER MAXIMILIAN von eynatten HANS-JUERGEN WOERLE

尽管已有理想的治疗选择,2型糖尿病(T2D)患者仍然伴有增高的肾脏损伤的风险,表现为白蛋白尿,许多患者还可发展为进行性加重的肾功能衰竭。之前已有证据显示DPP-4抑制剂利格列汀在替米沙坦治疗基础上可减少小鼠的白蛋白尿。我们就利格列...

尽管已有理想的治疗选择,2型糖尿病(T2D)患者仍然伴有增高的肾脏损伤的风险,表现为白蛋白尿,许多患者还可发展为进行性加重的肾功能衰竭。之前已有证据显示DPP-4抑制剂利格列汀在替米沙坦治疗基础上可减少小鼠的白蛋白尿。我们就利格列汀对于伴有早期糖尿病肾病的T2D患者的白蛋白尿的临床效应进行了探索。共有4项针对利格列汀不伴任何背景口服降糖药物治疗、利格列汀伴一种背景口服降糖药物治疗、利格列汀伴两种背景口服降糖药物治疗的随机、双盲、24周、安慰剂对照试验可提供

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利格列汀应用于2型糖尿病老年患者(≥70岁)的疗效和安全性

利格列汀应用于2型糖尿病老年患者(≥70岁)的疗效和安全性

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中华医学会糖尿病学分会第十六次全国学术会议

作者： ANTHONY H.BARNETT HOLGER HUISMAN RUSSELL JONES MAXIMILIAN von eynatten SAN JAY PATEL HANS-JUERGEN WOERLE

在老年患者中,针对2型糖尿病的管理经常会因为存在以下因素而变得复杂化:合并症、同时接受多种药物治疗、对药物的不良反应较敏感。此项安慰剂对照、Ⅲ期临床试验在年龄70岁及以上的2型糖尿病患者中对利格列汀24周治疗进行了评估。上述...

在老年患者中,针对2型糖尿病的管理经常会因为存在以下因素而变得复杂化:合并症、同时接受多种药物治疗、对药物的不良反应较敏感。此项安慰剂对照、Ⅲ期临床试验在年龄70岁及以上的2型糖尿病患者中对利格列汀24周治疗进行了评估。上述患者在接受二甲双胍和(或)磺脲类药物和(或)胰岛素

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