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An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence

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Advances in Aging Research 2017年第2期6卷 29-37页

作者： Elaine Wat Alex W. L. Lin Cyrus Mak Ivan lam Clara Bik-San lau Frency Sau-Fun Ng Patrick Chi-Leung Hui Ping-Chung Leung Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong Partner State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong Institute of Textiles and Clothing The Hong Kong Polytechnic University Hong Kong Neighbourhood Advice-Action Council Harmony Manor Hong Kong

Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer. While conservative means of treatment do not work, special incontinence apparel could be a good compromise. Objective: To create an absorbent, antiseptic, antiperspirant and deodourant diaper for the older and dependent people suffering from urinary incontinence. Material and Methods: Antiperspirant and antiseptic medicinal materials have been reported in Traditional Chinese Medicine and two herbs were screened out to provide the required effects. A combination of Fraxini Cortex, Calamine and Zinc oxide made in powder forms was impregnated into a pocket of the diaper. Laboratory tests were performed to confirm the antiseptic, antiperspirant and deodourant effects of the materials. A self-control clinical trial on the diaper was organized in an elderly home. Results: Antibacterial effects against Staphylococcus, E. coli and Candida were proven. Antiperspirant effects were confirmed using acetylcholinesterase inhibitor testings. Volunteers using the Sudoscan machine further demonstrated the weak antiperspirant effects of the herbs. A pilot study on 31 dependent diaper users gave positive feedbacks of more comfort, less leakage, odour and better skin conditions. The overall satisfaction reached 79%. Conclusion: A special diaper with antiseptic, antiperspirant and deodourant effects could be created with inexpensive herbal powder impregnated and could be recommended to the older and frail older people with urinary incontinence.

关键词： Urinary Incontinence Older And Frail Older Toilet Assistance Rehabilitation Adult Diaper

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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The immunological roles of human γδ-T Cells in Epstein-Barr Virus infection-induced diseases

The immunological roles of human γδ-T Cells in Epstein-Bar...

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第十一届全国免疫学学术大会

作者： Xiang Zheng Liu Yinping Zheng Jian lam Kowk-Tai Chen Qingyun Wang Xiwei Ni Ke Wen Kun lau Yu-Lung Tu Wenwei Department of Paediatrics and Adolescent Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Biomedical Translational Research Institute The Jinan University

Epstein-Barr virus(EBV)is a herpesvirus that latently infects human B cells in most individuals and a leading cause of several human malignancies,such as EBV-induced B cell lymphoproliferative disorders(EBV-LPD).Human Vγ9Vδ2-T cells represent a minor but crucial population in immune system and act as an important component of immune effector cells that contribute to immunosurveillance against viral ***,the immunological

关键词： γδ-T cell EBV infection viral immunology tumor immunology

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Targeting human Vγ9Vδ2-T cells to control Epstein-Barr virusinduced B cell lymphoproliferative disease

Targeting human Vγ9Vδ2-T cells to control Epstein-Barr vir...

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第九届全国免疫学学术大会

作者： Zheng Xiang Yinping Liu Jian Zheng Aizhen Lv Yulong Gao Kowk-Tai lam Godfrey Chi-Fung Chan Yu-Lung lau Wenwei Tu Laboratory for Translational Immunology Department of Pediatrics & Adolescent MedicineLi Ka Shing Faculty of Medicinethe University of Hong Kong

Epstein-Barr virus-induced lymphoproliferative disease(EBV-LPD)after transplantation remains a serious and lifethreatening ***,we showed that the aminobisphosphonate pamidronate-expanded human Vγ9Vδ2-T cells efficie...

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Pandemic of the aging society—sporadic cerebral small vessel disease

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Chinese Medical Journal 2021年第2期134卷 143-150页

作者： Alexander Yuk Lun lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok Division of Neurology Department of Medicine and TherapeuticsThe Faculty of MedicineThe Chinese University of Hong KongHong KongChina Gerald Choa Neuroscience Centre Faculty of MedicineLui Che Woo Institute of Innovative MedicineThe Chinese University of Hong KongHong KongChina Faculty of Medicine School of Biomedical SciencesLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina Margaret Cheung K.L.Cheung Research Centre for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhenGuangdongChina.

Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging *** widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic *** this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD.

关键词： Cerebral small vessel disease Clinical spectrum Pathophysiology

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Low-Cost High-Performance 10 G Transmitter and Receiver Optical Subassembly

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光学学报 2003年第S1期23卷 607-608页

作者： K.S. Cheng E. Cheung R. Cheung S. Cheung A. Chow C.W. Fan H.W. Ho A. Hui M.W.K. Mak S.K. lam S.L. lau K.S. Lee A. Siu S.K. Yau F. Tong Hong Kong Applied Science and Technology Research Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChina Also at the Information Engineering Department The Chinese University of Hong Kong Shatin Hong Kong China

We describe briefly here the recent R&D activities in the optical subassembly packaging technologies at the Hong Kong Applied Science and Technology Research Institute (ASTRI). We have designed, developed and prototyped multiple of low-cost high performance packages for serial and parallel transmitters and receivers, in particular, the novel chip-in-plastic (CiP) package designed for 10G serial transmission for data communications.

关键词： Science and Technology serial transmission data communications high performance Hong Kong

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Review of vedolizumab for the treatment of ulcerative colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第1期7卷 107-111页

作者： Michelle SY lau Her Hsin Tsai IBD Unit Gastroenterology Department Castle Hill Hospital HEY NHS Trust

The review summarises the key data on the efficacy and the safety of vedolizumab in the management of ulcerative colitis.

关键词： Ulcerative colitis Vedolizumab Biological therapy Pharmacology Safety and efficacy

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Towards creep property improvement of selective laser melted Ni-based superalloy IN738LC

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Journal of Materials Science & Technology 2022年第17期112卷 301-314页

作者： H.Y.Song M.C.lam Y.Chen S.Wu P.D.Hodgson X.H.Wu Y.M.Zhu A.J.Huang Monash Centre for Additive Manufacturing 15-17 Normanby RdNotting HillVIC 3168Australia Department for of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia Monash Centre for Electron Microscopy 10 Innovation WalkClaytonVIC 3800Australia Institute for Frontier Materials Deakin UniversityVIC 3216Australia

Nickel-based superalloy IN738LC produced by selective laser melting(SLM)exhibits inferior hightemperature creep properties than its cast counterparts due to relatively smaller grain size,particularly for the plane normal to the building *** work studied effects of post heating strategy on the microstructure and especially the grain size to improve the high temperature creep *** asbuilt microstructure exhibited a fine grain size and large quantities of MC carbides that could effectively hinder grain *** was found that unconventional two-step heat treatments could lead to substantial grain growth,and the effect is particularly prominent at a specific *** ease of grain growth was explained after classifying the microstructural evolution(boundary carbide transformation)during each heating step and related to the reduced grain boundary pinning force from MC *** tests validated the effect of the new heat treatment scheme on the SLM-processed IN738LC at 850℃.An extended creep fracture life(1.5 to 4 times improvement)and lower secondary creep rates were achieved with samples subjected to the newly optimized two-step heat *** complete creep curves are also firstly presented for SLM-IN738LC,confirming the effectiveness of grain growth and highlighting the importance of dedicated heat treatment for SLM superalloys.

关键词： Selective laser melting IN738LC alloy Creep properties Heat treatments Grain structure

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The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice

The Therapeutic Effect of Pamidronate on Lethal Avian Influe...

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第十届全国免疫学学术大会

作者： Jian Zheng Wai-Lan Wu Yinping Liu Zheng Xiang Ming Liu Kwok-Hung Chan Siu-Ying lau Kwok-Tai lam Kelvin Kai-Wang To Joseph Fuk-Woo Chan Lanjuan Li Honglin Chen Yu-Lung lau Kwok-Yung Yuen Wenwei Tu Department of Paediatrics & Adolescent Medicine University of Hong Kong State Key Laboratory of Emerging Infectious Diseases Department of Microbiology University of Hong Kong Guangzhou Institute of Respiratory Diseases Guangzhou Medical University State Key Laboratory for Diagnosis and Treatment of Infectious Diseases first Affiliated HospitalCollege of Medicine Zhejiang University

Objective:A novel avian influenza virus H7N9 infection occurred among human populations since *** thelack of sustained human-to-human transmission limited the epidemics caused by H7N9,the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent *** this study,we evaluated the potential of pamidronate,a pharmacological phosphoantigen that can specifically boost human Vdelta2-T-cell,on treating H7N9 virus-infected humanized ***:H7N9-infected humanized mice were treated with a human equivalent dose of pamidronate or saline of equivalent volume via injected intraperitoneal injection,or oseltamivir or saline of equivalent volume by oral *** weight change and survival of infected mice were monitored *** indicated time points,lungs from different groups were harvested for pathology examination,while the viral loads and the levels of human pro-inflammatory cytokines and chemokines in the supernatants of homogenized lung tissue were ***:Our results showed that intraperitoneal injection of pamidronate could potently decrease the morbidity and mortality of H7N9-infected mice through controlling both viral replication and inflammation in affected *** importantly,pamidronate treatment starting from 3 days after infection could still significantly ameliorate the severity of diseases in infected mice and improve their survival chance,whereas orally oseltamivir treatment starting at the same time showed no therapeutic *** for the mechanisms underlying pamidronate-based therapy,our in vitro data demonstrated that its antiviral effects were mainly mediated by human Vdelta2-T-cell through their secretion of IFN-γand cytotoxicity against virus-infected host cells dependent on the expressions of perforin,granzyme B and ***:As pamidronate has been used for osteoporosis treatment for more than 20 years,pamidr

关键词： Vdelta2-T cell Amidronate Oseltamivir Humanized mice

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Two-photon photopolymerization directly initiated by spiropyran photochromic molecules

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Light(Advanced Manufacturing) 2023年第1期4卷 12-22页

作者： Dandan Ge Jean Aubard Erell Bodinier Safi Jradi Stéphanie lau-Truong Nordin Felidj Renaud Bachelot Anne-laure Baudrion Light nanomaterialsnanotechnologies(L2n)LaboratoryCNRS EMR7004Universitéde Technologie de Troyes12 rue Marie Curie10004 Troyes CedexFrance UniversitéParis Cité CNRSITODYSF-75013 ParisFrance

Here,we report the ability of spiropyrans to initiate two-photon polymerization(TPP)for the first time in the *** comparison and synergies between the spiropyran photochromic molecule of interest,namely 6-nitro-BIPS,and well-known photoinitiators of radical photopolymerization have been *** spiropyran(SPy)molecule can initiate TPP in the presence of trifunctional acrylic monomers and create true 3D *** comparison with Irgacure 819,a well-known Type-I photoinitiator,shows that SPy has a comparable capability for *** addition,the combination of SPy with methyl diethanolamine increased the reactivity of both one-and two-photon *** the last section,we discuss which SPy isomer is the active photochromic species capable of generating radicals for initiating two-photon polymerization.

关键词： Spiropyran Direct laser writing Two-photon-photopolymerization Photochromism

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