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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-jin Liao Zhu Zhuo Qing Li Yoshihito Shiota jonathan p.hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World premier International(WpI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular photochromic X-ray induced Anion-directed folding Electron-deficient viologens

Update on nutritional status,body composition and growth in paediatric inflammatory bowel disease

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World journal of Gastroenterology 2014年第12期20卷 3191-3197页

作者： Rebecca j hill Children’s Nutrition Research Centre Queensland Children’s Medical Research Institute The University of QueenslandHerston School of Medicine The University of QueenslandHerston

Growth and nutritional status are important issues in paediatric inflammatory bowel disease(IBD).While linear growth is easy to assess,nutritional status is more complicated,with reports often compromised by the use of simple measures,such as weight and the body mass index,to assess nutritional status rather than more appropriate and sophisticated techniques to measure body *** review is an update on what is currently known about nutritional status as determined by body composition in paediatric ***,this review will focus on the impact of biologics on growth in paediatric *** lean mass deficits have been reported in children with IBD compared with controls,and there is evidence these deficits persist over ***,data imply that gender differences exist in body composition,both at diagnosis and in response to *** respect to growth improvements following treatment with biologics,there are conflicting *** some studies report enhancement of growth,others do *** relationship between disease severity,impaired growth and the requirement for biologics needs to be considered when interpreting these ***,key features associated with improvements in growth appear to be successful clinical response to treatment,patients in early stages of puberty,and the presence of growth failure at the onset of treatment.

关键词： Crohn’ s disease, Ulcerative colitis, Lean mass, pubertal status, Infliximab, Inflammatory bowel disease

A Multi-parametric programming Based Analytic Method to Compute Consumer Offer Curve for Reserves

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journal of Modern power Systems and Clean Energy 2022年第2期10卷 542-546页

作者： Weiye Zheng David j.hill Wenchuan Wu the School of Electrical power Engineering South China University of TechnologyGuangzhouChina the Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina the Department of Electrical Engineering Tsinghua UniversityBeijingChina

Abstract-An analytic method is proposed to compute the price-reserve offer curve at the consumer level in hierarchical direct load *** convexification of the consumer reserve provision is examined,and the analytic expression of the optimal solution within each critical region is ***,based on multi-parametric programming,a combinatorial enumeration method in conjunction with efficient reduction and pruning strategy is proposed to compute the optimal response of consumers in the whole price *** tests along with an application example in the bi-level aggregator pricing problem demonstrate the merit of this method.

关键词： Direct load control multi-parametric programming price-reserve offer curve analytic solution

Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： Manickam Ashokkumar Wenwen Mei jackson j.p.terson Yuriko Harigaya David M.Murdoch David M.Margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao jiang Edward p.Browne Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXp1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal primary CD4þT cell Single-cell multiomics HIV-regulating factor Machine learning

Advances in Stability Theory for Complex Systems and Networks

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Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma

第二十七届中国控制会议

作者： hill David j. Research School of Information Sciences and Engineering Australian National University

ISBN: (纸本)9787811243901

Throughout natural and engineered systems,questions about stability always *** a power network avoid blackouts?Will the Internet avoid traffic congestion?Will a species population survive?Engineered systems now have features comparable to living systems,namely massive scale,high degrees of nonlinearity,uncertainty and *** systems are summarized as being *** important class of such systems has a well-defined network structure where large numbers of nodes,typically described by nonlinear dynamical systems,are connected by *** theory faces many challenges in providing tools to assess stability and instability for such complex *** this assessment must allow for layers of feedback control which have been implemented to regulate local and global *** paper will describe the advancement of stability theory to deal with complex systems with some emphasis on interconnected systems featuring feedback and network structures.

关键词： Stability Complex systems Networks

来源： cnki会议评论

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Neural Regeneration Research 2016年第6期11卷 922-923页

作者： Lisa j hill Zubair Ahmed Ann Logan Neuroscience and Ophthalmology University of Birmingham

In this perspective,we discuss the use of an anti-fibrotic agent Decorin to treat established fibrosis associated with glaucoma originally published by hill et al.（2015）.Glaucoma describes a group of progressive opt... 详细信息

关键词： glaucoma trabecular originally irreversible progressive optic outflow ganglion progression elevated

Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.D.james j.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

Optimal coordinated voltage control of power systems

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journal of Zhejiang University-Science A(Applied physics & Engineering) 2006年第2期7卷 257-262页

作者：李艳君 hill David j 吴铁军 Institute of Intelligent Systems and Decision Making Zhejiang University Hangzhou 310027 China Department of Electronic Engineering City University of Hong Kong Hong Kong China

An immune algorithm solution is proposed in this paper to deal with the problem of optimal coordination of local physically based controllers in order to preserve or retain mid and long term voltage stability. This problem is in fact a global coordination control problem which involves not only sequencing and timing different control devices but also tuning the parameters of controllers. A multi-stage coordinated control scheme is presented, aiming at retaining good voltage levels with minimal control efforts and costs after severe disturbances in power systems. A self-pattem-recognized vaccination procedure is developed to transfer effective heuristic information into the new generation of solution candidates to speed up the convergence of the search procedure to global optima. An example of four bus power system case study is investigated to show the effectiveness and efficiency of the proposed algorithm, compared with several existing approaches such as differential dynamic programming and tree-search.

关键词： power systems Voltage control Immune algorithm Global optimization

Semi-transparent,flexible,and electrically conductive silicon mesh by capillarity-driven welding of vapor-liquid-solid-grown nanowires over large areas

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Nano Research 2020年第5期13卷 1465-1471页

作者： Thomas A.Celano Seokhyoung Kim David j.hill james F.Cahoon Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599-3290USA

Bottom-up synthesis of semiconductor nanowires(NWs)by the vapor-liquid-solid(VLS)mechanism has enabled diverse technological applications for these *** metallic NWs,however,it has been challenging to form large-area interconnected NW ***,we generate centimeter-scale meshes of mechanically and electrically interconnected Si NWs by sequentially growing,collapsing,and joining the NWs using a capillarity-driven welding *** fabricate meshes from VLS-grown NWs ranging in diameter from 20 to 100 nm and find that the meshes are three-dimensional with a thickness ranging from^1 to^10 microns depending on the NW *** extinction measurements reveal that the networks are semi-transparent with a color that depends on the absorption and scattering characteristics of individual ***,active voltage contrast imaging of both centimeter-and micron-scale meshes reveals widespread electrical *** a sacrificial layer,we demonstrate that the mesh can be liberated from the growth substrate,yielding a highly flexible and transparent *** transport measurements both on the growth substrate and on liberated,flexible films reveal electrical conduction across a centimeter scale with a sheet resistance of^160-180 kΩ/square that does not change significantly upon *** the ability to encode complex functionality in semiconductor NWs through the VLS process,we believe these meshes of networked NWs could find application as neuromorphic memory,electrode scaffolds,and bioelectronic interfaces.

关键词： semiconductor nanowire conductive network flexible electronics welding thermal annealing active-voltage contrast