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A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

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International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel Rafael O.Moreno-Tortolero Mark R.Shannon Nicola West darryl hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

关键词： interface den surface

A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota Jonathan P.hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World Premier International(WPI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(Sdas)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular Photochromic X-ray induced Anion-directed folding Electron-deficient viologens

Effect of self-modeling and self-controlled feedback on the performance of professional swimmers and waterpolo players

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Sports Medicine and Health Science 2024年第2期6卷 167-172页

作者： Masoud Mirmoezzi Mansour Sayyah Morteza Taheri Khadijeh Irandoust Mandana Sangari Fatemeh Mirakhori Ali Seghatoleslami Lee hill Katja Weiss Beat Knechtle Amine Ghram Faculty of Physical Education and Sport Science Islamic Azad UniversityTehranIran Kashan University of Medical Sciences KashanIran Department of Behavioral and Cognitive saciences in Sport University of TehranTehranIran Islamic Azad University Chalous BranchMazandaranIran University of Birjand BirjandIran Division of Gastroenterology&Nutrition Department of PediatricsMcMaster UniversityHamiltonCanada Medbase St.Gallen Am Vadianplatz St.GallenSwitzerland Institute of Primary Care University of ZurichZurichSwitzerland Cardiac Rehabilitation Department Heart HospitalHamad Medical CorporationDohaQatar Healthy Living for Pandemic Event Protection(HL-PIVOT)Network ChicagoIllUSA Department of Sport Sciences Imam Khomeini International UniversityQazvinIran

Self-modeling(SM)and self-control(SC)feedback can be presented as two solutions for learning ***,the aim of the present study was to investigate the effects of SM and SC feedback on 100-m freestyle performance of professional swimmers and waterpolo players.25 elite male swimmers and waterpolo players,were randomly assigned to four groups:swimmer group with SM,swimmer group with SM and SC feedback,waterpolo players group with SM,and waterpolo players group with SM and SC feedback.100-m freestyle times and performance were *** and SC feedback for the participants were utilized at the acquisition *** device used included a Lenovo B570 laptop and an Exilim ZR200 canon *** and SC feedback presented to the swimmers and waterpolo players led to improved speed and results,and the effect of presenting SM with SC feedback to swimmers had better *** conclusion,the present study indicates that SC modeling of watching video is a suitable method for professional *** polo trainers can also use SM and SC feedback to enhance their players'swimming technique.

关键词： Feedback Self-control Self-modeling Swimming Water polo

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov Todd Rosen Jennifer hill Meena Khandelwal Victors Kurtenoks Brendan Francy Noune Sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. Purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 240/7 - 286/7 gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10−4. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity Spontaneous Preterm Birth Tactile Ultrasound Probe

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林肯路1111号扩建

世界建筑导报 2024年第3期39卷 108-110页

作者： Robin hill(摄) 不详

林肯大道1111号是一个经过改造改变了其原有用途的框架结构。经过数年的运作,这座位于林肯大道西端的建筑成功地进行了经济转型,通过进一步的开发,在对现有建筑进行改造的同时还增加了一个包含商业零售的新建筑,并且在原太阳信托公司办... 详细信息

林肯大道1111号是一个经过改造改变了其原有用途的框架结构。经过数年的运作,这座位于林肯大道西端的建筑成功地进行了经济转型,通过进一步的开发,在对现有建筑进行改造的同时还增加了一个包含商业零售的新建筑,并且在原太阳信托公司办公楼北面的空地上建起了一栋住宅楼。新建筑平衡了两个看似矛盾的目标。一方面,它需要一个强大和清晰的特征以吸引林肯大道上的行人。另一方面,新建筑是现有总体规划的扩建部分,它并没有与1111号停车场形成竞争的局面。

关键词：经济转型信托公司框架结构商业零售现有建筑扩建部分总体规划停车场

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记忆中的食物

中学生英语 2024年第35期 13-15页

作者： Miriam hill 杨舟

"Mom,thanks for making barbecued meatballs and rice before I left,"said Betsy with *** hugged me goodbye while her dad finished loading2the car with packed *** daughter was moving from our home in Florida to her apartment in Washington,*** begin her new job.“I'm really going to miss your cooking,"she added.“妈妈,谢谢你在我离开之前做了烤肉丸子和米饭。”贝齐泪眼朦胧地说。她和我拥抱道别,而她的父亲正在往车里装打包好的箱子。我女儿要从我们在佛罗里达的家搬到她在华盛顿特区的公寓以便开始她的新工作。“我真的会想念你做的饭菜的。”她补充道。

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ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma

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中国神经肿瘤杂志 2003年第3期1卷 161-161页

作者： Gilbertson RJ hill da Hernan R Kocak M Geyer R Olson J Gajjar A Rush L Hamilton RL Finkelstein SD Pollack IF Brain Tumor Program and Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee 38105

PURPOSE:This study was conducted to investigate the incidence of ERBB1 amplification and overexpression in samples of diffusely infiltrative (WHO grades Ⅱ-Ⅳ) pediatric brain stem glioma (BSG) and determine the relationship of these abnormalities to expression and mutation of TP53 and tumor grade. Experimental Design: After central pathology review, the incidence of ERBB1 amplification and overexpression was determined in 28 samples (18 surgical biopsy and 10 postmortem specimens) of BSG using quantitative PCR and immunohistochemistry,

关键词： in of BSG ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Electrically pumped metallic and plasmonic nanolasers

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Chinese Physics B 2018年第11期27卷 158-166页

作者： Martin T hill School of Electrical Electronic and Computer Engineering The University of Western Australia

In recent years, there have been a significant number of demonstrations of small metallic and plasmonic lasers. The vast majority of these demonstrations have been for optically pumped devices. Electrically pumped devices are advantageous for applications and could demonstrate concepts not amenable for optical pumping. However, there have been relatively few demonstrations of electrically pumped small metal cavity lasers. This lack of results is due to the following reasons： there are limited types of electrically pumped gain media available; there is a significantly greater level of complexity required in the fabrication of electrically pumped devices; finally, the required components for electrical pumping restrict cavity design options and furthermore make it intrinsically more difficult to achieve lasing. This review looks at the motivation for electrically pumped nanolasers, the key issues that need addressing for them to be realized, the results that have been achieved so far including devices where lasing has not been achieved, and potential new directions that could be pursued.

关键词： semiconductor lasers laser diode microcavity and microdisk laser integrated optics