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Reconciling the Earth’s stratigraphic record with the structure of our galaxy

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Geoscience Frontiers 2019年第6期10卷 2147-2151页

作者： Michael Gillman hilary Erenler School of Life Sciences University of LincolnUK University of Northampton UK

The passage of our Solar System through the spiral arms has been implicated as a contributor to global environmental *** suggestion of a consistent structure within the arms,informed by density wave theory,raises the possibility of repeating patterns of events at each arm *** we test the hypothesis that the structure of the arms of our galaxy influences the stratigraphic record on *** construct independent structural and temporal models and colbine these to compare the timings of arm tracers,materials from the earliest Solar System and events on Earth,including the largest *** find that a recurring sequence of events across the four arms emerges with an average arm-passing time of 188 million *** suggest that the multiple temporal overlaps of events across arms,and their alignment with arm tracers and the earliest Solar System,presents an opportunity for a greater understanding of both Earth-based phenomena and galactic structure.

关键词： Spiral arms Stratigraphy Superchron Earliest Solar System Extinctions Glaciations

Air pollution and liver cancer: A systematic review

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Journal of Environmental Sciences 2023年第4期126卷 817-826页

作者： Ting Gan hilary Bambrick Shilu Tong Wenbiao Hu School of Public Health and Social Work Queensland University of TechnologyQueensland 4059Australia National Centre for Epidemiology and Population Health Australian National UniversityAustralian Capital Territory 2601Australia Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Air pollution has previously been linked to several adverse health outcomes, but the potential association between air pollution and liver cancer remains unclear. We searched Pub Med, EMBASE, and Web of Science from inception to 10 October 2021, and manually reviewed the references of relevant papers to further identify any related literature investigating possible associations between air pollution and liver cancer. Risk estimates values were represented by statistical associations based on quantitative analyses. A total of 13cohort studies obtained from 11 articles were included, with 10,961,717 participants. PM_(2.5)was the most frequently examined pollutant(included in 11 studies), followed by NO_(2)and NOx(included in 6 studies), and fewer studies focused on other pollutants(PM_(2.5)absorbance,PM_(10), PM_(2.5–10), O_(3), and BC). In all the 16 associations for liver cancer mortality, 14 associations reported the effect of PM_(2.5)on liver cancer mortality. Eight associations on PM_(2.5)were significant, showing a suggestive association between PM_(2.5)and liver cancer mortality. Among24 associations shown by risk estimates for liver cancer incidence, most associations were not statistically significant. For other air pollutants, no positive associations were presented in these studies. PM_(2.5)was the most frequently examined pollutant, followed by NO_(2)and NOx, and fewer studies focused on other pollutants. PM_(2.5)was associated with liver cancer mortality, but there was no association for other air pollutants. Future research should use advanced statistical methods to further assess the impact of multiple air pollutants on liver cancer in the changing socio-environmental context.

关键词： Air pollution PM_(2.5) Liver cancer Incidence Mortality Systematic review

Dexamethasone-Inducible Green Fluorescent Protein Gene Expression in Transgenic Plant Cells

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Genomics, Proteomics & Bioinformatics 2004年第1期2卷 15-23页

作者： hilary Collver Katherine Kinken Department of Biology Howell Science ComplexEast Carolina UniversityGreenvNC 27858-4353USA.Department of BiologyHowell Science ComplexEast Carolina UniversityGreenvNC 27858-4353USA.

Genomic research has made a large number of sequences of novel genes orexpressed sequence tags available. To investigate functions of these genes, a system for conditionalcontrol of gene expression would be a useful tool. Inducible trans-gene expression that uses greenfluorescent protein gene (gfp) as a reporter gene has been investigated in transgenic cell lines ofcotton (COT; Gossypium hirsutum L.), Fraser fir [FRA; Abies fraseri (Pursh) Poir], Nordmann fir(NOR; Abies nord-manniana Lk.), and rice (RIC; Oryza sativa L. cv. Radon). Transgenic cell lineswere used to test the function of the chemical inducer dexamethasone. Inducible transgene expressionwas observed with fluorescence and confocal microscopy, and was confirmed by northern blotanalyses. Dexamethasone at 5 mg/L induced gfp expression to the nearly highest level 48 h aftertreatment in COT, FRA, NOR, and RIC. Dexamethasone at 10 mg/L inhibited the growth of transgeniccells in FRA and NOR, but not COT and RIC. These results demonstrated that concentrations of inducerfor optimum inducible gene expression system varied among transgenic cell lines. The inducible geneexpression system described here was very effective and could be valuable in evaluating thefunction of novel gene.

关键词： inducible gene expression confocal microscopy transcriptional activatorGVG fluorescence microscopy

The Adaptation of Chinese Split-Site Business Students to British Classrooms:A Cross-Cultural Perspective

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Frontiers of Education in China 2018年第3期13卷 401-425页

作者： WANG Liyuan hilary NESI Foreign Languages School Jiangxi University of Finance and EconomicsNanchang 330013China School of Humanities Coventry UniversityCoventry CV15FBEngland

Chinese business education differs from British business education in many *** the whole,it focuses on the acquisition of theoretical knowledge,whereas British business education places far more emphasis on soft management skills and *** paper examines a split-site business degree program offered by a Chinese international school and a British business school,and explores the attitudes and expectations of the Chinese participants and their Chinese and British lecturers from an“English for specific purposes”*** study conducted classroom observation,semi-structured interviews,and a questionaire survey,and identifies areas of difficulty for Chinese business students in the UK,in particular regarding their beliefs about teacher and student roles,their learning priorities and learning strategies,and their“goal-oriented”approach to discussion,which is at odds with the more collaborative and exploratory Western discussion *** findings have implications for pre-sessional and in-sessional English course design,the management of split-site business degree programs,the teaching of Chinese students,and the enhancement of learning experiences generally in international business programs.

关键词： Chinese students tertiary business education cultures of learning English for specific purposes

An indisputable link between climate emergency and human health

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Advances in Climate Change Research 2023年第6期14卷 811-813页

作者： Shilu TONG hilary BAMBRICK Xiao-Yuan YAO National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China School of Public Health and Social Work Queensland University of TechnologyBrisbane QLD 400lAustralia National Centre for Epidemiology and Population Health The Australian National UniversityCanberra ACT 2600Australia

Climate change is one of the greatest health challenges that humanity *** Intergovernmental Panel on Climate Change estimates that 3.3 billion people worldwide are highly vulnerable to climate change and confront greater health risks as a consequence(IPCC,2023).The fact that climate change is a health issue is finally being widely recognised.

关键词： climate Climate consequence

Say no to drugs: wait and watch strategy for medications used in the neonatal intensive care unit (NICU)

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World Journal of Pediatrics 2020年第6期16卷 560-561页

作者： hilary Tice Shabih Manzar Nitin Walyat Kelsey Trimble University of Louisiana at Monroe.1501 Kings Highway Shreveport Campus1725 Claiborne Avenue.Shreveport.LA 71103USA Division of Neonatology Louisiana State University Health Sciences Shreveport1501 Kings HighwayShreveport.LA 71103USA Department of Pharmacy Ochsner-LSU Health Shreveport1541 Kings HighwayShreveportLA 71103USA

From the presentation of gray baby syndrome with chloramphenicol use to gasping baby syndrome with exposure from benzyl alcohol in bacteriostatic flushes,historical clinical precedence has shown that babies cared for in the neonatal intensive care unit(NICU)are at higher risk of adverse effects from medication administration than other populations[1,2].Historical precedence led to a discussion amongst the multi-disciplinary team questioning whether medications are used excessively in the NICU.A recent review paper by Hsieh et al.[3]has elaborated on this question in detail,in which a downward trend in the use of certain medications was shown.

关键词： medication drugs downward

Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies

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Neural Regeneration Research 2021年第8期16卷 1560-1561页

作者： Jie Zhang hilary Grosso Jasutkar M.Maral Mouradian Robert Wood Johnson Medical School Institute for Neurological Therapeutics and Department of NeurologyRutgers Biomedical and Health SciencesPiscatawayNJUSA

Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of α-synuclein(α-Syn) aggregates in Lewy bodies(LBs) and Lewy neurites(LNs) in Parkinson's disease(PD) and dementia with Lewy bodies(DLB), and in glial cytoplasmic inclusions in multiple system atrophy(MSA). α-Syn is a 140 amino acid intrinsically disordered protein, which tends to self-aggregate and form fibrils in these neuropathological hallmark inclusions. Several lines of evidence sug gest that misfolding and aggregation of α-Syn is a critical step leading to neuronal dysfunction and death.

关键词： atrophy therapeutic aggregation

Bio-inspired robotic manta ray powered by ionic polymer-metal composite artificial muscles

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International Journal of Smart and Nano Materials 2012年第4期3卷 296-308页

作者： Zheng Chen Tae I.Um hilary Bart-Smith Department of Mechanical and Aerospace Engineering University of VirginiaCharlottesvilleVA 22904USA

The manta ray(Manta birostris)is the largest species of rays that demonstrates excellent swimming capabilities via large-amplitude flapping of its pectoral *** this article,we present a bio-inspired robotic manta ray using ionic polymer–metal composite(IPMC)as artificial muscles to mimic the swimming behavior of the manta *** robot utilizes two artificial pectoral fins to generate undulatory flapping motions,which produce thrust for the *** pectoral fin consists of an IPMC muscle in the leading edge and a passive polydimethylsiloxane membrane in the trailing *** the IPMC is actuated,the passive polydimethylsiloxane membrane follows the bending of the leading edge with a phase delay,which leads to an undulatory flapping motion on the *** of the pectoral fin has shown that the fin can generate flapping motions with up to 100%tip deflection and 40◦twist *** test the free-swimming performance of the robot,a light and compact on-board control unit with a lithium ion polymer battery has been *** experimental results have shown that the robot can swim at 0.067 BL/s with portable power consumption of under 2.5 W.

关键词： ionic polymer-metal composite artificial muscle bio-inspired robot

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Tsinghua Science and Technology 2020年第5期25卷 604-613页

作者： Jinchang Hu Jinfu Chen Lin Zhang Yisong Liu Qihao Bao hilary Ackah-Arthur Chi Zhang the School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang 212013China

Developing secure software systems is a major challenge in the software industry due to errors or weaknesses that bring vulnerabilities to the software *** address this challenge,researchers often use the source code features of vulnerabilities to improve vulnerability *** the success achieved by these techniques,the existing studies mainly focus on the conceptual description without an accurate definition of vulnerability *** this study,we introduce a novel and efficient Memory-Related Vulnerability Detection Approach using Vulnerability Features (MRVDAVF).Our framework uses three distinct strategies to improve vulnerability *** the first stage,we introduce an improved Control Flow Graph (CFG) and Pointer-related Control Flow Graph (PCFG) to describe the features of some common vulnerabilities,including memory leak,doublefree,and ***,two algorithms,namely Vulnerability Judging algorithm based on Vulnerability Feature (VJVF) and Feature Judging (FJ) algorithm,are employed to detect memory-related ***,the proposed model is validated using three test cases obtained from Juliet Test *** experimental results show that the proposed approach is feasible and effective.

关键词： vulnerability feature Control Flow Graph(CFG) Memory Leak(ML) Double-Free(DF) Use-After-Free(UAF)