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Epidemiological, Clinical and Paraclinical Profile of Osteoarthritis of the Lower Limbs in Obese Patients at the Cocody University Teaching Hospital

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第2期14卷 69-76页

作者： Nzima Brice Kollo Aboubakar Bamba¹ Aboubacar Sidiki Condé Nzima hilary Ngon Kanbaye medom Ada Nina Kpami Yaya Coulibaly Kan Joseph Enoch Koffi Ehaulier Soh Christian Louis Kouakou mohamed Diomandé¹ Edmond Eti Rheumatology Department Cocody University Hospital Abidjan C&#244te d&#8217Ivoire Internal medicine Department Yaounde University Hospital Yaounde Cameroon Rheumatology Department Bouake University Hospital Bouake C&#244te d&#8217Ivoire

Objective: To describe the epidemiological, clinical and paraclinical characteristics of osteoarthritis of the lower limbs in obese patients at the Cocody University Teaching Hospital. methodology: This was an analytical cross-sectional study carried out in the rheumatology department of the Cocody UTH in Abidjan (Ivory Coast) from march 1 to April 30 2023. Patients who came for rheumatology consultation presenting with mechanical arthralgia of the lower limbs, who were obese, had radiographic images were included. All patients without radiographic images were excluded. Obesity was defined as a body mass index (BmI) greater than or equal to 30 kg/m. The Chi2 test was used to compare proportions and determine the existence of associations between osteoarthristis and obesity, obesity severity and radiographic stage of osteoarthritis as well as the functional impact. A p-value below a predefined threshold (p = 0,05) indicates a significant relationship between the variables. Result: Out of 185 patients received for osteoarthritis of the lower limbs during the study period, 136 were obese (74%). There were 115 women (84.6%) with an average age of 56.03 with a standard deviation of 12.72 years (extremes: 22 and 84 years). The main socio-professional category was the informal sector (30%). The majority of patients had a low socio-economic level (80.2%) and lived in urban areas (92.6%). The most common past medical history was hypertension (33.08%) followed by peptic ulcer disease (16.91%). Patients had a body mass index class 1 (81.6%), class 2 (15.40%) and class 3 (2.90%). The average duration of symptom progression until diagnosis was 11 months. Genu varum was the main static disorder (56.10%) and the knee joint was the dominant topography (90.4%) with a bilateral localization (80%). The average Lequesne index was greater than 8 (59.5%). The Kellgren and Lawrence radiographic stages were stage 1 (9.20%), stage 2 (46.90%), stage 3 (29.20%) and stage 4 (6.90%).

关键词： Osteoarthritis Lower Limbs Obesity Abidjan

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Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies

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Neural Regeneration Research 2021年第8期16卷 1560-1561页

作者： Jie Zhang hilary Grosso Jasutkar m.maral mouradian Robert Wood Johnson medical School Institute for Neurological Therapeutics and Department of NeurologyRutgers Biomedical and Health SciencesPiscatawayNJUSA

Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of α-synuclein(α-Syn) aggregates in Lewy bodies(LBs) and Lewy neurites(LNs) in Parkinson's disease(PD) and dementia with Lewy bodies(DLB), and in glial cytoplasmic inclusions in multiple system atrophy(mSA). α-Syn is a 140 amino acid intrinsically disordered protein, which tends to self-aggregate and form fibrils in these neuropathological hallmark inclusions. Several lines of evidence sug gest that misfolding and aggregation of α-Syn is a critical step leading to neuronal dysfunction and death.

关键词： atrophy therapeutic aggregation

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Can color vision variation explain sex differences in invertebrate foraging by capuchin monkeys?

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Current Zoology 2010年第3期56卷 300-312页

作者： Amanda D.mELIN Linda m.FEDIGAN hilary C.YOUNG Shoji KAWAmURA Department of Anthropology University of Calgary Department of Biological Sciences University of Calgary Department of Integrated Biosciences Graduate School of Frontier SciencesUniversity of Tokyo

Invertebrates are the main source of protein for many small-to-medium sized monkeys. Prey vary in size, mobility, degree of protective coveting, and use of the forest, i.e. canopy height, and whether they are exposed or embed themselves in substrates. Sex-differentiation in foraging patterns is well documented for some monkey species and recent studies find that color vision phenotype can also affect invertebrate foraging. Since vision phenotype is polymorphic and sex-linked in most New World monkeys - males have dichromatic vision and females have either dichromatic or trichromatic vision - this raises the possibility that sex differences are linked to visual ecology. We tested predicted sex differences for invertebrate foraging in white-faced capuchins Cebus capucinus and conducted 12 months of study on four free-ranging groups between January 2007 and September 2008. We found both sex and color vision effects. Sex： males spent more time foraging for invertebrates on the ground. Females spent more time consuming embedded, colonial invertebrates, ate relatively more ＂soft＂ sedentary invertebrates, and devoted more of their activity budget to invertebrate foraging. Color Vision： Dichromatic monkeys had a higher capture efficiency of ex- posed invertebrates and spent less time visually foraging. Trichromats ate relatively more ＂hard＂ sedentary invertebrates. We con- elude that some variation in invertebrate foraging reflects differences between the sexes that may be due to disparities in size, strength, reproductive demands or niche preferences. However, other intraspecific variation in invertebrate foraging that might be mistakenly attributed to sex differences actually reflects differences in color vision [Current Zoology 56 （3）： 300-312, 2010].

关键词： male Foraging Female Foraging Cebus Dichromacy Trichromaey Invertebrate Foraging

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Stable isotope analysis of diet confirms niche separation of two sympatric species of Namib Desert lizard

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Integrative Zoology 2016年第1期11卷 60-75页

作者： Ian W.mURRAY hilary m.leas. Robyn S.HETEm Duncan mITCHELL Andrea FULLER Stephan WOODBORNE Brain Function Research Group School of PhysiologyFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Biology Department Whitman CollegeWalla WallaWashingtonUSA iThemba Laboratories GautengSouth Africa Stable Isotope Laboratory Mammal Research InstituteDepartment of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa

We used stable isotopes of carbon and nitrogen to study the trophic niche of two species of insectivorous lizards,the Husab sand lizard Pedioplanis husabensis and Bradfield’s Namib day gecko living sympatrically in the Namib *** measured theδ13C andδ15N ratios in lizard blood tissues with different turnover times(whole blood,red blood cells and plasma)to investigate lizard diet in different *** also measured theδ13C andδ15N ratios in available arthropod prey and plant tissues on the site,to identify the avenues of nutrient movement between lizards and their *** the use of stable isotope mixing models,we found that the two lizard species relied on a largely non-overlapping but seasonally variable array of arthropods:*** primarily fed on termites,beetles and wasps,while *** fed mainly on ants,wasps and *** originating from C3 plants were proportionally higher for *** than for *** during autumn and late autumn/early winter,although not *** to the few available data estimating the trophic transfer of nutrients in ectotherms in mixed C3 and C4/crassulacean acid metabolism(CAm)plant landscapes,we found that our lizard species primarily acquired nutrients that originated from C4/CAm *** work adds an important dimension to the general lack of studies using stable isotope analyses to estimate lizard niche partitioning and resource use.

关键词： Namib Desert niche partitioning Pedioplanis Rhoptropus stable isotopes

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Identification of factors predicting scar outcome after burn injury in children:a prospective case-control study

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Burns & Trauma 2017年第3期5卷 186-198页

作者： hilary J. Wallace mark W. Fear margaret m. Crowe Lisa J. martin Fiona m. Wood Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia M318 35 Stirling Highway Crawley 6009 WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia

Background:There is a lack of rigorous research investigating the factors that influence scar outcome in children. Improved clinical decision-making to reduce the health burden due to post-burn scarring in children will be guided by evidence on risk factors and risk stratification. This study aimed to examine the association between selected patient, injury and clinical factors and the development of raised scar after burn injury. Novel patient factors were investigated including selected immunological co-morbidities (asthma, eczema and diabetes type 1 and type 2) and skin pigmentation (Fitzpatrick skin type). methods:A prospective case-control study was conducted among 186 children who sustained a burn injury in Western Australia. Logistic regression was used to explore the relationship between explanatory variables and a defined outcome measure:scar height measured by a modified Vancouver Scar Scale (mVSS). Results:The overall correct prediction rate of the model was 80.6%;80.9%for children with raised scars (>1 mm) and 80.4%for children without raised scars (≤1 mm). After adjustment for other variables, each 1%increase in%total body surface area (%TBSA) of burn increased the odds of raised scar by 15.8%(95%CI=4.4-28.5%). Raised scar was also predicted by time to healing of longer than 14 days (OR=11.621;95%CI=3.727-36.234) and multiple surgical procedures (OR=11.521;1.994-66.566). Conclusions:Greater burn surface area, time to healing of longer than 14 days, and multiple operations are independently associated with raised scar in children after burn injury. Scar prevention strategies should be targeted to children with these risk factors.

关键词： Burns Wound healing Hypertrophic scar Risk factors Children

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An Effective Long String Searching Algorithm towards Component Security Testing

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China Communications 2016年第11期13卷 153-169页

作者： Jinfu Chen Lili Zhu Zhibin Xie michael Omari hilary Ackah-Arthur Saihua Cai Rubing Huang School of Computer Science and Telecommunication Engineering Jiangsu University School of Electronic and Information Jiangsu University of Science and Technology College of Information and Electrical Engineering China Agricultural University

In the execution of method invocation sequences to test component security,abnormal or normal information is generated and recorded in a monitor log. By searching abnormal information from monitor log,the exceptions that the component has can be determined. To facilitate the searching process,string searching methods could be employed. However,current approaches are not effective enough to search long pattern string. In order to mine the specific information with less number of matches,we proposed an improved Sunday string searching algorithm in this paper. Unlike Sunday algorithm which does not make use of the already matched characters,the proposed approach presents two ideas — utilizing and recycling these characters. We take advantage of all matched characters in main string,if they are still in the matchable interval compared with pattern string,to increase the distance that pattern string moves backwards. Experimental analysis shows that,compared to Sunday algorithm,our method could greatly reduce the matching times,if the scale of character set constituting both main string and pattern string is small,or if the length of pattern string is long. Also,the proposed approach can improve the search effectiveness for abnormal information in component security testing.

关键词： component testing security detection monitor log abnormal information string-searching

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microchimerism in recurrent miscarriage

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Cellular & molecular Immunology 2014年第6期11卷 589-594页

作者： hilary S Gammill mary D Stephenson Tessa m Aydelotte J Lee Nelson Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA Department of Obstetrics & Gynecology University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Chicago Chicago IL USA and Department of Obstetrics and Gynecology University of Illinois at Chicago Chicago IL USA Division of Rheumatolegy University of Washington Seattle WA USA

maternal-fetal cell exchange during pregnancy results in acquisition of microchimerism, which can durably persist in both recipients. Naturally acquired microchimerism may impact maternal-fetal interaction in pregnancy. We conducted studies to ask whether microchimerism that a woman acquired from her own mother is detectable before or during pregnancy in women with recurrent miscarriage. Fetal microchimerism was also assayed. Women with primary idiopathic recurrent miscarriage （n=23） and controls （n=31） were studied. Genotyping was conducted for probands, their mothers and the fetus, a non-shared polymorphism identified and quantitative polymerase chain reaction performed to measure microchimerismin peripheral blood mononuclear cells. Preconception comparisons were made between recurrent miscarriage subjects and controls, using logistic regression and Wilcoxon rank sum. Longitudinal microchimerism in subsequent pregnancies of recurrent miscarriage subjects was described. There was a trend toward lower preconception detection of microchimerism in recurrent miscarriage versus controls, 6% vs. 19% （1/16 vs. 6/31, P=0.2）. During pregnancy, 3111 （27%） of recurrent miscarriage subjects who went on to have a birth had detection of microchimerism from their own mother, whereas neither of two subjects who went on to miscarry had detection （0/2）. This initial data suggest that microchimerism from a woman＇s own mother, while detectable in women with recurrent miscarriage, may differ from controls and according to subsequent pregnancy outcome. Further studies are needed to determine the cell types,quantities and any potential functional role of microchimerism in recurrent miscarriage.

关键词： microchimerism pregnancy recurrent miscarriage reproduction

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Design of a Low-Cost Air Quality monitoring System Using Arduino and ThingSpeak

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Computers, materials & Continua 2022年第1期70卷 151-169页

作者： Anabi hilary Kelechi mohammed H.Alsharif Chidumebi Agbaetuo Osichinaka UbadikeAlex Aligbe Peerapong Uthansakul Raju Kannadasan Ayman A.Aly Department of Aerospace Engineering College of EngineeringAirForce Institute of TechnologyKadunaNigeria Department of Electrical Engineering College of Electronics and Information EngineeringSejong UniversitySeoul05006Korea Department of Electrical Engineering and Information Engineering College of EngineeringCovenant UniversityCanaanlandOtaP.M.B 1023OgunNigeria School of Telecommunication Engineering Suranaree University of TechnologyNakhon RatchasimaThailand Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringChennai602117India Department of mechanical Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia

The impact of daily emissions of gaseous and particulate pollutants of machines and industries on human health and the environment has attracted increasing *** impact has significantly led to a notable increase in mortality in the highly industrialized ***,monitoring air quality and creating public awareness are important for a safer future,which led the governments globally to investmulti-billion in policymaking and solution stratification to address the *** study aims to design a realtime Internet of Things low-cost air quality monitoring *** system utilizes air quality and carbon monoxide sensors for monitoring gaseous ***,the system utilizes an Arduino Nano development board equipped with a WiFi module to effectively send readings to a ThingSpeak online channel platformfor instantaneous and real-time display of air *** ThingSpeak uses HTTP protocols to send emails in raising awareness of poor air *** level of concentration is monitored graphically through channels with the help of ThingSpeak to aid remote *** value is ***,when pollutants have become unhealthy and harmful,the system trips off an alarm,and e-mail notifications are sent to the *** results have shown that the work was successfully implemented a design of a low-cost air quality monitoring system using Arduino and ThingSpeak,showing that an air quality system can be implemented using a low-cost technology,Arduino and ThingSpeak.

关键词： IoT air quality mQ 135 sensor mQ-7 sensor air pollution

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CHECKING CONSISTENCY IN INFORmATION mODELS BY USING CONSTRAINT PROGRAmmING

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Transactions of Nanjing University of Aeronautics and Astronautics 2005年第1期22卷 30-37页

作者：方捷 KAHN hilary J CARPENTER Andy 曼彻斯特大学计算机学院曼彻斯特M139PL英国

This paper addresses the issue of checking consistency in information models. A method based on constraint programming is proposed for identifying inconsistency or proving consistency in information models. The system described here checks information models written in the ISO standard information modelling language EXPRESS. EXPRESS is part of the ISO STEP standard used in the manufacturing and process industries. This paper describes the checking procedure, including EXPRESS model formalization, constraint satisfaction problem (CSP) derivation from the formalized model and satisfaction checking of the derived CSPs. This paper shows a new domain in which constraint programming can be exploited as model verification and validation.

关键词： EXPRESS model constraint programming model verification

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The Gillenia trifoliata genome reveals dynamics correlated with growth and reproduction in Rosaceae

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Horticulture Research 2021年第1期8卷 3144-3157页

作者： hilary S.Ireland Chen Wu Cecilia H.Deng Elena Hilario Ali Saei Sylvia Erasmuson Ross N.Crowhurst Karine m.David Robert J.Schaffer David Chagn The New Zealand Institute for Plant and Food Research Ltd Private Bag 92196Auckland Mail CentreAuckland 1142New Zealand School of Biological Sciences The University of AucklandPrivate Bag 92019Auckland Mail CentreAuckland 1142New Zealand Genomics Aotearoa %Department of BiochemistryUniversity of OtagoPO Box 56Dunedin 9054New Zealand The New Zealand Institute for Plant and Food Research Ltd Private Bag 11600Palmerston North 4442New Zealand The New Zealand Institute for Plant and Food Research Ltd Private Bag 4704Christchurch Mail CentreChristchurch 8140New Zealand The New Zealand Institute for Plant and Food Research Ltd 55 Old Mill RoadRD 3Motueka 7198New Zealand

The Rosaceae family has striking phenotypic diversity and high syntenic *** trifoliata is sister species to the maleae tribe of apple and~1000 other *** has many putative ancestral features,such as herb/sub-shrub habit,dry fruit-bearing and nine base *** coalescence of ancestral characters in a phylogenetically important species,positions Gillenia as a‘rosetta stone'for translational science within *** present genomic and phenological resources to facilitate the use of Gillenia for this *** Gillenia genome is the fi rst fully annotated chromosome-level assembly with an ancestral genome complement(x=9),and with it we developed an improved model of the Rosaceae ancestral *** and NAC gene family analyses revealed genome dynamics correlated with growth and reproduction and we demonstrate how Gillenia can be a negative control for studying fl eshy fruit development in Rosaceae.

关键词： Rosaceae dynamics striking

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