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Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients

World Journal of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan Stephanie M Peterson Thomas J O'Byrne Mariana l laporta Cody C Wyles Paul J Jannetto Garvan C Kane Maria Vassilaki hil.l.maradit kremers Department of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKGROUND There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty(TJA)*** To determine the association of commonly used implant metals with echocardiographic measures in TJA *** The study comprised 110 TJA patients who had a recent history of high chromium,cobalt or titanium *** underwent two-dimensional,three-dimensional,Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal *** and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations(exposure)with echocardiographic measures(outcome).RESUlTS Higher cobalt concentrations were associated with increased left ventricular end-diastolic volume(estimate 5.09;95%CI:0.02-10.17)as well as left atrial and right ventricular dilation,particularly in men but no changes in cardiac *** titanium concentrations were associated with a reduction in left ventricle global longitudinal strain(estimate 0.38;95%CI:0.70 to 0.06)and cardiac index(estimate 0.08;95%CI,-0.15 to-0.01).CONClUSION Elevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some *** studies are warranted to better understand the systemic effects of metals in TJA patients.

关键词： Total joint arthroplasty Metal-on-metal Cardiotoxicity Heart failure Echocardiography Cobalt

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美国髋膝关节置换患者有多少?

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临床骨科杂志 2015年第6期18卷 719-719页

作者： maradit kremers H larson D R Crowson C S 李军

越来越多的个人生活与髋膝关节置换密切相关。作者对美国的髋膝关节置换情况做了流行病学调查,从美国国家出院调查和医疗成本数据库中调取了1969-2010年的数据,并加以分析。结果发现,行髋、膝关节置换的患者分别占总人口的0.83%和1.52%... 详细信息

越来越多的个人生活与髋膝关节置换密切相关。作者对美国的髋膝关节置换情况做了流行病学调查,从美国国家出院调查和医疗成本数据库中调取了1969-2010年的数据,并加以分析。结果发现,行髋、膝关节置换的患者分别占总人口的0.83%和1.52%,女性高于男性;80岁以上人群中,行髋、膝关节置换的患者分别占到10.38%和5.26%;且发病率趋向年轻化。

关键词：髋膝关节膝关节置换流行病学调查医疗成本个人生活公共卫生

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MS-ECRIS离子源进展报告(英文)

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Chinese Physics C 2007年第S1期31卷 13-17页

作者： G.Ciavola S.Gammino l.Celona F.Consoli G.Gallo D.Mascali S.Passarello M.Cavenago A.Galatà P.Spaedtke K.Tinschert H.Koivisto P.Suominen O.Tarvainen C.Baruè M.lechartier R.leroy J.P.M.Beijers S.Brandenburg H.R.kremers D.Vanrooyen D.Kuchler D.Hitz P.Seyfert l.Schachter S.Dobrescu Istituto Nazionale Fisica Nucleare-laboratori Nazionali del Sud Catania95123Italy Istituto Nazionale Fisica Nucleare-laboratori Nazionali di legnaro LegnaroItaly Gesellschaft für Schwerionenforschung mbH(GSI) DarmstadtGermany Department of Physics University of Jyvskyl(JYFL)JyvskylFinland) Grand Accélérateur National d'Ions lourds (GANIl) CaenPrance Kernfysisch Versneller Instituut (KVI) GroningenNetherlands The Svedberg laboratory (TSl) UppsalaSweden CERN AB Department GenevaSwitzerland CEA-DRFMC-SBT GrenobleFrance Nat.Inst.of Physics and Nuclear Engineering:NIPNE Bucharest Romania

The design of each component of the Multipurpose Superconducting ECR Ion Source(MS-ECRIS) has been completed and some items are *** magnets and the cryostat are under construction at ACCEl and the commissioning is scheduled for March *** mechanical have been optimized and their construction is under way;the microwave system is under refurbishment and the 65kV power supply is available and upgraded for afterglow *** and extraction system were adapted to the EIS testbench of GSI *** description of each part will be given in the paper along with a schedule of the forthcoming development and experiments.

关键词： ECR ion sources accelerator ion beams magnetic field microwaves

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具有绿色色盲基因型与表型的进行性视锥细胞营养不良

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 40-40页

作者： Scholl H.P.N. kremers J. Besch D. 廖新华 Department of Ophthalmology University of Bonn Ernst-Abbe-Strasse 2 53127 Bonn Germany

Purpose: To study the electroretinographic signals originating in the long-wavelength-sensitive (l) and middle-wavelengthsensitive (M) cone pathways by means of large-field and multifocal cone type-specific electroretinograms (ERGs) in a patient with progressive cone dystrophy. Methods: A 65-year-old male patient with colour vision disturbances (age at onset 10 years), loss of visual acuity (14 years), and central visual field defects (40 years) was investigated. large-field flicker-ERG responses to stimuli that exclusively modulated the l-cones or the M-cones, or the two simultaneously (both in-phase and in counter-phase), were measured. Short-wavelength-sensitive(S) cones were not modulated. Multifocal ERGs (mfERGs) were also recorded, with a pattern-reversing display that modulated only the l-or the M-cones at equal cone contrasts and average quantal catches. Genetic analysis of l-and M-pigment genes was performed on genomic DNA isolated from peripheral venous blood. Results: The patient showed a normal rod-drivenERG but reduced cone-driven electroretinographic amplitudes with normal implicit times in the International Society for Clinical Electrophysiology of Vision (ISCEV) standard ERG. The large-field flicker-ERG responses to pure l-cone modulation were significantly above noise level but were substantially reduced in comparison with both normal trichromatic subjects and (otherwise normal) deuteranopes. The l-cone driven electroretinographic implicit times and phases were within normal limits. The M-cone driven electroretinographic responses were not detectable. A model fit of all the l-and M-cone driven flicker-ERG data revealed that the responses were exclusively driven by the l-cones. Consistently, the cone type-specific mfERGs showed severely reduced but detectable responses to l-cone-isolating stimuli. The M cone driven multifocal-ERG responses were undistinguishable from noise. The l-and M-pigment gene array consisted of only a single l-pigment gene. The

关键词：视锥细胞色觉障碍视网膜电图视杆细胞视野缺损图形刺激细胞色素遗传学基础外周静脉血短波

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