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对于特应性干性皮肤局部使用烟酰胺后引起皮肤水分增加效应

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 50-51页

作者： Soma Y. kashima M. Imaizumi A. 惠海英 Department of Dermatology St. Marianna Univ. Sch. of Medicine2-16-1SugaoMiyamae-kuKawasaki216- 8511 Japan Dr.

Background: Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry skin is unknown. We examined the effect of topical nicotinamide on atopic dry skin and compared the results with the effect of white petrolatum in a left-right comparison study. Methods: Twenty-eight patients with atopic dermatitis, with symmetrical lesions of dry skin on both forearms, were enrolled, and were instructed to apply nicotinamide cream containing 2% nicotinamide on the left forearm and white petrolatum on the right forearm, twice daily over a 4- or 8- week treatment period. Transepidermal water loss and stratum corneum hydration were measured by instrumental devices. The amount of the stratum corneum exfoliated by tape stripping (desquamation index) was determined by an image analyzer. Results: Nicotinamide significantly decreased transepidermal water loss, but white petrolatum did not show any significant effect. Both nicotinamide and white petrolatum increased stratum corneum hydration, but nicotinamide was significantly more effective than white petrolatum. The desquamation index was positively correlated with stratum corneum hydration at baseline and gradually increased in the nicotinamide group, but not in the white petrolatum group. Conclusions: Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment adjunct in atopic dermatitis.

关键词：干性皮肤特应性烟酰胺白凡士林右前臂水合作用增湿剂左前臂胶带粘贴法丢失率

比较0.1%溴芬酸钠和0.1%吡嘧司特钾治疗过敏性结膜炎的疗效

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 51-52页

作者： Miyake-kashima M. Takano Y. Tanaka M. H. Fujishima 肖颖 Department of Ophthalmology Keio University School of Medicine35 Shinanomachi Shinjuku-ku Tokyo 160- 8582 Japan

Purpose: We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients. Methods: Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Bromfenac eye drops and the contralateral eye was treated with Pemirolast eye drops for 1 week. Subjective ocular symptoms and objective ocular signs evaluated by slit-lamp examination were scored and recorded before and after treatment. Results: Both drugs significantly decreased ocular signs after 1 week, but not symptoms. No significant differences in subjective symptoms or objective signs were observed between the two drugs. Ten patients (45.5% ) selected Bromfenac as more effective, nine patients (40.9% ) selected Pemirolast, and three patients found no difference in efficacy between the two drugs. Conclusion: Bromfenac sodium is as safe and effective for the treatment of allergic conjunctivitis as pemirolast potassium.

关键词：溴芬酸钠吡嘧司特过敏性结膜炎对侧眼裂隙灯检查客观体征非甾体抗炎药抗过敏药

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CD10在基底细胞癌的表达

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 46-47页

作者： Yada K. kashima K. Daa T. S. Yokoyama 罗素菊 Dr. Department of Pathology Fa culty of Medicine Oita University Hasama-machi Oita 879-5593 Japan

We investigated the expression of CD10 by an immunohistochemical method in 51 basal cell carcinomas (BCCs), eight pilomatricomas, five trichoblastomas, two tr ichofolliculomas, three sebaceomas, five sebaceous carcinomas, ten syringomas, t wo spiradenomas, ten poromas, four porocarcinomas, one eccrine duct carcinoma (n ot otherwise specified, NOS), six mixed tumors of apocrine origin, and nine squa mous cell carcinomas (SCCs). We detected strong expression of CD10 in tumor cell s of BCC(86%),and found that the smaller the number of positive tumor cells, th e larger the number of positive stromal cells, in particular in sclerosing BCCs. Spearman’s rank correlation test revealed a significant negative correlation i n BCCs between the expression of CD10 in tumor cells and that in stromal cells (P=0.001). In all pilomatricomas (100%) and in four trichoblast omas (80%), strong expression was also detected in tumor cells. There was no de tectable expression in trichofolliculomas. One sebaceoma (33%) and two sebaceou s carcinomas (40%)expressed CD10 in a similar fashion to BCCs. All tumors of ec crine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10. Five mixed tumors (83%) we re immunopositive. In SCC, CD10 was overexpressed only in the stromal cells. The se findings support the hypothesis that BCC is derived from the folliculo-sebac eous apocrine unit, especially having the same origin as trichoblastoma and pilo matricoma. CD10 might be an indicator of tumor invasiveness if it is expressed i n stromal cells, while it might be a marker of follicular differentiation if it is expressed in the actual tumor cells of cutaneous epithelial neoplasms.

关键词：基底细胞癌 CD10 毛囊瘤毛母质瘤汗孔瘤汗孔癌汗管瘤小汗腺皮脂腺癌混合瘤

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交联剂对PDLC膜电-光性能的影响

液晶与显示 2010年第4期25卷 531-533页

作者：鹿岛美纪赵秀婷曹晖杨槐北京科技大学材料科学与工程学院材料物理与化学系北京100083

在PDLC薄膜中,聚合物网络网孔的大小直接影响着PDLC薄膜的电-光性能。该实验选用光可聚合单体/交联剂/液晶复合材料,经紫外光照射制备PDLC薄膜,研究了交联剂对PDLC薄膜电-光性能的影响。在混合物体系中引入长柔性链的PEGDA1000和短分子... 详细信息

在PDLC薄膜中,聚合物网络网孔的大小直接影响着PDLC薄膜的电-光性能。该实验选用光可聚合单体/交联剂/液晶复合材料,经紫外光照射制备PDLC薄膜,研究了交联剂对PDLC薄膜电-光性能的影响。在混合物体系中引入长柔性链的PEGDA1000和短分子链的BDDA,影响了聚合物网络的微观形貌。交联剂分子链的长短对聚合物网络网孔的大小有明显的影响,进而影响了PDLC膜的电-光性能。

关键词：聚合物分散液晶交联剂聚合物网络透过率

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用于未来月球探测的ILOM技术现状

深空探测学报 2014年第3期1卷 200-204页

作者： Hideo HANADA Seiitsu TSURUTA Kazuyoshi ASARI Hiroshi ARAKI Hirotomo NODA Shingo kashima Ken-ichi FUNAZAKI Fuyuhiko KIKUCHI Koji MATSUMOTO Yusuke KONO Hiroo KUNIMORI Sho SASAKI 平劲松日本国立天文台RISE研究室综合研究大学院大学天文学部岩手大学工学院国立天文台水泽VLBI观测站国立信息通信技术研究院无线网络研究所大阪大学地球与空间科学部中科院国家天文台

使用面包板模型和仿真方法,在实验室内研究月球指向就位测量望远镜(ILOM)的基本特征,如望远镜星像中心点位置精度、温度效应、倾斜以及地面震动的影响。使用这个技术预期在月球表面观测月球自转时可以达到1ms的精度。将在地面上开展测... 详细信息

使用面包板模型和仿真方法,在实验室内研究月球指向就位测量望远镜(ILOM)的基本特征,如望远镜星像中心点位置精度、温度效应、倾斜以及地面震动的影响。使用这个技术预期在月球表面观测月球自转时可以达到1ms的精度。将在地面上开展测试验证观测以全面评价达到优于0.1″观测精度目标所需条件和特征。

关键词：月球 ILOM 望远镜照相天顶筒水银槽

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虚拟货币及其扩展:初步思考

金融监管研究 2016年第4期 46-71页

作者：何东卡尔·哈伯梅尔罗斯·莱科郭建伟郇志坚 Vikram Haksar Yasmin Almeida Mikari kashima Nadim Kyriakos-Saad Hiroko Oura Tahsin Saadi Sedik Natalia Stetsenko Concepcion Verdugo.Yepes 不详中国人民银行乌鲁木齐中心支行

随着信息加密和网络计算机技术日趋成熟,科技正在推动全球经济的转型变革。虚拟货币的产生在此过程中又显得至关重要。虚拟货币方案在许多情况下便于对等网络交互绕过传统的中央结算所。虚拟货币及其关联技术(特别是基于区块链的分布式... 详细信息

随着信息加密和网络计算机技术日趋成熟,科技正在推动全球经济的转型变革。虚拟货币的产生在此过程中又显得至关重要。虚拟货币方案在许多情况下便于对等网络交互绕过传统的中央结算所。虚拟货币及其关联技术(特别是基于区块链的分布式账本)正在迅速发展,其未来前景难以预测。虚拟货币带来了许多潜在益处,包括更快速、高效的支付和转账等,并将最终促进普惠金融。一些虚拟货币方案背后的分布式账本技术提供的潜在益处将远超虚拟货币本身。但是,虚拟货币的出现也引发了许多潜在风险,如成为洗钱、恐怖融资、偷税漏税和欺诈等犯罪的工具。虚拟货币虽然目前的规模仍非常有限,对现阶段货币政策实施产生的风险亦甚微,但随着新技术的广泛应用,其对金融稳定产生的影响会日益显现。有关虚拟货币的有效监管对策还处于起步阶段。虚拟货币的在国家层面跨越了不同机构的职责,并在全球范围内操作,其监管难度很大。并且,许多虚拟货币在传统金融系统之外运作,缺乏透明度,其操作过程更难以被监管。各国监管机构已开始着手应对这些挑战且方式各异。需要注意的是,国家主管部门需认真权衡监管方式,既要适当处置风险又不能扼杀创新。为了在国家层面推进发展进程和促进政策的完善,国际层面也应进行更多努力。随着经验的不断积累,可考虑提出国际标准和最优方法,为不同领域的最优监管对策提供指导,从而促进跨辖区的协调。也可在此类标准基础上,为一些领域设立跨国合作和协调的框架。

关键词：虚拟货币加密货币支付技术分布式账本区块链金融创新金融效率金融包容性反洗钱/反恐融资消费者保护偷税漏税外汇管制资本流动管理金融监管金融稳定货币政策国际合作

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veterana诺卡菌所致足菌病治愈1例

世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 38-38页

作者： kashima M. Kano R. Mikami Y. 罗素菊 Department of Dermatology Toyoko Hospital St. Marianna University 3- 435 Kosugi- cho Kawasaki Kanagawa 211- 0063 Japan

We report a successfully treated case of mycetoma from which an unusual Nocardia species was isolated. The isolate was identified as N. veterona by biochemical characterization and 16S ribosomal RNA gene sequencing, and it has not been previously reported as a causative agent of human mycetomas. Treatment with various antibiotics over 6 years and surgical resection failed to cure the disease. However, the combination of intravenous imipenem/cilastatin and amikacin along with oral clarithromycin and minocycline proved very effective in this case. This is the first case report of mycetoma due to N. veterana in a clinical setting.

关键词：诺卡菌 veterana 分离菌克拉红霉素米诺环素基因测序丁胺卡那霉素化学特征