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Baseline HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine

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World Journal of Gastroenterology 2007年第30期13卷 4085-4090页

作者： Hee Bok Chae hie-Won Hann Liver Disease Prevention Center Division of Gastroenterology and Hepatology Department of Medicine Jefferson Medical College and Thomas Jefferson University Hospital Philadelphia PA 19107 United States Department of Internal Medicine College of Medicine and Medical Institute Chungbuk National University Cheongju 362-711 South Korea

AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not. Clinical and virologic factors were compared between the two groups. RESULTS: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When several factors, including gender, duration of infection, baseline HBV DNA, and baseline ALT in HBeAg-positive chronic hepatitis patients were analyzed by logistic regression, the most important predictor of virologic breakthrough was the baseline HBV DNA (r2 = 0.12, P < 0.05). When HBeAg-postitive chronic hepatitis patients were divided into two groups by a point of 6.6 log HBV DNA, the incidence of virologic breakthough between two groups was significantly different. CONCLUSION: Lamivudine may remain an effective first line therapy for those HBeAg-positive patients with a baseline HBV DNA < 6.6 log10 copies/mL.

关键词： Hepatitis B Lamivudine Virologic breakthrough HBV DNA

Then and now: The progress in hepatitis B treatment over the past 20 years

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World Journal of Gastroenterology 2014年第2期20卷 401-413页

作者： Dina Halegoua-De Marzio hie-Won Hann Division of Gastroenterology and Hepatology Department of MedicineThomas Jefferson University HospitalPhiladelphiaPA 19107United States Liver Disease Prevention Center Division of Gastroenterology and HepatologyThomas Jefferson University HospitalPhiladelphiaPA 19107United States

The ultimate goals of treating chronic hepatitis B(CHB)is prevention of hepatocellular carcinoma(HCC)and hepatic *** the advent of effective antiviral drugs that appeared during the past two decades,considerable advances have been made not only in controlling hepatitis B virus(HBV)infection,but also in preventing and reducing the incidence of liver cirrhosis and ***,several recent studies have suggested the possibility of reducing the incidence of recurrent or new HCC in patients even after they have developed ***,six medications are available for HBV treatment including,interferon and five nucleoside/nucleotide *** this review,we will examine the antiviral drugs and the progresses that have been made with antiviral treatments in the field of CHB.

关键词： Chronic hepatitis B Treatment of hepatitis B Hepatocellular carcinoma Nucleoside analogues Nucleotide analogues

Deduction of a meteorological phenology indicator from reconstructed MODIS LST imagery

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Journal of Forestry Research 2020年第6期31卷 2205-2216页

作者： Chi Hong Lim Song hie Jung Nam Shin Kim Chang Seok Lee Department of Bio and Environmnetal Technology Graduate SchoolSeoul Women’s UniversitySeoul Republic of Korea Research Team on Ecological and Natural Map National Institute of EcologySeocheon Choongnam Republic of Korea Department of Bio and Environmnetal Technology Seoul Women’s UniversitySeoul Republic of Korea

Phenology is a valuable attribute of vegetation to assess the biological impacts from climate change.A challenge of phenological research is to obtain information on both high temporal resolution and fine spatial scale ***,we constructed an air temperature map based on temporal merging and spatial interpolation algorithms to overcome the cloud-related problem from the MODIS LST ***,we derived the accumulated growing degree days(AGDD)from the constructed mean air temperature map to use as a meteorological ***,we verified the indicator with the seasonal mean air temperature and the green-up date of a Quercus mongolica forest determined from the field-based *** AGDD threshold for each *** forest when the first leaf has unfolded was detected from the EXG trajectory extracted from digital camera images.A comparison between meteorological and MODIS-derived AGDD showed good agreement between *** was also high consistency between DoYs extracted from AGDD and EVI based on curvature K for *** forests of 30 sampling sites throughout South *** results prove that microclimatic factors such as elevation,waterbody,and land-use intensity were faithfully reflected in the reconstructed ***,the results of this study could be applied effectively in areas where microclimatic variation is very severe and for monitoring phenology of undergrowth,which is difficult to detect from reflectance imaging.

关键词： Climate change Digital camera Growing degree days MODIS Phenology Quercus mongolica

Frontier of digitalization in Biomass-to-X supply chain:opportunity or threats?

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生物质资源与工程(英文) 2023年第2期8卷 101-107页

作者： Adrian Chun Minh Loy Karen Gah hie Kong Juin Yau Lim Bing Shen How Department of Chemical and Biological Engineering Monash UniversityMelbourneAustralia Biomass Waste-to-Wealth Special Interest Group Research Centre for Sustainable TechnologiesFaculty of EngineeringComputing and ScienceSwinburne University of TechnologyKuching 93350Malaysia Integrated Engineering Department of Environmental Science and EngineeringCollege of EngineeringKyung Hee UniversityGyeonggi-do 17104Republic of Korea

The escalating climate crisis necessitates an urgent shift towards a sustainable business ***-der the context of bioeconomy,it has offered a promising alternative through its“Biomass-to-X”strategy for converting biological resources into value-added products or ***,the adoption of this approach remains scarce,which highlights the need to leverage digital technolo-gies to enhance its ***,this paper provides a comprehensive overview of the potential role of digital technologies in the Biomass-to-X supply chain,encompassing the entire value chain from upstream to downstream activities,specifically in the areas of 1)lab-to-fabrication transla-tion,2)biomanufacturing stage,and lastly,3)supply chain management ***,this study identifies and discusses research gaps in each niche area,along with potential future re-search prospects to facilitate the transition towards a sustainable bioeconomy,making it a crucial reference for stakeholders involved in decision-making processes.

关键词： Biomass valorization Internet of nano-things Bioeconomy Biomanufacturing Blockchain Biomass-to-X

Corneal blindness and current major treatment concerngraft scarcity

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1154-1162页

作者： Kah hie Wong Ka Wai Kam Li Jia Chen Alvin L.Young Department of Ophthalmology and Visual Sciences Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences Prince of Wales Hospital

According to World Health Organization, the global prevalence of blindness in 2010 was 39 million people, among which 4% were due to corneal opacities. Often, the sole resort for visual restoration of patients with damaged corneas is corneal transplantation. However, despite rapid developments of surgical techniques, instrumentations and immunosuppressive agents, corneal blindness remains a prevalent global health issue. This is largely due to the scarcity of good quality corneal grafts. In this review, the causes of corneal blindness, its major treatment options, and the major contributory factors of corneal graft scarcity with potential solutions are discussed.

关键词： corneal blindness keratoplasty corneal graft corneal donation eye banking

Long-term survival of occult hepatitis B associated hepatocellular carcinoma following surgery and antiviral therapy

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Hepatoma Research 2020年第8期6卷 29-35页

作者： Tina Boortalary Ernest Rosato Christopher Roth Xiangdong David Ren Selena YLin hie-Won Hann Department of Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Surgery Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Radiology Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Reniguard Life Sciences Inc. MalvernPA 19355USA JBS Science Inc.DoylestownPA 18902USA Division of Liver Disease Prevention Center Division of Gastroenterology and HepatologyThomas Jefferson University HospitalPhiladelphiaPA 19107USA.

Occult hepatitis B infection(OBI)is characterized by absent hepatitis B surface antigen(HBsAg),low or undetectable serum hepatitis B viral DNA(HBV-DNA),and detectable DNA in the *** is debate over whether OBI increases the risk of hepatocellular carcinoma(HCC).We present a patient with negative HBsAg and a large HCC tumor who underwent a large right hepatic ***,the etiology of HCC was unknown,but through more sensitive molecular testing,it was believed to be due to *** this case report,we discuss the patient’s clinical course,the effect of antiviral therapy,mechanism of carcinogenesis in OBI,and the need for more rigorous HBV DNA assay testing for the detection of OBI.

关键词： Occult hepatitis B infection OBI-associated HCC HBsAg negative HCC

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霍顿奇遇记

疯狂英语（初中天地） 2008年第3期 11-13页

作者： Trix hie 洪馥芝

一部由20世纪福克斯公司动画部(《冰河世纪》系列电影出品者)出品的全新CG动画电影将于今年三月上映。电影《霍顿奇遇记》

关键词：金·凯瑞福克斯盖泽尔奇遇记

国际功能、残疾和健康分类认识一种新的国际分类系统

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中国临床康复 2005年第20期9卷 170-171页

作者：何静杰中国康复研究中心北京博爱医院神经康复科北京市100068

目的:国际、残疾和健康分类是一种新的国际分类系统,是在国际障碍分类的基础上发展而来的,是为了记录健康状况及与健康相关的状况,而提供统一的、标准化的语言,使全世界不同学科和领域能够对有关健康和保健情况进行广泛交流。并提供了... 详细信息

目的:国际、残疾和健康分类是一种新的国际分类系统,是在国际障碍分类的基础上发展而来的,是为了记录健康状况及与健康相关的状况,而提供统一的、标准化的语言,使全世界不同学科和领域能够对有关健康和保健情况进行广泛交流。并提供了一种框架,可以对健康及与健康相关的信息进行编码(如诊断、残疾等)。方法:从基本特征,分类项目,应用领域等几个方面对国际、残疾和健康分类进行分析。结果:①国际、残疾和健康分类的基本特征明确了环境因素及个人因素的重要性,在国际、残疾和健康分类中均用肯定的形式表示,且各个项目间的关系是双向、关联、相互作用、相互制约的立体式模式。②涉及的范围较前更加广泛,涉列的项目内涵扩大,且各个项目的分类详细。③国际、残疾和健康分类所有的人均可以使用,是世界上惟一被承认的一种分类工具。结论:国际、残疾和健康分类系统表明医务工作者面对的不仅是疾病、残疾,也不只是针对身心功能障碍水平的简单处置,而是要全面把握对象的活动能力、参与水平、环境因素及主观意识状况,使其充分发挥主观能动性。

关键词：残疾人参考值功能恢复

不同虫态谷蠹侵害对小麦淀粉组分及微观形态结构的影响

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农业工程学报 2017年第13期33卷 303-309页

作者：周鸿达张玉荣暴洁河南工业大学粮油食品学院粮食储藏与安全教育部工程研究中心粮食储运国家工程实验室郑州450001

为了探讨不同生长发育阶段的谷蠹侵害对小麦淀粉组分及形态结构的影响。通过控制谷蠹侵害小麦的温度(30℃±1℃)、相对湿度(75%±5%)及虫口密度(1 000头/100 g),保证其完成一个生长发育周期,以谷蠹感染后的小麦为研究对象,对谷蠹不同发... 详细信息

为了探讨不同生长发育阶段的谷蠹侵害对小麦淀粉组分及形态结构的影响。通过控制谷蠹侵害小麦的温度(30℃±1℃)、相对湿度(75%±5%)及虫口密度(1 000头/100 g),保证其完成一个生长发育周期,以谷蠹感染后的小麦为研究对象,对谷蠹不同发育阶段(卵期、幼虫期、蛹期、成虫期)侵害后小麦中粗淀粉、破损淀粉含量、还原糖含量及淀粉颗粒形貌及结构、淀粉粒度和淀粉结晶度进行测定与分析。结果表明:不同生长发育阶段的谷蠹对小麦侵害后,与谷蠹未侵害的小麦对照样相比,粗淀粉含量除在卵期略有增加外其余各期均低于对照样,在4个发育阶段谷蠹侵害后均呈现显著差异性(P0.05);淀粉的扫描电镜图显示:随着谷蠹由卵期发育至成虫期,其小麦籽粒中淀粉颗粒表面逐渐变得粗糙不完整,形状变得无规则,且小粒径颗粒增多,破损淀粉含量增加,大粒径淀粉颗粒表面出现较大凹坑和破损。因此,在实际的小麦储藏过程,应关注谷蠹在发育过程中的幼虫期对小麦品质的影响。

关键词：储藏淀粉品质控制小麦谷蠹发育阶段