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Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

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World Journal of Gastroenterology 2005年第14期11卷 2072-2079页

作者： Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park hie-joon kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park School of Biological Sciences Seoul National University SeoulKorea Hepatology Center and Laboratory of Hepatocarcinogenesis Bundang Jesaeng General Hospital KyungkidoKorea School of Chemistry Seoul National University SeoulKorea Department of Pathology Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea General Surgery Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea Internal Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea

AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related ***: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically ***: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic ***: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.

关键词： Heat shock protein Hepatocellular carcinoma Dysplastic nodule Hepatocarcinogenesis Immunohisto-chemistry Dot immunoblot analysis

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离子排阻色谱法亚硫酸盐分析技术在食品和饮料工业中的应用

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邵阳高等专科学校学报 1990年第4期7卷 309-312页

作者： hie-joon kim 王尚荣

自从两年前发表这种方法以来(kim,H·J和kim,Y·K,1986,kim,H·J等,1987),用于亚硫酸盐分析的离子排阻色谱法与电化学检测(IEC—EC)已发展成为替代美国分析化学家协会(AoAc,1984)所采用的Monier—Williams法的一种适宜方法.IEC—EC法利... 详细信息

自从两年前发表这种方法以来(kim,H·J和kim,Y·K,1986,kim,H·J等,1987),用于亚硫酸盐分析的离子排阻色谱法与电化学检测(IEC—EC)已发展成为替代美国分析化学家协会(AoAc,1984)所采用的Monier—Williams法的一种适宜方法.IEC—EC法利用简单的浸提法和色谱分离技术,从而节省了分析时间。

关键词：亚硫酸盐离子排阻色谱法 EC法饮料工业分析技术葡萄酒中亚色谱图标签碱浸提

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Feasibility of wear reduction for soft nanostructured thin film through enhanced elastic recoverability and contact stress relief

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Friction 2023年第7期11卷 1292-1306页

作者： Kuk-Jin SEO Hyun-joon kim Dae-Eun kim Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Precision Mechanical Engineering Kyungpook National UniversitySangju 37224Republic of Korea Department of Advanced Science and Technology Convergence Kyungpook National UniversitySangju 37224Republic of Korea

This work shows that a soft,thin film comprising randomly aligned carbon nanotubes(CNTs)can reduce surface wear more effectively than a homogeneous thin film because of enhanced elastic recoverability and contact stress relief originating from its mesh *** investigate the wear characteristics of the mesh structure compared to those of the homogeneous thin film,multi-walled CNTs(MWCNTs)and diamond-like carbon(DLC)thin films were prepared to conduct nanoscale tribological experiments using the atomic force microscopy(AFM).The MWCNT thin film showed unmeasurably low wear compared with the DLC thin film under a certain range of normal *** demonstrate the wear reduction mechanism of the MWCNT thin film,its indentation and frictional behaviors were *** indentation behavior of the MWCNT thin film revealed repetitive elastic deformation with a wide strain range and a significantly lower elastic modulus than that of the DLC thin *** permanent deformation of the MWCNT thin film was observed through frictional experiments under relatively high normal load *** results are expected to provide insights into the design of highly wear-resistant surfaces using nanostructures.

关键词： carbon nanotube(CNT) thin film wear friction elastic recovery

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Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung kim Uk-Hee Jung Sung kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

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Hepatitis B virus mutations related to liver disease progression of Korean patients

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World Journal of Gastroenterology 2014年第2期20卷 460-467页

作者： Bum-joon kim Department of Biomedical Sciences Microbiology and ImmunologyLiver Research Instituteand Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 110-799South Korea

Hepatitis B virus(HBV)infection is a global health problem and more than 350 million people worldwide are chronic carriers of the *** the recent dramatic decline in HBV chronic patients through successful programs of hepatitis B surface antigen vaccination,South Korea is still recognized as an endemic area of HBV *** infections in South Korea exhibit several distinct features in epidemiologic and clinical *** this review paper,we summarize the distinct HBV mutation patterns related to clinical severity and the molecular epidemiologic traits in Korean chronic patients based on previous ***,several lines of evidence,including our previous results,have led to the conclusion that a combination of the exclusive predominance of genotype C2,which is prone to mutations,the high prevalence of basal core promoter double mutations,and the presence of distinct immune responses against HBV proteins in the Korean population may generate the distinct HBV variants rarely or not encountered in other areas,which results in distinct clinical manifestations in Korean chronic *** may provide a novel insight into the relationships between clinical severity,HBV genotype distribution,and HBV naturally occurring variants.

关键词： Hepatitis B virus Mutation South Korea Hepatocellular carcinoma Genotype C2

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Effect of BainiticTreatment on Microstructure and Mechanical Properties of TRIP Cold-Rolled Steel Sheets

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Journal of Iron and Steel Research International 2011年第S1期18卷 1004-1007页

作者： kim Sung-joon Korea Institute of Machinery Science Changwon 641010Korea

The effects of bainitic treatment on microstructure and mechanical properties of 0.10C-1.5Mn-l.5Al TRIP-aided cold-rolled steels have been *** samples were heated by intercritical annealing at 820℃for 2 min and quenched in banitic temperature with different hoding time for 5 to 300s,two salt bath were used for the heat *** results show that the yield strength and elongation increase with the increasing of bainitic holding time,while the tensile strength *** volume fraction of retained austenite rise at the beginning of bainitic holding and then reduce,the carbon content of retained austenite increase during the bainitic *** tensile strengthen multiply elongation reaches the highest value at *** mechanical stability of retained austenite fits well with strain hardening during deformation.

关键词： TRIP bainitic treatment microstructure mechanical properties retained austenite

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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

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Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz Bahar Hyun joon kim Deok Ryong kim Department of Biochemistry and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

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Byte Frequency Based Indicators for Crypto-Ransomware Detection from Empirical Analysis

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Journal of Computer Science & Technology 2022年第2期37卷 423-442页

作者： Geun Yong kim joon-Young Paik Yeongcheol kim Eun-Sun Cho Department of Computer Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Computer Science and Technology Tiangong UniversityTianjin 300387China

File entropy is one of the major indicators of crypto-ransomware because the encryption by ransomware increases the randomness of file ***,entropy-based ransomware detection has certain limitations;for example,when distinguishing ransomware-encrypted files from normal files with inherently high-level entropy,misclassification is very *** addition,the entropy evaluation cost for an entire file renders entropy-based detection impractical for large *** this paper,we propose two indicators based on byte frequency for use in ransomware detection;these are termed EntropySA and DistSA,and both consider the interesting characteristics of certain file subareas termed“sample areas”(SAs).For an encrypted file,both the sampled area and the whole file exhibit high-level randomness,but for a plain file,the sampled area embeds informative structures such as a file header and thus exhibits relatively low-level randomness even though the entire file exhibits high-level *** and DistSA use“byte frequency”and a variation of byte frequency,respectively,derived from sampled *** indicators cause less overhead than other entropy-based detection methods,as experimentally proven using realistic ransomware *** evaluate the effectiveness and feasibility of our indicators,we also employ three expensive but elaborate classification models(neural network,support vector machine and threshold-based approaches).Using these models,our experimental indicators yielded an average Fl-measure of 0.994 and an average detection rate of 99.46%for file encryption attacks by realistic ransomware samples.

关键词： computer security cryptography machine learning ransomware

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A mass and energy estimation for the hydrogen utilization in the iron-making process

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Science China(Technological Sciences) 2011年第7期54卷 1655-1660页

作者： Wan Ho kim Dong joon MIN Department of Materials Science and Engineering YONSEI University

The possibility of using hydrogen to lower CO 2 emissions in the iron-making process was confirmed by the heat and mass balances in the blast furnace operation. The mass and heat balances for hydrogen utilization in the blast furnace were estimated by using the basic concept of RIST operating diagram. In this study, the RIST operating diagram was modified to be suitable for representing the operation with respect to hydrogen, where the RIST operating diagram is a graphical representation of heat and mass balance in blast furnace operation. RIST operating diagram was applied here to some individual parameters of interest such as H 2 injection in blast furnace process to reduce coke (carbon consumption). It was observed that the point W moved to the right in the RIST operating diagram under the condition of increasing hydrogen injection at tuyere, which originates from the contribution of gas composition (O/H 2 ) equilibrated with Fe/FeO at a certain temperature. Point P also moved downward due to heat requirement with respect to hydrogen utilization, by which the new RIST operating diagram for hydrogen utilization was able to be constructed. Under the condition of hydrogen injection, the expected overall carbon consumption in the blast furnace decreased due to the contribution of hydrogen.

关键词： hydrogen carbon consumption (CO2 emission) mass and heat balances RIST operating diagram blast furnace

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A Universal Activation Function for Deep Learning

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Computers, Materials & Continua 2023年第5期75卷 3553-3569页

作者： Seung-Yeon Hwang Jeong-joon kim Department of Computer Engineering Anyang UniversityAnyang-si14028Korea Department of ICT Convergence Engineering Anyang UniversityAnyang-si14028Korea

Recently,deep learning has achieved remarkable results in fields that require human cognitive ability,learning ability,and reasoning *** functions are very important because they provide the ability of artificial neural networks to learn complex patterns through *** activation functions are being studied to solve problems such as vanishing gradients and dying nodes that may occur in the deep learning ***,it takes a lot of time and effort for researchers to use the existing activation function in their ***,in this paper,we propose a universal activation function(UA)so that researchers can easily create and apply various activation functions and improve the performance of neural *** can generate new types of activation functions as well as functions like traditional activation functions by properly adjusting three *** famous Convolutional Neural Network(CNN)and benchmark datasetwere used to evaluate the experimental performance of the UA proposed in this *** compared the performance of the artificial neural network to which the traditional activation function is applied and the artificial neural network to which theUA is *** addition,we evaluated the performance of the new activation function generated by adjusting the hyperparameters of *** experimental performance evaluation results showed that the classification performance of CNNs improved by up to 5%through the UA,although most of them showed similar performance to the traditional activation function.

关键词： Deep learning activation function convolutional neural network benchmark datasets universal activation function

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