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Globoside accelerates the differentiation of dental epithelial cells into ameloblasts

International Journal of Oral Science 2016年第4期8卷 205-212页

作者： Takashi Nakamura Yuta chiba Masahiro Naruse Kan Saito Hidemitsu Harada Satoshi Fukumoto Division of Molecular Pharmacology and Cell Biophysics Department of Oral Biology Tohoku University Graduate School of Dentistry Division of Pediatric Dentistry Department of Oral Health and Development Sciences Tohoku University Graduate School of Dentistry Division of Developmental Biology and Regenerative Medicine Department of Anatomy Iwate Medical University

Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside （Gb4）, a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly expressed in the neutral lipid fraction of dental epithelial cells. However, because its functional role in tooth development remains unknown, we investigated the involvement of Gb4 in dental epithelial cell differentiation. The expression of Gb4 was detected in ameloblasts of postnatal mouse molars and incisors. A cell culture analysis using HAT-7 cells, a rat-derived dental epithelial cell line, revealed that Gb4 did not promote dental epithelial cell proliferation. Interestingly, exogenous administration of Gb4 enhanced the gene expression of enamel extracellular matrix proteins such as ameloblastin, amelogenin, and enamelin in dental epithelial cells as well as in developing tooth germs. Gb4 also induced the expression of TrkB, one of the key receptors required for ameloblast induction in dental epithelial cells. In contrast, Gb4 downregulated the expression of p75, a receptor for neurotrophins （including neurotrophin-4） and a marker of undifferentiated dental epithelial cells. In addition, we found that exogenous administration of Gb4 to dental epithelial cells stimulated the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase signalling pathways. Furthermore, Gb4 induced the expression of epiprofin and Runx2, the positive regulators for ameloblastin gene transcription. Thus, our results suggest that Gb4 contributes to promoting the differentiation of dental epithelial cells into ameloblasts.

关键词： ameloblast differentiation enamel matrix epiprofin glycosphingolipids tooth development

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Effect of storage time on the characteristics of corn and efficiency of its utilization in broiler chickens

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Animal Nutrition 2017年第3期3卷 252-257页

作者： Dafei Yin Jianmin Yuan Yuming Guo Lee I.chiba State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Department of Animal Sciences College of Agriculture Auburn University

Corn is one of the staple food and feed ingredients in China, therefore its storage is of particular importance. Corn is typically stored for 2 or more years in national barns before it is sold as a food or feed ingredient. However, the effects of stored corn in national barns on the animal performance and nutrient utilization have not been investigated thus far. This study attempted to determine the effects of storage time on the chemical and physical characteristics of corn and its nutritional value, broiler growth performance, and meat quality. Corn grains used in the present study were stored for 4 different periods,from 2 to 5 yr, under the same conditions in a building at the Beijing National Grain Storage Facility. A total of 240 birds in Exp. 1 and 90 birds in Exp. 2 were used to compare the effects of storage time on the utilization of nutrients of corn, the performance, and meat quality of broilers. The content of starch, crude protein, amino acids, fatty acids, and test weight generally decreased with increasing storage time. Corn stored for over 4 yr showed decreased catalase(CAT) and peroxidase(POD) activities and increased fat acidity. Body weight gain(BWG) and European production index(EPI) of broilers from 0 to 3 wk tended to decrease linearly with storage time(0.05 0.05). The digestibility of histidine and arg

关键词： Broiler Corn Fat acidity Metabolizable energy Performance Storage

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Reflectance spectra analysis for mucous assessment

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 822-834页

作者： Toru chiba Masaharu Murata Takahito Kawano Makoto Hashizume Tomohiko Akahoshi Pentax_LifeCare HOYA CorporationAkishima-shi 196-0012TokyoJapan Center for Advanced Medical Innovation Kyushu UniversityFukuoka-shi 812-8582FukuokaJapan Department of Disaster and Emergency Medicine Graduate School of Medical SciencesKyushu UniversityFukuoka_shi 812-8582FukuokaJapan

This review report represents an overview of research and development on medical hyperspectral imaging technology and its *** imaging technology is attracting attention as a new imaging modality for medical applications,especially in disease diagnosis and image-guided *** the recent advances in imaging,this technology provides an opportunity for twodimensional mapping of oxygen saturation(SatO2)of blood with high accuracy,spatial spectral imaging,and its analysis and provides detection and diagnostic information about the tissue physiology and *** imaging also provides information about tissue oxygenation,perfusion,and potential function during *** algorithm has been examined,and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame *** technology is expected to provide promising biomedical information in practical *** studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders,particularly malignant tumor *** use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

关键词： Diffuse reflectance spectroscopy Endoscopy Hemoglobin saturation Hypoxia Gastrointestinal cancer Tumor

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High-temperature ultra-strength of dual-phase Re_(0.5)MoNbW(TaC)_(0.5) high-entropy alloy matrix composite

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Journal of Materials Science & Technology 2021年第25期84卷 1-9页

作者： Qinqin Wei Guoqiang Luo RongTu Jian Zhang Qiang Shen Yujie Cui Yunwei Gui Akihiko chiba State Key Lab of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Institute for Materials Research Tohoku UniversitySendai980-8577Japan

The dual-phase Re_(0.5)MoNbW(TaC)_(0.5) composite,consisting of refractory body-centered cubic(BCC)highentropy alloy and carbide with many fine eutectic structures,was successfully synthesized by arc *** phase stability,high-temperature mechanical properties and strengthening mechanism of the ascast composite were *** microstructure of the composite remained stable after annealing at 1300℃for 168 *** exhibited remarkably high-temperature strength,yield strength~901 MPa,and true ultimate compressive strength~1186 MPa at 1200℃.The BCC phase and carbide exhibited a semi-coherent interface with good bonding after severe deformation at 1200℃.The dipolar dislocation walls in BCC phase,restricted dynamic interaction between defects in carbide,and the pinning effect of semi-coherent interface offered effective strengthening effects.

关键词： High-entropy alloy Composite Eutectic structure Strength Strengthening mechanism

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An autopsy case showing massive fibrinoid necrosis of the portal tracts of the liver with cholangiographic findings similar to those of primary sclerosing cholangitis

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World Journal of Gastroenterology 2007年第4期13卷 639-642页

作者： Hiroshi Hano Ichiro Takagi Keisuke Nagatsuma Tomoe Lu Chenxi Meng Satoru chiba Department of Pathology Jikei University School of Medicine Tokyo Japan Department of Internal Medicine Division of Gastroenterology and Hepatology Jikei University School of Medicine Tokyo Japan

An 81-year-old Japanese man with jaundice was strongly suspected clinically of having primary sclerosing cholangitis based on clinical examinations and later died of hepatic failure. The entire course of the disease lasted about 10 mo. The autopsy revealed extensive fibrinoid necrosis in the liver, kidney, spleen, pancreas, lung, lymph nodes, and pleura. Particularly extensive fibrinoid necrosis in the portal tracts of the liver induced severe stenoses of the intrahepatic bile ducts, resulting in cholestasis in association with prominent liver injury. There were no findings indicating primary sclerosing cholangitis. The hepatic lesions in this case did not coincide with any known disease including collagen diseases. To clarify the cause of irregular stenoses of the intrahepatic biliary trees on cholangiographic findings, we postulate that some form of immunological derangement might be involved in pathogenesis of fibrinoid necrosis. However, the true etiology remains unknown.

关键词： Jaundice Fibrinoid necrosis Cholangiography Primary sclerosing cholangitis Liver Autopsy

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Quasi-in-situ study on{10-12}twinning-detwinning behavior of rolled Mg-Li alloy in two-step compression(RD)-compression(ND)process

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Journal of Magnesium and Alloys 2022年第10期10卷 2775-2787页

作者： Biaobiao Yang Chenying Shi Siyu Zhang Jingjing Hu Jianwei Teng Yujie Cui Yunping Li Akihiko chiba State Key Lab for Powder Metallurgy Central South UniversityChangsha 410083China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan

Twinning-detwinning(TDT)behavior in a strongly basal-textured Mg-Li alloy during two-step compression(RD)-compression(ND)process was investigated using quasi-in-situ *** behavior and TDT variants selection were statistically discussed with the loading path for the first ***-Schmid twinning behavior was observed in the first step compression,owing to the local stress fluctuations by neighboring twins;in contrast,Schmid’s law well predicted the detwinning variants *** asymmetrical TDT behavior was first investigated to date related with the strong basal texture and loading ***,with the progress of compression,Schmid factors for twinning demonstrated a decreasing tendency;however,those for detwinning during the second step displayed an abnormally increasing trend,fundamentally stemming from prior twinning behavior.

关键词： Twinning-detwinning Mg-Li alloy Quasi-in-situ Biaxial loading

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Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells toward S1P

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Cellular & Molecular Immunology 2006年第6期3卷 429-437页

作者： Hirofumi Matsuyuki Yasuhiro Maeda Kazuhiro Yano Kunio Sugahara Kenji chiba Takayuki Kohno Yasuyuki Igarashi Research Laboratory III (Immunology) Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Discovery Technology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Department of Biomembrane and Biofunctional Chemistry Graduate School of Pharmaceutical Sciences Hokkaido University Sapporo Japan

Sphingosine 1-phosphate （S1P）, a pleiotropic lysophospholipid, regulates signal transduction pathway via Gprotein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes. Higher levels of S1P4 mRNA as well as S1P1 mRNA are expressed in lymphoid tissues such as the spleen, thymus, lymph nodes, and Payer＇s patches. In contrast to S1P1 that plays an essential role in lymphocyte egress, little is known about the role of S1P4 in immune system. In this study, we found that S1P at 10 to 100 nM significantly induced the cell migration and the significant levels of S1P1 and S1P4 mRNA were expressed in mouse CD4 T cells, D10.G4.1 mouse Th2 cells, and ***-2 mouse thymoma cells. In D10.G4.1 and ***-2 cells, S1P-induced migration was almost completely inhibited by pretreatment with pertussis toxin, Clostoridium difficile toxin B, and （S）-enantiomer of FTY720-phosphate, a potent agonist at S1P1 and S1P4. The members of the Rho family small GTPase, Cdc42 and Rac were activated by S1P stimulation in these cells. The transfection with dominant negative or constitutively active forms of Cdc42 and Rac revealed that the activation of both Cdc42 and Rac is essential for S1P-induced migration of these cells. The immunoprecipitation assays using CHO cells co-expressing both S1P4 and S1P1 receptors indicated that S1P4 and S1P1 are associated on the cell surface. These results suggest that the association of S1P4 and S1PI plays an important role in migratory response of mouse T cells toward S1P.

关键词： S1Pi S1P4 S1P FTY720 T cell migration

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FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration

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Cellular & Molecular Immunology 2005年第6期2卷 439-448页

作者： Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima Mamoru Koyama Atsyshi Fukunari Kenji chiba Research Laboratory Ⅲ(Immunology) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Research Laboratory 1(CNS) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Discovery Technology Laboratory Ⅰ Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Research Laboratory Ⅲ(Immunology) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma Corporation1000 Kamoshida-choAoba-kuYokohama 227-0033.Japan.

FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, （S）-enantiomer of FTY720-phosphate [（S）-FTY720-P] on experimental autoimmune encephalomyelitis （EAE） in rats and mice. Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE, and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4^＋ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and （S）-FTY720-P. When FTY720 or （S）-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4^＋ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4^＋ T cells into the inflammation site. Cellular ＆ Molecular Immunology. 2005;2（6）：439-448.

关键词： FTY720 S1P receptor modulator lymphopenia EAE T cell infiltration

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Effect of Treatment Temperature on Iron Nitride Foils Irradiated with Nitrogen Plasma

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Journal of Materials Science & Technology 2000年第2期16卷 143-144页

作者： K.Niizuma and Y. Utsushiforwa (College of Industrial Technology, Nihon University, Narashino, chiba 275-8575, Japan) College of Industrial Technology Nihon University Narashino Chiba 275-8575 Japan

We investigated the effect of treatment temperature on the magnetic property of iron nitride foils irradiated with nitrogen plasma. The iron nitride foils irradiated with nitrogen plasma were composed of ε-Fe2/3N, γ'-Fe4N and γ nitrogen austenite in α-Fe of the matrix. The saturation magnetization of the iron nitride foils decreased with increasing the surface temperature. The coercive force of the iron nitride foils increased with increasing the surface temperature.

关键词： Effect of Treatment Temperature on Iron Nitride Foils Irradiated with Nitrogen Plasma

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Microstructural Characteristics of Underwater Shock Consolidated Aluminum Composites

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Journal of Materials Science & Technology 2003年第4期19卷 341-345页

作者： K.Raghukandan K.Hokamoto J.S.Lee A.chiba B.C.Pai Department of Mechanical Engineering and Materials Science Kumamoto UniversityKumamotoJapanShock Wave and Condensed Matter Research Center2-39-1 KurokamiKumamoto UniversityKumamotoJapanGraduate studentGraduate School of Science and TechnologyKumamoto UniversityKumamotoJapanDepartment of Mechanical Engineering and Materials ScienceKumamoto UniversityKumamotoJapanRegional Research LaboratoryThiruvananthapuramKeralaIndia

Metal matrix composites (MMCs) offer extra strength and high temperature capabilities in comparison with unrein-forced metals. Aluminum composites possess higher stiffness, strength, fatigue properties and low weight advantages. Carbon fiber reinforced Al composites (Al-Cf) and silicon carbide particulate reinforced Al composites (AI-SiCp) were shock densified using axisymmetric assemblies for underwater explosions. Unidirectional planar shock waves were applied to obtain uniform consolidation of the composites. The energy generator was a high explosive of 6.9 km/s detonation velocity. Irregular morphological powders of Al were the base material. The reinforcement ratio was 15 Vol. pet for Al-Cf composites and 30 Vol. pet for AI-SiCp composites. The microstructural and the strength characteristics of the shock consolidated Al composites are reported.

关键词： Shock consolidation Aluminum composites Microstructure Strength characteristics

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